Kamiya Hiroshi: I am grateful for the completed movie sequel to be shown!
Kamiya: Even if someone humble like me has a big TV at home, it’s not the same as watching it on the big screens! [laugh] That’s quite random, sorry about that. Well…now the exciting part will start from now on…everyone will be impressed with it, I just want everyone to be able to enjoy it, well…Hey it is because you are way too popular! It’s a wonderful thing to be able to watch this on the big screen. I want to add that the appeal of Levi’s 3DMG operating scene is something that I can’t experience from watching it at home.
Interviewer: Indeed there are a lot of highlights in the sequel screening. On the other hand, as for Ono-gurai (the honorific –gurai is the same as what Kamiya used), what would you like to point out?
Interviewer: My apologies.
Ono: I can’t believe that someone like me could become a famous VA and be able to have 21-inch TV at home. It’s just like what Kamiya said, to be able to watch the theatre version is really incredible and meaningful.
Ono: What are the difficulties you faced while working on Shingeki no Kyojin?
Isayama: Yes, I think it wasn’t all just fun and games.
Kamiya: He seems to want to know about our negative opinions!
Ono: To be honest, there was a long period of time when I didn’t understand Erwin, it was tough. I had to perform as this character, but when I started to think about what happiness means to Erwin, I felt anguish.
Isayama: When the author (Isayama himself) is feeling fluffy, the character also feels the same way.
Kamiya: That is way too blunt!
Ono: Initially when we were talking about being fluffy…
Isayama: At first glance he [Erwin] does look like superman…
Kamiya: That’s why, I am happy to be part of this movie made by the supervisor. And to respond to Isayama-sensei’s earlier question: the part that I hated was… I thought ‘there’s no way I can overcome such pressure!’ That’s the part I hated about it. As for now, I have come to feel that to be gifted with the role of being this character’s VA, I feel proud and am confident that there is no VA who could be this happy.”
Ono: Then, all preparations have been completed? From now on as well OFFER UP YOUR HEARTS for Shingeki no Kyojin!
「Learn Japanese」 参考までに as “just for reference" with Bungou Stray Dogs #01. (Anime Vocabulary)
僕は嫌ですからね！ Boku wa iya desu kara ne! (“I’m not doing this, okay?!”) それってつまり、餌ってことじゃないですか!! Sore tte tsumari, esa tte koto jyanai desuka!! (“This just means that you’re going to use me as bait, doesn’t it?!”)
報酬出るよー Houshuu deruyo- (“There’s a reward.”)
報酬？ 報酬って…いやいや、そんなものじゃ釣られませんからね! Houshuu tte… iyaiya, sonna mono jya tsuraremasen kara ne! (“What? A reward..? No, no, you’re not going to tempt me to with that!”) ち、ちなみに…参考までに聞きますが、その報酬というのは… (“B-By the way… This is just for reference, but this reward, how much are we talking about…”
Researchers at Penn Medicine have generated a brain development index from MRI scans that captures the complex patterns of maturation during normal brain development. This index will allow clinicians and researchers for the first time to detect subtle, yet potentially critical early signs of deviation from normal development during late childhood to early adult.
“Our findings suggest that brain imaging via sophisticated MRI scans may be a useful biomarker for the early detection of subtle developmental abnormalities,” said Guray Erus, PhD, a research associate in the department of Radiology at the Perelman School of Medicine at the University of Pennsylvania, and the study’s lead author. “The abnormalities may, in turn, be the first manifestations of subsequent neuropsychiatric problems.”
Among its key findings is the consistency in healthy brain development of young people. The study examined cognitive performance of outliers – adolescents whose brains developed faster or slower than the normal rates. Early maturers performed significantly better than those with delayed brain development in the speed at which they completed certain tasks. The improved speed of performance indicates increased efficiency in neuronal organization and communication. Slower performance in such tests is a precursor to neuropsychiatric disorders, (the research suggests), including adolescent-onset psychosis.
The 14 tests used in the Penn study evaluate a broad range of cognitive functions including abstraction and mental flexibility, attention, working memory, verbal memory, face memory, spatial memory, language reasoning, nonverbal reasoning, spatial processing, emotion identification, and sensorimotor speed.
Penn’s brain development index consolidates a number of complex visual maps derived from sophisticated analysis of MRI scans into a unified developmental template. By looking at an individual’s brain maps in relation to the consolidated findings, researchers can estimate the age of the subject. Subjects whose brain development index was higher than their chronological age had significantly superior cognitive processing speed as measured by the cognitive tests compared to subjects whose brain indices were lower than their actual age.
“This is analogous to producing growth charts used in pediatrics to screen for gross abnormalities of physical development,” said Christos Davatzikos, PhD, professor of Radiology and Electrical and Systems Engineering at Penn and one of the study’s co-senior authors. “We can assess individuals in terms of where they place in relation to the overall trends. While single image maps can be used for an accurate estimation of the age of the subject, the combination of all maps achieves a higher accuracy in age prediction than the accuracy of each map independently.”
Previous studies have outlined normative trajectories of growth for individual brain regions across the lifespan; the Penn study is the first to present a comprehensive index for the entire brain during late childhood, adolescence, and young adulthood – periods when the healthy human brain maturates in a remarkably consistent way, deviations from which possibly signify later neuropsychiatric problems.
The Penn study used a sample of 621 participants in the Philadelphia Neurodevelopmental Cohort, a Grand Opportunity study funded by the National Institute of Mental Health, designed to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness and how genetics impacts this process.
“All of our young study participants have received a standardized neuropsychiatric evaluation at intake, and all agreed to be contacted for future studies. Some are followed up longitudinally,” said Ruben C. Gur, PhD, director of the Brain Behavior Laboratory at Penn and the study’s other co-senior author. “We can therefore follow those who score low on our index and examine whether interventions such as cognitive remediation can mitigate potential symptoms.”