By blocking a widespread enzyme, Centenary researchers have shown they can slow down the movement of cells and potentially stop tumours from spreading and growing.
Using a new super-resolution microscope they’ve been able to see single molecules of the enzyme at work in a liver cancer cell line. Then they’ve used confocal microscopes to see how disrupting the enzyme slows down living cancer cells.
The enzyme is DPP9 (dipeptidyl peptidase 9) which the researchers at the Centenary Institute and the Sydney Medical School were first to discover and clone, in 1999. Ever since they’ve been studying what it does, with a view to its possible use as a cancer drug target.
“It was exciting to be able to watch the enzyme at work and then block DPP9, and see the cells slow down,” says A/Prof Mark Gorrell from Centenary’s Molecular Hepatology unit. “This gives us our clearest evidence yet that this enzyme will be a good cancer drug target.”
“What this work has shown us is that this enzyme is absolutely critical to cell movement, and without cell movement, tumors can’t grow or spread,” says Gorrell of the work, published in the the leading European cell biology journal BBA Molecular Cell Research.
Obama Derangement Syndrome has been pretty funny diversion for the past six years, but seeing Republicans leap to the anti-vaccination camp because Obama came out in support of vaccinations it moves away from ‘funny’ to 'pathological.’
The government has nothing to do with the issue of vaccinations, Bob, you stupid fuck. Nothing. It is about the health and well-being of children in general and society at large. This is not a partisan issue you goddamn, life-endangering moron. I don’t want you to die in a fire but I at least want you to get horribly burned so you can carry a reminder of your fuckwad ignorance with you for the rest of your life.
Or better yet, get polio. Go contract polio and spend the rest of your life in a wheelchair or an iron lung. That’ll really show Obama and those big government Democrats, won’t it, you mouth-breathing, shit-eating, collective-intelligence-lowering fuckface.
“remember when we had a president who actually was this terrible? man what a shitty guy, we remember the minute details of the incompetent things he said and did so well it’s part of the shared lexicon which at the slightest whiff can immediately conjure to mind the platonic ideal of the Shitty President. anyway fuck obam”
On this day in music history: November 14, 1960 - “Georgia On My Mind” by Ray Charles hits #1 on the Billboard Hot 100 for 1 week, also peaking at #3 on the R&B singles chart on the same date. Written by Hoagy Carmichael and Stuart Gorrell , it is the first number one pop single for the musician dubbed “The Genius”. Famed musician and songwriter Carmichael will write “Georgia” in 1930 and becomes one of his best known and loved songs. Recorded at Capitol Studios in New York City on March 25, 1960, Charles’ version is released from his album “Genius Hits The Road” (his first for new label ABC-Paramount). In 1979, Charles’ version of the pop standard will become the official song for the state of Georgia. Charles will also receive a public apology from Georgia state officials after having been banned from performing in the state when he refused to perform to segregated audiences in 1964. Ray Charles’ recording of “Georgia On My Mind” is inducted into the Grammy Hall Of Fame in 1993.