genetic-disorder

Fibrodysplasia ossificans progressiva (FOP) is a progressive genetic disorder that turns soft tissues into bone over time. The ACVR1 gene found in bone, muscles, tendons, and ligaments regulates growth and development of those tissues, and is normally responsible for turning cartilage into bone as children develop. However, mutations of this gene can allow ossification to go unchecked throughout a sufferer’s life, even turning skeletal muscle into bone and causing joints to fuse together.

This disorder occurs in about 1 in 2 million people, and there are currently no treatments or cures. Trauma exacerbates the condition, so attempts to remove bone surgically just results in the body producing even more bone in the area.

2

On July 9, 1989, Patricia Stallings and her husband David Stallings rushed to the hospital with their three-month-old son Ryan Stallings after he had been experiencing difficulties with breathing and vomiting for at least two days. The test results reportedly showed that Ryan’s blood contained high levels of ethylene glycol, one of the main ingredients in antifreeze. The Pediatrician who treated Ryan suspected he had been poisoned by either Patricia or David Stallings. Eight days later, Ryan was released from the hospital and placed in a foster home due to the suspicion that his parents might be responsible for the pain little Ryan had to endure. During the time Ryan lived in foster care, the Stallings’ contact to their son was very limited and they were allowed to visit him for one hour one day per week. In September, 1989 three days after Patricia was left alone with Ryan for a brief period of time, he was hospitalized again and died a short time later. She was arrested the following day after Ryan’s death. Unbeknownst to Patricia at the beginning, she was pregnant again and while being in jail awaiting trial, Patricia gave birth to the couple’s second son, David Jr. After being placed in a foster care home, David Jr. displayed the same symptoms the first son of the Stallings’ did, although David Jr. met the criteria for a rare genetic disorder called MMA in which the body can’t properly process certain types of proteins and fats and produces methylmalonic acid, which is identical to the chemicals found in antifreeze. He was treated and fully recovered. However, when Patricia was tried, the judge didn’t allow Stalling’s attorney to present the theory that Ryan’s cause of death wasn’t because of antifreeze poisoning, but MMA. She was convicted of first degree murder and assault and got a life sentence. Months after the sentencing, the case was featured on a show called “Unsolved Mysteries” which biochemist William S. Sly of St. Louis University happened to see. He tested Ryan’s blood and eventually proved that Ryan suffered from MMA. Piero Ronaldo of Yale University also confirmed that the cause of death was indeed MMA. In July, 1991 Patricia was released from jail. On September 20, 1991, all charges were dropped and prosecutors apologized to the Stallings family and on the same day their second son, David Jr, was finally given to his parents.

Xeroderma pigmentosum is an autosomal recessive disorder that results in the skin’s inability to repair damage caused by ultraviolet light. This results in symptoms such as severe sunburn, development of excessive freckles, cry skin, blisters and corneal ulcerations. One of the most common causes of death in people with Xeroderma pigmentosum is skin cancer - specifically metastatic melanoma and squamous cell carcinoma.

Marfan Syndrome - explained!

What is it? -

● Marfan syndrome is a genetic disorder.

● It affects the body’s connective tissue that holds all the body’s cells, organs and tissue together.
(Think of it as the main glue that holds your body together)

● Marfan syndrome is caused by a defect (or mutation) in the gene that tells the body how to make fibrillin-1.
This mutation results in an increase in a protein called transforming growth factor beta, or TGF-β. The increase in TGF-β causes problems in connective tissues throughout the body, which in turn creates the features and medical problems associated with Marfan syndrome and some related disorders.

● Marfan syndrome can affect many different parts of the body.

● Features of the disorder are most often found in the heart, blood vessels, bones, joints, and eyes.


● Some Marfan features can be life threatening.

● The lungs, skin and nervous system may also be affected.

● Marfan syndrome does not affect intelligence.

Who can get Marfans? -

● 3 out of 4 people inherit it, meaning that it’s passed on from one or both parents.

● Some people can get it by having a spontaneous mutation in their DNA.

● There is a 50% chance that Marfans will be passed onto a child.


● People with Marfan syndrome are born with it, although it may not be clear right away.

● Some people have a lot of Marfan features, whilst others don’t.

● As it is a degenerative condition, people are more likely to develop symptoms & other related diseases as they grow up and age.

● Generally, Marfan syndrome deteriorates and gets worse over time.


What are the signs? -

● Enlarged aorta or heart problems.
● Long arms, legs and fingers.
● Tall and thin body type.
● Curved spine (scoliosis)
● Chest sinks in or sticks out.
● Flexible joints or hypermobile.
● Flat feet.
● Crowded teeth or high arched palate.
● Stretch marks on skin that aren’t related to weight loss, pregnancy or weight gain.
● Sudden lung collapses.
● Eye problems such as dislocated retinas, serve nearsightedness, blindness ect.
● Photosensitivity (very sensitive to lights)


Is there any cure or treatment? -

Sadly there hasn’t yet been a lot of research into Marfans, so consequently ther isn’t any cure or treatment.

However, there are ways of managing the condition/s with medication, light excersice & lifestlye changes.

Marfan syndrome needs to be kept an eye on with regular check ups for the whole body & organs.

People with the condition find that they have to be on medication for the rest of thier life, with the posibility of surgery for various complications & connected reasons.


Marfan syndrome is a rare disorder / disease, especially in the UK where getting health care & support for it is extremely difficult or near impossible.

There isn’t enough knowledge or understanding of Marfans in the UK as there is compared to the USA or Canada.

There isn’t any family support groups or clinics to go to, never mind people who have Marfans or similar disabilities.

ambuck  asked:

Hi Cassie, with mundane medicine being forbidden in the Shadowhunter world I'm wondering what would happen to those with rare genetic diseases. My daughter has one called cystinosis and requires a lot of medicine to keep her healthy. Would a genetic disorder be something that the Silent Brothers could heal? Or would her family need to become mundane so she could live? Are Shadowhunters even susceptible to genetic disorders? Thank you for your time :)

They would be treated by the Silent Brothers. The Silent Brothers and their magic are actually really useful — there are some areas that we’ve seen in which Silent Brothers are not the optimum option for treatment. Anything the Shadowhunters don’t believe exists, for starters! But in terms of sicknesses of the body, there are a lot that Silent Brothers can simply cure early in life. There are disadvantages to being a Shadowhunter, but also advantages, and access to the magic and medicine of Silent Brothers and warlocks is one of them. If Shadowhunters didn’t die so often in battle, they would likely have longer lifespans than mundanes.

Human DNA: A history

DNA is an important part of modern crime evidence, but it is important to know when DNA is actually used in history, and the experiments it took to actually get DNA to be the robust science it is today. Hopefully this is helpful for your writing needs!


DNA Timeline

1866 – Gregor Mendel determines the principles of genetic inheritance

1902 – Sir Archibald Edward Garrod associated Mendel’s theories with human disease alkaptonuria (black urine or black bone disease, genetic disorder where the body cannot process the amino acids phenylalanine and tyrosine)

1944 – Oswald Avery, working with MacLeod and McCarty determines DNA as the “transforming principle”, while working with Streptococcus pneumoniae (bacteria causing pneumonia), it was determined that dead/heat-killed S-strain (which is lethal) can “transform” living R-strain (which is non-lethal) into lethal bacteria

1950 - Chargaff’s rules was developed by Edwin Chargaff, it basically states that there is a 1:1 ratio of pyrimidine and purine bases, that adenine = thymine, and guanine = cytosine, an important rule for base pairings and the DNA double helix structure

1952 – Alfred Hershey and Martha Chase experimented with T2 phage and elemental isotopes; phosphorus-32 labelled DNA while sulfur-35 labelled the proteins; the progeny infected unlabelled bacteria, and since phosphorus-32 showed up, it confirmed that DNA is the genetic material

1952 – Rosalind Franklin uses X-ray crystallography to photograph DNA fibres

1953 – James Watson and Francis Crick uses Franklin’s crystallography and previous research material to determine the double helix structure of DNA

1959 – an extra chromosome 21 is linked to Down’s syndrome

1965 – Marshall Nirenberg worked with E.coli bacteria cells to determine how DNA is involved with RNA and protein expressions, he helped decipher the codons of the genetic code

1977 – Frederick Sanger develops a technique for rapid DNA sequencing, the Sanger sequencing is also known as chain termination method based on selectively incorporating chain-terminating dideoxynucleotides (ddNTPs)

1984 – Sir Alec Jeffreys developed the multi-locus RFLP probes, a method to compare the variations in DNA of different individuals, leading way to genetic fingerprinting

1986 – The first use of DNA testing in a forensic case, using Jeffreys’ multi-locus RFLP probes for DNA typing to catch Colin Pitchfork, who sexually assaulted and murdered Lunda Mann in 1983 and Dawn Ashworth in 1986

1990 – the Human Genome Project begins, with the goal of mapping all of the 3.3 billion bases of the human genome, and the genome of other organisms, this project costed about $2.7 billion (this amount wasn’t calculated for inflation) and took almost 15 years to complete, compare that to now where it will take about $1000 to sequence the human genome and it will take about a day to do so

2013 – it was discovered that identical (monozygotic) twins actually have differences in their genetic make-up, with differences/mutations called Single Nucleotide Polymorphism (SNPs)

Why Mutants In X-Men Are a Great Analogy for Neurodivergents

I’m gonna look at it from an autism perspective but most of it applies to pretty much all neurodivergents, I think. :)

1. Autism is a mutation. Technically, we are mutants already.

What is a mutation? A variant form of a gene, which can be genetically passed on. 

What is autism at its core? A variation in brain thinking patterns and cognition which can be genetically passed on.

Ergo, we autistics (along with our neurodivergent brethren) are mutants.

2. They are misunderstood and judged based on their mutation.

How many times have you seen someone arrested for killing/trying to kill someone and they mention “Oh, he’s autistic” as if it had anything remotely to do with anything. 

How many times have you heard about how burdensome a child with autism is and how they’re such a burden that they’re the reason their parents break up.

How many times have you heard someone say that autistics are broken because they don’t “function properly”.

3. They are told their mutation needs to be “cured” even though the vast majority of mutants are against it.

Rogue: Is it true? That they have a cure?

Professor X: Yes, Rogue. It would seem so.

Storm: No. No it’s not, ‘cause there’s nothing to cure. Nothing’s wrong with any of us, for that matter.

———————-

Doctor: I just wanted to help you people.

Quill: Lady, does it look like we need to be saved?

4. They have to live in the closet out of fear of being treated differently if anyone finds out they’re mutants

There’s a reason why as soon as I was old enough to understand, my mom (who’s also autistic) taught me to NEVER tell anyone because they’ll treat me differently for no reason and judge me based on that 1 aspect of who I am rather than my actions and beliefs; that they’ll see me by my disorder rather than me as a whole person.

How many of us hesitate getting officially diagnosed based on the fear that it’ll affect our job prospects and/or relationships with people.

How many doctors don’t officially diagnose us because they’re “afraid it’ll have a negative effect”.

5. They have special abilities due to their mutation.

Heightened empathy, hypersensitivity, higher IQ, being able to break down highly complex systems in our minds instead of writing or drawing it out,  image/pattern/verbal thinking, being able to notice problems neurotypicals would never notice, etc  might not be as cool as flying or controlling the weather, but they’re special abilities nonetheless.

6. Their mutation is often a double-edged sword.

All our special abilities have their pros and cons, just just like the mutants’s powers.

Dirk Gently's Holistic Detective Agency

A government experiment turned private detective teams up with a wannabe rockstar with questionable morals and a Navy reject with unstable emotions and uses a kitten that’s really a hammerhead shark to help him find a corgi that’s really a time-traveling millionaire’s daughter. Meanwhile, a serial killer kidnaps a computer hacker and a young girl with a genetic neurological disorder runs away with psychic vampire stalkers. Pandemonium ensues. There’s blood everywhere. (You really should watch this show already…)

Top 10 Things I really wish people would understand about autism

1. Autism is CLEARLY an autosomal recessive genetic trait that is not effected by gender, class or race. (meaning black women are just as likely to be autistic as white boys people!) This also means autism doesn’t just magically go away at age 18; it is  forever.  Negative symptoms of Autism can get better or worse by learning coping strategies or getting more overwhelmed physically and mentally.


2. There is no way vaccines could cause autism; even if autism wasn’t a genetic trait, which it is!


3. Being autistic means you are smarter, have an overall higher cognition level of most things/a higher I.Q. ,not lower compared to most people.

Autistic people tend to be far more creative, intelligent, strong willed and honest then the average person.


4. If a person cannot speak this doesn’t mean that person can’t hear you, understand you, or that they are incompetent or unintelligent.


5. Being “socially stupid” does not mean that you are stupid at everything else.


6. Some Autistic kids really need home school and some really need the push for more social interaction in public school.


7. The main “problem for autistic people” isn’t “behavior issues” it’s communication issues and having a nervous system that makes the person 10 times more sensitive then the average person which is mentally and physically overwhelming.


8. Because autistic people are so overly sensitive to everything, people need to realize things that are just a little harmful for all people like :

dust, pollen, gluten, high sugar diets, sound pollution, light pollution, florescent lights, everyday chemicals

are horrible for autistic people and can cause them to be so overwhelmed they cannot speak/ are in extreme discomfort daily.


9. Because autistic people are so overly sensitive to everything, people need to realize things that are just a little good for all people like:

building ramps instead of stairs to houses, living in a clean, quiet, peaceful environment. Using pet therapy, swimming therapy, occupational therapy, seeing a councilor once in awhile, brushing therapy, weight therapy, having a very comfortable bed, eating and exercising correctly, being your own best advocate

can REALLY help any autistic person be so much happier, healthier and independent.


10. Sometimes a parent and autistic child can do everything right and an autistic child will still not be able to be independent, safe alone, will still be in agony and cannot speak. Until we recognize that the main problem for Autistic people is a hyperactive nervous system and address this scientifically there will be little hope of change for these people.

people with overbites are cute. people with underbites are cute. people with teeth gaps are cute. people with chipped teeth are cute. people with yellowish teeth are cute. people with general teeth problems whether it be because they have a genetic disorder or mental disorder or an addiction or just generally cannot take the best care of their teeth as well as they wish they could are cute. your teeth do not define you. you’re cute either way.

“Make-A-Wish. Can I help you?”

I want to thank all the wonderful Tumblr-folk I tagged in this for contributing to one of the best reads I’ve had in a while. I would also like to apologize to those whose contributions I might have missed.

———————————————————————————–

I wonder if, in superhero universes, the villains ever get contacted by those “Make a Wish Foundation” and similar people.

I mean, the heroes do. Of course they do. Kids who want to meet Spiderman or Superman or get to be carried by the Flash as he runs through Central City for just thirty seconds.

But surely there are also the kids, who - because they are kids and sometimes kids are just weird - decide that what they really, really want is to meet a supervillain. Because he’s scary or she’s awesome or that freeze ray is just really, really cool, you know?

The heroes would be so weirded out by it. The villains with codes of ethics would totally band together to force the villains without one (should they be the one requested) to do their part for the cause.

But imagine the person who has to track down the villains and organize everything?

Like, the first time it happens, no one actually thinks it’s possible, but one of the newbies volunteers to at least try. They get lucky, the kid wants to meet one of the villains who is well known to have a personal code of ethics (eg one of the rogues), and it takes them weeks to track the villain down to this one bar they’ve been seen at a few times, plus a week of staking out said bar, but they finally find them.

So they approach the villain, very politely introduce themselves and explain the situation, finishing with an assurance that, should the villain agree, no law enforcement or heroes will be informed of the meeting.

The villain, assuming it’s a joke, laughs in their face.

At this point, the poor volunteer, who has giving up weeks of their time and no small amount of effort to track down this villain, all so a sweet little girl can meet the person who somehow inspired them, well, at this point the employee sees red.

They explode, yelling at this villain about the little girl who, for some unknown reason, absolutely loved them, had a hand-made stuffed toy of them and was inspired by their struggle to keeping fighting her own and wasn’t the villain supposed to have ethics? The entire bar is witness to this big bad villain getting scolded by some bookish nobody a foot shorter than them.

When the volunteer is done, the villain calmly knocks back their drink, grips the volunteers shoulder and drags them outside. The bar’s patrons assume that person will never be seen again, the volunteer included. But once they’re outside, the villain apologizes for their assumption, asks for the kid’s details so they can drop by in the near future, not saying when for obvious reasons. They also give the very relieved volunteer a phone number to call if someone asks for them again.

A week later, the little girl’s room is covered in villain merchandise, several expensive and clearly stolen gifts and she is happily clutching a stack of signed Polaroids of her and the villain.

The next time a kid asks to meet a villain, guess who gets that assignment?

Turns out, the first villain was quite touched by the experience of meeting their little fan, and word has gotten around. The second villain happily agrees when they realize it’s the same volunteer who asked the other guy. Unfortunately, one of the heroes sees the villain entering the kid’s hospital and obviously assumes the worst. They rush in, ready to drag the villain out, but the volunteer stands in their way. The hero spends five minutes getting scolded for trying to stop the villain from actually doing a good thing and almost ruining the kid’s wish. The volunteer gets a reputation among villains as someone who can not only be trusted with personal contact numbers but who will do everything they can to keep law enforcement away during their visits.

The volunteer has a phonebook written in cypher of all the villain’s phone numbers, with asterixes next to the ones to call if any other villains give them trouble.

Around the office, they gain the unofficial job title of The Villain Wrangler.

The heroes are genuinely flabbergasted by The Villain Wrangler. At first, some of the heroes try to reason with them.

Heroes: “Can’t you, just, give us their contact details? They’ll never even have to know it was you.”

The Villain Wrangler: “Yeah sure, <rollseyes> because all these evil geniuses could never possibly figure out that it’s me who happens to be the common thread in the sudden mass arrests. Look man, even if it wouldn’t get me killed, it would disappoint the kids. You wouldn’t want to disappoint the kids would you?”

Heroes: “… no~ but…”

The Villain Wrangler: “Exactly.”

Eventually, one of the anti-hero types gets frustrated, and decides to take a stand. They kidnap the Villain Wrangler and demand that they give up the contents of the little black book of Villains, or suffer the consequences. It’s For the Greater Good, the anti-hero insists as they tie the Villain Wrangler to a pillar.

The Villain Wrangler: “You complete idiot, put me back before someone figures out that I’m missing.”

Anti-hero: “…excuse me?”

The Villain Wrangler: “Ugh, do I have to spell this out for you? Do you actually want your secret base to be wiped off the map? With us in it? Sugarsticks, how long has it been? If they get suspicious, they check in, and then if I miss a check-in, they tend to come barging into wherever I am just to prove that they can, even if they figure out that they’re not being threatened by proxy. Suffice to say, Auntie Muriel really regretted throwing my phone into the pool when she strenuously objected to me answering it during family time. If they think for even one moment that I’ve given them up, they won’t hesitate to obliterate both of us from their potential misery. You do know some of the people in my book have like missiles and djinni and elemental forces at their disposal, right?”

Anti-hero: “Wait, what? I thought they trusted you?!”

The Villain Wrangler: “Trust is such a strong word!”

Villain: “Indeed.”

Anti-hero: “Wait, wha-” <slumps over, dart sticking out of neck>

The Villain Wrangler: “Thanks. I thought they were going to hurt me.”

Villain: “You did well. You kept them distracted, and gave us time to follow your signal.” <cuts Villain Wrangler free>

The Villain Wrangler: <rubbing circulation back into limbs> “Yeah well, you know me; I do whatever I have to. So I’ll see you Wednesday at four at St Martha’s? I’ve got an 8yo burns unit patient recovering from her latest batch of skin grafts who could really use a pep talk.”

Villain: “… of course. Yes… I… yes.”

The Villain Wrangler: “I just think you could really reach her, you know?”

Villain: <unconsciously runs fingers over mask> “I… yes, but, what should I say?”

The Villain Wrangler: “Whatever advice you think you could have used the most just after.”

Villain: <hoists Anti-hero over shoulder almost absently> “….yes.”

The Villain Wrangler wasn’t lying to the Anti-hero. They know that the more ruthless villains would not hesitate if they thought for one second that the Anti-hero would betray them.

But this is not the first time the Villain Wrangler has gone to extreme lengths to protect their identities.

Trust is a strong word. The Villain Wrangler earned it, and is terrified by what it could mean.

My first official Deadpool headcanon is this. This this this.

Okay but this whole concept actually makes a lot of sense, because villains are a lot more likely to be disfigured/disabled/use adaptive devices (bc ableist tropes), so of course, say, a child amputee is going to be more interested in the villain with a robot arm who almost destroyed New York than the heroes that took him down.

Also, imagine one of the kids gets better, and a few years down the line becomes a villain themselves, except their crimes are things like smuggling chemo drugs across the border for families that can’t afford treatment, or stealing from corrupt businessmen to make donations to underfunded hospitals (idk this turned into a Leverage AU or something) and every time the heroes encounter her, they’re like “oh no. she’s getting away. Curses. Welp, nothing we can do.” Though it isn’t that she can’t take them on; bc of course once the villain from way back when found out what she was up to, he started helping/training her.

“I thought they just hired someone to dress up and pretend to be you,” she says, amazed, when he reveals himself. “I didn’t think they actually got the real you!”

Every year the Villain Wrangler gets a very expensive gift basket from the pair.

And for the kids who don’t get better the villains are there too, they show up to every funeral, they bear too small coffins on their shoulders and the heroes stand aside

They are fierce with grieving families assuring them that their child will not be forgotten, and they don’t balk at negative emotions, they don’t tell people to be strong or “celebrate their child’s life,” because these parents have every right to their grief and anger

And the lost children are never forgotten. Flowers appear on graves during birthdays and anniversaries, heroes find pictures of those kids and they carefully take them down and ensure they’re delivered to the villain’s cell, and a few villains can be seen with friendship bracelets wrapped around their wrists the cops have learned not to try and take them off

They are fierce with grieving families assuring them that their child will not be forgotten, and they don’t balk at negative emotions, they don’t tell people to be strong or “celebrate their child’s life,” because these parents have every right to their grief and anger

And then one day, one of the evil geniuses who happens to specialize in inducing bizarre genetic mutations meets a young fan who was born with a rare genetic disorder that is slowly killing them, and realizes that they can help.

Another, who created their own exosuit, talks to a young fan and suddenly understands how much the technology that they have built for themselves could revolutionize quality of life for people with muscular dystrophy, or paraplegia, or other disorders that confine people to wheelchairs with little mobility.

A third thinks of a way that their nanobots could be used to detect and remove cancer cells when their fan, who had been in remission, writes to say that the doctors have found a new metastasizing tumour.

Then shortly after, an evil genius specializing in cloning is contacted by an old colleague asking if a suitable heart couldn’t be grown for their young fan with a congenital heart condition who needs a donor.

Suddenly, a pattern of villains offering (and marketing) their insights and resources to improve medical science starts to arise. Many who had previously been operating on society’s fringes are shocked to receive public accolades, research grants and job offers from major companies because of their work.

A grassroots movement arises advocating for imprisoned villains with appropriate qualifications and/or experience to have access to resources to conduct research for the public good. The Second Chance Rehabilitation Project launches.

(It is an open secret that only people who have been vetted by the Villain Wrangler are allowed to join, because the Villain Wrangler has by now a meticulously set up method and intelligence network to run background checks and character references through ensure that none of the children wishing to meet their role models get hurt.)

This is all soooo good, but I wonder what effect this has on the villains. Like, can they really wreak indiscriminate havoc when they know the kids that worship them might be in the area? Like, what if they attack a shopping mall and it just so happens that Annie’s mom ran in for a pair of shoes or something? What then?

So what you’re saying is that there is now an organization of henchmen who do round the clock, exhaustive research in order to make sure the villain’s plan isn’t going to ruin the life of some kid. Just imagine some aunt getting a call from an unlisted number.

“I swear I am not a bill collector ma’am. It’s just. Well. Ok and I swear I am not a stalker even if this is actually going to be a very creepy phone call, but you said you were going to the mall at four? Is it possible you could reschedule or postpone that trip for about an hour? That mall is way too close to…well. It just wouldn’t be safe. I could wire you some money, and you could go to the much nicer mall one town over? Would that work for you? No? You are calling the police? Yes. Yes that is the sensible thing to do. Definitely do that. You have a nice day, ma’am. Tell Marcus Doctor Evil says hello and to have a nice day.”

And then the poor minion has to call the villain and explain why robbing X bank isn’t a good idea that day.

“Yes. Hello. Sir? Oh good I caught you before you left the base. Look, Marcus Smithson’s aunt is going to be near the blast radius for that job you have scheduled so-yes. Yes I am aware that rescheduling is going to be a lot of work since most everything is already set up, but….but, sir think about poor Marcus! She’s his favorite aunt, and the woman refused to ‘reorder her life around some crazy mastermind’. ……no…..no, please do not kidnap the aunt, sir. It’s terribly rude. Yes I realize you weren’t going to keep her or doing anything other than drop her off at an alternative location, but, well, citizens frown upon that sort of thing and….yes….Yes, of course. You have a good day, too, sir.”

And they turn to their coworker and are just like “So if I don’t come in to work tomorrow it’s because Doctor Evil threw me in his dungeon and/or sent his hellhounds to maul me. Please remember to send help.

But but but… what happens when one falls through the cracks? When Lord Dominion or whatever does a typical baddie thing but then Penny’s new best friend gets caught up in the damage and Lord D didn’t even KNOW Penny had a new bestie so how was he to know? But now the kid is devastated and it’s all his fault? I mean, how does that even shake out?

Penny SWEARS REVENGE! Lord D is distraught but also somewhat proud. He sends Penny a very sincere apology and also a bunch of tips on how to execute a proper vengeance plot, in case she decides not to accept the apology. He sends henchmen to spy on her, and he keeps the surveillance photos of her sitting in her room, plans and schematics strewn all over her desk. He puts them in his wallet and brags to all his villain friends that one of his kids is taking up scheming, look at her go, she’s already started on pattern analysis of his latest heists. He’s so proud. Later this month he’ll show up on her way home from school so she can have her first Confrontation.

There will inevitably be mistakes and tragedies.

Penny is an intelligent kid. She catches on to the spying henchmen pretty quick and bribes some of them to her side with snacks. That first confrontation does not go like Lord Dominion expected because Penny has minions (minions that are using his OWN WEAPONS against him, even)

Lord Dominion is the proudest villain ever, even if he did almost lose an ear thanks to the impeccable aim of a nine year old with a grudge. He does let the laser blast graze him just so he can have a scar to show people because that girl is a villain after his own heart.

He doesn’t want to ask his villain rivals to help her out because that would imply he doesn’t think she’s capable of eventually growing strong enough to kick his ass. Turns out Penny already thought of that and has mailed letters asking for advice to Lady Sinister, Lord Dominion’s long time, mostly friendly rival. (She mailed a letter to Lord D’s arch nemesis, but man. Heroes are always trying to make you do The Right Thing. Penny doesn’t have time for the high road. Plus, the low road has lasers.)

Lady Sinister thinks Penny is the best thing ever and while she has mostly stopped kicking Lord D’s ass, she still breaks into his hideout to sit in his favorite chair with a glass of wine and brags about her new favorite up and coming villainess. (She doesn’t warn Lord D about the attack rabbits she agreed to train for Penny as a favor, and for obvious reasons, she is going to be a bystander at the next confrontation, filming everything on her phone to post the dark web so all their villain friends can see this)Being able to say that one is involved with the Project begins to look really good in parole hearings. The Villains involved perform their own quality checks on one another, because if one of their kids got hurt, then all of their kids could potentially lose out, and the ones that are serious about the Project are not having that. (Also, the ability to collaborate with other geniuses is the most interesting thing to happen to most of them since losing to various heroes, and most consider the intellectual stimulation to be worth putting up with the ridiculous egos and inevitable personality clashes that arise.)

Reformed Villains come out of the woodwork to advocate about better mental healthcare, and support systems. Savvy universities and private labs quietly take their advice, setting up better mental health supports and laboratory safety standards to prevent the Brain Drain caused by losing their less stable scientists to the Costumes.

The Villain Wrangler watches all of this develop with a smile.

Their plan succeeded beyond their wildest dreams.

I’m so down for these posts that assume the best of people instead of the worst

Okay, this part caught my attention: “…the Villain Wrangler has by now a meticulously set up method and intelligence network…to ensure that none of the children…gets hurt.” Which led me to the heartbreaking realization that one DID. Get hurt, that is, by the villain they idolized.

And all I can think is that the Villain Wrangler didn’t call in the heroes. They didn’t call in another heart-of-gold villain. No. The VW rolled up their sleeves and went after this person themselves. This project is their baby, after all. If they get the accolades for the successes, they must also shoulder the burden of the failures.

The VW hunts down the villain that crossed the line. Their punishment is swift and horrifying; no hero would have the stomach to mete out justice in such a way, and no villain would have the desire to get quite that much blood on their own hands.

There’s. So. Much. Blood.

The Villain Wrangler never forgets. They increase security, increase the hours and background checks, they increase the graveside visits to the child they failed.

Just the one. But one is one too many.

{ ��=����

I want to delve into a dangerous topic. I want to talk about abortion and eugenics.

Even when abortion was illegal, it was sometimes performed legally in hospitals if the pregnant person was at risk of death, or if they were disabled. People with Down Syndrome sometimes found themselves forced into hospitals to have their pregnancies terminated, often against their will. Then abortion was legalized and I will say, flat-out that this was a good thing.

I believe in free, unlimited access to legal, safe abortion. Whether you believe life begins at conception or at birth, you still have no say over somebody else’s bodily autonomy. It is abhorrent to force somebody to carry a pregnancy to term if they don’t want it. Especially considering what a toll pregnancy has on a body. Also, legislating abortion only increases the number of unsafe, back alley abortions, with more and more people becoming injured or dying by coat hangers and knitting needles. Abortion needs to be safe and legal and accessible, full stop.

Over the last few decades there has been a rise in availability of pre-natal testing. Sonograms and amniocentesis leads to pregnant people finding out sooner and more frequently if their fetus has an impairment or a genetic disorder. Since genetic testing has become more available, the number of abortions due to “defect” are on the rise. Fetuses that are screened and found to have Down Syndrome or spina bifida are being aborted more and more, with promises from doctors and nurses that the parents can always “try again.”

Over the past few decades more and more money is going into genetic autism research, in the effort to create a test to reveal whether or not a fetus will become an autistic person.

Aborting a fetus simply because of impairment or disease is eugenics.

Pro-choice advocates often say things like “forcing a woman to carry a disabled fetus to term is abuse,” with emphasis placed on the idea that disabled children are burdens on their parents and society. They talk about “quality of life” of both the parents and the potential child, but usually weighted more to the parents. This is all ableist rhetoric. To be entirely honest, all children are “burdens” in that they need to be taken care of and protected and housed and fed and clothed without being able to contribute to society. But we don’t usually tell parents that all their healthy, able-bodied kids are burdens, do we? We call children “gifts” and “treasures.”

Anti-choice advocates often say things like “Disabled children are a gift from God! They’re a blessing!” But this is ableist rhetoric too. It dehumanizes disabled children, turns them into objects and life lessons. Disabled children are human beings just like everyone else, with gifts and faults.

When a pregnant person is told by the doctors that their fetus is disabled or has a genetic disorder, they hear a lot of ableist rhetoric. They’re told by doctors that their future child will have no quality of life. That they’ll be a burden. That they’ll suffer. That their life is basically worthless. Doctors often urge and wheedle and even bully pregnant patients into terminating disabled fetuses. They are told that even if they follow through with the pregnancy but give the baby up for adoption–because they can’t afford to take care of a special needs child–the child will likely not be adopted because “nobody wants a broken child.”

So where do we draw the line? Do we make it illegal to terminate a disabled fetus? No. That sets us down a slippery slope and then it’s only a short trip from “some fetuses can’t be terminated” to “no abortion for anyone,” which leads us right back to back-alley knitting needle abortions.

Do we limit access to pregnancy screenings? Maybe. In India, when more and more couples were aborting fetuses determined to be female due to institutionalized sexism and misogyny, they made it illegal, as of 1994, to find out the sex of your child during pregnancy. But that could also lead us down a slippery slope. After all, parents are entitled to be prepared for what’s coming next right? And especially in regards to genetic diseases like Tay-Sach’s, where the child will be in excruciating pain and suffering, and then die by age four, isn’t it sometimes kinder to know? I’m not sure, this is an ethical discussion that I’m not sure I’m qualified to make a definitive ruling on.

Here’s what I think should happen. I think that when a pregnant person discovers their child has an impairment or genetic disorder, they need to be immediately educated. They should be given research into the condition, and introduced to living adults who have the condition in question. Not just parents who believe their disabled child is a burden, but living adults who can tell their own stories about growing up with the condition in question, and give voice to their own quality of life. Pregnant people should be encouraged to make informed, educated decisions, not just jump at their doctors suggestions uninformed.

Also, we need increased access to support systems and services. It should be a lot easier than it is to take care of a “special needs” child and raise them to be an independent adult.

We need to destroy the systemic ableism that tells us disabled people are burdens, disabled people are pitiable, disabled people suffer, disabled people can never be healthy and happy and live long successful lives. We also need to destroy the idea that quality of life is determined by accomplishment and productivity.

Also, please remember that doctors are not the be-all, end-all definitive voice of what is. A doctor’s opinion is an educated OPINION. Feel encouraged to get a second opinion and to do your own research.

Our enemy is not disability. Our enemy is not abortion. Our enemy is ignorance and oppression and a society that benefits from racist, sexist, ableist exploitation and oppression.

anonymous asked:

My dream dog is a Newfoundlander, and I have a responsible breeder already picked out for when I have a big enough yard and a steady job, but I'm finding it hard to find much info on them. Opinions?

They are a relatively rare breed owing to their size, fur and drool, but I have known a few of them over the years.

These dogs are just… messy.

(Image Source)

They are big they seriously shed and they drool like a running tap, which essentially sticks that shed hair to every available surface like glue. This is a breed so fundamentally unsuitable for my personal lifestyle that I swiftly change the topic every time the boyfriend brings up that he wants one. Speaking of changing topics, lets look at them from a medical standpoint. You may want to make yourself a cup of tea, this will be a long post.

Hips are a major issue with this breed. The Orthopedic Foundation for Animals ranks their hips, as a breed, as worse than the notorious German Shepherd. Worse again, symptoms of hip dysplasia are often aggravated by the increased size or weight of the animal, and this breeds is one of the largest ones. This causes pain and suffering. 25% of them are estimated to have dysplastic hips, with only 8% estimated to have ‘good’ hips.

Elbows are another weakness for this giant breed. Again around 20-25% of these dogs are estimated to be afflicted with elbow dysplasia. Some unfortunate individuals with have both elbow and hip dysplasia, leaving them without a good leg to stand on. Problems often develop by18 months of age, and will cause pain for the dog for the rest of its life.

Tears of the cranial cruciate ligament are also fairly common, due to sheer size and probably other orthopedic dodginess. If not treated surgically this will cause severe lameness and arthritis in the joint.

By the way, if you were wondering about the costs of these surgeries to patch up a Newfoundland skeleton, you’ll probably spend $2.5-3k on the dysplastic elbows, $2.5-3.5k per cruciate tear, and between $1.4k and $7k each side for the dysplasitc hips, depending whether they are diagnosed young, or so late that only a total hip replacement will help. Just so you know.

The consequences of leaving these conditions untreated is arthritis far sooner in the dog’s life than is fair. Some dogs will be unable to walk without daily medication from 4 years of age. Many will be put to sleep simply because their  mobility has become so impaired that they can no longer to doggy things.

Do you need a break? Because we’re not even halfway through yet.

Originally posted by sternenpalast

Personally, I have a thing against bad eyes. I can’t stand eyes that look painful, it gives me the heebie-jeebies. These poor dogs, as you probably have guessed, are prone to multiple eye conditions.

While they do get cataracts, 3rd eyelid gland prolapse and ectropion, the biggest one that concerns me is entropion. This means that the eyelids rolls inwards towards the eye. This means that instead of lovely, soft, moist conjunctiva touching the eyeball, you have prickly eyelashes or haired skin. These prickly hairs rub against the eyeball, constantly, and will cause pain, inflammation, corneal ulcers and secondary effects of healing them.

That’s just constant irritation and pain. It requires surgery to fix, again.

They also get subaortic stenosis (SAS) far too frequently.This heart condition is congenital, it’s present at birth but is often not apparent until 4+ months of age, just long enough to get that puppy well loved in a new home. While it can be managed with medication or heart surgery, only 25% of affected dogs live for more than 4 years. It can cause fainting and sudden death.

(Thanks Richard for picture)

That’s not a great disease to have running through the breed. If they don’t succumb to that heart disease young, they may also get dilated cardiomyopathy when they’re older. You know, because one heart disease wasn’t enough.

Also located under that shaggy mess of drool covered fur is another genetic disorder that can cause them to excrete cystine into their urine, resulting in urinary crystals or great big bladder stones that may require more surgery.

And of course these big, deep cheted dogs are a classic breed that gets Gastric Dilatation Volvulus (GDV aka Bloat) which can happen without warning, leaving you with a choice of either major, expensive surgery or euthanasia.

Working towards the outside of this giant breed, their thick fur might look cute, it it takes maintenance. Prepare for everything you own to be liberally coated in dog hair.

They are also profuse droolers. Their flappy jowls produce some of the most drooly dogs I’ve been, often soaking their own chest fur.

Which brings me back to Hot Spots, (aka moist dermatitis). Persistently wet skin, especially on a thick coated breed that loves water like the newfoundland, A hot spot can be huge and they spread rapidly, sometimes affecting the whole neck. Because these dogs often have some degree of skin folding there, that makes the problem even worse. The same issue happens at the other end if they have diarrhea. And being in Australia, in Summer, when more people than usual take their dogs swimming, there is also a high risk of flystrike in that constantly wet fur with infected skin. Don’t think about that too much.

These dogs are far from being an ‘easy keeper’ and in my experience the estimates lifespan of 10-12 years that one often sees on the internet s a bit optimistic. I do know people who are addicted to this breed and just can’t live without one, but it’s important to know what you’re getting into and I would strongly recommend looking into pet insurance for this breed.

The hours spent writing this blog are supported by Dr Ferox’s Patreon. From as little as $1 a month you too can show your support and choose future topics for the blog.

Guess Who Asked? : Spencer Reid x Reader

Originally posted by netflixandi

“Excuse me?” You say, tapping a blonde woman in a blazer on the shoulder. “Do you know where I can find Doctor Spencer Reid?”

You read the name off a card that was given to you by Dr. Reid himself whenever he met you for a genetic analysis of the most recent suspect’s DNA in their case in northern Virginia. 

“Oh, hi, I’m Agent Jennifer Jureau or JJ and you are?” She extends a hand toward you and you shake it lightly.

“I’m Dr. (Y/F/N), genetic analyst and forensic criminologist, odd combo, I know.” You smile, dropping JJ’s hand. “Dr. Spencer Reid contacted me about conducting a genetic analysis on Mr. Louis Green for your case and I had some very interesting findings.”

You pull your manila file closer to your chest as JJ leads you to a little office where Spencer had set up. 

“Spence, there is a Dr. (Y/F/N) here with some results that you requested.” JJ shuts the door behind you as you make your way closer to the man that requested your assistance. 

“Hi, Dr. (Y/F/N), it’s great to see you again.” Spencer smiles as you hand him the file.

“Please, call me (Y/N). The only people that actually refer to me as ‘doctor’ are my parents,” you laugh.

Spencer chuckles slightly as he speeds through your findings. “With Mr. Green,” you start. “The reason why your eye witness testimonies and DNA testing doesn’t match is because he has a rare genetic disorder in which the DNA in his blood differs from the DNA in his semen. His blood was tested against the semen in the rape test kit, which rendered the results inconclusive. He most likely absorbed a twin in the womb before the twin was detected and inherited the DNA from there.”

“A human chimera,” Spencer whispers. He closes the file and looks up at you. “Thank you so much, (Y/N). This helps our case tremendously.”

“It’s really no problem. I’m happy to help any time.”

Spencer walks out of the room with the file in hand as Morgan gives him a clap on the back. 

“Hey, it’s one step in the right direction, lover-boy,” Morgan chuckles. You could hear them through the door, but waited to see where the conversation was going.

“(Y/N) is an amazing genetic analyst and is extremely smart, I just asked for a professional opinion. From one doctor to another.” You can see Spencer start to blush a little and you can feel heat rising to your cheeks too.

“Alright, if that’s all you wanted, then you won’t mind if I ask (Y/N) out then, hm?” Anyone could tell that Morgan was just trying to get on Spencer’s nerves, and it was working. 

“Really, Morgan?” Spencer asks, obviously slightly annoyed.

“I’m just joking, kid. You go get ‘em, just make sure (Y/N) doesn’t leave before you ask.” He walks away and as soon as he passed the office you were in, you stepped out. You head toward the doors, hoping Spencer will stop you before you get there. As soon as you have a hand on the door, you hear someone call your name.

“(Y/N)!” Spencer jogs over to catch up with you at the front of the station. “I was wondering if you would like to meet up sometime away from work? Maybe go see a foreign film or go to the Smithsonian together.”

“I would love to see a foreign film sometime, but the Smithsonian sounds like a better option. We can actually talk without disturbing anybody,” you laugh.

“That sounds great.” Spencer takes your card from you before opening the door to the station. “I’ll let you know when the case is over so we can go to the museum!” he called after you.

“Perfect. Talk to you soon.” You hop in your car and just take a second to process what happened. 

Spencer walks back inside and shows Morgan your card. “Guess who asked?”

Brooklyn nine-nine  sentence starters 

change pronouns as fit, lots of trigger warnings ahead, taken from multiple characters

  • “Click. I just captured the exact moment you realized you had failed. I guess we all got something out of this.”
  • “I appreciate the offer, but I work best alone. Except when it comes to sex. Actually, sometimes including sex.”
  • “People receive meaningless threats all the time. It’s really no big deal.”
  • “I’m surprised you’ve read Othello.”
  • “Well, no one asked you. It’s a self-evaluation.”
  • “We’re a package deal, everyone knows that.
  • "Oh, great! I’ll take my shirt off.”
  • “I’m in unspeakable pain.”
  • “Oh, I really came in here with the wrong energy.”
  • “I am flummoxed! That’s a word I learned for this party, and I am it!”
  • “Anyone over the age of six celebrating a birthday should go to hell.”
  • “I’d rather walk into the freezing ocean.”
  • “I remember that old bag. She was my favorite.”
  • “Thanks, good note. I was going for extremely harsh. I’ll turn it up.”
  • “"Kind, sober and fully dressed.” Good news, everyone. We found the name of [name]’s sex tape!“
  • ” Can you magically make everyone kind, sober, and fully dressed?“
  • "Of course. Totally. I mean, why would a death threat be a big deal? Oh, that’s right ‘cause it threatens death!”
  • “ When it comes to shooting patterns, I like to go PB&J. Penis, Brain, Jaw.”
  • “You don’t out grow punk, sir/ma'am.”
  • “Here, wear my shirt. I was gonna take it off anyway.”
  • “I’m really into rented clothes. I love how many butts have been in them.”
  • “ No one knows. I am a rock. I am an island. I have lapsed into song lyrics again.”
  • “Not a gift, snitch. It didn’t cost me anything. Just my worthless man hours.”
  • “Don’t remind me. I’m going to be untangling that web for a month.”
  • “And when this is over, I’m going to find you, and I’m going to break those little fingers.”
  • “Nope. I’m gonna wait 'til I’m on my deathbed, get in the last word and then die immediately. ”
  • “I’ve only said I love you to three people. My mom, my dad and my dying [relative]. And one of those I regret.”
  • “ I’m gonna punch him so hard in the mouth that he bites his own heart.”
  • “Thank you, [name]. Your entire life is garbage.”
  • “I cannot believe that I’m considering a non-violent option.”
  • “My [erelative] always said, "Bad news first because the good news is probably a lie.” Fun fact: she/he/they made me cry a lot.“
  • "Yeah, I might buy my shoes at a kids store and yeah, I might be scared of geese, but I am a damn good [profession] and I will not be made a fool of.”
  • “I thought he was faking it. I wanted to splash the lies out of him.”
  • “Seriously, you are beautiful. If he/she/they ever lies to you again, you can call me.”
  • “Okay, just so we’re clear, from this point forward, my call sign will be Death Blade.”
  • “Yeah, I’m not an idiot. I know how to trick my best friend into eating his/her/their fiber.”
  • “Why are you giving candy to a baby in the first place? Don’t give candy to a baby! They can’t brush their teeth!”
  • “ I’ve talked a lot about [name] in my departmentally-mandated therapy sessions.”
  • “You should take my minivan.”
  • “ I was working out and I saw a muscle in my shoulder I’d never seen before. I thought it might have been a scientific discovery.”
  • “Your head is so small. It is so small. Where do you keep your brains?”
  • “Probably not. I mean he/she/they seems like the kind of laid back guy/girl/person who delights in having his/her/their mistakes exposed.”
  • “ Don’t move as a group! You’re not gazelles!”
  • “I feel like a proud mama hen whose baby chicks have learned to fly!”
  • “Baby, I’ve got some bad news. Someone painted a giant penis on our minivan.”
  • “I threw away the photo because I think it’s ostentatious to hang pictures of yourself, especially when you haven’t earned a place on the wall.”
  • “I even managed to eat some plain toast this morning.”
  • “So nice of you to greet us, [name]. I thought surely you’d still be crushed under that house in Munchkinland.”
  • “approval ratings are - pardon my language - in the commode.”
  • “Look at that. You’ve helped me find my smile.”
  • “That is amazingly funny.”
  • “You’re a grown man/woman/adult, [name]. Strong like an Oak.”
  • “Their components have a long shelf life, they’re cost effective, and they’re so simple a child could make them.”
  • “Dress it up however you want, that’s some disgusting animal kingdom nonsense.”
  • “So you choose your [relative] over me, your co-worker who hates you?”
  • “Every time you talk I hear that sound that plays when Pacman dies.”
  • “Honestly, I’m going to last forever. You hear that bitches? I’m gonna last forever.”
  • “My mother cried the day I was born, because she knew she would never be better than me.”
  • “All men/women/people are at least 30% attracted to me.”
  • “At any given moment, I’m thinking about one thing: [name] hunkered over eating dog food.”
  • “Turns out I gave up easy. You hear that bitches? I gave up so easy.”
  • “Mmm-kay. No hard feelings, but I hate you. Not joking. Bye.”
  • “Hi, [name], the human form of the 100 Emoji.”
  • “Hold it up. You’re gonna let some quack doctor just knife around down there?”
  • “You are blessed with a great power, and you should never snip its wings. You should let it soar.”
  • “I am prepared to light [name] on fire in protest.”
  • “After zero consideration, I’m happy to say, "hard pass.”“
  • "Sounds like a genetic disorder.”
  • “We didn’t want to say anything that would get us uninvited.”
  • “You called us useless. You called us incompetent. You called us zeroes in the sack.”
  • “Yeah, no doy. How do you think we got to be the oldest guys here?”
  • “Get your act together, or so help me God, you won’t live to see retirement.”
  • “Oh, I am as serious as a heart attack. No offense, [name].”
  • “Just drop down onto the ground and wiggle.”
  • “Who wants to have sex with a tree?”
  • “Take me to the land of vending machines.”
  • “It takes a big person to admit when they’re being a total dumb-dumb.”
  • “Can’t spill food on your shirt if you’re not wearing one.”