genetic engineer

I know we’re always talking about how Pacific Rim embraces the ridiculousness of the human race because “just build a giant robot to punch them in the face” is probably the most full-on human bullshit response we could have thought of to an invasion of giant aliens, but can we pause and also consider that the aliens are basically doing the same thing

like they wanted to invade us and their first thought about how to do so was “let’s genetically engineer giant fucking monsters that will crawl out of the depths of the ocean and trample cities”

Pacific Rim is just the story of two species that on a scale from 1 to 10 respond to every problem with a 17

Been seeing a lot of these Humans Are Space Orcs posts around- which is good, because I love them- and I started thinking: in sci-fi stories, humans in the future often have a bit of genetic engineering- like disease immunity or faster healing or even just a lack of body hair.

And I had a thought- what if that’s just us? What if we’re the only species to engineer ourselves like that? Imagine how freaked out they’d be;

“You’re telling me that you alter your own genetic code?”

Or take it a little further- we’re the only species to use vaccines. Every other race just toughed it out and evolved past it, but humans injected ourselves with weakened diseases to make ourselves stronger. 

Or even further back, when people used to drink poison to gain an immunity- imagine that reaction:

“OH MY GROP THEY DRINK POISON TO GET STRONGER THAT’S IT FUCK THIS PLANET I’M OUTTA HERE”

  • what i expected going into see Logan: a bloody gory action packed Wolverine film with zero chill and maximum violence
  • what i got: a father/ son father/daughter roadtrip flick through children of men stylescape of dystopian heartbreak that deals with issues of human trafficking and the exploitation of women of color's bodies and genetic engineering ethics that made me cry multiple times

A groundbreaking gene therapy treatment which boosts a patient’s own immune cells has been shown to clear disease from one third of terminal patients.

US pharmaceutical company Kite Pharma released results from the first six months of its trial of the new treatment, called CAR-T cell therapy.


Some 36 per cent of the 101 patients on the trial were still in complete remission at six months, and eight in 10 saw their cancer shrink by at least half during the study.

“The numbers are fantastic,” said Dr Fred Locke, a blood cancer expert at Moffitt Cancer Center in Tampa who co-led the study.

“These are heavily treated patients who have no other options.”

The treatment, which has been dubbed ‘a living drug’ by doctors, works by filtering a patient’s blood to remove key immune system cells called T-cells, which are then genetically engineered in the lab to recognise cancer cells.

Cancer cells are very good a evading the immune system, but the new therapy essentially cuts the brakes, allowing immune cells to do their job properly.

Martin Ledwick, Cancer Research UK’s head cancer information nurse, said: “These results are promising and suggest that one day CAR-T cells could become a treatment option for some patients with certain types of lymphoma.

“But, we need to know more about the side effects of the treatment and long term benefits.”

Patients in the study had one of three types of non-Hodgkin lymphoma, a blood cancer which affects 13,600 patients in Britain, and had failed all other treatments. Most patients with such an advanced condition only live for six months but half of the trial group are still alive nine months since the trial began, and a third may be cured.

Dimas Padilla, 43, of Orlando, who was warned his case was worsening after chemotherapy stopped working, is now in complete remission after undergoing the therapy last August.

After learning his cancer was probably terminal he said: "I was thinking how am I going to tell this to my mother, my wife, my children,” he said.

After CAR-T therapy he saw his tumours “shrink like ice cubes” and is now in complete remission.

“They were able to save my life,” Mr Padilla added.

However there are still concerns that the treatment has significant side effects, and can even kill some patients, as it puts the immune system into a state of over-drive. During the trial two people died from the therapy, rather than their cancer.

Of the study participants, 13 per cent developed a dangerous condition where the immune system overreacts in fighting the cancer, and roughly a third of patients developed anaemia or other blood-count-related problems.

Nearly one third also reported neurological problems such as sleepiness, confusion, tremor or difficulty speaking, but these typically lasted just a few days.

The scans show how cancer has disappeared after just three months, and the remission has continued
The scans show how cancer has disappeared after just three months, and the remission has continued
Full results will be presented at the American Association for Cancer Research conference in April and the company plans to seek approval from European regulators later this year.

“It’s a safe treatment, certainly a lot safer than having progressive lymphoma,"said the cancer institute’s Dr Steven Rosenberg,

Other companies, such as Juno Therapeutics, have had to halt trials into CAR-T treatments following patient deaths.

anonymous asked:

Do u know any fics where Sherlock is jealous?

NONNNNYYYYYY YES. 

I love Jealous Sherlock so much. I know I’m missing a tonne of them here, but these are the ones I could quickly find or remember being Jealous!Sherlock! I’m also adding Possessive Sherlock here as well, because I LOVE LOVE LOVE “his / My John” SO SO MUCH and literally I fave every fic that has it in there. GUH. 

JEALOUS SHERLOCK

  • Unimpressed by 221b_hound (M, 3106 w.) – Sherlock has no intention of attending the Met’s New Year’s Eve party. The start of a new year is all but meaningless to him. But he ends up there anyway, having odd conversations, and John does not find Sherlock’s jealousy the slightest bit cute. And then there is dancing. Part 10 of Unkissed
  • Unforgiven by 221b_hound (M, 4721 w.) – Sherlock’s latest case is for his ex boyfriend, the brilliant and handsome Professor Victor Trevor. John is not too happy about that. But things aren’t what they seem, an old friend of John’s is involved in the case, and John has a few surprises up his sleeve. Also - a proposal! Part 16 of Unkissed
  • Mine (He Says While Still Being Smol) by beejohnlocked (E, 1,319 w.) – A suspect flirts with John. Sherlock gets a bit jealous. Okay, a LOT jealous.
  • Maintaining A Personal Life by Gingerhermit (E, 24,284 w.) – Sherlock and John discover some interesting revelations about each other’s sexuality, which lead them both to question the assumptions they’ve made about one another for years. In the midst of their mutual discoveries, a dangerous psychopath looms on the side-lines who threatens to destroy their new beginning.
  • For you, there’s only me by shock_blanket (E, 19,557 w.) – Sherlock realizes he has fallen in love with John, but believes he is unlovable. Cue lots of pining and jealousy on Sherlock’s part, followed by our favorite cuddly marksman making it all better. Because for Sherlock, there’s only John.
  • Matters of National Security by mistyzeo (E, 8,465 w.) – John starts dating a male client of Sherlock’s, and Sherlock can’t figure out why he’s so incensed about it.
  • Velvet by headlessjess (G, 1,155 w.) – It’s the day, the wedding day - John and Mary, getting married. And then there’s Sherlock, in pain and in love, without knowing how to deal with it.
  • 5 Times John Got the Girl (and lost her) and 1 Time John Got the Guy (and kept him) by LiviKate (M, 21,695 w.) – John has always had good luck with the ladies. He’s charming, friendly and funny, not to mention great in bed. However, his usual skill with the opposite sex is constantly being thwarted by Sherlock and his outbursts. How will John ever get a leg over when Sherlock is always cockblocking him?
  • Five Times John Noticed But Didn’t Really by ScandalousMinds (T, 6,383 w.) – 5 times John (thought) he noticed something peculiar about his and Sherlock’s relationship but really missed the obvious.
  • The Kissing Disease by cottonballz_of_death (E, 30,856 w.) – John brings home a boyfriend, shocking Sherlock, who long ago gave up hope that his straight flatmate would ever take a romantic interest in him. In a bid to reconnect with John, he tries to infect himself with a “harmless” virus. Neither of them is prepared for the emotional fallout that results.
  • Surety by hudders (G, 2,477w.) – “Sherlock is pissed because it seems that four pints of larger, two shots of tequila and a glass of wine has resulted in Lestrade becoming a little bit too friendly with everyone. And by everyone, Sherlock really means John.”
  • Butterfly, Pinned Under Glass by billiethepoet (E, 4,648 w.) – It started as a desire to keep John safe and whole, and ended up as just desire.
  • Correspondence by Cleo2010 (T, 8031 w.) – Sherlock’s been spirited away on a case for Mycroft. Part of the deal was that he and John could communicate via letter until the case was completed. Maybe the cliche is true, absence does make the heart grow fonder. Or perhaps something is growing on the feet in the fridge. Read their letters month by month. Written after series one.
  • Presence by LostGirl (M, 8625 w.) – Sherlock has recently noticed a shift in his own perceptions, but he can’t quite figure out when it started.
  • Obsession, Appassionato by shinychimera, Yeomanrand (E, 4,249 w.) – John is late, and he hasn’t called, and Sherlock works himself into a state. Part 1 of Love and Ysaye (FAVE!!)
  • Interlude by sussexbound (SamanthaLenore) (G, 2,837w.) – “Are you actually doing anything?” Sherlock scowls. “What?” “Are you busy? Because if not, I could use your help peeling potatoes.” “I’m not eating what you’re making. Why should I peel the potatoes?” John just shakes his head. “Because it might be a polite and thoughtful thing to do for the person who loves you. Just a tip.”Oh…Part 8 of The Homecoming
  • Understanding by sussexbound (SamanthaLenore) (T, 4,556 w.) – John’s face stretches into a smile that fades again, just as quickly. “It just comes like that, sometimes—all of a sudden. You don’t expect it.” He murmurs against Sherlock’s skin. “What does?” “Grief.” Part 9 of The Homecoming
  • Sibling Rivalry Or Fighting Over John Watson by Jessa7 (T, 8K+ w., Romance and Humour, FFNet) – Mycroft is just as much of a genius as Sherlock is. He keeps randomly kidnapping John for chats, and the locations get better. Cue Sherlock’s younger sibling complex rearing up and jealousy ensues.
  • Come Home by hudders-and-hiddles (E, 3,763 w. | more pining than jealous but close enough) – When John leaves for a medical conference, Sherlock tries to entice him back home.
  • The Semantics of Crop Circle Formation: a case study by Sherlock Holmes [unpublished] by canolacrush (M, 41,710 | Cockblocking Sherlock) – “Look at these photographs,” I said, gesturing to the wall of crop circles. “What do you observe?”“Crop circles,” John replied.“Obvious. What else?”“Are…are those intestines surrounding them?”“Yes. The majority are bovine and ovine in origin. The farmers who have acquired these crop circles in their fields have also had a tenth of their livestock murdered and arranged thus.”“Why?” John said, presumably in a rhetorical fashion.I detest rhetorical questions. “That is what I must find out, John.”
  • Down with this Ship by FrostedFlame (PinkOrchid) (M, 10,862 w.) – Sherlock drags John undercover to a gay bar - for a case, of course - looking forward to seeing John flustered by their surroundings (since you know, he’s NOT GAY). John decides that he has hidden both his orientation and his feelings for his daft flatmate for far too long. He is done hiding, time to be honest with his bloody best friend in the world. He just hopes it won’t change anything between them. And then it does.
  • That Partitioning of the Things of Youth by wearitcounts (Sher_locked_up) (E | 35,353 w.) - Victor Trevor is in town, and nobody’s happy. [[I really like this one. Jealous John AND Sherlock and lots of Angst]].
  • Paparazzi by SilentAuror (E, 10,543 w.) – John moves back into 221B Baker Street after his marriage falls apart and the paparazzi won’t leave him and Sherlock alone about the status of their supposed relationship. Sherlock, of course, never denies it, until one day he does…
  • Pattern Behaviour by SilentAuror (E, 14,835w) – Sherlock doesn’t even know why he resents John’s dates so much. Until the day he does know. Slight angst, unrequited feelings (but don’t let that scare you off!) (FAVE!) 

OBSESSIVE / POSSESSIVE SHERLOCK

  • Perdition’s Flames by i_ship_an_armada (E, Treklock, 63,435 w., | mild Possessive Sherlock) – Sherlock would do anything to save him. Risk anything. Give anything. His money, his life. His soul. What he does, though, is change both of their destinies forever. Genetic re-engineering is the only option left. It turns out researchers underestimated the life expectancy and potential abilities of genetically re-engineered subjects. The British government and what would eventually become the United Federation of Planets, however, had not. Part 1 of PF Universe
  • The Things You Hide *Adult Edition* by verityburns (E, 10,821 w.) – Sherlock and John have been working and living together for nearly a year, each finding the other’s friendship to be the one thing they would not risk or want to live without. Until something happens to disturb the status quo…
  • Let Go by thisisforyou (G, 2,743 w.) – In the end, separating John’s things from Sherlock’s in the chaos of their sitting room is like pulling a limpet from a wet rock. Especially when the rock is clinging on for dear life, because Sherlock doesn’t want to let go. 
  • In the cherry blossom’s shade by Eliane (M, 3,934 w.) – “This isn’t new. Sherlock has already done this – has gone through cities, and dingy hotels, and sleepless nights but it was different before. John wasn’t there before. They’re in this together.”
  • The Marriage Proposal Negotiation by Goddess_of_the_Night (G, 2161 w.) –  Sherlock hasn’t ever really done anything the traditional way, so of course it wouldn’t bother him to propose to John even though they’re not even dating. And the fact that John is already on a date with someone else when he decides to do it? Tedious. Marrying John was the only thing he could do to ensure John was his.
  • The Light of Day by allonsys_girl (M, 7297 w.) – Rewrite of the end of Sign of Three. John actually notices Sherlock leaving the reception early, and chases after him. Angsty Johnlock. Happy ending, for sure. Part 1 of The Light of Day
  • Let the Sun Fade Out by nothingislittle (E, 2711 w.) – “He could warm the sun itself, Sherlock thinks, could heat their flat with just his presence, could brighten the room with one dazzling smile or just the sparkling in his eyes. Everything hurts when John looks this beautiful, but it’s a dulcet, aching pain, one that consumes Sherlock from the inside, that sends soft pangs through his abdomen and lodges a lump solidly in his throat. John glows, he glitters, he’s light itself, Sherlock thinks, and doesn’t even bother to scold himself for exaggerating, because he’s not, he’s not, John is everything, he’s beautiful and he shines, he’s everything.”
  • On a Sunday Morning by SD_Ryan for jimmytiberius (G, 3136 w.) – Sherlock has a little problem. He can’t stop obsessing about John Watson.
  • His by I’m Nova (T, 1K+ w., Humour & H/C) – Sherlock doesn’t share what he’s fond of. (FAVE!!)
  • Foresight by niffler09 (K, 2K+w) – It’s raining and neither John nor Sherlock have an umbrella so they huddle under Sherlock’s coat. And then Mycroft walks past and makes smartass remarks. (FAVE!!)
  • Possessive by Fang323 (T, 850w. H/c & Friendship) – His John did not belong. Not here. Not in this blasted hospital. It simply was not logical.

As I’ve said in the past, all my rec lists are of fics I’ve read, so I’m sure I’m missing a tonne more that are probably on my MFL list, but please feel free to add your own recs! 

the year is 2097. phase 32 is in motion, jamie and damon are both heads in jars like all those people in futurama. scientists have genetically engineered stem cells to create the perfect, real gorillaz. they revolt against the establishment. somewhere, the evangelist and cyborg noodle play cards together

this blog was created in a laboratory by scientists that were created in an experiment in a different laboratory with the goal of genetically engineering the most basic, milquetoast human beings imaginable while still fitting within the confines of the laws of physics and reality

reddit.com
Reddit Science AMA on genetically engineering American chestnuts
Hi Reddit! We are a team of scientists at the College of Environmental Science and Forestry in Syracuse, New York, and we’ve been working for 27...

TLDR: This project is using genetic engineering to create American chestnut trees that are blight-resistant so they can restore the species to the wild!  It’s really cool and controversial, and if you have ever had questions about GMOs, how they work and whether you should really fear them or not, you should go ask these guys!

The long version:

About 100 years ago, the American chestnut began to effectively go extinct, thanks to an invasive fungus.  Before then, there were about 4 billion of them, and they made up about ¼ of forests in eastern North America, and they produced loads and loads of nuts that made up a large part of the natural diet of North American wildlife.  It was a huge deal, even though a lot of us who were born since then don’t really notice what a massive change it made to the health of the North American environment.

So this team of scientists has been using genetic engineering to create an American chestnut tree that is resistant to the chestnut blight.

It’s controversial work–it would be the first genetically engineered organism to be deliberately released into the wild–but the team has spent 30 years successfully creating this tree, and now they’re spending the next five years running tests to make sure it’s safe and can earn regulatory approval (assuming the federal situation doesn’t go completely bananas in the near future).  Their argument is that this tree is all but identical to native American chestnuts–the only difference is they’ve extracted a single gene from wheat that confers blight resistance and inserted it into the chestnut trees. 

Yes, that does make this tree technically a GMO.  But GMO is actually a pretty complicated thing, and you don’t get the full story either from Monsanto or from the anti-GMO purists.  These guys work for a public college and are not going to patent their work, and they are willing to talk freely about EXACTLY what the process is and what regulatory approval entails and how this technology can be used in both responsible and dangerously irresponsible ways.

youtube

They made a spider goat for some reason

writingisproseandpotatoes-deact  asked:

Hi! I'm writing a story, and I was wondering if it were possible for birds to evolve to glow in the dark within the next hundred years? If that is impossible, could they be made to glow?

So they definitely could be made to glow! There’s lots of genes out there that code for fluorescent proteins. My favorite is a jellyfish gene called GFP (which stands for green fluorescent protein), which codes for a green protein that glows under blue-violet or UV light. (however, it doesn’t necessarily glow in the dark, I’ve looked over the other known fluorescent proteins and I’m not sure of one that specifically glows in the dark, but I believe GFP or one of its derivatives would do the job, as they’re specifically related to jellyfish bioluminescence! It’s also possible I’m getting way too into specifics here, so moving forward, feel free to read GFP as ‘generic fluorescent protein which also glows in the dark because scifi’)

This gene is easily extracted and has been sequenced already (fun fact: we do need to sequence genes before we can work with them extensively - that’s why it was such a big deal to sequence the human genome!) so it’s often used as a marker in the biotech industry (not sure if your gene is being expressed? Just add GFP! You’ll know if it glows!)

To actually make an organism glow, you’d need to combine GFP with a gene that codes for a protein involved in the actual structure of the organism. For example, when I was in school, I did a project where I made yeast cells glow by combining GFP with one of the major structural genes of yeast, creating what’s called a recombinant gene. This meant that instead of just coding for the protein it originally coded for, (which was used to build the cytoskeleton) it coded for both that protein, and for GFP. When I put this gene into new yeast cells and let them colonize, their cytoskeletons also contained GFP, making them glow!

This is what GFP looks like in action! Yeast cells are pretty simple, being single-celled organisms and all, but birds are a little more complicated. It could be done (and combining some mammal DNA and even human DNA with GFP already has been done!), but it would take more time than just a semester. I would say several years at the minimum, and they might run into some problems with animal rights laws/ethics laws depending on the government where your scientists are science-ing.

You also wouldn’t have all birds glowing, just a specific species, probably manmade. It’s possible this could happen naturally, but unlikely, and you’d probably only see isolated cases unless something in their environment was making it more useful to glow than not. (It’s likely the opposite would happen - it would make them much more visible to predators, for one, and I’m not sure what might offset that to make it useful enough to be selected for. However, birds are weird, and sometimes select for things harmful to their survival because they think it looks pretty, so it’s entirely possible that happened.) You’d be unlikely to see an entire glowing species develop within 100 years from natural evolution alone unless the glowing trait was being heavily selected for.

This is such a neat idea! Good luck with your story!

anonymous asked:

Hey hun. So I am a Disney/fairytale/fantasy nut and was wondering if you could recommend any good Johnlock "Disney princess" or fairytale AU fics? Ta!

Hi Lovely!

I actually haven’t read any that come to mind immediately, other than these ones:

MOVIE /TV UNIVERSES

The Swan Triad Series by Pennin_Ink (T, 121,660 w. across 3 works || Swan Princess AU) – Sherlock and John grow up spending every summer together. Their mothers’ attempts to play matchmaker only fuel their mutual resentment and scorn. But then, one summer…

The Frost Child by twistedthicket1 (M, 9,944 w. || Frozen-ish AU || Angst, Fluff)In a world where people are born with a Gift of varying levels, simple John Watson is the last person one might look at when thinking of any strong Magick capabilities. Hiding comfortably in the shadow of Sherlock’s brilliant deducing abilities, John is content to keep it that way…

Perdition’s Flames by i_ship_an_armada (E, 63,435 w., | Treklock AU) – Sherlock would do anything to save him. Risk anything. Give anything. His money, his life. His soul. What he does, though, is change both of their destinies forever. Genetic re-engineering is the only option left. It turns out researchers underestimated the life expectancy and potential abilities of genetically re-engineered subjects. The British government and what would eventually become the United Federation of Planets, however, had not. Part 1 of PF Universe

Coventry by standbygo (E, 52,020 w. || Dollhouse AU) – “Let me get this straight,” John said, wondering when his life had become a science fiction film. “Some guy orders up a personality, a person, to his specifications, and they program this into a real live person, who has consented to do this, and she goes to this person and acts as his wife, or lawyer, or Royal Marine, or Navy Seal or what have you, and she has all the skills, all the knowledge, everything? Then you say the magic words, and she follows you back to The House, and they erase it all until her next appointment?”

The Boy Who Drank Stars by kinklock (E, 36,187 w. || Howl’s Moving Castle | Slow Burn, Romance, Pining) – “I’m looking for a castle,” John informed the scarecrow. “A moving one.” Except that, as it turned out, it was not a moving one at all.

Impossible Improbable Truth by KaraRenee (M, 24,308 w. || Labyrinth AU) – John and Sherlock take a case investigating the disappearance of a teenage girl and her toddler half brother. What they find is an impossible adventure that leads them on a journey of discovery of their sexuality. {{I haven’t read this, but it’s on my Marked for Later and I remembered putting it on there LOL}}

Through Dangers Untold by hogwartswitch (E, 32,003 w. || Labyrinth AU) – The Goblin King has fallen in love with John Watson and visits him in dreams. But the evil wizard who cursed the Goblin King cannot allow that to continue. Will John survive the labyrinth? Or will he become a lost goblin like all the rest? {{I think I started this when it was a WiP, so I never finished it, hah. I don’t remember it all.}}

Malediction by MapleleafCameo (M, 36,680 w. || Ladyhawke AU) – Cursed to a half-life, John and Sherlock must fight the forces of evil to be reunited once again. {{I read this once a LONG time ago. I remember loving it.}}

Bel Canto by bendingsignpost (T, 96,751 w. || Phantom of the Opera AU || Major Character Death) – After years of waiting for wealthy patrons to faint, Dr John Watson discovers a far more interesting patient in the opera house basement. {{ Another I never finished, but this is the  “go to” PotO fic}}

The Dragon’s Soldier by twistedthicket1 (M, 154,667 w. || Smauglock || Past Rape/Non-con, H/C, Dragonlock) – When the dragons “came out” to the rest of the world, nobody expected the resulting War that broke out between Humans and Beasts. Both sides afraid and suspicious of each other, Humans drove Dragons into slavery, imprisoning them and turning their children into weapons for the military. Forced into hiding, many Dragons disguised themselves as Human and kept their secrets locked away, awaiting for the day when the royal blood line long since vanished would once again reappear and lay waste to the Humans that oppressed them. Can Dragon and Man really get along? Or even more, become friends? {{Another on my MFL list, haven’t read this yet so read at your own risk}}

The Soul Remembers by i_ship_an_armada (E, 43,636 w. || Oblivion AU || Dreams, Sci-Fi, Action/Adventure, Bittersweet Ending) – John Watson is the lone security repairman stationed on a desolate, nearly-ruined future Earth. His dreams are plagued by a tall, dark-haired man, and when his dreams meet reality, he will be forced to question everything he believes is the truth about his life.

Deducing Daisies by LlamaWithAPen (G, 144,583 w. WIP || Pushing Daisies AU || Friendship, Death, Humour) – What if you could touch someone and bring them back to life? Sherlock Holmes, the Detective, is a seemingly ordinary man with an extraordinary gift: he can bring the dead back to life with a single touch. {{Haven’t read this yet, it’s on my MFL list, read at own discretion}}

Once Upon a Beast Becoming by antietamfalls (T, 24,042 w. || Beauty and the Beast AU || Magical Realism, Romance) – An act of pride, a druid’s curse, an enchanted leaf; Sherlock’s torment has lasted an age. Hope arrives in the form of one John Watson, a man uniquely suited to break the spell. But with a single night to win his affections, Sherlock finds his carefully laid plans disrupted by a monstrous killer whose sights are set on the only thing he has left to lose: John. {{Haven’t read this yet, on MFL list. Read at your own discretion}}

SPECIAL ABILITIES

We Bleed into the Grey by QuinnAnderson (T, 4,989 w. | Fluff and Angst, Supernatural Elements) – It was stupid, really. What was the point of having an ability if it wasn’t even a useful one? Sherlock would just as soon be rid of his. Until he meets John Watson, that is. {{Sherlock can see Auras}}

An Experiment in Empathy Series by belovedmuerto (G to T, 62 397w across 13 stories) –  In which John is an empath, Sherlock is Sherlock, and an epic bromance happens. In the aftermath of The Great Game, John creates an unexpected bond between himself and Sherlock. Now they have to learn how to deal with it. John is better at this than Sherlock is. {{I LOVE this SERIES SO MUCH.}}

An Experiment in Apathy Series by belovedmuerto (G to E, 28,701 w. over 13 stories, WIP) – John and Sherlock navigate their complicated relationship. I adore this series, and it feels complete where it leaves off :)

Invisible by chappysmom (K+, 25+K w. || No Slash, semi-canon compliant) – John had had the knack for as long as he could remember. It wasn’t that he could become invisible, exactly. The laws of physics worked quite well in his vicinity, thank you very much. It was just that people tended … not to see him. {{This was one of the first AU’s I read, and I still love it to this day}}. SEQUELSStill Invisible (ASiB) || Too Visible (THoB) || Invisible Once More (TRF) All are very good and should all be read.

Conductivity by Coquillage Atlas (K,11K+ w.|| Fantasy and Friendship) – John Watson, alone in London with a healing power he can hardly bear. A description of his life with magic, before and after Sherlock. {{Another really good AU!}} SEQUELS: Resistance || Reciprocity 

Left by lifeonmars (M, 45,153 w. || Magical Realism) – John Watson is left-handed. He’s tried not to let it affect his life, but as any Lefty knows, that’s almost impossible. (FAVE!!)

ANGELS AND DEMONS / WING!LOCK

I Used to Live Alone Before I Knew You by etothepii (T, 11,052 w. | Winglock) – Where Mycroft is an angel, Sherlock is a demon, and John is still John. {{I like this one because John is so perfect in it, and Sherlock cares so much about John}}

Fallen Series by Belladonna_Q & mamishka (T, 222,094 w. across 3 works, WiP || Angel!John, Fae & Fairies) – In a world where myth, mystery, and the supernatural flourish beneath the veneer of modern civilization, Sherlock is a master of magic as well as science and deduction. But there are some things that he cannot see, riddles he cannot unravel, even when they walk right beside him in the form of one John Watson…

A Certain Kind of Hunger by MapleleafCameo (E, 5,881w. || Somnophilia, Incubus!John, Tail Things) – A concerned Sherlock watches as John seems to be rapidly losing weight. What he discovers is that John really isn’t normal. And he is very, very hungry. The tail was the real surprise.

Angel by MrsNoggin (T, 1K+w. || Friendship, Winglock-ish) – John is an angel. That can be the only explanation. This is an interesting take on the Winglock universe.

Not The Hands That Kill by You_Light_The_Sky (M, 6,201 w. || Winglock, Implied Sex) – Having wings does not make Sherlock Holmes a guardian angel, not in the way that John Watson is his.

Guidelines by WithLoweredVoices (M, 43,018 w. || Winglock, Fantasy, BAMF!John) – The Good Soldier, one of the oldest and strongest of the fallen, is offered a bargain: to live as John Watson and to Guide a fledgling archangel so that he will stay on the path of good. Of course, Sherlock Holmes has different ideas about his destiny. Warnings for violence, occasional gore, and a whole load of hurt and angst.

It’s After That Hurts by jonnyluvssherlock (T, 2,791 w. || Winglock, Pining Sherlock, Minor Gore, Fallen Angel, Friends to Lovers) – Sherlock’s an angel stuck as a guardian to danger addict John Watson. Everything is fine until he gets too involved. Now he has to make the choice, eternity alone or one life time with a man who may or may not love him. {{This is only one chapter and it feels like it should be more… I love it but feels incomplete. Kind of an AU of City of Angels}}

VAMPIRES AND WEREWOLVES

John Watson’s Moon by patternofdefiance (E, 11,314 w. || Werewolf!John, First Time) – Sherlock finds out John is a werewold and wants to see the transformation. It, uh, gets really kinky.

An Acquired Taste by kinklock (E, 31,059 w. || Bat!Sherlock, Humour, Misunderstandings) – At Montague Street when Sherlock was forced to sate his body’s needs, he was at least able to wander about the flat as much as he pleased. At Baker Street, it was mini-bags in a mini-fridge and bedroom confinement.

Bleed Me Out by antietamfalls (E, 87,987 w. || Soul Bonding, John Whump, Fluff and Angst, H/C) – John isn’t exactly surprised to discover that Sherlock isn’t human. His vampirism doesn’t pose a problem, even when their relationship gradually grows into something more. That is, until a deadly revelation about John’s blood sends their lives spinning dangerously out of control.

MAGIC AND FANTASY

Shatter the Darkness (Let the Light In) by MojoFlower (E, 109,683 w. | GenieLock, Torture, H/C, Magical Realism) Fairy tales are for those who remember how to dream; not John Watson, broken and hiding from his bleak future in a beige bedsit. But then he discovers a lamp and finds himself in the dangerous riptide of an enigmatic man whose very existence is unbelievable, murder charges against his sister, and the growing pains of feeling alive once more. {{This is a REALLY great story, which tears at your heart consistently}}.

De Veritate Unicornis Moderni by tepid sponge bath (T, 5K+ w. | Fantasy & Drama) – John Watson, a unicorn of this day and age, is trapped in a mortal body. Life as it is seems pretty pointless, almost unendurable, until he meets one Sherlock Holmes, consulting detective and very much a virgin. {{This is such an interesting take on unicorn mythology}}.

To Mend A Heart by dee-light (G, 1,472 w. || Magical Realism, H/C) – Hearts can be broken, and mended, and broken again. Good thing, then, that hearts are only the seat of all emotion, and not something Sherlock needs in order to live.

Winter of Life by You_Light_The_Sky (T, 5,178 w. || Magic Realism, Fluff, Christmas, Angst) – It was an experiment, really. On Christmas, Sherlock wrote to Santa asking for a friend. He got a broken toy soldier instead. This is the story of how he finds him again and again.

Software Malfunction by tiger_in_the_flightdeck (E, Tumblr fic || Android!lock, Jealous, Angst, Unhappy Ending) – Assigned as the head of Medical Research on the Baker, John Watson meets- and quickly falls in love with- Sherlock, a specially commissioned Companion android with a malfunction.

No Strings Attached by Elster (G, 2,714w. || Fae / Faeries, Love Confessions, Fairy Tales) – To save John from being spirited away Under the Hill, Sherlock challenges the fairy queen to a fiddle contest.

SUPERNATURAL AND UNEXPLAINED

The Semantics of Crop Circle Formation: a case study by Sherlock Holmes [unpublished] bycanolacrush (M, 41,710 w. || Sherlock POV, Aliens, Wordplay, Casefic) – “Look at these photographs,” I said, gesturing to the wall of crop circles. “What do you observe?”“Crop circles,” John replied.“Obvious. What else?”“Are…are those intestines surrounding them?”“Yes. The majority are bovine and ovine in origin. The farmers who have acquired these crop circles in their fields have also had a tenth of their livestock murdered and arranged thus.”“Why?” John said, presumably in a rhetorical fashion. I detest rhetorical questions. “That is what I must find out, John.”

The Red Dianthus by kinklock (T, 11,382 w. || BAMF!John, Misunderstandings, Halloween, Fluff) – The boys investigate a mysterious disappearance in a supposedly haunted house, and get much more than they bargained for.

Upon Waking by joolabee (E, 3,901 w. || Somnophilia, Mildly Dubious Consent, Angst) – It sets on slow: John can only be awake while Sherlock sleeps, and vice versa. Their lives are codependent, but never meeting. Like a set of scales.

London’s Ghost by JustlikeWater (K+, 5K+ w.|| Tragedy/Angst, MCD, TRF AU, Sherlock POV) – "Today, it’s been weeks since Sherlock died. Other times, years. He doesn’t know for sure, though. Time passes differently for the dead" 

Electric Potential by pygmymeese (T, 5K+ w. || Supernatural) – It’s not clear why everyone in the world suddenly gets a ghost only they can interact with. All John Watson knows is that he’s stuck with a brilliant, if smug, ex-consulting detective, and that life is definitely looking up.

Second Waltz by Atiki (T, 6,685 w. || MCD, Angst, Fluff, Cancer) – "The night I died, you wished I could wait for you.“

Where The Ghosts Have Voices by HappyJuicyfruit (M, 37,665 w. || John Whump, Magical Realism, Ghosts, Coma, Happy Ending) – John has lived his whole life as an outcast. It is only when he meets Sherlock, that be realizes being a freak might not be such a bad thing, and that the curse he has lived with his whole life may be a gift after all. {{Haven’t read this yet, it’s on my MFL list, read at your own discretion}}

SOULMATES / TATTOOS

The Heart On Your Sleeve by flawedamythyst (T, 5,441 w. || Heartmark, Stubborn Sherlock) –  Sherlock stared at the imperfect circle on his left wrist in horror, then sat down on his bed with a bit of a thump. After over thirty years, his heartmark was finally showing activity. This was not good.

The Best Picture of the Human Soul by SwissMiss (T, 5,776 w. || Tattoos, Finding Your True Love) – The stories of our lives are written on our skin. Every time you fall in love, you gain a mark. Part 1 of Imagines Moti

With All My Heart by QuinnAnderson (E, 19,257 w. || Tally Marks, Magical Realism, Fluff and Angst) – AU in which every time a person falls in love, a red line like a tally mark appears on their wrist. Sherlock is determined to keep himself from ever gaining one of these marks for fear that love will corrode his mental faculties. Then he meets John Watson.

Finding John by orphan_account (T, 5,456 w. || Symbolic Rings) – Sherlock Holmes has met exactly twenty-four Johns in his life. They have all been the wrong John. He’s getting tired of waiting, staring at the inscription on his finger and wondering when his John will turn up, if ever. Part 1 of Inscriptions

what’s in a name by flight815kitsune (NR, 1,285 w. || Soulmate Names) – There were some things you just knew. The name, if you were lucky enough to get one, was one of those things

the fearful passage of death-mark’d love by urcool91 (T, 1980 w. || Tattoos, H/C, Angst) – The first time that John meets Sherlock Holmes, the younger man has his sleeves pushed up to his elbows, wrists bare of any hint of ink. Within 48 hours, John has added “Jefferson Hope” to his clavicle. (Or: The One Where, When You Kill Someone, Their Name Shows Up On Your Arm)

OTHER

{{SEE ALSO: Johnlock Body Swap Fic Rec List}}

Bringing Colour to the World by SD_Ryan (G, 1,168w. || Est. Relationship, Sickfic, Fluff, Schmoop) – In which we encounter a sick detective, a snuggle on the couch, and a silly fairytale.

The Steadfast Tin Watson by what_alchemy  (T, 3,973 w. || Fairytales) – When the fairies left, they took their stories with them. But they left the characters behind.


Otherwise, I actually have a lot on my Marked for Later list, all of which have come from Alexx’s lists:

“Aah, but the dinosaurs in jurassic are inaccurate”

-In the book, it explains that exact cloning of preserved dinosaur DNA wasn’t possible, and so the dinosaurs at the park were a product of very fine genetic engineering- therefore, they weren’t really dinosaurs ‘brought to life’, but designer animals made to look like our idea of dinosaurs, and it bothers me so much that this concept was only vaguely explained 

League of Villains: this is Noumu. He’s gifted with more than one incredibly powerful quirk and is genetically engineered to be one of the strongest creatures in the world, capable of defeating even All Might

Class 1-a: this is our dad Aizawa we love him he’s fast

anonymous asked:

You always have such great fic recs! I have a looong cross-country flight coming up and am looking for some multi-chapter fics to wile away the hours in the flying tin can. Preferences in order of priority: *very* in-character (anything OOC kills it for me), slow burn/first time, not AU (ACD is good tho!) Any rating. Have read all the fandom classics so looking for less-known or newish. For reference two of my favorite ever fics are Quiet Man, & Safe Distance. Thank you Steph! You are the best!!

AHHH Nonny!! Sorry I just saw this, so I hope I’m not too late for your cross-country flight! All I saw was “multi-chapter long” and I put it aside to attach to 2 other asks of similar requests. BUT because this is time-sensitive, I’ll give you a few to tide you over! I’m actually working on a TONNE of fic rec lists:

(essentially I create a new textedit document every time I get a “different” request from others I have) and was going to add this ask to my “long fics” request I received a month or so ago. Okay, so instead, I’ll pull some long fics from my “Fave Fics Ever” List for you that I have so far (I still have 15 more pages of bookmarks to go through, plus all 1000 fics on my FFNet account, so, WHEE. Being meticulous is ridiculous). 

It’s hard to choose, so I limited it to my go-to long fics for you that I have ALREADY sorted on my lists you see in that window above there :D I’ve put them in word count order for you :D


TOP 20 FAVE 40K+ w. FICS || APRIL 2017

Goodness Gives Extras by mydwynter (E, 39,629 w. || Fluff & Angst, Case Fic, Oral / Anal, Humour, First Time, Miscommunication, Snark, Christmas) – Christmas time. ‘Tis the season to settle down with a drink, some food and a present or two, and to enjoy the quiet relaxation of the holiday. Instead, there’s a case that drags them all over, missing presents, disappointed kids, angry parents, and a freak snowfall. On top of that John has to deal with Sherlock, who is being even more of a prat than usual. He really shouldn’t have expected anything different. (okay I’m cheating with the word count on this one but it’s so good!! One of my ALL TIME FAVES)

Right Hand Man by SilentAuror (E, 42,031 w. ||  H/C, Injury, Slow Burn, Infidelity, Mary is Not Nice) – When John’s left arm becomes paralysed after a car accident, Mary asks Sherlock to take him back to Baker Street to recuperate, as she’s about to give birth. Despite the fact that the search for Moriarty is ongoing, Sherlock takes John in and takes responsibility for overseeing his rehabilitation as he adjusts to the loss of his arm. (FAVE FAVE FAVE)

Guidelines by WithLoweredVoices (M, 43,018 w. || Winglock || Angels, Fantasy, Angst, BAMF! John, War) – The Good Soldier, one of the oldest and strongest of the fallen, is offered a bargain: to live as John Watson and to Guide a fledgling archangel so that he will stay on the path of good. Of course, Sherlock Holmes has different ideas about his destiny. Fantasy AU. Warnings for violence, occasional gore, and a whole load of hurt and angst.

The Case of the Vanishing Pants by SwissMiss (E, 44,025 w. || Post-TRF, Case Fic, UST, Homophobia, Friends to Lovers) – Five times John and Sherlock lost their pants in the course of a case.

Left by lifeonmars (M, 45,153 w. || Magical Realism) – John Watson is left-handed. He’s tried not to let it affect his life, but as any Lefty knows, that’s almost impossible.

The Norwood Love Builders by flawedamythyst (T, 47,798 w. || Fake Relationship, Slow Burn, Post TRF Angst) – Sherlock and John go undercover to solve the murder of Joanna Oldacre, but things are complicated by the many feelings John has been repressing in the wake of Sherlock’s faked death and return.

Triage by scullyseviltwin (E, 51,612 w. || Character Injury, Introspection) – Sherlock’s mind goes exceedingly, devastatingly quiet and gray-blank. When he speaks it’s through a thick haze, it’s through molasses, he’s so disconnected from the words that it may as well be the unconscious shooter speaking.

Coventry by standbygo (E, 52,020 w. || Dollhouse AU, First Time/Kiss, BAMF John, Slow Burn, Falling in Love, Case Fic) – “Let me get this straight,” John said, wondering when his life had become a science fiction film. “Some guy orders up a personality, a person, to his specifications, and they program this into a real live person, who has consented to do this, and she goes to this person and acts as his wife, or lawyer, or Royal Marine, or Navy Seal or what have you, and she has all the skills, all the knowledge, everything? Then you say the magic words, and she follows you back to The House, and they erase it all until her next appointment?”

Guilty Secrets by Ellipsical (E, 55,055 w. || Drumsticks, First Time, Love Confession, Self-Sexual-Discovery) – John has a prostate exam and discovers something surprising about himself. Experimentation follows. Sherlock wants to help. They’re in love. You know the drill.

Wars We Fought, Things We’re Not by blueink3 (M, 55,204 w. || Parentlock, Fluff & Angst, Kidnapping, Whump, Post-TAB, UST, Slow Burn, Couple for a Case) –  Five months after John’s world has fallen apart, Mycroft sends the consulting detective and his doctor on a case that neither is prepared for.

The Progress of Sherlock Holmes by ivyblossom (E, 62,006 w || Sherlock POV, Pining, Angst, Slow Burn, Infidelity, Sherlock Learns About Himself, Happy Ending) – Sherlock struggles with his feelings for John, makes a mistake, and learns just how important he and John are to each other. Non-BBC Mary / John, but it’s a *complicated* relationship.

Perdition’s Flames by i_ship_an_armada (E, 63,435 w., || Treklock AU, Est. Rel, Genetic Engineering, Angst & Fluff, BAMF!John) – Sherlock would do anything to save him. Risk anything. Give anything. His money, his life. His soul. What he does, though, is change both of their destinies forever. Genetic re-engineering is the only option left. It turns out researchers underestimated the life expectancy and potential abilities of genetically re-engineered subjects. The British government and what would eventually become the United Federation of Planets, however, had not. Part 1 of PF Universe

The Green Blade by verityburns (T, 72,929 w. || Casefic, Bromance) – As a serial killer hits the headlines, the police are out of their depth and the next victim is out of time. With faith in Sherlock Holmes at an all time low, this is a case which will push loyalties to the limit…

The Moonlight and the Frost by CaitlinFairchild (E, 77,289 w. || Case Fic, Post-HLV, Self Harm, Virgin Sherlock, First Time, Oral/Anal/Rimming, Romance, Angst, Mary is Not Nice) – John has to somehow rebuild his life in the wake of Mary’s betrayal and Sherlock’s deceptions.

A Case of Identity by jkay1980 (T, 91,009 w. || Fake Relationship, Post-TRF, Case Fic) – John and Sherlock have succeeded in rebuilding their friendship after Sherlock’s fake suicide, but an unusual case puts their relationship to the test. They pretend to be engaged and attend a marriage counseling workshop. Under the pretext of the case, Sherlock turns out to be a master of seduction, and John finally learns he might like Sherlock more than he thought. Slowly, John discovers that he loves Sherlock not only in a friendly, brotherly way, but both men have to fight their own demons before they can think of taking their relationship to a new level… [[I love this fic SO MUCH]]

Shatter the Darkness (Let the Light In) by MojoFlower (E, 109,683 w. || GenieLock, Torture, H/C, Magical Realism) Fairy tales are for those who remember how to dream; not John Watson, broken and hiding from his bleak future in a beige bedsit. But then he discovers a lamp and finds himself in the dangerous riptide of an enigmatic man whose very existence is unbelievable, murder charges against his sister, and the growing pains of feeling alive once more. {{This is a REALLY great story, which tears at your heart consistently}}.

Breakable by MissDavis (E, 117,627 w. || Established, Fluff/Angst, Depression, Paralysis, Happy-ish Ending) – After John is seriously injured, Sherlock struggles to figure out how to help him, keep himself sane, and maybe, just maybe, get their life back to the way it’s supposed to be. Part 1 of Breakable Not Broken

Midnight Blue Serenity by BeautifulFiction (E, 151,907 w. || Friends to Lovers, Gay Bar / For a Case, Drugs, Pining, Case Fic, UST) – When Sherlock infiltrates a club in order to track down a serial killer, his altered appearance is enough to make John question his assumption that Sherlock is beyond his reach. However, is he the only one who appreciates his flatmate’s charms, or is Sherlock at risk of becoming the next victim?

A Fold in the Universe by darkest_bird (E, 152,857 w. || O-John, A-Sherlock || Body Swap, Crossing Universes, DubCon, H/C, Angst, Happy Ending) – Alpha Sherlock and Omega John are in a relationship. Prime Sherlock and Prime John are not. So what happens when a freak fold in the universe switches one John for the other?

Performance In a Leading Role by Mad_Lori  (E, 156,714 w. || Hollywood AU, Coming Out, Show Business) – Sherlock Holmes is an Oscar winner in the midst of a career slump. John Watson is an Everyman actor trapped in the rom-com ghetto. When they are cast as a gay couple in a new independent drama, will they surprise each other? Will their on-screen romance make its way into the real world?

Interviewer: Was Toby Stephens your first choice?

Jon Steinberg: Let me put it this way. From the moment we saw his audition he was our only choice. Toby Stephens is amazing. There were a couple of actors actually, where ahh…  I didn’t fully understand the character we had written until I saw their audition. Which is a weird thing to feel. We knew who they were. We knew what they were suppose to do. But there were just something missing. Then you watch an actor step into that role and suddenly it all makes sense. And Toby was one of them. We actually, when we sat out, we said, wouldn’t it be great if we could find a guy who’s kind of typecast as a villain, we haven’t seen much of him lately and he just kind of needed to grow into himself to become a star. And then Toby walked in. That’s just perfect. We’ll take it. And he’s just the nicest guy and a total pro.

Interviewer: Well, he comes from a, how shall I say this? A very royal background to a certain extant, so It’s not surprising.

Jon Steinberg: Toby Stephens is genetically engineered to be a star. He’s great. I love him.

Robert Levine:We needed Flint to be a lot of things that are kind of contradictory. We needed him to be a statsman, a visionary but we also needed him to be a little unhinged, to have that potential for violence, and we needed him to be funny, we needed him to be wounded and chamming and every time Toby picks up a scene, he delivers on that and surprises you..and, and I can’t wait for people to see the rest of the season because your understanding of him keeps growing with each episode.

Originally posted by significanceofmoths

X - The writers of Black Sails talk about Toby Stephen as Captain Flint.