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“AMÁVEL” | Directing and Cinematography by António Morais from António Morais on Vimeo.

LEICA SL Camera Test:

Camera - LEICA SL

Lenses - Vario-Elmarit L mount 24-90 f2.8-4 zoom, Summilux M mount 50mm f1.4 Asph, Summicron T mount f2 23mm.

With the production support from SL Cameras slcameras.com

and Comercial Foto comercialfoto.pt

Special thanks to:

Amável Alves Antão (the artisan)
Paulo Silveira (co-producer)
Vanessa Ribeiro Rodrigues (editing advisor)

Music: “ALVORADA” - Eduardo Francisco Veiga - Gaiteiro “Dias” - Deilão, Bragança

Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

PubMed: Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?

Sci Rep. 2016;6:20164

Authors: Alemi M, Gaiteiro C, Ribeiro CA, Santos LM, Gomes JR, Oliveira SM, Couraud PO, Weksler B, Romero I, Saraiva MJ, Cardoso I

Abstract
Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, suggesting TTR involvement in brain Aβ efflux and/or peripheral clearance. Here we showed that TTR promotes Aβ internalization and efflux in a human cerebral microvascular endothelial cell line, hCMEC/D3. TTR also stimulated brain-to-blood but not blood-to-brain Aβ permeability in hCMEC/D3, suggesting that TTR interacts directly with Aβ at the blood-brain-barrier. We also observed that TTR crosses the monolayer of cells only in the brain-to-blood direction, as confirmed by in vivo studies, suggesting that TTR can transport Aβ from, but not into the brain. Furthermore, TTR increased Aβ internalization by SAHep cells and by primary hepatocytes from TTR+/+ mice when compared to TTR-/- animals. We propose that TTR-mediated Aβ clearance is through LRP1, as lower receptor expression was found in brains and livers of TTR-/- mice and in cells incubated without TTR. Our results suggest that TTR acts as a carrier of Aβ at the blood-brain-barrier and liver, using LRP1.

PMID: 26837706 [PubMed - in process] http://dlvr.it/KQDKx8

sol em si

O gaiteiro riu um riso baixo

e tocou em sol -

dó não tinha nem de mi(m) 

nem de si;

deu a ré e seguiu pra frente

- lá ele tinha um jeito fá

(cil) de ser.

Músico, gaiteiro, alma leve que subiu ligeiro.



dó de mim que não sei 

ainda 

rir esse mesmo riso que faz sol em si.