gabae

gabae replied to your postIs it really odd that we put our Christmas tree before December?

I’m not putting up a Christmas tree this year! D’:

what? why? D:

kayburg replied to your postIs it really odd that we put our Christmas tree before December?

lolll i thought it was early too, i’m surprised your tree doesnt dry out by christmas o_o unless you use a fake one. usually we buy the xmas tree like two weeks before cause we’re always late with these things LOL. but whatev, xmas trees are awesome

oho, I wish it was authentic, but alas it is fake lol ;;

I think my parents just want to get the decorating done with so that they don’t have to stress about it during December~ BUT THEY HAVE ME TO DECORATE IT SOOOO

anonymous asked:

Do you have any sites that you would recommend to someone looking to teach English in Japan? Such as programs that employ you to teach over there? Ty in advance!

Hello! 

1) Your best (and possibly easiest, and definitely best-paid-for-an-entry-job) way into English teaching in Japan is the JET program.

2) Your second-best option is the big schools that recruit overseas: ECC Japan,  Aeon (株式会社イーオン), GABA Japan, Interac Japan, Berlitz Japan. They all have websites with clear instructions about applying for a job. Just Google ‘em. :)

3) Third alternative is job sites, but you need to be in Japan for these jobs. I add them anyway, in case it might help others:

http://www.ohayosensei.com/

http://www.eltnews.com/jobs/

https://www.japanenglishteacher.com/

https://jobs.gaijinpot.com/

Finally, just to remain clear-headed, read this (and everybody’s comments). Your best option for a long-term job is university teaching, but that requires specific qualifications and, usually, a few years’ experience.

Having said that, if your dream is to teach in Japan, go for it. Good luck!

L’eterna lotta tra lo spionaggio e il farsi i cazzi propri.

Decido di fare una pausa a lavoro e di partire per la Cina passando per l’Alaska e lo stretto di Bering ma ho promesso al piccolo di tornare per cena e preparare insieme le fragole, così opto per un semplice caffè alle macchinette.

In realtà, per un momento, un altro, mi ricordo che due piani sopra al mio lavorano con la cocaina e gli effetti nei recettori GABA dei topi e penso che magari una sniffatina non se ne accorgono mica se viene a mancare, ma sapete quando pensate una cosa e nel frattempo ne avete già iniziata un’altra?

Così mi ritrovo già in ascensore, direzione distributori di caffè. In cuffia - è importante per capire questa storia - sto ascoltando gli Earth, Wind & Fire. Per i più giovani un gruppo tendenzialmente omosessuale di gente di colore stranamente sopravvissuta agli Stati Uniti. Per la precisione Fantasy. Live. 

A cazzo dritto mentre ascolto gli EWF e faccio finta di essere un corista vestito con una tutina d’argento, mi avvio al distributore dei caffè. Arrivo davanti e realizzo di aver lasciato il mio badge sul bancone del laboratorio. I distributori mi guardano, da dietro una porta trasparente a vetro. Io non posso entrare. Loro non possono uscire.

Intanto Fantasy continua a suonare nella mia testa o meglio, nelle mie cuffie, quando vedo passare una aitante giovane ricercatrice made in USA. Lo capisco perchè è una bianca caucasica e bionda con la codina e il france manicure alle dita dei piedi, escluso l’alluce dove c’è un basso rilievo del Tintoretto che riproduce la conquista del West a cavallo. 

Io: “Carine le sue unghie, io ho una calamita uguale appesa sulla caldaia di casa mia.”
Lei: “Lei chi è?”
Io: “Mi chiamo Luca, lavoro al terzo piano”
Lei: “…”
Io: “Volevo prendere un caffè ma ho scordato il badge in laboratorio e ora non posso entrare e neanche tornare indietro. Sono bloccato in questo limbo con gli Earth, Wind & Fire e nonostante la cosa mi piacca anche vorrei un caffè e tornare poi alle mie cose”
Lei: “Ha il bdage?”
Io: “Lei dev’essere una che si è laureata dopo che hanno riformato i test d’ingresso al ribasso, giusto?”
Lei: “Ce l’ha un documento?”
Io: “FBI?”
Lei: “…”
Io: “CIA?”
Lei: “Lo sa che le persone non autorizzate non possono stare qua?”
Io: “Almeno posso offrirle prima delle caramelle?”
Lei: “Pronto, sicurezza”
Io: “No, non lo faccia. Già mi vedo i titoli. Terrorista calabrase fan degli Earth, Wind & Fire prova a distruggere distributore dei caffè in un centro di ricerca del Nebraska. Allah non me lo perdonerebbe mai. Abbi pietà.”
Lei: “Sicurezza? C’è un tipo strano al primo piano”.

La sicurezza era un tizio di 214 libbre che conosco di vista. Ha dovuto comunque chiedermi un documento d’identità. Alla fine sono riuscito pure a prendere il caffè. God bless Trump!

Interesting Papers for Week 29, 2016

Using an Insect Mushroom Body Circuit to Encode Route Memory in Complex Natural Environments. Ardin, P., Peng, F., Mangan, M., Lagogiannis, K., & Webb, B. (2016). PLOS Computational Biology, 12(2), e1004683.

Biological movement and the encoding of its motion and orientation. Benton, C. P., Thirkettle, M., & Scott-Samuel, N. E. (2016). Scientific Reports, 6, 22393.

Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. Branchereau, P., Cattaert, D., Delpy, A., Allain, A.-E., Martin, E., & Meyrand, P. (2016). Scientific Reports, 6, 21753.

Non-monotonic Temporal-Weighting Indicates a Dynamically Modulated Evidence-Integration Mechanism. Bronfman, Z. Z., Brezis, N., & Usher, M. (2016). PLOS Computational Biology, 12(2), e1004667.

Beyond the point of no return: effects of visual distractors on saccade amplitude and velocity. Buonocore, A., McIntosh, R. D., & Melcher, D. (2016). Journal of Neurophysiology, 115(2), 752–62.

Evidence against perfect integration of sensory information during perceptual decision making. Carland, M. A., Marcos, E., Thura, D., & Cisek, P. (2016). Journal of Neurophysiology, 115(2), 915–30.

Rapid and continuous activity-dependent plasticity of olfactory sensory input. Cheetham, C. E. J., Park, U., & Belluscio, L. (2016). Nature Communications, 7, 10729.

Temporal Evolution of Spatial Computations for Visuomotor Control. Franklin, D. W., Reichenbach, A., Franklin, S., & Diedrichsen, J. (2016). Journal of Neuroscience, 36(8), 2329–2341.

The Emotional Gatekeeper: A Computational Model of Attentional Selection and Suppression through the Pathway from the Amygdala to the Inhibitory Thalamic Reticular Nucleus. John, Y. J., Zikopoulos, B., Bullock, D., & Barbas, H. (2016). PLOS Computational Biology, 12(2), e1004722.

Balanced feedforward inhibition and dominant recurrent inhibition in olfactory cortex. Large, A. M., Vogler, N. W., Mielo, S., & Oswald, A.-M. M. (2016). Proceedings of the National Academy of Sciences, 113(8), 2276–2281.

Phase Locking of Multiple Single Neurons to the Local Field Potential in Cat V1. Martin, K. A. C., & Schroder, S. (2016). Journal of Neuroscience, 36(8), 2494–2502.

A Feedback Model of Attention Explains the Diverse Effects of Attention on Neural Firing Rates and Receptive Field Structure. Miconi, T., & VanRullen, R. (2016). PLOS Computational Biology, 12(2), e1004770.

Plasticity-Driven Self-Organization under Topological Constraints Accounts for Non-random Features of Cortical Synaptic Wiring. Miner, D., & Triesch, J. (2016). PLOS Computational Biology, 12(2), e1004759.

Small-World Propensity and Weighted Brain Networks. Muldoon, S. F., Bridgeford, E. W., & Bassett, D. S. (2016). Scientific Reports, 6, 22057.

Confidence through consensus: a neural mechanism for uncertainty monitoring. Paz, L., Insabato, A., Zylberberg, A., Deco, G., & Sigman, M. (2016). Scientific Reports, 6, 21830.

Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference. Rahmati, V., Kirmse, K., Marković, D., Holthoff, K., & Kiebel, S. J. (2016). PLOS Computational Biology, 12(2), e1004736.

Human Hippocampal Structure: A Novel Biomarker Predicting Mnemonic Vulnerability to, and Recovery from, Sleep Deprivation. Saletin, J. M., Goldstein-Piekarski, A. N., Greer, S. M., Stark, S., Stark, C. E., & Walker, M. P. (2016). Journal of Neuroscience, 36(8), 2355–2363.

Somato-dendritic Synaptic Plasticity and Error-backpropagation in Active Dendrites. Schiess, M., Urbanczik, R., & Senn, W. (2016). PLOS Computational Biology, 12(2), e1004638.

Optimal Information Representation and Criticality in an Adaptive Sensory Recurrent Neuronal Network. Shriki, O., & Yellin, D. (2016). PLOS Computational Biology, 12(2), e1004698.

Recovery of Dynamics and Function in Spiking Neural Networks with Closed-Loop Control. Vlachos, I., Deniz, T., Aertsen, A., & Kumar, A. (2016). PLOS Computational Biology, 12(2), e1004720.

anonymous asked:

hey owlet! can you give a brief rundown of GABA? i dont even know if its a proper neurotransmitter and im having trouble understanding the wikipedia page. I have pretty bad nerve pain and i take a lot of gabapentin, id like to understand whats going on in my brain at least a little. i know neurologists and people dont really understand neuropathic pain but at least i can know what my meds do.

Ok sure no problem, I’ll try to keep the jargon down on this one.

The main things GABA is doing is inhibiting signal transduction. The exact nature of how it does that with ion channels isn’t terribly important here so I’ll skip on that. 

Gabapentin is structurally rather close to GABA, however it’s function doesn’t relate to the receptors GABA uses, even if it’s function is somewhat similar in that  Gabapentin also inhibits signal transduction, however it probably (we don’t actually know, it’s just a suggestion currently being discussed) works through inhibiting glutamaterg neurons.

That would be neurons that have glutamat receptors (yes that stuff that makes food taste better is related to this). Anyhow, back to gabapentin. As said, we’re not really sure to why it does what it does, but there are some ideas.

1) at least in vitro (so not on the living subject but in cell culture) it seems to kick off GABA production thereby possibly providing more inhibitory signal to your body (here)

2) It modulates the activity of a ion channel associated with pain, possibly dialing that down, too

3) it interacts with a bunch of other enzymes, at least some of which are inflammatory cytokines, meaning that these messenger proteins do regulate your inflammatory response somehow. So if Gabapentin hits on say a pro-inflammatory cytokine and ‘mutes’ it, you get less inflammatory response and therefore less inflammatory related pain. It also interacts with a number of other things and receptors (here) but I think that the detailing there might be a bit much over all.

So basically it does, for the most part, seem to turn down pain transmission in your body, thereby making your hurt less. However, gabapentin is not effective for all kinds of neuropathic pain, for example Complex Regional Pain Syndrome doesn’t seem to benefit from it (here) while diabetic neuropathy does seem to react to it (here) however the quality of the evidence isn’t super great in part because people might simply not have done enough research on that particular medication yet.

I hope this was helpful to you in some fashion? 

nikkilbook  asked:

Hi. I was hoping for some advice—I've come to suspect that I may have chronic fatigue syndrome, as well as delayed sleep phase disorder (all mixed with autism/anxiety). As far as I can tell, empirical proof of either of those requires doctors and monies, and I am poor. I was wondering if y'all had any suggestions for things to ease symptoms/preserve spoons whilst I attempt to exist at college. (OK to post)

Going to direct you here for my answer:  http://chronicillnessmemes.tumblr.com/post/147265490116/i-dont-have-the-most-vocal-followers-and-you

The only thing not on that list is that I found GABA helps for anxiety.  But as with the melatonin and any other supplement, you need to be very careful.  Just because something is a supplement, doesn’t mean it can’t hurt you or have long term side effects.  You should talk to a doctor as we are not medical professionals.  But if you can’t, please do as much research as possible before you start taking anything.

And maybe some followers have some more advice.

Admin J

“You’re so talented! How did you learn all that?”
“Takka! Robaapaskit…  Hakkiah?“
“Alone!? Woah that’s so cool! You’re a natural! C’mon, everyone’s gotta meet you! They’ll love you!”
“….Gaba?  Atchi nosty?”
“Yeah come on! … Ah, you’ll like them as well!”
“Graazi, goobaja!”
“That’s the spirit!”

That feeling when you meet another alien kid(?) and they also know how to play the ukulele

Backgroud from here! (is this wrong? Should I be doing this? I’m sorry…?)