Strawberry protein nice cream topped with rawnola, shredded coconut, kiwi, fresh strawberries and a nakd bar!
Nice cream is the most appropriate food for this heat- 28 degrees Celcius and blazing sun ☀️ but I am not complaining!
Study Identifies Memory Suppressor Gene That Could Hold Key to New Alzheimer’s Disease Treatments
While research has identified hundreds of genes required for normal
memory formation, genes that suppress memory are of special interest
because they offer insights into how the brain prioritizes and manages
all of the information, including memories, that it takes in every day.
These genes also provide clues for how scientists might develop new
treatments for cognitive disorders such as Alzheimer’s disease.
Scientists from the Florida campus of The Scripps Research Institute
(TSRI) have identified a unique memory suppressor gene in the brain
cells of Drosophila, the common fruit fly, a widely recognized substitute for human memory studies.
The study, which was led by Ron Davis, chair of TSRI’s Department of Neuroscience, was published April 14, 2016, in the journal Neuron.
Davis and his colleagues screened approximately 3,500 Drosophila
genes and identified several dozen new memory suppressor genes that the
brain has to help filter information and store only important parts.
One of these suppressor genes, in particular, caught their attention.
“When we knocked out this gene, the flies had a better memory—a
nearly two-fold better memory,” said Davis. “The fact that this gene is
active in the same pathway as several cognitive enhancers currently used
for the treatment of Alzheimer’s disease suggests it could be a
potential new therapeutic target.”
When the scientists disabled this gene, known as DmSLC22A, flies’
memory of smells (the most widely studied form of memory in this model)
was enhanced—while overexpression of the gene inhibited that same memory
“Memory processes and the genes that make the brain proteins required
for memory are evolutionarily conserved between mammals and fruit
flies,” said Research Associate Ze Liu, co-first author of the study.
“The majority of human cognitive disease-causing genes have the same
functional genetic counterparts in flies.”
The gene in question belongs to a family of “plasma membrane
transporters,” which produce proteins that move molecules, large and
small, across cell walls. In the case of DmSLC22A, the new study
indicates that the gene makes a protein involved in moving
neurotransmitter molecules from the synaptic space between neurons back
into the neurons. When DmSLC22A functions normally, the protein removes
the neurotransmitter acetylcholine from the synapse, helping to
terminate the synaptic signal. When the protein is missing, more
acetylcholine persists in the synapse, making the synaptic signal
stronger and more persistent, leading to enhanced memory.
“DmSLC22A serves as a bottleneck in memory formation,” said Research
Associate Yunchao Gai, the study’s other co-first author. “Considering
the fact that plasma transporters are ideal pharmacological targets,
drugs that inhibit this protein may provide a practical way to enhance
memory in individuals with memory disorders.”
The next step, Davis added, is to develop a screen for inhibitors of
this pathway that, independently or in concert with other treatments,
may offer a more effective way to deal with the problems of memory loss
due to Alzheimer’s and other neurodegenerative diseases.
“One of the major reasons for working with the fly initially is to
identify brain proteins that may be suitable targets for the development
of cognitive enhancers in humans,” said Davis. “Otherwise, we would be
guessing in the dark as to which of the more than 23,000 human proteins
might be appropriate targets.”
More pink smoothie bowls because I just can’t get enough these days👌 Bananas, jackfruit, and raspberries blended with almond milk and maca powder 👅 How are you guys doing up your smoothie bowls these days? Have any favourites to recommend? I’d love to hear about them! #vegan #veganeats #veganfood #veganfoodshare #vegancommunity #vegansofig #vegansoftoronto #plantbased #smoothie #smoothiebowl #bananas #banananicecream #healthy #fresh #fruit #whatveganseat #personal