Steve Universe is a children’s animation that has themes of mourning, identity, romance both straight and lbgt, representation, a predominately female group in a scifi/fantasy setting
Gravity Falls is an enthralling mystery with suspense, horror, strained relationships within a family, having a positive outlook on an uncertain future. Also a children’s animation
Avatar the Last Airbender is an Asianic inspired adventure where an eclectic group of protagonists, powered and non, all under the age of 15 are responsible for ending a 100 year war. Is nonspecific oriented in terms of age demographic
The Amazing World of Gumball uses an eclectic array of animation/art styles, has genuine humor and toys with trope expectations, but also deals several heart warming moments. Definitely intended for children, but has a few more adult jokes.
Clarence is a light hearted look into the almost idealistic world of childhood memory and experiences. Once again a Children’s animation.
Regular Show is, while intended for children, a stoner comedy with themes of growing up and dealing with relationships romantic or non, particularly moving on.
Adventure Time, despite in my personal opinion straining under its own weight in recent years, delves into aspects of depression, nurodiversity, responsibility, themes of growing up, accepting mortality, morality is a grey area being a reoccurring theme. Also a children’s animation.
Star VS the Forces of Evil, a children’s animation with a female protagonist and a Hispanic male lead, is a subversion of the magical girl genre in anime with unique style and humor, deals with the aftereffects of colonialism(both from the oppressed and the descendants of oppressors)
Bojack Horseman, an adult animation, delves into the psychosis of an alcoholic struggling with depression and self loathing, toxic relationships, the effects of having and loosing fame, has an asexual supporting character, and heavily deals with the consequences of our actions for better or for worse.
The Adventures of Rick and Morty, another adult animation, deals with existentialism, depression, surviving an attempted sexual assault, sacrificing your freedom for your family, and much, much dark humor.
Meanwhile Seth Macfarlene is still swimming in the stagnate pile of decaying fecal matter and vomit that is his three series, Family Guy being the worst offender. Littered with horrible messages, shock humor that tries far too hard and is pathetic to watch, and completely insulting to everyone. Hell, even the Simpsons are still fresh and interesting after a decade on the air. And the remakes of Teen Titans and Power Puff Girls are an insult to the original series, and are peddled off as for children.