estrogenic activity

Quick fact. Ready?
An enzyme, known as aromatase, performs conversions of free testosterone to estrogen. This is a common fear among men, in which one experiences higher levels of estrogen activity and affects in the body.

A Closer Look at Trenbolone

Not too many steroids have an air of mystique about them quite like trenbolone. It is one of those agents that you will hear talked up aggressively by some guy in the gym, to later find he has not even tried it himself yet. The bodybuilding literature is full of strong, unusual, and often-inaccurate statements about this drug, and consequently an air of misunderstanding has begun to cloud our view of trenbolone. The unusual history of this compound, including prolonged periods of very limited availability and high selling prices, has no doubt played a part in shaping the view of this steroid in the minds of athletes. It seems when anything is out of reach, overly expensive or both, people start looking at it in a different way. I therefore thought it would be a good idea to take a closer look at the physical properties of trenbolone, as well as its current state of availability and use.

Although derived from nandrolone, trenbolone is comparatively far more androgenic than this steroid. In fact it is several times stronger in this regard than our primary androgen testosterone as well. The first contributing factor to this of course is that trenbolone is a strong binder of the androgen receptor. This trait is also characteristic of its parent nandrolone, which is several times more active than testosterone in this regard. Androgen binding is in fact further enhanced by the introduction of double bonds in delta-9,11, which makes trenbolone an even more potent agonist of the androgen receptor than nandrolone. Perhaps more significant though is the fact that unlike nandrolone, the strong receptor binding potency of trenbolone is not diminished in androgen sensitive tissues by 5-alpha reductase. Trenbolone does not seem to undergo 5-alpha reduction in humans to any appreciable degree at all, which is evidenced by the fact that the major urinary metabolites of trenbolone all possess the original tri-en structure with an intact delta-4 group. So trenbolone retains its original potency as it enters cells in androgen target tissues with high 5AR concentrations, as this enzyme is not affecting it. These factors work together to allow trenbolone to be a potently androgenic steroid, instead of a primarily anabolic one in nature like nandrolone.

It has been reported in other bodybuilding literature that trenbolone does not exhibit any activity as a progestin in the body. I am not certain where this belief originated, as trenbolone does appear to exhibit the classic progesterone receptor binding ability that is characteristic of nandrolone and its derivatives. One study looking at the bovine uterine progesterone receptor for example found trenbolone to be a very potent binder, startlingly even more so than progesterone itself. Another looking at the binding of various compounds to the androgen, estrogen, progestin, mineral corticoid and glucocorticoid receptors found trenbolone to be a more potent binder of the progestin receptor than nandrolone, a steroid normally noted for its usual activity in this regard. What does this mean for trenbolone? I don’t think it really means that much. Trenbolone clearly doesn’t cause gyno, water retention or fat buildup, which one might attribute to estrogenic or progestational activity. So whatever slight action it does have as a progestin on paper doesn’t amount to all that much in the real world. The absence of estrogen may be a significant factor, as progesterone is believed to cause gyno by enhancing estrogen’s stimulation of mammary gland growth. Perhaps when trenbolone is taken with other aromatizable compounds it could affect a person’s sensitivity level to gyno and water/fat retention. This seems logical, at least in a technical sense, although admittedly I have seen no evidence to support this.

Mass or Cutting Agent
The potently androgenic and non-aromatizing nature of trenbolone makes it an extremely effective hardening and cutting agent. In fact, it is thought of as unmatched in its capacity as a body-sculpting steroid. Many competitive bodybuilders similarly find it indispensable to any good pre-contest cutting stack. For this type of purpose I doubt another steroid would serve you better. Many people do additionally find they make very good muscle gains with trenbolone. It is a potent muscle-builder, although we should probably not consider it an ideal mass-builder when used alone. The absence of estrogen is an important factor, as this trait seems integral in this type of steroid. This probably has to do not only with water retention but also interactions between estrogen and muscle glucose utilization, GH release and androgen receptor proliferation. Today we are finally starting to understand why this hormone is needed for optimal growth. Trenbolone is probably still the most potent muscle-building agent of all the non-estrogenic steroids though, and admittedly is quite unusual in its potency in this regard. But I would still think that if mass were the goal and you were choosing only one steroid, testosterone, Dianabol or Anadrol would be more productive every time in terms of overall size, weight and muscle mass gain.

Availability
As mentioned in the opening of this article, trenbolone has been plagued by periods of manufacturing inconsistency, high prices and scarce availability since it first hit the market in the early 80’s. There is probably little need to revisit in detail the rise and fall of Finajet in the 1980’s, or the demise of Parabolan in 1997. Clearly the colorful history of trenbolone is well discussed. But today’s situation is no less interesting, as we are in a unique situation. For the first time in four years we have a legitimate injectable trenbolone again, as the Mexican veterinary drug firm Laboratories Ttokkyo has recently started producing Trenbol, a 10 ml bottle of trenbolone acetate (TA) in the strength of 75mg/ml. This product is not cheap, and usually sells for upwards of $150 a bottle. Reportedly Denkall is working on a similar item, and there are some reliable underground generics floating about as well that sell for a better price and usually supply a comparable amount of TA. There have been some questions about raw material supply lately though, and whether or not both types of product would remain on the market. This discussion was heightened by the recent removal of Trenbol from Ttokkyo’s website, which is making a lot of people nervous that this product may be on the way out. Hopefully this is just a website problem and not a repeat of the fate that fell on Finajet and Parabolan. If these products do dry up, trenbolone will still be available, but in the form of cattle implant pellets. In Part II of this article I will take a closer look at these unusual products, as well as the various methods utilized by bodybuilders in an effort to effectively use them.

sobs–I found resources for getting top surgery without being on T and your breasts will NOT grow back even if you’re still actively producing estrogen because the amount of breast tissue left just….isn’t enough for it to grow

like yeah you might get moobs if ur chunky like me but that is Not The Same and I just

thank fuck because I’m still super nervous about going on T and while I DEFINITELY want top surgery, I haven’t made my mind up about HRT–which means I don’t wanna do it until I move forward w/ other stuff in my life y’know?

so this is so fucking comforting goddamn

Ok! So.
1. Looks through a paper of a professor’s friend and they go say, “this plant needs to be tested for any estrogenic activity”
2. Sets up experiment. Writes thesis things. Tests plant through decoction and administering decoction on food mixture for test subjects. It a diluted amount, a mixture of water, extract, and honey and depends on percentage.
3. Gets results. No significant difference..
Still have to rewrite RRL and Intro, need to recount those follicles and make a damn stat analysis.. And I still need to write a discussion…

anonymous asked:

People keep mentioning >2 biological sexes, but no one will identify them. I understand if there are no names, but what do they DO? What kind of gametes do they make, if not sperm or eggs? Or is it just that their ability to produce sperm or eggs is ambiguous, impaired or deactivated? By remaining vague you appear to be pushing back against biological essentialists with some remixed biological essentialism of your own, which just makes all parties look foolish and drives away biologists.

[TW for discussion of bodies and cissexist language.]

Let the record reflect that I do not appreciate your implication that I do not know what I am talking about. This is information I have shared, multiple times, on this blog and elsewhere. This is information that is available via google search. I am going to give you a summary and then some assigned reading. 

Now obviously, because you are here, you are at least dimly aware that binary gender is a faulty construct and a whole spectrum of gender experience exists. Very shortly we are going to see that binary sex is also a faulty construct. 

There are more than two sexes or, more accurately, the construct (as in, the notion made up by humans) of binary sex fails to map onto biological reality.

So, what exactly is binary sex? It is the notion that there are two “biological” sexes, and these sexes have distinct certain traits. 

These sexually dimorphic traits include kariotype, genital arrangement, endocrine activity, reproductive system (including gamete production) and secondary sexual characteristics (there may be more that I’m missing atm). 

The idea is that “female” people have XX chromosomes, a “typical” dfab genital arrangement, cyclical estrogen and progesterone activity and relatively low testosterone, produce eggs, and breasts and hips, while “male” people have XY chromosomes, a “typical” dmab genital arrangement, high testosterone and low progesterone and estrogen activity, produce sperm, and wide shoulders and narrow hips.

In reality, none of these traits necessarily go together. You can have any combination of these things, and basically every combination you can conceive of actually happens in humans. Furthermore, most humans fail to map on to every trait of their assigned binary sex at some point in their lives. 

There are a myriad of possible kariotypes (XX, OX, XY, XXY, XXX, XYY, etc.) If you have a kariotype other than XX or XY, you could walk around your entire life never knowing, or be diagnosed in childhood due to associated symptoms, or anything in between.

There are a myriad of genital arrangements, including intersex genital arrangements, and a wide variation of genital arrangements even within the categories of dfab and dmab. 

There are countless ways in which endocrine function can vary, from insensitivity syndromes to high levels of one hormone or another to deficiency in the production of a hormone, etc. 

There are countless ways the reproductive system can vary, and not all people successfully produce gametes, or possesses the associated parts to successfully reproduce. Sterility occurs in humans, as do conditions which make successful coupling impossible, etc, not to mention the wide variety in sexual behavior and mate selection that can affect the decision to reproduce or not reproduce. 

There are a myriad of body types, and not all dfab people have breasts, and some dmab people have wideset hips, etc. 

So when we’re talking about bodies, binary sex is woefully inadequate to define what’s actually happening. 

Go read Kinsey’s takedown of the construct of binary sex here [link] and my rant about the genderbread man here [link