drug delivery system

like taking poison and waiting for the other person to die

Tony is still furious at Steve over the events of Civil War. But when Steve gets kidnapped using Stark technology, Tony feels responsible and figures out a plan to save him - by getting kidnapped himself.

Tony had designed the restraint tech in a hurry, after he’d been told he had 24 hours to bring in Cap and his team. The design was a rush job, lacking override controls, not his finest work. When they’d fought, the ankle restraints had lasted all of about five seconds before they were smashed apart by Cap’s shield, and Tony hadn’t thought about them since.

He hadn’t thought about Rogers since then, either.

So he told himself.

Rogers had made his choice. He’d chosen himself and his nostalgia for the past over his team and a present which needed him. Over Tony.

And that was fine. It wasn’t as if Rogers owed him anything (for the house, the funding, the moral support, the fami… the team). And it wasn’t as if there was any way he could have got through the man’s goddamn stubbornness. Tony had tried arguing, he’d tried cajoling, he’d tried threatening and begging and compromising.

And he’d ended up alone, abandoned in a freezing bunker in Siberia, his chest caved in and pain blooming throughout his body as the light from the arc reactor faded. He’d been ready to die. Would have welcomed it, even. But no. His punishment was to keep living, with yet another scar ripped across his heart by someone he thought he could trust.

He didn’t care if Rogers was on the run or in hiding, and wasn’t inclined to use what little precious influence he had left to protect him any further. Rogers had made his bed, now he could lie in it.

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Sorry guys, I’ve really dropped the ball on updating the blog more often! I will try to get on more often and mix in news with personal experiences so that I can share more often.

Anyhow… here is an awesome application of nanoparticles! Inhalable insulin is not a new idea, but this shows promising future results. The past models had to be large, and bulky due to the drug delivery system. Because inhaling drugs often results in a very diluted amount with a lot of it not being absorbed correctly, in order to have the correct dosage of insulin it was difficult. Also it was very difficult to clean, got messy and eventually was taken off the market within a few years. 

Here, by using nanoparticle insulin they were able to compact the device (increased delivery transfection). I really look forward to seeing this new Afrezza in action as it leaves the FDA and clinical trial stages (the graveyard of inventions) to do great things!

Nano Particles Introduction

With my move and new school, I also began research at a nanomedicine lab. Its only been 2 weeks, but I have learned so much, and I wanted to share with all of you some of the amazing things that have been happening with nanoparticles! 

So stay tuned for some awesome drug delivery systems, non-viral gene therapy techniques and new methods of tracing particles throughout the body!

In this chapter, it didn’t have so many terms that I needed to memorise so what I did was that after reading a subtopic, I wrote down the stuff that I could remember. This time, I didn’t use post it notes because I needed lots of space where I could write so I used my notebook instead. 

This method seemed really to be working because it exercises my brain to remember things that I just read and there’s a high tendency that the things that I just read would be retained rather than just reading.

So whenever I review, I just read my notes written on my notebook or scan the book and try to recall what is that specific subtopic all about or I try to define the orange-highlited words. These words that are highlighted in orange are important terms that are needed to be remembered. On the other hand, the yellow ones are for the definition. So basically, I only use two colours of highlighters but I’m planning to use another colour for the lectures. But I still have to figure it out lol 

Basically, it’s just reading and writing. These two work perfectly!

Remember Me

A/N: So here we have some fun stuff going on. You can all thank carry-on-my-wayward-imagines for this one. 

Summary: Little angst. Little Sam. Nothing you won’t enjoy. Oh but there is this wraith issue in Miami. Might want to check in on that. 

p.s. I’m really feeling the dry dead humor right now. If you hadn’t picked that up yet. Oh and if you don’t like blood, or spiders, or being paralyzed, you’ve been warned. Also thank you to a certain awesome buddy for proofing this for me! 

Part Two- “Some Assembly Required”  Part Three- “Dream a Little Dream” 

“Sam! Sam look at me! Sam please!” You held your tall lover’s face as he lay on the hard ground, slipping in and out of consciousness. There was a line of blood running out of his ear and the deep puncture wound at the base of his neck. He was slipping fast and you could only sit there and put pressure on the wound, trying to keep his attention while you waited for Dean to help you carry him to the car and then hospital. “Dammit!”

A Few Hours Earlier…

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Newly-Approved Brain Stimulator Offers Hope for Individuals With Uncontrolled Epilepsy

A recently FDA-approved device has been shown to reduce seizures in patients with medication-resistant epilepsy by as much as 50 percent. When coupled with an innovative electrode placement planning system developed by physicians at Rush, the device facilitated the complete elimination of seizures in nearly half of the implanted Rush patients enrolled in the decade-long clinical trials.

That’s good news for a large portion of the nearly 400,000 people in the U.S. living with epilepsy whose seizures can’t be controlled with medications and who are not candidates for brain surgery.

Epilepsy is a chronic neurological condition characterized by recurrent seizures that disrupt the senses, or can involve short periods of unconsciousness or convulsions. “Many people with epilepsy have scores of unpredictable seizures every day that make it impossible for them to drive, work or even get a good night’s sleep,” said Dr. Marvin Rossi, co-principal investigator of the NeuroPace Pivotal Clinical Trial and assistant professor of neurology at the Rush Epilepsy Center.

The NeuroPace RNS System uses responsive, or ‘on-demand’ direct stimulation to detect abnormal electrical activity in the brain and deliver small amounts of electrical stimulation to suppress seizures before they begin.

The device is surgically placed underneath the scalp within the skull and connected to electrodes that are strategically placed within the brain where the seizures originate (called the seizure focus). A programmed computer chip in the skull communicates with the system to record data and to help regulate responsive stimulation.

The unique electrode placement planning modeling system developed at Rush uses a computer-intensive mapping system that facilitates surgical placement of electrodes at the precise location in the brain’s temporal lobe circuitry. When stimulated, these extensive epileptic circuits are calmed. The modeling system predicts where in the brain the activity begins and spreads, so that the device can better influence the maximal extent of the epileptic pathway.

The device also acts as an implanted EEG for recording brain activity. This function was first shown at Rush to help determine whether the patient will further benefit from a surgical resection, in which surgeons remove a portion of the temporal lobe network. Dr. Richard Byrne, chairman of Neurosurgery at Rush, implants the electrodes in the temporal lobes.

As a result, physicians at Rush can offer patients the new implantable neurostimulator device, a surgical resection or both with the possibility of completely eliminating seizures. “This device is also being used at Rush as a foundation and inspiration for building cutting-edge hybrid stimulation therapy-drug molecule delivery systems,” said Rossi.

“Devices that treat epilepsy may offer new hope to patients when medication is ineffective and resection is not an option,” said Rossi. “Not long ago, it was highly unlikely that these patients would ever be free of their seizures. Now, several of our Rush patients with this device are actually able to drive, lower or even eliminate their medications and aren’t as limited as they once were. There is no doubt that quality of life of the majority of our implanted patients is significantly improved.”

According to the Centers for Disease Control and Prevention, in 2010, epilepsy affected approximately 2.3 million adults in the U.S. and 467,711 children under the age of 17.

Sorry I haven’t been updating more often! I have been fairly busy learning a ton of new things to share with all of you. 

Well here is a beautiful picture of what a micelle would look like. A Micelle is one of the very first ideas that people have had for a drug delivery system. The thing that makes it so perfect is the combination of its self forming properties due to hydrophobic effects and its ability to get through the lipid bilayer. By doing this, we can delivery drugs with poor solubility. 

That’s a short blurb about micelles, but this is just the beginning! I have so much more to share with you all both about drug delivery and just my experiences.