dopamine activity

I googled science pick-up lines and I was not disappointed
  • You’re so hot, you denature my proteins. 
  • Do you have 11 protons? ‘Cause you’re Sodium fine!  
  • You make my anoxic sediments want to increase their redox potential. 
  • I’m more attracted to you than F is attracted to an electron. 
  • We fit together like the sticky ends of recombinant DNA. 
  • You’re hotter than a bunsen burner set to full power. 
  • If I were a neurotransmitter, I would be dopamine so I could activate your reward pathway. 
  • According to the second law of thermodynamics, you’re supposed to share your hotness with me. 
  • How about me and you go back to my place and form a covalent bond?
  • I wish I were Adenine because then I could get paired with U.
  • If you were C6, and I were H12, all we would need is the air we breathe to be sweeter than sugar.
  • I want to stick to u like glue-cose.
  • You must be the one for me, since my selectively permeable membrane let you through. 
The signs as shit that happens in Tales from the Borderlands
  • Aries: Rip a guy's heart out with your bare hand while your best friend makes it rain 10 million dollars
  • Taurus: Slap your friend's ass because a dead CEO possessed your robotic arm
  • Gemini: Just scoop that general's eyeball out with a spork. Just fucking do it.
  • Cancer: Blow a crime lord's head off while cool sunglasses fall from the sky and onto your face in a freezeframe
  • Leo: Serious finger-gun shootout with all of the Hyperion accounting team
  • Virgo: Bro that's bro bro for bro bro bro bro bro bro bro bro bro bro bro bro
  • Libra: Get arrested for shooting a diamond pony statue at a VIP tour and then watch it bleed
  • Scorpio: Here's a tiny broken flying and perpetually screaming robot that can shock people and then die, have fun
  • Sagittarius: That's it. Peel that face off like a serial killer. You're sick.
  • Capricorn: Escape certain death via contact-activated-dopamine-injecting CEO wheely chair
  • Aquarius: Order a robot to push over an Atlas statue by its butt cheeks
  • Pisces: All the money you saved for the Mystery Vault Hunter is for Claptrap
Dopamine, Methamphetamines, and You

First things first – What does dopamine do anyway?
1) Dopamine is critical to the way the brain controls our movements. Not enough dopamine – can’t move, or control our movements well. Too much dopamine? Uncontrollable/subconscious movements (like picking, tapping, repetitive moments, jerking, twitching). Remember that the heart is a muscle, too, and too much dopamine will result in increased pulse and blood pressure.

2) Dopamine controls the flow of information from other areas of the brain, especially memory, attention and problem-solving tasks. This becomes important when we talk about amphetamine-induced psychosis that is common in meth abusers.

3) When dopamine is released it provides feelings of enjoyment and reinforcement to motivate us to do, or continue doing, certain activities. Dopamine is released by naturally rewarding experiences such as food and sex. This pre-programmed reward system makes sure that people do eat, do desire to procreate, and basically survive. Without enough dopamine, people feel the opposite of enjoyment and motivation – they feel fatigued and depressed, and experience a lack of drive and motivation.

How do brain chemicals like Dopamine work?
Brain chemicals, including Dopamine, are stored in cells, which you can think of like barrels full of that chemical. When something occurs like a good meal or great sex the brain pours out some dopamine from the dopamine barrels into an open space in the brain called a synapse. It floats around there. Think of the synapse like a street, and dopamine is like little cars driving around aimlessly on the street.

Across the street (not far) from the barrels of dopamine are Dopamine receptors. These receptors have little parking spaces on them that only fit Dopamine (or a substance VERY similar in chemical shape to Dopamine) into them, like a lock and key. As the Dopamine floats around in the synapse, it finds parking spaces at Dopamine receptors, and “plugs in” to the receptors. THIS is the point where we feel good, when the Dopamine is parked in a receptor’s parking space. There are, however, a limited number of receptors with “Dopamine only parking” available, and each receptor has a limited number of parking spaces. So some of the dopamine may not be able to find a place to park.

When all the parking spaces are taken, the remaining dopamine that didn’t find a place to park is normally recycled. There are “reuptake molecules” that do this – think of them like tow trucks. They find the extra dopamine, and tow it back to the barrels of Dopamine so that it can be re-used the next time. After some time has passed, the receptors release the Dopamine that was parked in their parking spaces, and the tow trucks take those Dopamine molecules back to the barrel too.

The brain has a safety-check system that will destroy any excess Dopamine that isn’t in a parking space, and didn’t get picked up by the tow truck. There are special chemicals in our brains that will break down this extra dopamine. Think of this like the toxic waste crew coming in and sweeping up the street.

As a last resort, after repeated long-term over-stimulation, the brain will shut down Dopamine receptors so that nothing can park there ever again. Think of this like the demolition team coming in and permanently barricading off the driveways.

This is your brain on Meth!
So now that we have a basic understanding of how things work normally, I’ll try to explain how things work when meth is ingested.

When someone eats, snorts, injects, or otherwise gets meth into their system, meth stimulates those barrels of Dopamine to pour out Dopamine. Meth continues to tell the cells to pour out dopamine until the body can break down the meth, which is typically 12 hours or so.

So Dopamine is poured out into the synapse (street) and finds parking spaces at dopamine receptors and makes the user feel high.

But meth is a tricky little chemical. It is shaped closely enough to Dopamine that the tow trucks get confused, and pick up meth thinking that it is dopamine. So the tow trucks are busy driving around hijacked by meth molecules leaving the extra Dopamine molecules floating around in the street (synapse). Well… that means the toxic waste crew comes in and destroys that dopamine that did not get recycled. So for the 12 hours or so it takes for the body to break down the meth, it is also spending that time destroying dopamine.

As long as the user keeps ingesting more meth, this process continues until there is not enough dopamine left to feel high from. When the user finally stops using, and the brain breaks down the meth molecules, the recycle trucks try to salvage what dopamine there is left, while the user crashes.

The end result of a “run” or “binge” on meth is a marked decrease in the amount of dopamine left in the brain. This leaves the user feeling exhausted, hungry, depressed, possibly suicidal and definitely unmotivated. They are literally suffering from a brain chemical imbalance. Self-inflicted mental illness.

How can the brain ever be normal again?
Well, luckily, the human body is pretty resilient. We do have the ability to make replacement dopamine. However, the body was not designed to need to do this in large quantities or in quick supplies. So we don’t have a mass-production plant making dopamine. It’s a 3 to 4 step process, too.

The process: Phenylalanine –> Tyrosine –>L-dopa –> Dopamine

Phenylalanine is the first “pre-cursor”. It can be found in the following foods: soybean protein, frozen tofu, dried and salted cod, shellfish, lean meat, organ meat, skin-free chicken, cheese, milk, eggs, many seeds (watermelon, fenugreek, roasted soybean nuts), and chocolate. Equal artificial sweetener also contains Phenylalanine. The body can turn Phenylalanine into Tyrosine.

Tyrosine can also be found in food. This would eliminate the need for the body to synthesize it from Phenylalanine. One step closer to dopamine! Meat, dairy, eggs as well as almonds, avocados and bananas are good sources of Tyrosine.

From there, the body will convert Tyrosine into L-Dopa, and then on to Dopamine (and other neurotransmitters like norepinephrine).

So… to replace dopamine destroyed while high on meth, the recovering user must eat sources of Phenylalanine or Tyrosine.

To aid the body in making Dopamine, the person can use what dopamine they DO have left as often as possible. This tells the body that they need more of it. While you sleep, you use very little dopamine. Exercising, even just a walk around the block will use dopamine (remember, it controls movement). So setting a reasonable sleep schedule, and trying to get some exercise will help speed up recovery from Self-inflicted Dopamine Destruction (aka meth addiction)!

Be patient – remember, we weren’t designed to waste dopamine, we were supposed to be recycling it. The process of replenishing dopamine takes months. Studies show that recovering meth addicts who have abstained from meth use have about 80% of normal dopamine levels after 18 months of abstinence. This WILL be a long battle. It CAN be won.

What about the receptors that were destroyed?
Well, good news again. Even though those receptors can never heal or recover, the brain is able to use existing receptors and find new pathways to accomplish the same results. Some receptors will even get a home equity loan and build on extra parking spaces!

Are there any medicines that can help?
A doctor should always be consulted and included on any medication treatment for a recovering user. Many recovering addicts have found Wellbutrin (Bupropion) to be helpful after a few months of clean time. What Wellbutrin does is block some (not all) of the tow trucks for a little while so that the dopamine the person has left can be more effective. It does not, however, stimulate the barrels to pour out dopamine. The person has to have enough dopamine in their brain before Wellbutrin can help.

anonymous asked:

Namjoonnie why do you keep listening to depressing songs ??

Well it’s actually quite interesting, you see.

Over the past few years, research has been made into why people listen to sad songs when they themselves are in a bad mood, place or situation and what it basically comes down to is that there’s two ways of looking at it, the psychological or the chemical.

The psychological version also splits into two options;
(1) is the notion in which one person’s mood lifts up simply from the knowledge that there are other(s) that have it worst than him.
(2) is the way sad music makes you feel validated, like you’re not wrong for feeling like you do.

The chemical and neuroscience way of looking at it is also a bit split to different opinions; 
It’s a known fact that music activates our dopamine, which is essentially the same neurotransmitter we release during sex, when we eat or when using drugs, so basically what gives you pleasure. 

So then maybe it’s a combination of dopamine and the psychological way our mid works.

It’s also been proven by science and research that most if not all creative individuals suffer from some level of depression and that that in itself fuels the  individual in creating even more. t’s like a sad balance where the negativity helps you reach new potentials.

anonymous asked:

While I like the idea of Anx and Logan sweet talking each other, I can also see them only expressing their affection to each other in very snarky (A: Having you around makes this place suck less.) or scientific (L: Your presence causes a rush of endorphins, which brings me great pleasure.) way. It's weird but they get it, neither are good at typical compliment, so it works for them. But Princey keeps calling the "unromantic nerds" so they decide to get back at him. (1/2)

(2/2) They start complimenting each other more, but its like, L: My affection for you is almost as vast as Roman’s ego. R: Hey! A: You’re so handsome you make Princey look like a flaming dumpster. R: HEY! Until, R: If I apologize for calling you unromantic, will you stop. L: As long as you apologize for calling us nerds as well. R: *sigh* Deal.

writting out Logan lines hurt me. It HURT me

Brain, sarcasm, and pettiness

Analogical

Warnings: none that I can think of

-0-0-0-0-

The first time Roman ever heard the couple being “romantic” he was… well, shocked wasn’t a strong enough word to explain his reaction

“Anxiety, I love you with all the synaptic connections of my brain”

As if that wasn’t weird enough Anxiety rewarded the confession with a blush and pulling the glasses clad man down into a kiss. Roman left the room silently, shaking his head. Weird

-0-

The second time the couple was being… “Romantic” it was a few minutes before movie night. Morality was busy making popcorn and Roman was searching for a decent enough movie. Anxiety and Logic were cuddling in the loveseat.

“I tolerate you more than I stand the rest”

Roman looked at them almost with disgust, while Logic laughed, hugged the younger one more close to him and kissed his forehead.

-0-

From then it was a constant, every time Roman saw the two being “Romantic” it was in their own twisted and weird way of romance

“You activate my dopamine system”

“It’s comforting how you understand reality better”

“My oxytocin levels raise when im with you”

“You are the lest lame in this house”

Roman could not stand it; he was so done, so absolutely done. After a few more weeks of those two confessing in their own weird way Roman sat them down and finally snapped

“You two, I just! UGH!”

“What is the matter Roman?”

“Yeah, what’s up?”

“You two wouldn’t recognize romance if it slapped you upside the head!”

“Wha- But we-”

“NO! No Anxiety, don’t you dare tell me you two are romantic around the other! Who even talk the way you two do?”

“Do you have a problem with our-”

“Indeed I do, you two are just… unromantic nerds!”

After getting that out of his chest the Royal boy left the room, leaving the other two to stare at each other a little worriedly. Anxiety… anxieties were already kicking in and he looked at his boyfriend for grounding

“Im not… you don’t-”

“I’m aware you are rather fond of me Love”

Anxiety nodded, as long as Logan knew his feeling it was okay with him. But now he was getting angry, why did the royal one think he had any say in how they expressed their feelings? Anxiety was gonna get his revenge and Logan was going to help him, if he knew his boyfriend as well as he thought then the logical trait was also feeling pissed at the regal one commentary

“So, what are we gonna do now?”

“Well, if he has problems with how we express ourselves then maybe we can use him as example”

“What‘d you mean?”

“Prince seems to think we are not romantic enough, correct?”

“Yeah”

“The lets use him as a literal example

“Oh… oh! Sounds like a plan”

Both sat there smirking, oh they were going to get their revenge okay? And it was going to be amazing

-0-

The following morning Roman walked into the kitchen and saw Anxiety and Logic, the younger one sitting in the teachers lap and using his shirt, eating together and lightly talking. Roman smiled gently; maybe his pep talk actually had helped?

“I feel for you more than Roman for himself”

Wait, what?

“You shine brighter than the Royal-pain-in-the-neck crown”

What the heck?

“My affection for you is almost as vast as Roman’s ego”

“HEY!”

“You’re so handsome you make Princey look like a flaming dumpster”

“WHA- ANXIETY!”

The two more gloom sides smirked, and even if they were sitting down it still felt like they were looking down on Roman who huffed indignantly and left the kitchen. Once he was out of earshot the other two laughed, it was always hilarious to get a raise out of the Royal side.

-0-

After weeks, and weeks, and really long weeks of the other two flirting while attacking Roman at the same time the Royal one gave up. He walked up to the couple and put his hands on his hips, looking down at them with flaming eyes

“What?”

“If I apologize for calling you two “unromantic” will you stop?”

“As long as you apologize for calling us nerds as well”

Roman sighed, the whole sigh being extremely dramatic, and put a hand on his head

“Deal”

  • Basic human knowledge: "This pleasant activity releases dopamine in the human brain, creating a sensation of pleasure."
  • Some shitty fucking Facebook news page: "BREAKING: COLORING BOOKS HAVE THE SAME EFFECT ON CHILDREN BRAINS AS THE COCAINE DRUG!!!!!!!!!!!"
Chem & Bio Pick Up Lines
  • If I were an enzyme, I'd be DNA helicase so I could unzip your genes.
  • You're so hot, you denature my proteins.
  • Can I be the phasor to your electron and take you to an excited state?
  • Are you made of Copper and Tellurium? Because you are Cu-Te
  • Do you have 11 protons? 'Cause you're Sodium fine!
  • Do you like Science? Because I've got my ion you!
  • You must be gibberelin, because I'm experiencing some stem elongation.
  • You make my anoxic sediments want to increase their redox potential.
  • Are you made of Nickel, Cerium, Arsenic and Sulfur? Because you've got a NiCe AsS!
  • Hey baby, will a little more alcohol catalyze this reaction?
  • Didn't you know that chemists do it periodically on the table?
  • I bet you're like calcium bicarbonate - if I get you wet, the reaction will be explosive!
  • Are you made of Fluorine, Iodine, and Neon? 'Cause you are F-I-Ne
  • Me and you would undergo a more energetic reaction then Potassium and water.
  • Are you a compound of Beryllium and Barium? Because you're a total BaBe.
  • Im more attracted to you then F is attracted to an electron.
  • I will fondle your vesicles while you caress my golgi body.
  • I want to work on your leucine zipper with my zinc fingers.
  • If you were oxygen, I would be an alkali metal so i could get in you and explode!
  • We fit together like the sticky ends of recombinant DNA.
  • You are the photon to my photosystem: you excite my electron until I reach my reaction centre.
  • You're hotter than a bunsen burner set to full power.
  • If I were a neurotransmitter, I would be dopamine so I could activate your reward pathway.
  • Hey, wanna put your alpha helix in my beta barrel?
  • Hey baby, why don't you get your ligase working on my okazaki fragment and lengthen my strand.
  • Hey, are you an alpha carbon, because you look susceptible to backside attack!
  • Do you want to extract some protein from my column?
  • According to the second law of thermodynamics, you're supposed to share your hotness with me.
  • Everyone knows its not the size of the vector that matters, but the way the force is delivered.
  • How about me and you go back to my place and form a covalent bond?
  • If I was an endoplasmic reticulum, how would you want me: smooth or rough?
  • We can make a mess as I've hired some lysosomes to clean up after.
  • My hypothalamus must be secreting serotonin because baby, I want you!
  • I wish I was an Ion so I could form an exothermic bond with you.
  • You’re so cute you make my zygomaticus muscles contract.
  • I wish I were Adenine because then I could get paired with U.
  • You’re like telophase, I admire your cleavage.
  • Hey baby, want to form a synapse with me and exchange neurotransmitters?
  • Hey baby, want to form a zygote?
  • It’s a good thing you've got evaporative cooling, cause I’m going to make you sweat
  • If I were a Shwann cell, I'd squeeze areound your axon and give you a fast action potential.
  • Want to be my substrate/enzyme?
  • If my right leg is the cell wall and my left the membrane, do you want to be the cytoplasm?
  • If you were a concentration gradient I'd go down on you.
  • If you were C6, and I were H12, all we would need is the air we breathe to be sweeter than sugar.
  • Whenever I am near you, I undergo anaerobic respiration because you take my breath away
  • I want to stick to u like glue-cose.
  • You must be the one for me, since my selectively permeable membrane let you through.
  • Can I be your enzyme? because my active site is dying for a chemical reaction.
  • You give me more jolt than a mitochondria!
  • Right now we’re just two RNA, but maybe we could transcribe together and become DNA.
  • I have a smooth endoplasmic reticulum but know that I like it rough, if you know what I mean.
  • I also prefer my ribosomes bound tight. Spin me round with your basal body and make sure it's turgid.
  • Do you like aerobic respiration as much as I do?

anonymous asked:

in ref to the ask u posted from saavok feb 21 - i've been a bit worried that i was misusing my meds since one of the biggest things they do for me is help me wake up and not sleep all day, but since seeing becca's answer mentioning that that's how they work for her too i feel a lot better! i wasn't sure if that was actually a part of me adhd but it didnt make sense otherwise since im pretty diligent about getting enough sleep

I’m glad my answer gave you some comfort! Being constantly tired despite getting enough sleep is something that I’ve dealt life pretty much all my life (although it started getting noticeably impairing in my teenage years), and none of the doctors I went to for it could really tell me anything useful. They told me it was a normal teenage thing, and to get enough sleep, and keep a regular sleep schedule. No matter how much I tried to convince them that I did get a lot of sleep but still just couldn’t keep myself from falling asleep in pretty much every class (or at my desk, or the dinner table, or on a bus, or on the floor…) they weren’t able to do anything about it. I tried everything, and nothing helped. Eventually doctors started telling me that some people are just tired all the time and that’s how they are. 

The fact that I was suddenly able to stay awake throughout the whole day and actually feel awake too was one of the very happy side effects of my medication. I brought this up with my doctor and we discussed how this is actually pretty common in ADHD. How awake we are is regulated by certain parts of our brains associated with the neurotransmitter dopamine, which some might recognize as one of the neurotransmitters that ADHDers have much lower levels of (note that this is a very simplified version of the neurobiology involved). This lack of dopamine makes it hard for our brains to control when we feel awake and when we feel tired (which can lead to chronic tiredness but also chronic insomnia, like it did in my case). ADHD medication like Ritalin or Adderall works by stimulating dopamine production and preventing re-uptake, making dopamine active for longer in our brains. These higher levels lead to a much more efficient regulation of awake states. 

This turned into a longer answer than I was anticipating, but I’m glad I could help you understand some of the causes behind your tiredness. I hope others recognize themselves in this too, and that it helps them find better solutions than most doctors will suggest. ADHD is so much more than just inattention and hyperactivity; I think that’s something people easily forget, and something we should definitely pay more attention to.

-Becca

Reyes Vidal Week, Day 2: SAM in love

Today, I didn’t reaaaally follow the prompt. But Reyes is chilling on the Tempest - does that count?

In this one-shot, Reyes and SAM have a heart-to-heart. This is the first thing I’ve written from first-person perspective. Please let me know what you think!! <3


It starts with vasodilation.

Increased blood flow to Ryder’s lips and cheeks turns them pink. The tissues of her genitals swell and become moist. Her pupils dilate. Oxytocin and dopamine flood her brain when he kisses her. She gasps when he bites her shoulder, but her nervous system floods with endorphins and dopamine; she finds his bites pleasurable, not painful. Her nipples harden and her breasts swell at the touch of his hands and tongue. When intercourse commences, dopamine activity increases further, and there is heightened neural activity in her basal ganglia. Her respiratory rate and heart rate increase. He quickens the rhythm of his copulatory movements, and her genital muscles begin to contract and spasm as she cries out. A burst of neurotransmitters and hormones, muscle contractions, and widespread neural activity overtake her body. Her physiological signs are very clear: she is euphoric, all bodily signals indicating pleasure and reward.

Through Ryder, I observe, and I learn, and I feel what it is to be euphoric.

***************

Ryder’s reactions to Mr. Vidal have always been different than her reactions to the rest of the crew. When we first met Mr. Vidal, I initially analyzed him as a threat. The Pathfinder had experienced a spike in adrenaline and cortisol, and her pupils had dilated, so it was my impression that she was experiencing a fight-or-flight response. However, there was a surge of dopamine in her brain at the moment that he spoke, indicative of reward. These signals were contradictory, so I did not act. Further information was required.

Keep reading

17 Crazy Interesting Facts About Dopamine

Originally posted by deepwintergirl

What does dopamine do? Well, at the most basic level, everything you think, do, and are is basically part of one big chemical reaction. That’s not an altogether comfortable thought for some people - but it’s the science. It’s hard to deny when you start looking into incredible brain chemicals and neurotransmitters like dopamine.

Keep reading

Molecule of the Day: Methylphenidate

Methylphenidate (C14H19NO2), also known as Ritalin, is a white powder that is slightly soluble in water. It is commonly used to treat ADD, ADHD, and narcolepsy.

Methylphenidate inhibits dopamine and norepinephrine transporter proteins, thus preventing dopamine and norepinephrine in the synaptic cleft from being reuptaken into the presynaptic knob. The resultant higher concentration of these substances in the synapse causes the receptors on the postsynaptic knob to be stimulated at a greater frequency, thus achieving greater synaptic transmission. This produces a psychostimulant effect, allowing it to be used in the treatment of ADHD.

In small amounts, methylphenidate has also been shown to enhance memory and control, caused by the activation of dopamine and adrenergic receptors. However, in large doses, it can have the opposite effect.

It has few side effects, which include loss of appetite, nausea, and insomnia. However, like many strong dopamine reuptake inhibitors, it can result in dependence, and is often seen as a gateway drug. 

Methylphenidate is industrially synthesised through a multi-step pathway from 2-bromopyridine and benzyl cyanide.

Requested by @zenbra

oneelevenone  asked:

Hey there! So um... I'm writing a story about a boy who's lost his ability to feel empathetic (basically he struggles to feel any emotions due to a large amount of abuse in his past) and he's saved by another boy who stumbles on the building he was being held captive at. I'm not able to really write any proper bonding moments between them as my main character can't stand physical contact (Physical abuse ;( ) Could I maybe ask for your help? I really love your blog. Your prompts are amazing <3

Luckily, there are more ways to for people to bond than any sort of physical intimacy! Sure, things will be more difficult given your character’s abusive past and lack of empathy, but it doesn’t make it impossible. It simply gives a greater challenge for the characters. Consider these options!

1) Have the second boy talk about himself. If the abused character won’t open up or get close, a significant show of good will would be to stay in his company and talk about himself. It can just be random little things (“You know, when I was six, I got stuck in a tree for four hours.”) or it could be something more meaningful and personal (I’ve always had an intense fear of people leaving me, so I kinda tend to over do it trying to make friends.”) This can bring an emotional intimacy, as it shares information between the two, and may make the first boy more likely to open up himself.

2) Have them just hang out and do fun things. Some of the best ways to bond with someone is by sharing a hobby or other sort of fun activity. This can be a sport, a video game, a craft, so on and so forth. If the activity increases dopamine, then the characters will be more relaxed, more content, and less guarded. This gives a good time to bring a more intimate moment.

3) Have the second boy express his care. In my experience, people who have gone through a lot of terrible things need time and reassurance that you care in order to get closer. You can’t rush it, and you have to be patient. Have him express his care at random, and at points when the first boy seems be needs it most. Helping him gently and genuinely through a hard time will bring a lot more trust, especially if he doesn’t appear judgemental or like a know-it-all about it.

Know that over time, as the two get closer, that it’s okay for the abused character to become more comfortable with him physically as well, and to change around the second boy specifically. I hope this helps (sorry it’s so long!) and thank you for the kind words!

Using Meth—Getting the Most Out of It

ately, there have been a few posters I have replied to who don’t actually know how works. If you don’t have a basic understanding of what’s going on in your body, you will waste it when you really can’t get any higher, cause damage with an overdose and in so doing, also create a dependency by trying to force a high.
Reading this may save you money, give you a better high, do less damage to your body, and hopefully keep you from becoming addicted or better manage an <. I’ve left out some details and made a few generalizations to keep this as simple to understand as I can.Methamphetamine</a> directly affects release. Dopamine is an organic chemical in the brain that works with two other chemicals, serotonin and norepinephrine. All affect our moods, our actions, our outlook on life—our wants and needs. When dopamine is released into the brain as ater">neurotransmitter, it seeks out dopamine receptors in different areas of the brain. When the dopamine is activated at these points, it affects motor control, motivation, arousal and reward, including sexual gratification.

When you get an initial rush, this is when a much higher release of dopamine (hundreds of times more than normal) saturates the dopamine receptors. The brain is overwhelmed trying to process this massive amount of a potent chemical. After the receptors adjust to this onslaught, the rush is over, but it continues to give you a high. This is the main mechanism.

What happens after this hit or shot (especially noticeable with an IV injection), the dopamine receptors realize you have too much dopamine at work and send some of the dopamine back to the neurotransmitters for later use. The dopamine pathways also shut down, making it impossible to send more dopamine to the receptors. This leaves less dopamine in the brain before it has time to manufacture more and the dopamine pathways open up again.

As the high lessens, users begin thinking they want the stimulation of the initial high and re-dose. The signal goes out again to release dopamine, but there’s not as much in your brain as you had before. There’s not enough to release at one time to give you a rush, but the high goes back up to a degree.

If the booster still isn’t enough, more meth is used over and over, trying to get to the level of the initial high. This is when people start mentioning tolerance levels and become disappointed with their high. The truth is, you’ve run out of fuel (dopamine). At this point, the meth is being wasted and you are chasing a high that physically can’t be attained.

Because of the over stimulation of the dopamine receptors, some of them are trying to compensate and temporarily begin shutting down, cutting off availability of the active chemical. Over time, with a more than casual use of meth, the receptors will shut down for longer times, or if become damaged, permanently. It isn’t really a tolerance level that has changed. Parts of the brain simply aren’t working at the moment.

The only way to get another rush and a higher high is to stop using meth for a while and let the dopamine settle down and rebuild its stockpile. Depending on how much meth has been used up to this point will have a direct bearing on how long it takes for the brain to recover.

Because I want a good rush without too much expense, I want to wait a week until I know dopamine levels are down to about as low they can go to do their normal maintenance. Before my shot, I won’t take a hit off a pipe or do a line, as they will only release part of the dopamine and not leave enough to give me the best rush. I understand some people can’t wait this long, so they use more and more meth, thinking their “tolerance level is up,” trying to milk every last molecule of their dopamine out of the transmitters.

This increased usage creates what can be termed a vicious cycle of continually using more to get less. It develops into a mental craving and signals that addiction has begun. Methamphetamine first creates a mental addiction. When the mental addiction can’t be satisfied, the body responds by giving you physical signals, initiated by the brain to try to make contact with you. It’s a temper tantrum of sorts.

I can’t explain all of the side effects from using meth, but an important one is that a greater amount of dopamine in the system will shut down norepinephrine release. Anyone who is familiar with depression and has taken medication for it may be familiar with the terms selective serotonin reuptake inhibitorp?title=SSRI" title=“SSRI”>SSRI)” or “serotonin norepinephrine reuptake inhibitor (SNRI).” Serotonin is actually a precursor to norepinephrine. You need the one to have the other. In any case, reduced amounts in the brain will cause a state of depression (slight or more severe) and brings on some of the unpleasant side effects evident in a comedown. It also acts as a vasoconstrictor, tightening veins to reduce blood flow. In some cases it brings on nausea.

Since methamphetamine is a stimulant it can greatly reduce the ability to sleep. Sleep deprivation can cause hallucinations and eventually psychoses. Before methamphetamine was taken off the over-the-counter market in the last century, it was the basis for the best diet pills created. It kills the appetite. There is also a tendency to become dehydrated while using it. Hunger and dehydration can do real damage to the body and if you recognize them, they are a warning that your consumption of meth has reached a dangerous level because you have not taken preventive care along the way during your high. (See The Meth Medicine Cabinet on how to manage this.)

Better understanding of what meth does to your body can also give you control over what you don’t want it to do.

When you get an initial rush, this is when a much higher release of dopamine (hundreds of times more than normal) saturates the dopamine receptors. The brain is overwhelmed trying to process this massive amount of a potent chemical. After the receptors adjust to this onslaught, the rush is over, but it continues to give you a high. This is the main mechanism.
What happens after this hit or shot (especially noticeable with an IV injection), the dopamine receptors realize you have too much dopamine at work and send some of the dopamine back to the neurotransmitters for later use. The dopamine pathways also shut down, making it impossible to send more dopamine to the receptors. This leaves less dopamine in the brain before it has time to manufacture more and the dopamine pathways open up again.
As the high lessens, users begin thinking they want the stimulation of the initial high and re-dose. The signal goes out again to release dopamine, but there’s not as much in your brain as you had before. There’s not enough to release at one time to give you a rush, but the high goes back up to a degree.
If the booster still isn’t enough, more meth is used over and over, trying to get to the level of the initial high. This is when people start mentioning tolerance levels and become disappointed with their high. The truth is, you’ve run out of fuel (dopamine). At this point, the meth is being wasted and you are chasing a high that physically can’t be attained.
Because of the over stimulation of the dopamine receptors, some of them are trying to compensate and temporarily begin shutting down, cutting off availability of the active chemical. Over time, with a more than casual use of meth, the receptors will shut down for longer times, or if become damaged, permanently. It isn’t really a tolerance level that has changed. Parts of the brain simply aren’t working at the moment.
The only way to get another rush and a higher high is to stop using meth for a while and let the dopamine settle down and rebuild its stockpile. Depending on how much meth has been used up to this point will have a direct bearing on how long it takes for the brain to recover.
Because I want a good rush without too much expense, I want to wait a week until I know dopamine levels are down to about as low they can go to do their normal maintenance. Before my shot, I won’t take a hit off a pipe or do a line, as they will only release part of the dopamine and not leave enough to give me the best rush. I understand some people can’t wait this long, so they use more and more meth, thinking their “tolerance level is up,” trying to milk every last molecule of their dopamine out of the transmitters.
This increased usage creates what can be termed a vicious cycle of continually using more to get less. It develops into a mental craving and signals that addiction has begun. Methamphetamine first creates a mental addiction. When the mental addiction can’t be satisfied, the body responds by giving you physical signals, initiated by the brain to try to make contact with you. It’s a temper tantrum of sorts.
I can’t explain all of the side effects from using meth, but an important one is that a greater amount of dopamine in the system will shut down norepinephrine release. Anyone who is familiar with depression and has taken medication for it may be familiar with the terms selective serotonin reuptake inhibitorp?title=SSRI" title=“SSRI”>SSRI)” or “serotonin norepinephrine reuptake inhibitor (SNRI).” Serotonin is actually a precursor to norepinephrine. You need the one to have the other. In any case, reduced amounts in the brain will cause a state of depression (slight or more severe) and brings on some of the unpleasant side effects evident in a comedown. It also acts as a vasoconstrictor, tightening veins to reduce blood flow. In some cases it brings on nausea.
Since methamphetamine is a stimulant it can greatly reduce the ability to sleep. Sleep deprivation can cause hallucinations and eventually psychoses. Before methamphetamine was taken off the over-the-counter market in the last century, it was the basis for the best diet pills created. It kills the appetite. There is also a tendency to become dehydrated while using it. Hunger and dehydration can do real damage to the body and if you recognize them, they are a warning that your consumption of meth has reached a dangerous level because you have not taken preventive care along the way during your high. (See The Meth Medicine Cabinet on how to manage this.)
Better understanding of what meth does to your body can also give you control over what you don’t want it to do.

The Meth Medicine Cabinet


This is a Reference Guide and is quite long, but the information provided will help you remain healthier and your body will thank you for it.

Some people want meds to take the unpleasantness away after using methamphetamines. Others want to take “something” to keep from getting the same reactions before using meth. The wiser will be the second group. For those of you who know little or nothing about the upkeep of your body and what meth is doing to it: There is NO magic pill.

Obviously, we can’t cover every condition or medical problem associated with using meth, but we can give you an essential guide to using the basics of vitamins, minerals and even herbal supplements that can be used preventatively, during and after use.

We won’t discuss any chemicals that may be found in other sections of Drugs-Forum dealing with bringing down the high, forcing sleep or in any way induces the body to react in a manner you might like it to. We are not polyusers and don’t subscribe to it. Combining uppers with uppers, or uppers with downers can become quite dangerous—and that is not Harm Reduction.

The use of meth causes a rapid chemical change in the mind and body, and the body reacts to it as a toxin, which it is. Our idea is to reduce the damage caused.

Preparation for a meth session is extremely important. If the body is not ready for this onslaught, the damage comes on faster and with more force. Two things we might not find in the medicine cabinet, but more likely the refrigerator, are the essentials you need, in liquid and solid form.

Keeping the body hydrated is the #1 rule. What does this mean? Simply making sure we have consumed enough water and metabolites, and continue to do so, while meth does its thing. Water is the base liquid, but the addition of metabolites such as potassium and sodium, are critical to maintain your body’s fluid, regulate blood pressure and heart function. Sports drinks are recommended by many.

Once meth enters the body, it’s a fight for survival and blood is routed to the organs that cleanse the body. The blood has to be moving fast—free-flowing—and that means it’s not sticky and dehydrated. Those organs need to remain healthy to do the job at hand and survive while doing it.

Eating. A nutritious diet of fresh fruits and vegetables, as well as high protein foods such as red meats will give your body the majority of vitamins and minerals you need to keep you healthy. Fatty foods such as French fries and deep-fried cheese sticks do not contain them.

Hydrating and Eating are your 2 top priorities, bar none.

Now, let’s go see what’s in the medicine cabinet. On the top shelf—the most important one–the first item is Multivitamins (and minerals). Do you really need them? Do you eat 3 nutritiously balanced meals a day along with drinking 3, 8-oz. glasses of homogenized milk, including a good workout regimen in the sun? Most people don’t, and that’s why you need a multivitamin.

Many meth users have asked what kind of a multivitamin they should take. If you research them on the internet, it seems the ratings on each chart are somewhat dependent on who is sponsoring the charts of the best. I’ve looked around, read reviews, and come up with two that actually rate somewhere better than the middle of the charts and aren’t that expensive. Just remember: take one per day, and only one.

For Men: Centrum Silver Men 50+. The experts say you should ignore the “men 50+,” because the combination is correct for any male. These multis don’t contain any iron and you already get enough from your food. Go to the Centrum Silver website and get a $3.00 off coupon for them!

For Women: One-A-Day Women’s contain the amount of iron needed for premenopausal women, in addition to the other essentials you should find in a multi. Go to the One-A-Day Women’s website and get a $1.00 off coupon!

While included in the multis, there is one other vitamin that needs to be increased in the meth users’ diet, as well as those who also smoke cigarettes. It is Vitamin D3. You need vitamin D3 to properly absorb calcium. Meth leaches the body of calcium and it’s vital you maintain blood calcium levels. You also need D3 to help your body continue to build strong and healthy bones all throughout your life. It also can reduce inflammation and hold your immune system in check. The most natural way the body gets Vitamin D3 is from the sun. Milk is also fortified with Vitamin D3. But since you didn’t drink your milk and didn’t go outside to exercise in the sun, you really need these. I take one 5,000I.U. soft gel every day.

The next bottle on the top shelf is Calcium, Magnesium & Zinc. Even though they are already included in your multi (but only at 25%-30% of daily recommended value for Calcium and Magnesium), the way meth uses these minerals up, you really need more. Calcium, of course, builds strong bones, but it also makes muscles move and contract, allows nerves to carry messages, keeps blood vessels throughout the body healthy, and helpsneurotransmitter release! If you know and love dopamine, then you know how really important this is. Unless you are on a heavy fig and rutabaga diet, then you need this supplement.

Magnesium is important for the functioning of your heart, muscles, kidneys, and balancing other nutrients such as calcium and potassium. It also improves blood pressure. Once you know what the deficiencies of magnesium cause, you will ask no more questions. They are: anxiety, weak bones, low energy, weakness, inability to sleep, PMS and hormonal imbalances, irritability, nervousness, headaches, abnormal heart rhythm, muscle tension, spasms, cramps, and fatigue. Now get this—one of the biggest complaints we have—TEETH CLENCHING, or Bruxism, is also a Magnesium deficiency. And it seems the magnesium does a better job resolving it when it has a fresh supply of calcium helping it.

Zinc helps you maintain a healthy immune system and fights infections. (Take note, IV users.) Zinc is necessary for the functioning of more than 300 different enzymes and plays a vital role in an enormous number of biological processes.

What a one-two-three knockout punch these guys have. And only two tablets a day will take care of all these things for just pennies.

Potassium Gluconate. I think I was taking these tablets before meth was invented. Potassium is an electrolyte (along with sodium), which is why I encourage people to use sports drinks, as they are included. The potassium helps regulate (lower) blood pressure and heart function. As you know, when using meth, your blood pressure skyrockets, so why not help curb the possibility of a stroke? As a matter of fact, there was a Harvard study that showed taking potassium supplements along with a diuretic (yeah, give me a couple of those potassiums with a cup of coffee), reduced the incidence of a stroke by 60%. Potassium is what makes our cardiovascular and nervous systems function. I’ve found it also works with magnesium to prevent cramping, and it aids during the recuperation part of your meth escapades.

The tablets contain 595mg of potassium, which is slightly more than the potassium found in a medium-sized banana. Take your pick. Have one of each. But be sure to double that number over the period of a day. Potassium doesn’t stay in the system for a long time. Oh, and one more very important thing: potassium is one of the prime movers, along with zinc, in elimination of wastes. That’s where all of those toxins the body is trying to get rid of are hanging out. And if they hang out inside of you too long, you become a recipient of toxic buildup—not a good thing.

Those, believe it or not, are your “prepping for meth use” essentials. Food, drink, and 4 bottles of vitamins and minerals. And when you look at it, and how complete it really is, it reminds me of prepping for the flu. You know the invader is coming, and you are prepared.

Before we have a look at the 2nd shelf, let me tell you that the supplements industry brings in over $60 billion a year. Once some people start taking them, it becomes almost an…addiction. “Horny Goat Weed sounds good. I think I’ll try that along with the Horsetail Shavegrass.” About $1,000 later and a cabinet full of supplements, these people realize all they are doing is taking supplements. They can’t even remember the last time they cooked a meal. So, let’s not get too carried away and fill the shelf too full.

Another point of view involves human nature. If we make a list of things to take every day that is too long, because of the hassle and time involved, a lot of people will fall out of the program. However, if we have simply the essentials that will do the job, the tablets or capsules can be assembled and swallowed in less than a minute.

My first two personal picks not only are helpful when using meth, but also fulfill a couple of other needs I have. The first is L-arginine. It’s a dietary supplement that produces Nitric Oxide (NO). Nitric Oxide should not be confused with Nitrous Oxide, the laughing gas. But it’s still a gas and what is does is enter the bloodstream and drop off these little bubbles on the insides of the vein walls, stretching them out, making them wider. My primary use is because I have a slight high blood pressure condition, and it allows the blood to flow smoother. But, if you’re a meth user, too, you might have figured out it works against vasoconstriction, or tightening of the veins. Many men cope with vasoconstriction when high. The more meth they use, the tighter the blood vessels, until no more blood can get through to make an erection. Relief is possible with just a couple of capsules a day, two times a day. Also, for IV users who have a difficult time finding veins, I have discovered that as the veins plump a little, they also become more visible in some areas.

The next supplement is HGH Dopa 400, also known as mucuna pruriens. I don’t bother with the HGH (human growth hormone) efficacy as it is small, even if true, but the plant material ground up and put in these capsules is full of L-dopa, a precursor to making dopamine. Now why would anyone want their brains to produce more dopamine? Besides the fact I’m getting a bit old and maybe the dopamine production isn’t as good as it used to be (normal), maybe I just don’t want to run out of dopamine when I’m high and want to stay that way.

The next couple of bottles contain supplements that are popular, and effective.

Omega-3 fatty acids. Omega-3s are not produced by the body and naturally are derived from eating fish. Research shows that omega-3 fatty acids reduce inflammation and may help lower risk of chronic diseases such as heart disease, cancer, and arthritis. Omega-3 fatty acids are highly concentrated in the brain and appear to be important for cognitive (brain memory and performance) and behavioral function. It may also assist in controlling high blood pressure and, in people with Bipolar disorder, reduce mood swings. Symptoms of omega-3 fatty acid deficiency include fatigue, poor memory, dry skin, heart problems, mood swings or depression, and poor circulation. Daily dosing should be based on the amount of EPA (180mg) and DHA (120mg) acids, not total amount of fish oil.

Coenzyme Q10, or CoQ10 vitamin supplement, is naturally made in the body, but sometimes (especially with aging) the necessary levels of this enzyme-protein that speeds up the rate at which chemical reactions take place in the body, drop to below what is considered normal. Its main function, however, is as an antioxidant. While many trials have been run, peer reviews have not been overwhelmingly positive, due to the lack of further studies. The antioxidant function of CoQ10 appears strongest in reducing neurological damage or decline, including that of dopamine neurotransmitters. My next door neighbor, who is 80, says this is the closest thing to a miracle drug. Do you want to live that long? My answer is that I take this stuff. Since it is fat-soluble, I take it at the same time as my Omega-3. Daily dosage is 200mg-600mg.

At this point in time, I am satisfied with the above list. The dietary regimen that we started off with, along with these vitamins, minerals and supplements, are really the glue that binds in keeping our bodies whole, especially for the meth user. They are also the most protective and restorative additions we can make without breaking the bank.

There are other supplements that seem to be common with meth users. Perhaps the most often mentioned is melatonin. This is a hormone that is found in all biological organisms, and as such, we know we produce it ourselves, in the pineal gland from the raw material Tryptophan. Melatonin regulates our internal clock and maintains the Circadian Rhythm of our body. But we know what happens when we start using meth. All of a sudden our internal clock is shattered and we are officially on “Meth Time.” Depending on usage patterns and amounts, we find one Meth Day can extend itself past 24, 36, 48 hours and even beyond. At some point, the user may decide to end this prolonged day and get some sleep. But the meth is still active and sleep is hard to arrive.

Melatonin turns off the meth clock and helps reset the body to the biological clock function. It also promotes sleep and affords the body a long restful period, where deep sleep begins and allows the body to start healing itself. Taking the recommended tablets returns the body to normal levels of Melatonin where sleep becomes automatic.

Melatonin is also used by some people along with benzodiazepines; however there is a possibility of creating a benzo dependency with long term use. (As mentioned earlier, I can’t talk about or recommend using uppers with uppers or uppers with downers as there sometimes are consequences that cannot be predicted.) There are also several other chemical interactions with a supplemental dose of melatonin which can reduce the efficacy of other medications you may be taking. It was for that reason, I decided not to use melatonin.

If we were to look at the lower level of the Meth Medicine Cabinet, we also might find other things that might be used. For instance, that bottle ofisopropyl alcohol, which is mostly used to sterilize any areas of the skin that might be met by an IV needle, a broken piece of a glass pipe or other minor cuts and scratches. A tube of Hydrocortisone 1% Cream used to treat itching and small burns, and a tube of Triple Antibiotic Ointment (Neosporin) to be applied on a damaged area to prevent infection are a couple of great first aid musts. Not to mention only accidents that happen when doing your drug, think of all of those times you’ve experienced spun out people pulling things apart, moving things around, falling on their butts and creating minor mayhem.

What’s this bottle? Viagra! For those men who have really serious consequences trying to get their manhood going while under siege from vasoconstriction, a half-tab of this stuff may do the trick. The caution is that it’s trying to relax those veins while the norepinephrine release is doing just the opposite. There’s a tug-o-war going on here that can stress the body, especially the heart.

Yohimbe 2000 is over there in the corner. It’s a natural stimulant, what I call “Poor Man’s Meth.” One of the better features of this herbal product is that it actually acts as a vasodilator, while still stimulating the body. Yohimbe has been known as an aphrodisiac for centuries, which most likely has been based on how it stimulates. Let’s say you are all out of your man-made stimulant but still feel ready to go that extra mile. Using one or two of these capsules may just let you make it to the finish line. But be careful, as there is a very thin line between being good and being bad. Too much of this stuff, and the nausea and other bad vibe reactions kick in, simply spoiling the moment.

Sitting up behind the Yohimbe bottle are a couple of sanitary wrapped prophylactics. They are there as a reminder that meth users, as a group, become a pretty high percentage of people who spread STDs, HIV/AIDS, and other infectious diseases along with assorted cooties, which are not the same as meth bugs.

Below the Meth Medicine Cabinet, there’s a basket full of goodies. Let’s investigate. I see a couple of toothbrushes, some toothpaste and dental floss. I think we’re onto something! Taking care of your teeth and mouth are extremely important, whether a meth user or not. But when meth gets ahold of your mouth, the damage can increase at the speed of light. Next to those items is a big bottle of ACT Restoring Mouthwash, great for restoring enamel and it helps mineral recrystallization on the teeth. Next to the ACT is a bottle of Biotene, a mouthwash specifically made for dry mouth. Meth dries out the mouth and gives you the common “Meth Mouth.” A dry mouth means bacteria can form, causing ulcerations—mouth sores. Biotene also comes in gel form, which is designed to keep your mouth from going dry for 6-8 hours. There’s also a salt shaker and an empty glass. Falling short of the commercial methods, you can always gargle with warm salt water to kill off the bacteria. Just do it more often.

Recommendations—Good and Bad

Here are a couple of items I have seen people recommend, but they come with some advisories. There are many of our multivitamins that are also sold individually as Super Paks or under other marketing names. Let’s take the Vitamin B Complex group as one such item. And I am sure they have some benefits that your multis don’t have. But the fact remains that they are already in your multis at 100% Recommended Values. Before proceeding to take the both, and therefore at least doubling recommended amounts, I would want to research them to see at what level they become toxic.

Here’s another that I see recommended from time-to-time, and for the life of me I can’t understand why, except whoever started this trend did not do their homework. L-tyrosine is abundant in our foods and we get more than enough of it without supplementation. But, it’s also known to convert to L-dopa. And that’s where the research must have ended. They didn’t read how it also produces a lot of norepinephrine, that Dark Knight of Vasoconstriction–that bugaboo of irony created when using meth. But there’s more. It just might be that adding the supplement puts you over the top and actually shuts down your production of dopamine. That’s what L-tyrosine can do in larger amounts.

Some people simply cannot eat when high, due to other conditions they may suffer, or their own body chemistry. There is an alternative in liquid form that you can use to replace the solid food. Many meth users prefer to use protein shakes, such as Ensure.

Before we end this, let’s talk about dosages. More people than I want to imagine must believe that if one tablet is good, two must be better. That is not the case. Even vitamins and minerals have toxic levels. Always read recommended dosages and warning labels on any vitamins, minerals, supplements, and medicines you may also be taking. As I had to remind a friend one time: taking too many vitamins is not going to get you high, but it might get you sick.

There’s still more room in the Meth Medicine Cabinet. Maybe you have something you’d like to recommend. If you have something neat you have discovered and use, then let us know. But just don’t name it. Tell us how it helps your body, if there are any contraindications, and if there are any downsides to using it. You should at least be able to explain this, since you are using them.

Neurological Fireflies (Part Two)

Part One | Part Two | Part Three

Summary: It’s been a few weeks since Thomas created the Sides and he’s surprised to see how much they’ve grown and changed since then. They have their own personalities and dynamic relationships with each other. It’s a lot to for him to take in, if he’s being honest.

Pairing(s): N/A… yet.

Word Count: 1,788

Warning(s): None that I can think of! Let me know if you find any and I’ll tag accordingly!

Author’s Note: So… these first few chapters sort of feature Thomas as the main character but I promise that won’t last for long. I love the guy but I feel weird writing him as a character, you know? But for the purpose of the story I need him there to kinda guide the sides into being who we know and love today. Anyway, enjoy!

Keep reading

My 2 cents about JD from Heathers the Musical in a biological aspect.

In the movie version I believe he was a sociopath because he didn’t feel anything. In the musical he felt too much so he’s a psychopath. He feels too much obsession for Veronica. Pretty much Yandere territory. His upbringing is part of the blame but on the other hand he used his slushies to block out his feelings by causing brain freezes. Chemically this could mean he wants to activate dopamine in order to cope with his lonely life. When a person causes pain to themselves or eats a hot pepper or other spicy stuff, the body thinks its in trouble so it sends this special chemical to combat the pain. Then in came Veronica. When they had sex, she activated his Oxytocin, the bonding chemical. This is new to him. Like a drug. He got by on dopamine alone but adding that with Oxytocin and you get the ultimate high. She became a mission, a light in his life, a purpose to exist. Now oxytocin can be released when one is having sex or shooting a gun. Both of which he does. First loves, especially in the beginning, can be a wonderful thing. However it really still depends upon what we decide to do to keep that relationship. Lets face it love makes us do crazy things. But its what crazy things we do that define us. When he scares Veronica by acting violent in her name and she decides to break up with him, that’s denying a high. When a Junkie is denied, they will do anything to get it back. I bet my last dollar that the slushy thing doesn’t cut it anymore. Hence wanting to blow up the school. When she attempts to sacrifice herself he takes her place willingly. So if he can feel emotions and bonding, then he is not a sociopath but technically a junkie. 

anonymous asked:

Our sex ed teacher told us that masturbation, porn, and having multiple sexual partners depletes your dopamine and oxytocin levels so you will have trouble bonding with others and finding pleasure in sexual stuff ever again. It made me really afraid to try masturbation and sex. Is what she said true?

Nope not at all. There are so many things that cause a release of oxytocin and dopamine. Not only sexual activity, intimacy, child birth and breast feeding but also hugging, being charitable, being in social situations, laughing, exercising, talking to people, certain foods, deep breathing, petting and playing with animals, getting a massage, singing, competition, gambling, playing games, yoga, acupuncture, the list goes on and on. I’d like to quote an article on scarleteen (http://www.scarleteen.com/blog/heather_corinna/2010/08/04/pump_up_the_voleume_talking_oxytocin) that if that teacher’s logic was true then these statements would also be true: 

  • Mothers who deliver by C-section or who do not breastfeed will not be able to bond to their children.
  • Post-menopausal women have a decreasing ability to bond with other people. (Grannies are gonna love that one.)
  • Massage therapists can’t pair-bond because they touch too many people.
  • Mothers who deliver or breastfeed more than one child will be less and less able to bond to subsequent children.
  • Because birth apparently creates the biggest oxytocin surges we know of, women may bond with anyone involved in their birth. Good news for obstetricians!
  • People who have and care for pets will be less able to bond with other pets or people.
  • People who sing in choirs or bands may as well be having orgies for all the oxytocin they’re hurling around.
  • People with autism may not be able to bond to anyone, ever

Masturbate and have sex as much as you want! Hug all the people! Get all the massages! Pet all the animals you can find! Smell all of the babies! Laugh all the time! None of these things will “deplete your hormonal levels” whoever thinks that really needs to take a class on biology.

-FYSE

Decriminialisation - A healthful approach to drug use rather than reactive moral panic

Amidst ferocious backlash, The Greens have this week pushed for the decriminalization of illegal drugs. They have cited the successful track record of countries such as Portugal who have implemented similar drug related policies. It’s safe to say the war on drugs has been lost. Australia boasts some of the leading illicit drug use statistics in the world. Drug seizure rates have doubled over the past decade. Cannabis use is the highest by world figures. The Australian government annually spends $1.7 billion on this war against its own civilians. This has certainly come at a high cost, when we measure more than economic loss. There is the acute social breakdown, loss of lives, dissent for authority, fear, untreated mental illness, and costly, ineffective, and archaic incarceration.

Zero tolerance laws treat drug use like crime rather than a public health issue. This is despite decades of research from mental health professionals suggesting the role of psychiatric health and addiction. Drug use disorders are featured in the current Diagnostic and Statistical Manual of Mental Health Disorders. The National Bureau of Economic Research indicates that “there is a definite connection between mental illness and the use of addictive substances”. If society wishes to begin treating mental illness in the same manner it treats physical illness, it is likewise to punishing a diabetic for his use of insulin. There is proposals of altered brainwave activity and dopamine levels, mental hierarchies, poor impulse control, and self medication that exists in the addict’s cerebral activity. Many mental health problems precede drug habits.

We have heard the predictable response from opponents. There are unfounded fears decriminalization will result in higher rates of drug use, crime, and violence. There are those who claim drug use will be ‘encouraged’ and ‘cultivated’ among society. There is no doubt drug education and public perception must continue focus heavily on the dangers and risk associated with drug use. But directing resources toward rehabilitation of those who are suffering addiction, and offering a safe place for those with drug problems to come forward without fear of prosecution is a much more holistic and socially considerate approach that supports those who are losing the combat in their own mind. Despite reactive statements that drug use will increase, statistics from Portugal indicate that the prevalence of usage has not altered with the change of law since 2001. The Greens policy will likely be unsuccessful until a time the government, and the Australian population in general is more prepared to utilize evidence based policies and become recovery focused rather than gearing up for battle with those who have already lost to their own war.

Written by Cherry amber

Science pick-up lines masterpost
  • If I were an enzyme, I’d be DNA helicase so I could unzip your genes.
  • You’re so hot, you denature my proteins.
  • Can I be the phasor to your electron and take you to an excited state?
  • Are you made of Copper and Tellurium? Because you are Cu-Te
  • Do you have 11 protons? ‘Cause you’re Sodium fine!
  • I’ve got my ion you baby!
  • You must be gibberelin, because I’m experiencing some stem elongation.
  • You make my anoxic sediments want to increase their redox potential.
  • Are you made of Nickel, Cerium, Arsenic and Sulfur? Because you’ve got a NiCe AsS!
  • Hey baby, will a little more alcohol catalyze this reaction?
  • Didn’t you know that chemists do it periodically on the table?
  • I bet you’re like calcium bicarbonate - if I get you wet, the reaction will be explosive!
  • Are you made of Fluorine, Iodine, and Neon? 'Cause you are F-I-Ne
  • Me and you would undergo a more energetic reaction then Potassium and water.
  • Im more attracted to you then F is attracted to an electron.
  • I will fondle your vesicles while you caress my golgi body.
  • I want to work on your leucine zipper with my zinc fingers.
  • If you were oxygen, I would be an alkali metal so i could get in you and explode!
  • We fit together like the sticky ends of recombinant DNA.
  • You are the photon to my photosystem: you excite my electron until I reach my reaction centre.
  • You’re hotter than a bunsen burner set to full power.
  • If I were a neurotransmitter, I would be dopamine so I could activate your reward pathway.
  • Hey, wanna put your alpha helix in my beta barrel?
  • Hey baby, why don’t you get your ligase working on my okazaki fragment and lengthen my strand.
  • Hey, are you an alpha carbon, because you look susceptible to backside attack!
  • Do you want to extract some protein from my column?
  • According to the second law of thermodynamics, you’re supposed to share your hotness with me.
  • Everyone knows its not the size of the vector that matters, but the way the force is delivered.
  • How about me and you go back to my place and form a covalent bond?
  • If I was an endoplasmic reticulum, how would you want me: smooth or rough?
  • We can make a mess as I’ve hired some lysosomes to clean up after.
  • My hypothalamus must be secreting serotonin because baby, I want you!
  • I wish I was an Ion so I could form an exothermic bond with you.
  • You’re so cute you make my zygomaticus muscles contract.
  • I wish I were Adenine because then I could get paired with U.
  • You’re like telophase, I admire your cleavage.
  • Hey baby, want to form a synapse with me and exchange neurotransmitters?
  • Hey baby, want to form a zygote?
  • It’s a good thing you’ve got evaporative cooling, cause I’m going to make you sweat
  • If I were a Shwann cell, I’d squeeze areound your axon and give you a fast action potential.
  • Want to be my substrate/enzyme?
  • If my right leg is the cell wall and my left the membrane, do you want to be the cytoplasm?
  • If you were a concentration gradient I’d go down on you.
  • If you were C6, and I were H12, all we would need is the air we breathe to be sweeter than sugar.
  • Whenever I am near you, I undergo anaerobic respiration because you take my breath away
  • I want to stick to u like glue-cose.
  • You must be the one for me, since my selectively permeable membrane let you through.
  • Can I be your enzyme? because my active site is dying for a chemical reaction.
  • You give me more jolt than a mitochondria!
  • Right now we’re just two RNA, but maybe we could transcribe together and become DNA.
  • I have a smooth endoplasmic reticulum but know that I like it rough, if you know what I mean.
  • I also prefer my ribosomes bound tight. Spin me round with your basal body and make sure it’s turgid.
  • Do you like aerobic respiration as much as I do?

anonymous asked:

Bad pickup lines? MY TIME HAS COME!!! If I were a neurotransmitter, I would be dopamine so I could activate your reward pathway.  If I were an enzyme, I'd be DNA helicase so I could unzip your genes.  Do you have 11 protons? 'Cause you're Sodium fine!  I only know science pickup lines, but they're all like this. -tinysidestrashcaptain

I love and understand every single one.

Scientists Believe the Universe is Littered With Billions of Dead Aliens

Originally posted by terrooristswin

It is a question that has long loomed over us as humans, and has had scientists scratching their heads for centuries… Are we alone in this universe?

Recently, it seems as though two scientists undertaking research at the University of Washington might have come to a conclusion on the matter after reworking a decades-old equation used to calculate the possibility of life on other planets.

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