Sugar in the form of blood glucose provides essential energy for cells. When its usual dietary source — carbohydrates — is scarce, the liver can produce it with the aid of fat. But new research from Johns Hopkins now adds to evidence that other tissues can step in to make glucose when the liver’s ability is impaired, and that the breakdown of fats in the liver is essential to protect it from a lethal onslaught of fat.
The ability to maintain blood glucose during starvation, known as gluconeogenesis, requires the breakdown and processing of fatty acids, known as fatty acid oxidation. It is thought that about 90 percent of gluconeogenesis occurs in the liver, while the other 10 percent occurs in the kidneys and gut, but when researchers deleted the gene Cpt2, which is necessary for fatty acid oxidation, from mouse liver cells, the mice survived without a continual supply of carbohydrates.
“Mice live for the first two weeks on milk from their moms, which is high in fat and low in carbs,” says Wolfgang, “so we were surprised that they did OK when their liver’s ability to burn fat to make glucose and ketones was crippled.”
says Michael Wolfgang, PhD.
Although, according to Wolfgang, they were consuming a lot of calories and essentially eating butter for every meal, their livers couldn’t handle the fat, and the diet was eventually lethal to the mice. The mice had seemingly dissolved all fat tissue throughout their bodies, but their livers were engorged with fat molecules.
“The liver knew it needed to burn fat to make glucose, so it kept asking fat tissue to send fatty acids. But it couldn’t burn those fatty acids, so it just absorbed them and got too fat to function.” Wolfgang says.
Funding: This work was supported by grants from the National Institute of Diabetes and Digestive and Kidney Diseases (P30DK072488), the National Institute of Neurological Disorders and Stroke (R01NS072241, K08NS069815), the National Institute of General Medical Sciences (T32GM007445) and the American Diabetes Association (#1-16-IBS-313).
Raise your voice in support of expanding federal funding for life-saving medical research by joining the AAMC’s advocacy community.
I just got back from my endo apt. And for once I didnt get chewed out! My a1c is coming down, I ve been doing 4 tests a day! It looks like I might be able to qualify for a pump under my goverments health care!!! YAY
He was recently diagnosed with diabetes and I only caught it because he started bumping into things. Half is nose is cut up and scarred from running into sharp corners. It’s truly heartbreaking to watch.
For those that care, I’m going on hiatus until he gets well enough that he doesn’t need almost 24 hour monitoring since he is my current priority.
Dear dog-owning friends, please pay close attention to them, especially as they age. They can’t tell you when they don’t feel well. I realized his condition too late, but still hoping for some recovery, and I hope no one else or their dear canine friends will have to go through this.
I don’t know how many people have heard of www.stickmancommunications.co.uk but they make great key ring cards that explain various medical conditions, mental illnesses and symptoms like sensory overload in simple and often humorous language.
Great if you have too many conditions to fit onto a traditional medical alert bracelet. They even sell lanyards so you can wear them round your neck.
I got the EDS, M.E., Fibro, Tummy Troubles, Sensory Overload, Joint Problems, Allergy and Emergency Contact cards :)
They also have various cards for Autistic Spectrum Conditions including Communication Cards.
fun things you get to experience when you have diabetes
getting to stab yourself with needles all the time for fun! except not for fun, but to keep you alive
that one oral med you’re on? yeah sometimes it’s just gonna give you diarrhea lol have fun figuring out when
your whole body being hot and cold at the same time. like you’re cold, but you’re overheated and you want to take your shirt off but if you do you get massive chills and there’s no winning
walking up the stairs when your sugar is high? more like you’ve never done squats that burn this much
really bad circulation in your extremities. like your torso is hot but your toes are fucking freezing as hell.
being told that your kidney function is “thankfully still okay” or that “you don’t have retinopathy yet”
stumbling to the kitchen in the middle of the night and having to decide which food will work best to treat a low when your brain doesn’t work and your body doesn’t work and if you don’t pick fast enough you’ll pass out and maybe die
going to bed in range and waking up feeling like hell on earth
dealing with shit like this:
having to force yourself to drink water when you’re really really nauseated and want to throw up everything in your stomach. nausea so bad water makes you want to puke
ppl telling you it takes 15 minutes to recover from a low when it’s more like 2 hours before you feel like your previous self (and recovery from a really bad high takes like 3 days)
an achey body for no good reason
friends being like “we should work out together” but you’re like “how tf do I manage my blood sugar while I’m doing that”
having to push through and still go to work/school when you feel like shit
things that hurt. those pump sites and injections that feel like you’ve been stabbed. your body begging you to feed it. your eyes. your muscles. your head. your stomach. your lungs. everything hurts.
having to hear diabetes jokes “lol it was so sweet it gave me diabetes” “omg it’s like a big bowl of diabetes” SHUT THE FUCK UP THATS NOT HOW DIABETES WORKS YOU PIECE OF SHIT but having to hear it and stay calm
losing the ability to tell when you’re low so lol you’re in the 30’s and you only just realized
having to stop having fun or hanging out with people or having to go home because you’re out of insulin or strips or needles or your site fill out. and by extension, never really being able to do something spontaneous because you always have to think how will i manage the sugaz when I do
always worrying about food. where it’ll come from, how to count it, where you can get some of you suddenly drop. food is your biological imperative. if you can’t answer those questions you’re this much closer to dying.
you don’t even know who you are without this disease. you know it’s not everything about you but it consumes you. literally. it eats away at your body, eats away at how long you have left to live.
having to deal with the monetary cost. like, pay or die? what kind of life is that?
never getting to take a break from the ridiculously difficult task of keeping yourself alive.
Just a few months ago I was doing great. My A1c went down to a 6 and everyone around me was so beyond proud of me. And then a couple months after the study I got depressed again and stopped caring. I didn’t want to live and I wound up in the hospital in June because of it. And tomorrow is my first appointment with my endocrinologist and I know she’s going to be disappointed. I just hope I can fight harder again. It’s just so much harder when your mind tells you no one will care in the end anyways.
Animal excrement and other agricultural runoff from large-scale farms has polluted nearly one-third of rivers in the U.S.
12. Preserve the Rainforest
The World Bank reports that the majority of Amazon deforestation has been to clear land for cattle grazing and growing feed for farmed animals.
13. Respect Farmed Animal Intelligence
According to Christine Nicol, a professor of animal welfare at Bristol University, chickens are capable of mathematical reasoning and logic, including numeracy, self-control, and even basic structural engineering. These traits are not seen in children until the age of four.
14. Live Longer
According to a report published in Men’s Journal, a large-scale study of 73,000 Americans shows that eating a vegetarian diet promotes longevity.
15. Enjoy Delicious New Foods
With the wide array of delicious plant-based foods on the market, there’s never been a better time to ditch meat, dairy, and eggs. For a list of meat and dairy alternatives, click here.
16. Create a Better World
Factory farms, and the widespread problems they create, are simply out of step with the values of the majority of Americans. We can all work towards a less violent, more compassionate (and sustainable) world just by eating vegan versions of our favorite foods.
So there you have it! 16 great reasons to eat vegan in 2016!
Click here to take the pledge to go veg in 2016, and we’ll send you a FREE Vegetarian Starter Guide along with a bunch of tips and tricks to make the transition easy!
Click here for a list of things every new vegans need to know.
“A friend has asked for one of these to be made and embroidered. What a great idea!! For adults and children! Not only for autism but for any condition or illness. Could be a lifesaver in an emergency. If paramedics saw this no matter what the condition they know straight away what to do and what to avoid. Allergies etc 💓💙 home made belt covers with embriodery £8 £1 to post smaller items xx”
They’ve already begun testing it in a small number of diabetic patients. If it works as well in patients as it has in animals, it would amount to a cure, ending the need for frequent insulin injections and blood sugar testing.
ViaCyte and Johnson & Johnson’s Janssen BetaLogics group said Thursday they’ve agreed to combine their knowledge and hundreds of patents on their research under ViaCyte, a longtime J&J partner focused on regenerative medicine.
The therapy involves inducing embryonic stem cells in a lab dish to turn into insulin-producing cells, then putting them inside a small capsule that is implanted under the skin. The capsule protects the cells from the immune system, which otherwise would attack them as invaders — a roadblock that has stymied other research projects.
Researchers at universities and other drug companies also are working toward a diabetes cure, using various strategies. But according to ViaCyte and others, this treatment is the first tested in patients.
If the project succeeds, the product could be available in several years for Type 1 diabetes patients and down the road could also treat insulin-using Type 2 diabetics.
“This one is potentially the real deal,” said Dr. Tom Donner, director of the diabetes centre at Johns Hopkins University School of Medicine. “It’s like making a new pancreas that makes all the hormones” needed to control blood sugar.
Two years ago, Anja Busse, then 11, created a video andonline petition urging popular toymaker American Girl to add a little something to its lineup of toy offerings.
Three months earlier, Anja had been diagnosed with Type 1 diabetes, an autoimmune disease that causes the body to stop producing insulin, a hormone that regulates blood sugars. Without replacing insulin, either via multiple daily injections or an insulin pump, a Type 1 diabetic like Anja will die.
The new American Girl Diabetes Care Kit includes all the things a Type 1 diabetic needs: a blood sugar monitor, lancing device, insulin pump, insulin pen, medical bracelet, glucose tablets, log book, ID card, stickers, and carrying case.
This isn’t the first time American Girl has made an effort to create toys for kids facing differences or challenges.
They’ve made several accessories, like a hearing aid and arm crutches, and even a lunch kit for kids with food allergies.
facebook post:eating artichokes stops you getting diabetes!!!!!
me:holy shit. holy. shit. all this fucking time. artichokes. the cure to my chronic disease. wow. if only i had known. if only i had seen this post shared on facebook 15 years earlier so i could have eaten a fucking artichoke and stopped getting diabetes. wow. amazing.
Stop making people feel like their self worth is in a college degree or the job they work. You’re killing people w those assumptions. not everyone is capable of that. Realize that just bc its easy for u, not everyone can manage physically / mentally. Don’t assume everyone works and goes to school? Stop.