Alzheimer’s disease may cause different changes in the brain, or
pathologies, in African-Americans than in white Americans of European
descent, according to a study published in the July 15, 2015, online
issue of Neurology®, the medical journal of the American Academy of Neurology.
“Because some studies suggest that Alzheimer’s disease is more common
among older African-Americans than European-Americans, we wanted to see
whether the brain changes caused by Alzheimer’s are different in these
two racial groups,” said study author Lisa L. Barnes, PhD, with Rush
University Medical Center in Chicago. “Studying how Alzheimer’s disease
looks in the brain in individuals of different races may help us to
further understand the disease and pinpoint strategies for prevention
The study included 41 African-Americans with a clinical diagnosis of Alzheimer’s dementia from the memory clinic, who had an autopsy of their brain performed after death. They were then compared to 81 deceased European-Americans who had Alzheimer’s dementia with the same level of disease severity and were of the same age, sex and education level. Researchers looked for typical signs of Alzheimer’s disease (plaques and tangles) as well as other brain changes that can cause dementia, such as infarcts (the brain changes associated with stroke) and Lewy bodies (associated with Lewy body or Parkinson’s disease). They noted whether people had just one pathology or more than one. They also looked at small and large blood vessel disease.
Almost all participants in the study had Alzheimer’s disease in their brain. Only about half of the European-Americans had pure Alzheimer’s disease pathology (no additional pathologies contributing to dementia) whereas the rest had Alzheimer’s disease pathology with either infarcts or Lewy bodies. In contrast, less than 25 percent of the African Americans had pure Alzheimer’s disease pathology. On the other hand, almost three-quarters (71 percent) of African-Americans had Alzheimer’s disease pathology mixed with another type of pathology, compared to 51 percent of European-Americans. Clinical Alzheimer’s disease in African-Americans was much more likely to involve pathologies other than Alzheimer’s disease pathology. African-Americans also had more frequent and severe blood vessel disease.
“Our study has important clinical implications because it may suggest a
need for different types of Alzheimer’s prevention and treatments in
African-Americans. Indeed, current Alzheimer’s drugs primarily target
specific Alzheimer pathologies in the brain. Given the mixed pattern of
disease that we see in African American brains, it will be important to
develop new treatments that target these other common pathologies,
particularly for African-Americans,” said Barnes.