The Persistence of Memory in Mice

It’s frequently said that scent is the sense most powerfully tied to memory. For mice, it turns out, that’s especially true—at least when it comes to a sniff of the urine of potential mates.

According to a study published in Science by researchers from the University of Liverpool, female mice exposed to the potent pheromone darcin (found in male mouse urine) just a single time will repeatedly return to the exact site of exposure up to 14 days later, even after the pheromone is taken away.

“We have shown that a male sex pheromone in mice makes females …remember exactly where they encountered the pheromone and show a preference for this site for up to two weeks afterwards,” said lead author Sarah Roberts in a statement. “Given the opportunity, they will find that same place again, even if they encountered the scent only once and the scent is no longer there.”

“This attraction to the place they remember is just as strong as attraction to the scent itself,” said co-author Jane Hurst. “Darcin, therefore, induces mice to learn a spatial map of the location of attractive males and their scents, to which they can easily return.”

The researchers determined that the important factor was the pheromone darcin because the same results occurred when a synthetic version of the chemical was put into a petri dish on its own. Additionally, when the female mice were exposed to female urine instead, there was no indication of a preference, because darcin isn’t present in the females’ urine.

Interestingly, the pheromone also produced a powerful effect on another group of mice: competitor males. When they were used in the same experiment, they also demonstrated a preference for the place where they remembered smelling other males’ urine, but they didn’t show this type of spatial memory when the urine used was their own. The researchers speculate that this is because of a motivation to linger near the site and mark the territory with their own pheromone scent, to advertise their availability to female mates.

The scientists speculate that this lingering affinity for the memory of urine is used by the mice as a mental shortcut for finding mates. In a natural setting (instead of cages), rather than having to smell the pheromones from a distance and then track them to the source, they can simply camp out by urine deposited by a potential mate and wait for their likely return.


Only two more to go before I finish up these doodles I still owe!

First up, One of the Fox guard twins for Tapewolf. They were featured in a past arc of Project Future where they fought with each other over who would get shot in the head first, and begged around for coins or a dice to decide.

It was very disturbing! Very disturbing! But they are alright and they are adorable and I hope they are happy and not fighting over who gets to die first anymore. 

Second. For Cideon! Keldar the Earth Pony, with a magic cupcake. I dunno if it’s magic magic, or magically delicious, but he’s quite happy to have the cupcake. I want a cupcake. Weh. 

Third. For Darcin7! Noel the Ferrin comes at ya! Maybe to punch you if you said something mean. Seriously tho I love her outfit, it’s very cute. I love stuff with fluff on the edges :)