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Quincy Freeman, better known as “Cue,” has had an undying passion for food ever since he could remember, but recalls that this particular love affair officially began after Cue tried In-N-Out Burger fries while on a road trip with his dad and his Uncle Ronnie. Since then, the blogger has been on a several-year journey “eating everything from everywhere.” Cue the Critic is the place where the charismatic Cue can share, express, write and generally make the rest of us jealous with his extensive culinary adventures. This particular endeavor started out in 2013 after Cue was finally convinced to start his own foodie site, which initially began with a single post on the history of the Bloody Mary, and soon began to take shape as an impressive collection of food-related goodness. The blogger’s love for food permeates the site and we can see that there are few out there as sincere and dedicated as him. As the blog says in its motto, you can consider the site as “your definitive guide to gastronomic suicide.”  Cue explains that what this exactly refers to is the fact that most of the things we eat, no matter whether they’re at our home or in a restaurant, typically have the capacity to eventually kill us. Because of this, you might as well enjoy the best possible tastes and flavors out there and enjoy the process. This is more or less what Cue tries to help us achieve, with his entertaining stories, commentaries, mouth-watering photographs and all around good mood atmosphere. The site’s unique layout will surely be a feast for your eyes with the bright, tasty photos being the central focus of and organizational structure of the blog. You can search through the different categories on the site which include everything from burgers to health and wellness, and are sure to not only provide you with some great tips and information but likewise keep you smiling while you’re at it. We highly recommend you check out Cue the Critic!

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Human Stem Cell Model Reveals Molecular Cues Critical to Neurovascular Unit Formation
Real-time tracking of cellular behavior during human development provides new insights

Crucial bodily functions we depend on but don’t consciously think about — things like heart rate, blood flow, breathing and digestion — are regulated by the neurovascular unit. The neurovascular unit is made up of blood vessels and smooth muscles under the control of autonomic neurons. Yet how the nervous and vascular systems come together during development to coordinate these functions is not well understood. Using human embryonic stem cells, researchers at University of California, San Diego School of Medicine and Moores Cancer Center and Sanford-Burnham Medical Research Institute created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time, how autonomic neurons and blood vessels come together to form the neurovascular unit.

The study is published May 21 by Stem Cell Reports.

“This new model allows us to follow the fate of distinct cell types during development, as they work cooperatively, in a way that we can’t in intact embryos, individual cell lines or mouse models,” said co-senior author of the study David Cheresh, PhD, Distinguished Professor of Pathology, vice-chair for research and development and associate director for translational research at UC San Diego. “And if we’re ever going to use stem cells to develop new organ systems, we need to know how different cell types come together to form complex and functional structures such as the neurovascular unit.”

The neurovascular unit comprises three cells types: endothelial cells, which form the blood vessel (vascular) tube; smooth muscle cells, which cover the endothelial tube and control vascular tone; and autonomic neurons, which influence the smooth muscle’s ability to contract and maintain vascular tone.

The study revealed that separate signals produced by endothelial cells and smooth muscle cells are required for embryonic cells to differentiate into autonomic neurons. The researchers discovered that endothelial cells secrete nitric oxide, while smooth muscle cells use the protein T-cadherin to interact with the neural crest, specialized embryonic cells that give rise to portions of the nervous system and other organs. The combination of endothelial cell nitric oxide and the T-cadherin interaction is sufficient to coax neural crest cells into becoming autonomic neurons, where they can then co-align with developing blood vessels.

In addition to answering long-standing questions about human development and improving the odds that scientists will one day be able to generate artificial organs from stem cells, this new insight on the autonomic nervous system also has implications for rare inherited conditions such as neurofibromatosis, tuberous sclerosis and Hirschsprung’s disease.

“These observations may help to explain certain human disease syndromes in which abnormalities of the nervous system appear to be associated, for previously unclear reasons, with vascular abnormalities,” said co-senior author Evan Snyder, MD, PhD, professor and director of the Center for Stem Cells and Regenerative Medicine at Sanford-Burnham. “Furthermore, we demonstrate here that modeling human development and disease in the lab must take into account multiple cell types in order to reflect the actual human condition. We can no longer rely on merely examining pure populations of one cell type or another.”

Pictured: Autonomic neurons (green) co-patterning with blood vessels (red).

Human stem cell model reveals molecular cues critical to neurovascular unit formation

Human stem cell model reveals molecular cues critical to neurovascular unit formation

Human stem cell model reveals molecular cues critical to neurovascular unit formation

Using human embryonic stem cells, researchers have created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time, how autonomic neurons and blood vessels come together to form the neurovascular unit.


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Human stem cell model reveals molecular cues critical to neurovascular unit formation

Human stem cell model reveals molecular cues critical to neurovascular unit formation

Using human embryonic stem cells, researchers have created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time, how autonomic neurons and blood vessels come together to form the neurovascular unit. …read more Source:: Science Daily. Mind & Brain

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Human stem cell model reveals molecular cues critical to neurovascular unit formation

Using human embryonic stem cells, researchers have created a model that allows them to track cellular behavior during the earliest stages of human development in real-time. The model reveals, for the first time, how autonomic neurons and blood vessels come together to form the neurovascular unit.http://dlvr.it/9wlzGG