S1m0ne (August 23, 2002)

This film, about a computer-generated actress, was made around the time that the fear of virtual avatars and their potential to steal the jobs of actors and news anchors was at its peak. 

That concern seems to have actually affected the film’s production, according to this piece of trivia (which now seems hilariously dated):

“After seeing the photo-realism of the computer generated actors in Final Fantasy: The Spirits Within (2001), the producers started to lean toward the idea of having Simone actually be a computer generated actress. However, after heavy opposition from the Screen Actor’s Guild, claiming in so many words that replacement of actors in ALL movies would be the next logical step, the idea was scrapped.”

One scene even showcased the idea of a hologram concert, years before Hatsune Miku and Tupac


(This edition of the manga reads left-to-right).