collagen synthesis

4

Collagen Synthesis

  • Reduced hydroxylation of proline and lysine due to Vit C deficiency  => SCURVY
  • Gene mutations of collagen (usually type I & III) and lysine hydroxilase => EHLERS DANLOS
  • Gene mutations of gene ATP7A results in Copper deficiency, reducing the activity of lysil oxidase => MENKES DISEASE (or Copper transport disease, or Kinky Hair Disease)