collagen synthesis


Collagen Synthesis

  • Reduced hydroxylation of proline and lysine due to Vit C deficiency  => SCURVY
  • Gene mutations of collagen (usually type I & III) and lysine hydroxilase => EHLERS DANLOS
  • Gene mutations of gene ATP7A results in Copper deficiency, reducing the activity of lysil oxidase => MENKES DISEASE (or Copper transport disease, or Kinky Hair Disease)

anonymous asked:

People always say vitamin c serums are good for fixing acne scars and sun spots.. Do you have any brand recommendations? The only one I know is the Klairs one but it has ingredients like Propylene Glycol and Butylene Glycol.

They’re right! Vitamin C is a powerful antioxidant, treats hyperpigmentation, and can stimulate collagen synthesis. Put simply, you want to use it if possible.

BUT (and there’s always a but), some conditions must be met in a serum to actually provide you with these benefits. Vitamin C serums are notoriously unstable. Unstable = ineffective:

  • 20% concentration of your vitamin c derivative is best (but not necessary, especially for beginners)
  • Water-based serums need to be at a certain pH to be most effective
  • Contain ferulic acid to boost stability

Some vitamin C serums that do meet these criteria:

  • Drunk Elephant C-Firma Day Serum
  • Timeless 20% Vitamin C+E+Ferulic Acid Serum 
  • Mad Hippie Vitamin C Serum
  • Skinceuticals CE Ferulic Antioxidant Serum

I wouldn’t use the Klairs Freshly Juiced Vitamin Drop because it’s a low percentage of vitamin c with too high of a pH. It’s ineffective. I’d recommend you try one of the serums above.

anonymous asked:

do you have any recommendations for healing deep acne scars (not the pigmented kind, the indented, crater kind)?

honestly honey u will likely need professional treatment with lazers or microneedling to achieve the kind of collagen stimulation and restructuring required to heal atrophic scars. these can be really pricey and they will probably require multiple visits to a dermatology clinic, but pls resist the temptation to try to diy these types of procedures (im talking specifically about at home dermarolling). the chance of infection or accidentally traumatizing the skin further is too great for someone who hasnt been trained. if u cant afford those treatments, ur next best bet is to incorporate ingredients that aid in collagen synthesis– there was a really interesting study that showed that treatments combining retinoic acid and glycolic acid (DONT try mixing these at home, you can seriously hurt ur skin. they need to be professionally formulated, possibly prescribed by a doctor) significantly helped ppl with pitted acne scars, and that research seemed the most promising out of everything i read. vitamin c (ascorbic acid is a cofactor of collagen production), copper tripeptides (copper is a cofactor for lysyl oxidase, which is the enzyme that in turn primes the amino acids lysine and hydroxylysine to form the basic crosslinks of collagen and elastin), and niacinamide might all help somewhat as well, although none of this is a guaranteed cure. atrophic scars are sometimes impossible to completely get rid of bc the tissue damage can be so extensive, so if you try these solutions and nothing helps, u can try using humectants to plump the skin and make your scars less noticeable (hyaluronic acid and glycerin would be most helpful for this).


💫🍓  Blushed fruits that my friends and I have been having everyday 🍒🍃 Eating foods that are beneficial for my skin has kept it so hydrated and naturally radiant! We had cherries & strawberries (my favourite), which are high in vitamin C for collagen synthesis, along with mango, nectarines and apricots with peppermint which was very hydrating on a warm day.

jimincena  asked:

hi! I was wondering what your opinion on derma rolling is? I've cleared up my skin after using accutane but now I've got a bunch of ice pick scars from picking them before I went on it. (btw i love your blog and it's the main reason that I got more serious about my skincare)

Hi, and thank you!

I think dermarolling can be very helpful, just make sure you use the correct length needles. If the needles aren’t at least 0.5mm, they won’t induce collagen synthesis, which is needed to fix scarring. This is a good length to start at. Further reading.

Depending on the severity of your scarring, you may need to go to a professional for dermarolling treatments because it isn’t safe to use needles longer than 1.5mm at home. (x)

As long as you inform yourself first, I say go for it!

anonymous asked:

Are you aware that collagen scaffold synthesis and recellularisation technologies are rapidly advancing and that twenty years from now, when those transed kids you're talking about have grown up, they'll be available to fully reverse the physical damage? As much as I get that being volunteered as a guinea pig in a social experiment by imbecile parents who have nothing but scathing disdain for "little" things like social integration will have a battery of other consequences... take heart, y'know?

Oh, I have no doubt that plastic surgeons and endocrinologists are already busy at work on all sorts of methods for manipulating the human form even more. The trans media outlets (the same publications that used to be the “gay press”–now dead as a door nail) are already publishing frothy articles about uterus transplants for trans women and advances in penile prostheses. After all, the real answer to self hatred, profound body dysmorphia, and internalized homophobia and misogyny can no longer be therapy to help resolve those feelings of disconnection. No, we have to carve and mold and reconstruct all those “wrong bodies.”  And hey–maybe in a few decades, they will even do chromosome transplants, so the pesky TERFs won’t be able to talk about XX=female and XY=male anymore. And–think of the profits!

Of course, the way things are going with the ongoing destruction of planet earth and climate change, we’ll be lucky if we still have an electric grid (vs a few survivors cooking over open fires), so I’m not particularly hopeful that the sterilized regretters will have high-tech surgeries available to reverse the damage. But given how the genderists are now in the business of brainwashing 3-year-olds and their parents to believe they are the opposite sex, will there even be any regretters? The surgically and pharmaceutically constructed humans won’t have any concept of what it would be like to not have to do daily neovagina dilations or neophallus pumping; to not have to inject themselves with hormones every week. They will never know what it would have been like to have a fully functioning body and mind unaltered by human technological ingenuity. and greed. Happy campers, all!

We’re in a Brave New World now, where research “studies” of trans kids have no control groups (because it’s now “unethical” to help kids feel ok about their natal bodies), where it’s “normal” to be sterilized at 13.

But then, maybe it will also become “normal” to want to reverse all the damage when you’re 40. A whole new industry for detransitioners might spring up, so that flip-flopping back and forth between “presenting” as male or female will be as “normal” as can be… A detransition industry would open up a whole new field of practice profit. Surely, some intrepid research surgeon must already be writing grants!