“Ah, it’s a pity, such a beautiful girl talking and laughing to herself; too bad that she has lost her mind.”
Also, this bit of the folktale about the lady marrying the snail? Where she and her husband chat happily together but nobody can see him and all the people they pass think she’s lost her mind?
Mataro: She’s talking to her uniform again! That’s so creepy!
Barazo: If it weren’t for that, she’d be such a great girl.
It is basically this scene from episode 5 of Kill la Kill.
Ryuko is talking to her uniform again. She would be great if she didn’t do that…
Or this scene from the manga.
She’s started up again… She’s a totally normal girl aside from the way she talks to her uniform sometimes…
Or this one.
And it’s probably totally coincidental and a fairly common trope when you’ve got non-human characters and it really probably doesn’t mean anything at all, but then again, with as many references as Kill la Kill makes…