Chinese scientists to pioneer first human CRISPR trial

Chinese scientists are on the verge of being first in the world to inject people with cells modified using the CRISPR–Cas9 gene-editing technique.

A team led by Lu You, an oncologist at Sichuan University’s West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month. The clinical trial received ethical approval from the hospital’s review board on 6 July.

“It’s an exciting step forward,” says Carl June, a clinical researcher in immunotherapy at the University of Pennsylvania in Philadelphia.

The Chinese trial will enrol patients who have metastatic non-small cell lung cancer and for whom chemotherapy, radiation therapy and other treatments have failed. “Treatment options are very limited,” says Lu. “This technique is of great promise in bringing benefits to patients, especially the cancer patients whom we treat every day.”

Lu’s team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR–Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells. The gene encodes a protein called PD-1 that normally acts as a check on the cell’s capacity to launch an immune response, to prevent it from attacking healthy cells.

The gene-edited cells will then be multiplied in the lab and re-introduced into the patient’s bloodstream. The engineered cells will circulate and, the team hopes, home in on the cancer, says Lu.

Genes in immune cells will be edited in an effort to turbocharge their attack on tumours. STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARY

this is completely ignorant of history and whatever else but my personal opinion is like

it’s okay to call the language you’re learning “Chinese” - be it Mandarin, Cantonese, etc.

Chinese is the written language, common across dialects. Mandarin is the spoken language. I feel like it’s common practice to refer to any “dialect” of Chinese as Chinese. if you tell someone who isn’t knowledgeable about languages, “Hey, I’m learning Chinese” that’s perfectly fine?? if you’re talking about it with someone who knows the difference, it’s also okay to specify? 

Obviously Chinese is extremely different from Spanish dialects but I feel like it does draw a parallel - you wouldn’t tell a non-linguaphile that you’re learning Castilian Spanish or Argentinian Spanish, you would just say Spanish. now, unlike Chinese, you can still understand between Argentinian and Castilian, but there are some major differences. so why are some people so upset about the naming of the language? 

i just feel like it’s common practice to refer to it as Chinese and i don’t think it’s a big deal. like, shouldn’t we be supporting Chinese learners anyway, because yay! they’re learning Chinese! no matter what they call it?

White person visits Chinese grocery store -> How can I make this about black people?

Additional context:

I’m Korean but the girl who made the post is Chinese-American.

When someone called out on her she commented that dreads are an act of anti-black racism, then went on to unfriend the other person lmao

Also, from TiA

Huh. How odd, I could’ve sworn the family that owns the Asian market I frequent, were happy to have my money. If not, maybe they should stop recommending stuff for me to try.

venting

my studying habits are really bad. i aim to study a lot and then i get distracted and go off task. i’m someone who wants to do well but never goes through with any of my plans. my personality is very frustrating.
i have big dreams of living in Asia but i don’t seem to be making a lot of effort. When i study Chinese i don’t think i’m putting my all into it, and i get frustrated. i have goals. i need to reach my goals and succeed.
i promise i will give it my all. no more halfheartedly studying if i want to touch the tip of my dreams i need to put so much more effort into it.

when i study languages my family get frustrated because i neglect my other school subjects. but they express that frustration in the wrong ways and describe my language learning as “pointless”, i dont think they understand that for me language learning isnt just about learning a language but learning the culture and other things that come with it. Like through learning Korean and Chinese  i learnt about cultures that are completely different than mine. and every now and then i find myself immersed in their history like recently i started learning about Wu Zetian. My passion in languages has put passion into learning my other subjects. And someone on tumblr (idk if i should tag or not) recently spoke to me about how i could connect them all and it made the whole idea of learning them much more exciting. 

and eventhough i hit a kind of block? which makes learning really hard and question why im actually learning them even if i dont take a language kind of career i hope languages are something i pursue until i die.

Hey! Are there any langblrs who tend to post mostly original content? Not necessarily masterposts/vocab lists… more like progress updates and such. I’d like to follow more langblrs, and those types of posts really motivate me to try and make progress with my language journey as well :)

I’m a French / Chinese / (soon to be) Japanese langblr so I prefer to follow similar, but really any language is fine with me ^^

youtube

I rearranged my bookshelf yesterday, as some of you might have seen on a previous photo post. So now here’s a little tour about how I organized my books along with a sneak peek into some of my language notebooks. Enjoy!
(via https://www.youtube.com/watch?v=ai8QJ9Xfj28)