chemotherapy

This is my best friend Ali, who’s more like a brother to me. He has MPNST (Malignant peripheral nerve sheath tumor) which is basically Cancer. The cancer has spread to his lungs and he’s going to need intensive chemotherapy to reduce the size of the tumors before surgery. As if this wasn’t bad enough, he also has a tumor in his brain and multiple smaller tumors in his back. All this feels like it isn’t real and it’s actually not happening. I just want him to go back to normal and go back to having steeped tea,sitting in my car in the parking lot talking and debating about random things, I really miss that. Go back to listening to Nusrat fateh Ali khan, singing qawali and playing my guitar haha I want things to go back to normal and I know they will InshAllah, it’s just going to take time. In the meantime I kindly request all of you reading this to pray for his quick recovery and well being, Thank you all!

Blood-Brain Barrier Opened Non-Invasively With Focused Ultrasound for the First Time

The blood-brain barrier has been non-invasively opened in a patient for the first time. A team at Sunnybrook Health Sciences Centre in Toronto used focused ultrasound to enable temporary and targeted opening of the blood-brain barrier (BBB), allowing the more effective delivery of chemotherapy into a patient’s malignant brain tumor.

The team, led by neurosurgeon Todd Mainprize, MD, and physicist Kullervo Hynynen, PhD, infused the chemotherapy agent doxorubicin, along with tiny gas-filled bubbles, into the bloodstream of a patient with a brain tumor. They then applied focused ultrasound to areas in the tumor and surrounding brain, causing the bubbles to vibrate, loosening the tight junctions of the cells comprising the blood-brain barrier and allowing high concentrations of the chemotherapy to enter targeted tissues.

“The blood-brain barrier has been a persistent impediment to delivering valuable therapies to treat tumors,” said Dr. Mainprize. “We are encouraged that we were able to open this barrier to deliver chemotherapy directly into the brain, and we look forward to more opportunities to apply this revolutionary approach.”

This patient treatment is part of a pilot study of up to 10 patients to establish the feasibility, safety and preliminary efficacy of focused ultrasound to temporarily open the blood-brain barrier to deliver chemotherapy to brain tumors. The Focused Ultrasound Foundation is currently funding this trial through their Cornelia Flagg Keller Memorial Fund for Brain Research.  

“Breaching this barrier opens up a new frontier in treating brain disorders,” said Neal Kassell, MD, Chairman of the Focused Ultrasound Foundation. “We are encouraged by the momentum building for the use of focused ultrasound to non-invasively deliver therapies for a number of brain disorders.”    

Opening the blood-brain barrier in a localized region to deliver chemotherapy to a tumor is a predicate for utilizing focused ultrasound for the delivery of other drugs, DNA-loaded nanoparticles, viral vectors, and antibodies to the brain to treat a range of neurological conditions, including various types of brain tumors, Parkinson’s, Alzheimer’s and some psychiatric diseases.

The procedure was conducted using Insightec’s ExAblate Neuro system. “This first patient treatment is a technological breakthrough that may lead to many clinical applications,” said Eyal Zadicario, Vice President for R&D and Director of Neuro Programs, Insightec.

While the current trial is a first-in-human achievement, Dr. Kullervo Hynynen, senior scientist at the Sunnybrook Research Institute, has been performing similar pre-clinical studies for about a decade. His research has shown that the combination of focused ultrasound and microbubbles may not only enable drug delivery, but might also stimulate the brain’s natural responses to fight disease. For example, the temporary opening of the blood-brain barrier appears to facilitate the brain’s clearance of a key pathologic protein related to Alzheimer’s and improves cognitive function.

A recent study by Gerhard Leinenga and Jürgen Götz from the Queensland Brain Institute in Australia further corroborated Hynynen’s research, demonstrating opening the blood-brain barrier with focused ultrasound reduced brain plaques and improved memory in a mouse model of Alzheimer’s disease.

Based on these two pre-clinical studies, a pilot clinical trial using focused ultrasound to treat Alzheimer’s is being organized.

huffingtonpost.com
Chemotherapy Isn't Only for Cancer Patients
Upon hearing the word 'chemotherapy,' most people jump to the same conclusions, with the same general consensus on how chemo works, who receives it and what side effects it has on the body. The truth is chemotherapy isn't only for cancer patients, and affects each patient differently depending on how it is used.

A great wee article. I have had to take chemotherapy drugs to treat my Crohn’s and so have many other Crohn’s warriors

This is Emily and her sisters, Meg and Colleen. Emily (on the left) has had a rare brain disease for a long time now and it is her dream to meet Taylor Swift! I’ve only met her a couple times and everyone who knows her agrees: she is one of the most sweet, positive, and strong kids in the world. Please help her out by reblogging and tagging taylorswift or retweeting this tweet:

https://twitter.com/tmvmav/status/620692334431367168

I will follow everyone who reblogs this and do everything in my power to help these girls. please please help them…

8

I have a stage 4 rare cancer called cholangio-carcinoma and need as much financial help as I can possibly get. I have two gorgeous children and my soldier that I’ve been married to for 10 years that need me. This cancer is rare and because of that there’s not many people donating to that specific cancer so there arent very many many financial resources for it. Ive called and spoken to so many resources and been turned away I had a huge break down because of it yesterday. I’m not just asking because I want to, but because I’ve turned to a lot of other organizations and been turned away before trying to raise money on my own. I need this treatment or I’ll die. Today I had to put back a pair of slippers I need due to some pretty shitty side-effects of chemo because I couldn’t afford them and gas for the next week. (because of the chemo pills I take, the skin is literally falling off the bottoms of my feet and is very painful, thus the need for slippers.) My children need me, my family needs me and I need your help. My babies are only,9 & 7. I lost my mom at 12 and I cant have my kids go through that pain and heartache. Please for hells sake, donate we need it and I need it to stay alive. www.gofundme.com/donate2CharityA

Targeting Newly Discovered Pathway Sensitizes Tumors to Radiation and Chemotherapy

In some patients, aggressive cancers can become resistant to chemotherapy and radiation treatments. In a paper published in the journal Nature Communications, University of California, San Diego School of Medicine researchers identified a pathway that causes the resistance and a new therapeutic drug that targets this pathway.

“It was previously known that RAF (a family of proteins that regulate cellular signaling) governs resistance to therapies. We discovered an undescribed role for RAF and learned precisely how it occurs in a broad range of cancers,” said lead author Sunil Advani, MD, assistant professor in the Department of Radiation Medicine and Applied Sciences.

The pathway is used by tumor cells to protect DNA from damage. By inhibiting the pathway using a drug-like compound called KG5, researchers were able to reverse the resistance of tumors to both radiotherapy and certain classes of chemotherapies that induce genotoxic stress. The hope is to increase survival rates among patients with highly aggressive cancers, said Advani.

“We are taking the tumor’s defenses away by targeting this pathway. By developing this drug, we have the potential to enhance radiation sensitivity of cancer while sparing healthy tissue. This drug increases the DNA-damaging effects of radiation and certain chemotherapies,” said principal investigator, David Cheresh, PhD, Distinguished Professor of Pathology and associate director for Innovation and Industry Alliances at Moores Cancer Center at UC San Diego Health. “We essentially get more anti-tumor activity with less radiation or chemotherapeutic drug. This allows us to see the anti-tumor effect while reducing terrible side effects. We have seen this in pancreatic, brain and lung cancer cells both in cell culture and in tumors growing in mice.”

Radiation is the therapy of choice for certain cancers. In follow-up studies, researchers hope to enhance the design of KG5 to further improve its radio-sensitizing activity and safety profile so that it can be tested in patients.

“For patients with aggressive cancers, there may be no good options left,” said Advani. “Armed with this new approach, our goal is utilize such a drug to improve the clinical outcomes of some of the most widely used anti-cancer therapies.”

Knew this was coming.

Rising antibiotic resistance increasing risks of routine surgery – study

Routine surgery and chemotherapy may become all but impossible unless urgent action is taken to halt the waning efficacy of antibiotic drugs, according to research.

A paper says rising resistance to antibiotics routinely used to prevent patients getting infections during and after surgery is a disaster. It will mean increased risk for operations such as caesareans, hip replacements and appendix removal, and also treatment for cancer patients, who are given antibiotics because chemotherapy drugs undermine their immune system, making them vulnerable to infections.

Antimicrobial resistance is recognised as a looming threat to health, but usually because the drugs are losing their power to fight and cure serious infections, from tuberculosis to gonorrhoea and hospital-acquired superbugs.

But antibiotics are also used to prevent infections. A study in the journal Lancet Infectious Diseases has, for the first time, quantified the potential impact of resistance in the operating theatre and in chemotherapy. If the drugs lose just 30% of their efficacy, it says, there could be 120,000 more infections and 6,300 infection-related deaths each year in the US alone.

Photograph: Christopher Furlong/Getty Images

hlfteam.com
Doctor’s groundbreaking discovery: chemotherapy kills cancer patients faster than no treatment at all

For those living in the early 1900’s, the chances of getting cancer was 1 out of every 100 people, about fifty years ago the chances increased to 1 in 50. Today, it is said that a little less than 1 out of every 3 people will get cancer, soon to be 1 in 2. If you get cancer, where will you turn for treatment? Your options are Chemotherapy, which is refused by 75% of doctors, works only 2-3% of the time, and has been shown in a study to cause more cancer, or, you can utilize natural substances found in nature that science has shown are powerful Cancer Cures, with virtually no side effects.

(Image caption: MR images taken before (left) and 28 weeks after (right) the initiation of chemoradiation treatment for glioblastoma show an enlargement of the brain’s ventricles, reflecting a loss of brain tissue. Credit: ©2015 American Academy of Neurology)

Study reveals effects of chemoradiation in brains of glioblastoma patients

A study from Massachusetts General Hospital (MGH) Cancer Center researchers – the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients – reveals not only specific structural changes within patients’ brains but also that the effect of cancer therapy on the normal brain appears to be progressive and continues even after radiation therapy has ceased. The report has been issued online and will appear in the August 25 issue of Neurology.

“It is well known that whole brain radiation can have adverse, neurotoxic effects and causes loss of brain volume in some individuals,” says Jorg Dietrich, MD, PhD, of the Pappas Center for Neuro-Oncology at MGH, senior author of the Neurology paper. “This is the first prospective and longitudinal study to characterize structural brain changes resulting from standard radiation and chemotherapy in patients with malignant brain tumors. Further studies with neuropsychological evaluation will be needed to characterize the functional consequences of these structural changes.”

The study enrolled 14 glioblastoma patients who were scheduled to receive chemotherapy and radiation after surgical tumor removal. Before and during the 35-week standard treatment protocol – which was not altered for the current study – MR images were taken with the high-power 3T scanner at the MGH-based Martinos Center for Biomedical Imaging. In the 8 participants for whom an adequate number of imaging studies were completed, whole brain volume – the overall amount of brain tissue – decreased significantly throughout the study period. The reduced volume was apparent within a few weeks after initiation of treatment and was primarily seen in grey matter. The size of the brain’s ventricles – cerebrospinal fluid-filled spaces deep within the brain – became progressively larger during the course of treatment, and changes were also seen within the subventricular zone, one of two structures in which new brain cells are generated in adults.

“We were surprised to see that these changes – reduced grey matter volume and ventricular enlargement – occurred after just a few weeks of treatment and continued to progress even after radiation therapy was completed,” says Dietrich. “While this was a small study, these changes affected every patient at least to some degree. Now we need to investigate whether these structural changes correlate with reduced cognitive function and whether neuroprotective strategies might be able to stop the progression of brain volume loss. Establishing novel imaging biomarkers of treatment-associated neurotoxicity – such as ventricular enlargement, which can be tracked with any MR scanner – will be a critical step towards developing more selective therapies that are targeted to the tumor and spare normal brain tissue.”

When faced with a drug shortage, how do you ration out the available drugs to patients? Do some get preference over others? Who do you exclude from a life-saving treatment? Clinicians are frequently faced with these difficult questions, but the development of guidelines may be a first step in reaching the most ethical decision when vital medications are scarce.

Image: “Scary” by Nicki Dugan Pogue. CC BY-SA 2.0 via Flickr.

thetruthaboutcancer.com
The Truth About Chemotherapy - Toxic Poison Or Cancer Cure?
Discover what the medical establishment doesn't want you to know about chemotherapy drugs.

Obvious Signs That Chemotherapy Is Highly Toxic

Think about it… a person’s hair falls out, their immune system is destroyed,  he/she is  constantly nauseous and often vomits. Frequent dizziness is also the norm as are severe headaches. Are these signs that maybe, just maybe chemotherapy  is poison and doesn’t belong in the human body? I’m not a doctor, but I think this is a very, very strange way to “heal” someone.

Chemotherapy is a derivative of the mustard gas used in World War I. As the Seattle Times reported, “A just-completed study from the U.S. Centers for Disease Control (10 years in the making and the largest to date) confirms that chemo continues to contaminate the work spaces where it’s used and in some cases is still being found in the urine of those who handle it…”

Yet drugs (like Tamoxifen) are routinely used to “treat” breast cancer even though the World Health Organization declared Tamoxifen to be a “known carcinogen” in 1996. The level of quackery in the cancer industry is amazing. Chemotherapy doesn’t work at anything other than causing cancer! If you have cancer and are considering chemotherapy, please ask yourself this vitally important question:  If chemotherapy causes cancer, how can it also treat or cure cancer?

sciencealert.com
Researchers kill drug-resistant cancer in the lab using 50 times less chemo
This is awesome.
By Fiona MacDonald

Researchers in the US have just made an existing chemotherapy drug way more effective, managing to kill drug-resistant lung cancer cells in the lab using 50 times less of the medication than is currently required.

“That matters because we may eventually be able to treat patients with smaller and more accurate doses of powerful chemotherapy drugs, resulting in more effective treatment with fewer and milder side effects,” explained lead researcher Elena Batrakova, a pharmacologist at the University of North Carolina at Chapel Hill.

What’s really exciting about the result is that it didn’t rely on any new or experimental medications - the researchers were able to kill the drug-resistant cancer using chemotherapy that’s already been tested and is known to work in humans - all they did was make it a whole lot better by figuring out a new way to package and deliver the medication.