centre of addiction and mental health

This is your brain on fried eggs

High-fat feeding can cause impairments in the functioning of the mesolimbic dopamine system, says Stephanie Fulton of the University of Montreal and the CHUM Research Centre (CRCHUM.) This system is a critical brain pathway controlling motivation. Fulton’s findings, published in Neuropsychopharmacology, may have great health implications.

“Our research shows that independent of weight gain and obesity, high-fat feeding can cause impairments in the functioning of the brain circuitry profoundly implicated in mood disorders, drug addiction, and overeating – several states and pathologies that impinge on motivation and hedonia,” Fulton explained. Hedonia relates to a mental state of wellbeing. “Another key finding is that the effects of prolonged high-fat feeding to dampen the sensitivity of this brain reward system are specific to saturated fats – palm oil used in this study – but not monounsaturated fat such as the olive oil used in this study.”

The research team obtained these findings by working with three groups of rats. The first group of rats was the control group: they were given a low-fat diet containing roughly equal amounts of monounsaturated and saturated fatty acids. The second group was given a monounsaturated high fat diet, of which 50% of the calories were from fat derived from olive oil. The third group was given a saturated high fat diet – again, 50% of the calories were from fat, but this time derived from palm oil. The high-fat diets were all the same in terms of sugars, proteins, fat content and caloric density, and the animals were free to eat as much or as little as they liked. After eight weeks, all of the rats still had comparable body weights and levels of insulin, leptin (which are major metabolic hormones) and relative glycemia.

At this time, the rats underwent a series of behavioural and biochemical tests known to be indicative of the functioning of rats’ dopamine system. “We established that the rats on the palm diet had a significantly blunted dopamine function,” said Cecile Hryhorczuk, the first author of the study. “Our research group and others hypothesize that this leads the brain to try to compensate by heightening reward-seeking behaviour, much like the phenomenon of drug tolerance where one has to increase the drug dose over time to get the same high. So, a person consuming too much saturated fat may then compensate a reduced reward experience by seeking out and consuming more high-fat and high-sugar foods to get the same level of pleasure or reward.”

Fulton’s study is the first of its kind to show that, regardless of weight changes, unrestrained intake of saturated fats can have negative effects on the controls of motivation by the brain. “As we were able to control for changes in body weight, hormones and glucose levels, we think that the fats may be affecting the dopamine system by a direct action in the brain,” Fulton said. “We in fact have separate evidence that brain inflammation could be involved in this process, as it is evoked by saturated high-fat feeding, which will be presented in a future publication.”

Words cannot explain how much I love and admire and look up to natvanlis Ever since I first got into ‘Carmilla’, I’ve admired the entire cast and how genuine and sweet they all are, but there’s just something about Natasha that’s just ugh. For one, she likes fostering rescued dogs, that was a big thing for me, I’m a huge dog lover and I love when people rescue dogs. 🐶 She volunteered at a local centre for addiction and mental health, which is a beautiful thing. She’s wrote a children’s book. 🙊 She’s a huge advocate to the lgbtq community, she’s so outspoken about her sexuality and I think that incredible, I’ve read so many people’s stories on tumblr about how much they admire Natasha for everything she does, and that her talking about her sexuality has helped them in so many ways. Alsoooo, she sings, beautifully. 😍 She just released 2 demos (which she didn’t think the fandom would like but here we are all dead after them) which are unbelievable. 😭 She cares so much about her fans, and she just seems like the sweetest most caring human being ever, and I just want to take time to thank her for everything she’s ever done for me, I know Carmilla hasn’t been out for that long, but the show, and cast, and her have made a huge impact on my life and I’m forever grateful for that. ❤️

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The Cambridges + Patronages (1/♛ )

100 Women in Hedge Funds Initiatives
William: January 1, 2010
Catherine: January 1, 2013
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1851 Trust
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Mission: The 1851 Trust will inspire and engage a new generation into the sport of sailing, providing them with the skills and training to become the innovators of the maritime technology of the future.

Action on Addiction
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Anna Freud Centre
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Mission: Anna Freud Centre is a charity which transforms the experience of children, young people and their families with mental health issues by carrying out research, developing and offering services, teaching and training.

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Mission: The BBMF operates flypasts (Lancaster, Hurricanes and Spitfires) and serves as a tribute to the young men who gave their lives in the service of this Country in WWII and in subsequent conflicts.

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Centrepoint
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Mission: National charity providing accommodation and support for socially excluded, homeless young people.