cell-signalling

off limits | 02 (m)

pairing: kim seokjin x reader
genre/warnings: smut, dirty talk, dom! Jin 
words: 7,520
summary: you’ve been lusting after your brother’s best friend for a while now, ever since you met him at a house party, flirting it up a storm as you failed to realise who the other was. That was months ago now and things are still awkward, but you can’t ignore the sexual tension that’s simmers between the two of you…and it keeps getting worse…

» playlist | 01 | 02 | 03 |

a/n: if you squint, you can see the beginnings of a plot haha!

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Neurons - Anatomy Overview

Going to be covering nerves and synapses this week so here’s a recap!

  • Soma (cell body) contains the nucleus which produces RNA to support cell functions, + organelles surrounding the nucleus which are mostly made of up endoplasmic reticulum. Supports and maintains the functioning of the neuron.
  • Dendrites - cellular extensions with many branches ‘dendritic tree’. majority of input occurs via the dendritic spine. The sum of all excitatory (neuron fires) or inhibitory (prevents firing) signals determines whether the neuron fires or not. If firing the action potential is transmitted down the axon.
  • Axon - fine, cable-like projection that can extend thousands of times the diameter of the soma in length. The axon carries nerve signals away from the soma (and also carries some types of information back to it). Can undergo branching - communication with target cells. 
  • Axon hillock - where the axon emerges from the soma. the part of the neuron that has the greatest density of voltage-dependent sodium channels - therefore the most easily excited part of the neuron and the spike initiation zone for the axon - most negative action potential threshold. Can also receive input from other neurons.
  • Axon terminal where neurotransmitters are released into the synaptic cleft to signal the next neuron

Myelin sheath

Myelin is a fatty material that wraps around axons and increases the speed of electrical transmission between neurons. It is broken up by nodes of Ranvier, between which electrical impulses jump. Myelin is produced by schwann cells in the PNS and oligodendrocytes in the CNS.

Classes of neurons

Sensory neurons bring information into the CNS so it can be processed.

Motor neurons get information from other neurons and convey commands to  muscles, organs and glands.

Interneurons,found only in the CNS, connect one neuron to another. 

Types of neuron

Multipolar neurons have one axon and many dendritic branches. These carry signals from the central nervous system to other parts of the body eg muscles and glands.

Unipolar neurons are also known as sensory neurons. They have one axon and one dendrite with branches. Pass signals from the outside of the body, such as touch, along to the central nervous system.

Bipolar neurons have one axon and one dendrite branch. They pass signals from one neuron to the next inside the central nervous system.

Pyramidal neurons have one axon and two main dendrite branches. These cells pass signals inside the brain and tell the muscles to move.

Purkinje neurons are found in the cerebellum, controlling balance, coordination, and timing of actions. They have one axon and a dense and complicated dendrite arrangement.

Artist Alley Gothic

(co-authored by @kytri and @spazzbot)

- You’re not sure what time it is. There are no windows. It is both noon and midnight. Time does not exist.

- The florescent lights do not change. They are eternal, they blaze upon you like stars. You saw the sun once, though you don’t really remember.

- There is food somewhere. The table next to you has food. It’s chicken nuggets and fries. You go to get food. It’s nuggets and fries. It's​ the only food for miles. You’ve never eaten anything else. You are so hungry.

- You saw a print you liked. You go to find it, but you can’t. There are so many tables, so many prints. The table is gone, the artist is nowhere to be seen. Maybe they were never there.

- You try to find table F6. You’ve been through the alley ten times. You’ve seen the same prints and plushies over and over. Table F6 is nowhere. You are growing old.

- There is a sound echoing from somewhere. It is loud and shakes the floor. You cannot find the source.

- You have no cell signal. You stand on the chair, but get nothing. The outside world ceases to exist. Your face is on a milk carton somewhere.

pulled the daisies fine // nurseydex

a/n: thought i’d reverse a typical fandom trope and send dex up to nursey’s for the new year. it goes about as well as you would expect. HAPPY NEW YEAR!!!!!

word count: 4.3k

“Hm, so, this would be fun if we weren’t collegiate level hockey players who learned how to skate when we were ten,” Dex deadpans after about five minutes of skating around the Rockefeller Center ice rink.

“This is fun!” Nursey insists, squeezing Dex’s hand through his chunky mittens, “it’s relaxing.”

Off to their left about three different toddlers start crying at once, and Dex gives Nursey a look.

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5

If you’ve ever wondered how much of an asshole my roommate is, in the hour I spent doing calc homework without cell signal, she sent me the transcriptions of the following: The Gettysburg address, The lyrics to 5 Jon Cozart songs, And last but not least, Obama’s farewell address. (Followed quickly by a meme)

This is what I put up with.

@alazypizza

How to Write Horror: A Word On Vulnerability

Horror has a lot of superficial overlap with other genres, which can make it hard to define. Paranormal, suspense, mystery, thriller, dark fantasy - all of these can have scary scenes, monstrous villains, and other horror tropes.

But, as far as I’m concerned, there is one thing that can reliably differentiate a horror story from any other genre: The vulnerability of its characters.

Horror stories feature characters who are not empowered against the villain. They are regular everyday people dealing with things far beyond their understanding or skill set. They may in fact be even more vulnerable than the average person - Why else are so many horror movies told about families with young children? Why is the archetype of the “final girl” so prevalent?

Therefore: If your goal is to write a true horror tale, you must first consider how to populate your story with vulnerable characters.

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3

Cell Signaling 
Requested by oceanliquidation
(Cliffnotes AP Biology Workbook 4th Edition)

Please note there are 2 more types of signal receptors: 
Protein Kinase Receptors: transmembrane-protein enzymes that are kinases, that add a phosphate group to  protein. The best understood of these are Receptor Tyrosine Kinases.
Intracellular Receptors: receptors positioned in the cytoplasm or nucleus, and are able to pass through the phospholipid membrane. 

A Fear Itself game where your teenage PCs find themselves lost in the woods at the middle of the night with no cell-phone signal. They stumble on a isolated, seemingly abandoned house. They knock.

The inhabitants invite them in, make them some dinner, give them a place to stay and drive them to the nearest town in the morning, pleasantly wishing them luck on their travels.

Roleplay enjoying the rest of your spring break!

Dialogue Prompts #1

1. “Guess I am good for nothing after all" 

 2. "You can’t keep self destructing like this and expect everyone else to be there when the bomb finally hits." 

 3. "I love you”

    “Go suck a dick”

 4. “You should have given up years ago. Why do you keep coming back to me?!" 

    "You’re the only thing I have left" 

 5. "I want a puppy." 

 "And I want world domination but lemme tell you only one of us getting what we want today. Give me the lamp”

 6. “And she/he just pushed me away in the end. Like I’m not good enough and no one else will ever be." 

 7. "People like me don’t get happy endings”

   "People like you don’t get to treat other people like that. Don’t twist this around to be about you.“ 

 8. "The spirits are all around you" 

   "Alright sure Pocahontas just give me my hash browns”

 9. “Where are we?”

   “The middle of nowhere Nebraska.”

   “No cell signal? Why is there no cell signal? That only happens in horror movies. This is a horror movie! Oh my god you’re gonna kill me?”

10. “I always knew I’d die a dramatic death”

    *From far away* “You just stubbed your toe you’re not gonna die!”

11. “We have a serious problem!”

      “What?”

      “I accidentally stole from the senators house again.”

      “Then you have a serious problem I will not be an accomplice this time.”

12. “One day this drinking is going to kill you and when it does everyone you know will be long gone because we can’t watch you waste your life away like this anymore.”

An excerpt from a longer Enjoltaire “get together” slash “Enj has anxiety” fic that will probably never see the light of day

⚠️: Panic attack

Enjolras presses the tip of his tongue against his teeth and counts - 1 2 3 in, 1 2 3 4 hold, 1 2 3 4 5 out. And repeat. And repeat. And repeat. And -

“Are you okay?”

Enjolras jolts his head up. Is he okay? Enjolras wants to snort.

Oh sure. Fine. Just - losing his mind on the subway but he’s fine. 1 2 3 in. Everything will be okay. 1 2 3 4 hold -

“Hey,” the guy, the one who spoke before, moves closer. “Are you, uh. You look like you might pass out.”

Enjolras tries to focus. Green eyes and a frown, brown leather, and curls and - breathe Enjolras, you know how to breathe, it’s easy, in and out and in and out and

“Maybe you should sit down?” The guy says, like it’s a question.

“I should ..?” Enjolras breaks through the panic for a moment and realizes he’s hunched over, “Yeah, yes - okay.”

He sits heavily and tries to calm down. He can’t stop his breath from stuttering. He rips off his scarf, and his fingers scrape against his neck. Fuck, it’s hot. And loud.

The R train screeches through the tunnel, metal on metal, a high, shrill noise that cuts the air.

Enjolras flinches and a few people stare openly. His whole body must have jerked but he can’t tell, he’s never, fuck, he’s never had this happen underground before.

“Hey are you..having a panic attack?” The guys looms over him.

Enjolras nods tightly. Yes, he thinks, I’m having a panic attack. He’s having a panic attack and Combeferre is laying in the hospital and now he’s stuck on the subway, left trying to recycle stale air when he can barely unclench his teeth.

“Okay, that’s okay.” The guys says. “Do you know where you are?”

“Yes,” Enjolras grits out. He doesn’t want attention, he wants fresh air, and a cell signal. Fuck; what if someone tries to call him and they can’t get through. It’ll go straight to voicemail. What if there were complications and now Combeferre is - is - no, he can’t go there.

“Cool, that’s good” the guy sits next to Enjolras.

Enjolras takes a shuddering breath in and tries to hold it. Instead, he’s left with small gasps that scrape against the back of his throat.

“Can I touch you?”

Enjolras tenses - he doesn’t like being touched. But touch is what helps ground him, and some small scrap of logic left in him outweighs pride. Enjolras nods.

“I’m just going to take your hand, that cool?” Enjolras doesn’t respond but the guy must see some affirmation because he takes Enjolras’ arm and guides a hand to his chest. “Cool, that’s great, can you try to match your breath to mine?”

The guy takes a deep exaggerated breath in, and then exhales slowly. Enjolras tries to match. They sit together and the train inches along.

A few stops go by and Enjolras can finally breathe enough to feel the low ache of shame taking up space against his ribs.

“I’m okay now,” Enjolras says, and his voice is steadier than before.

“You’re shaking,” the guys says, but releases Enjolras’ hand.

“Adrenaline.”

“Yeah I know how that goes.”

They sit in silence. The train doors open, and a few people step in.

“Thank you,” Enjolras says, and meets a pair of vivid and searching eyes.

“Hey sure, glad I could help.” The guy glances at him, sidelong. “Are you…okay?”

“Yes,” Enjolras says, shoving his hands in his pockets. “they’ll stop shaking in a second.”

“I kind of meant - did something happen?”

Enjolras fidgets. He doesn’t know how to answer. What Enjolras can’t do, or at least, what Enjolras can’t do well, is talk about his feelings. He’d rather choke on anxiety than share it. On the best days, he can pack anxieties into a backpack, shoving guilt and grief deep inside. On the worst days, the weight of it all slumps his shoulders so much that his back might break.

“My best friend is in the hospital.”

“Shit, I’m sorry.”

Enjolras nods once, and searches the guy’s face. There’s no pity there. His forehead is scrunched up and his lips pursed, he looks concerned - maybe a little confused. Enjolras’ shoulders drop.

“A taxi side-swiped his bike. He hit his head. They’re not sure..”

“Fuck. Fuck, man I’m sorry. Really.”

“Thanks,” Enjolras says. He means it.

They ride in silence for a little longer.

“My stops next,” the guy says.

“Thank you,” Enjolras gives the most genuine smile he can muster.

“I - uh. I’m Grantaire. By the way.”

“Enjolras.”

The train screeches loudly again and then shudders to a stop. Their knees brush and Grantaire stands up.

“Bye, I guess” he says. “Take care of yourself.”

He walks off just as the doors close.

Enjolras takes a deep breath. And then another, and another, and watches through the subway window stained with fingerprints as a head of dark, curly hair gets swallowed into the crowd.

Neuro chip records brain cell activity at higher resolution

Brain functions are controlled by millions of brain cells. However, in order to understand how the brain controls functions, such as simple reflexes or learning and memory, we must be able to record the activity of large networks and groups of neurons. Conventional methods have allowed scientists to record the activity of neurons for minutes, but a new technology, developed by University of Calgary researchers, known as a bionic hybrid neuro chip, is able to record activity in animal brain cells for weeks at a much higher resolution. The technological advancement was published in the journal Scientific Reports.

“These chips are 15 times more sensitive than conventional neuro chips,” says Naweed Syed, PhD, scientific director of the University of Calgary, Cumming School of Medicine’s Alberta Children’s Hospital Research Institute, member of the Hotchkiss Brain Institute and senior author on the study. “This allows brain cell signals to be amplified more easily and to see real time recordings of brain cell activity at a resolution that has never been achieved before.”

The development of this technology will allow researchers to investigate and understand in greater depth, in animal models, the origins of neurological diseases and conditions such as epilepsy, as well as other cognitive functions such as learning and memory.

“Recording this activity over a long period of time allows you to see changes that occur over time, in the activity itself,” says Pierre Wijdenes, a PhD student in the Biomedical Engineering Graduate Program and the study’s first author. “This helps to understand why certain neurons form connections with each other and why others won’t.”

The cross-faculty team created the chip to mimic the natural biological contact between brain cells, essentially tricking the brain cells into believing that they are connecting with other brain cells. As a result, the cells immediately connect with the chip, thereby allowing researchers to view and record the two-way communication that would go on between two normal functioning brain cells.

“We simulated what Mother Nature does in nature and provided brain cells with an environment where they feel as if they are at home,” says Syed. “This has allowed us to increase the sensitivity of our readings and help neurons build a long-term relationship with our electronic chip.”

While the chip is currently used to analyze animal brain cells, this increased resolution and the ability to make long-term recordings is bringing the technology one step closer to being effective in the recording of human brain cell activity.

“Human brain cell signals are smaller and therefore require more sensitive electronic tools to be designed to pick up the signals,” says Colin Dalton, adjunct professor in the Department of Electrical and Computer Engineering at the Schulich School of Engineering and a co-author on this study. Dalton is also the facility manager of the University of Calgary’s Advanced Micro/nanosystems Integration Facility (AMIF), where the chips were designed and fabricated.

Researchers hope the technology will one day be used as a tool to bring personalized therapeutic options to patients facing neurological disease.

ELI5: why do you see weird patterns when you close your eyes and apply pressure onto them?

This phenomenon is called phosphene.

When light hits the cells in the eye, these cells send a signal to the brain to give an image of what is seen. These cells are called photoreceptor cells, and their main means of activation is when a photon of light hits them. Another way to activate them is via mechanical stimulation (aka applying pressure to they eyes). When you apply mechanical stimulation, the subsequent activation of the cells will be random (not patterned), and when this signal is transmitted to the brain areas that are responsible for generating an image, you will see weird patterns instead of the normal images that would be generated by photon-induced stimulation.

Explain Like I`m Five: good questions, best answers.

  • me, having a calm night reading through the SCP wiki: I see my cellular device is showing... a notification
  • boy [text]: hey ;)
  • me [text]: hello
  • boy [text]: wyd
  • me [text]: I am having a calm night reading through the SCP wiki
  • me: does not ask in return what he is doing or what he wants to be doing
  • boy [text]: haha but what would you be doing if I was there with you rn ;)
  • me, triangulating the position of the entity's cell signal, recording it, slamming my phone into the wall, picking up its remains, and locking said remains in a lead-lined 30.0 x 20.0 x 10.0-centimeter box, as I close out of all programs on my laptop to enter DEFCON 1 XK-Class Emergency Mode, typing: SCP-XXXX is any one of a number of malicious entities which seek copulation with human women whom they perceive to be heterosexual and attracted to solely heterosexual, monogamous, white, cisgender males such as themselves. 95 percent of SCP-XXXX entities are speculated to be between the ages of 18 and 25 years, and are frequently found roaming college campus football stadiums. Care must be taken when addressing SCP-XXXX instances as they frequently
  • me, radioing the MTF unit commander as I continue typing: I've got another one on the radar lads, ready the containment teams,
Fanfic Ideas From My Life

I recently came to the conclusion that my life is one long string of bad fanfic tropes, so I decided to share with everyone. If you make something based on this list, please let me know so that I can see it!

  • I’ve been flirting with this barista at the local coffee shop for weeks and he’s been flirting back, but I just noticed the wedding ring on his finger abort mission abort mission
  • excuse you my friend is far too young for you to be grinding on her at this school dance, however I am two years older and also gay as hell, please come over her and dance with me
  • what do you mean I’m going to be stuck in this car for the next three days with my parents and two large dogs and my cell signal is shit so I can’t text my friends??? Oh nooo the person working the counter at the gas station next to the hotel is super cute
  • I’m really sorry that my dog knocked you over but you’re holding a frisbee and she loves frisbees more than life itself and even food so really you were kind of asking for it - oh no you’re hot
  • “wow you two are such a cute couple omg!! Wait, what? You’re not together?? Why not???? Oh, your roommate is his girlfriend, I see.”
  • we’re the only two people who showed up to this study group and wow you’re even worse at math then I am, do you want some help? also how dare you be so attractive that isn’t helping with the whole study thing
  • I just accidentally made a really sexual joke in the middle of class because my mouth is faster than my brain sometimes and you’re the cute girl who sits next to me and you laughed really hard and are smiling at me and that’s not helping my blush damnit
  • Look I just want to practice my instrument in peace okay that’s what practice rooms are for but you’re apparently under the impression that you’re in a concert hall that seats 1000 and your deaf grandma is sitting in the back can you please play a bit quieter and also not be so attractive damnit I just want to work on my Bach piece
  • I swear to god I’m not trying to flirt with you this is just how I talk please stop dropping innuendos like they’re going out of style we’re on a field trip to a museum and I’m actually interested in what the guide is saying
  • this snorkeling class might be getting me my phys. ed. credit but I did not take into account the amount of cute people in swimsuits that would be present or apparently how cute I am in this pink and purple one piece??
  • I’m like 87% sure I broke my little toe last night while trying to keep my dog from chasing a cat and you just stepped on my foot and I yelled but I can even be mad because you’re super cute when you’re sheepish