me, having a calm night reading through the SCP wiki:
I see my cellular device is showing... a notification
I am having a calm night reading through the SCP wiki
does not ask in return what he is doing or what he wants to be doing
haha but what would you be doing if I was there with you rn ;)
me, triangulating the position of the entity's cell signal, recording it, slamming my phone into the wall, picking up its remains, and locking said remains in a lead-lined 30.0 x 20.0 x 10.0-centimeter box, as I close out of all programs on my laptop to enter DEFCON 1 XK-Class Emergency Mode, typing:
SCP-XXXX is any one of a number of malicious entities which seek copulation with human women whom they perceive to be heterosexual and attracted to solely heterosexual, monogamous, white, cisgender males such as themselves. 95 percent of SCP-XXXX entities are speculated to be between the ages of 18 and 25 years, and are frequently found roaming college campus football stadiums. Care must be taken when addressing SCP-XXXX instances as they frequently
me, radioing the MTF unit commander as I continue typing:
I've got another one on the radar lads, ready the containment teams,
Okay but aliens who are human enthusiasts. Like they collect all of our little sound bites that escape into outer space. The ones that are considered the most rare and precious are the ones of people just sitting around chatting with each other about benign things, especially ones that come from cell phone signals. On the flip side, the most common and worthless ones are ones from important events. The most common ones that every collector has are the signals that were purposely sent out to space. Like the ones from SETI, the ones that say “hey we’re here” cause, duh, everyone knows you’re there.
If you’ve ever wondered how much of an asshole my roommate is, in the hour I spent doing calc homework without cell signal, she sent me the transcriptions of the following:
The Gettysburg address,
The lyrics to 5 Jon Cozart songs,
And last but not least,
Obama’s farewell address.
(Followed quickly by a meme)
Please note there are 2 more types of signal receptors: Protein Kinase Receptors: transmembrane-protein enzymes that are kinases, that add a phosphate group to protein. The best understood of these are Receptor Tyrosine Kinases. Intracellular Receptors: receptors positioned in the cytoplasm or nucleus, and are able to pass through the phospholipid membrane.
Neuro chip records brain cell activity at higher resolution
Brain functions are controlled by millions of brain cells. However,
in order to understand how the brain controls functions, such as simple
reflexes or learning and memory, we must be able to record the activity
of large networks and groups of neurons. Conventional methods have
allowed scientists to record the activity of neurons for minutes, but a
new technology, developed by University of Calgary researchers, known as
a bionic hybrid neuro chip, is able to record activity in animal brain
cells for weeks at a much higher resolution. The technological
advancement was published in the journal Scientific Reports.
“These chips are 15 times more sensitive than conventional neuro
chips,” says Naweed Syed, PhD, scientific director of the University of
Calgary, Cumming School of Medicine’s Alberta Children’s Hospital
Research Institute, member of the Hotchkiss Brain Institute and senior
author on the study. “This allows brain cell signals to be amplified
more easily and to see real time recordings of brain cell activity at a
resolution that has never been achieved before.”
The development of this technology will allow researchers to
investigate and understand in greater depth, in animal models, the
origins of neurological diseases and conditions such as epilepsy, as
well as other cognitive functions such as learning and memory.
“Recording this activity over a long period of time allows you to
see changes that occur over time, in the activity itself,” says Pierre
Wijdenes, a PhD student in the Biomedical Engineering Graduate Program
and the study’s first author. “This helps to understand why certain
neurons form connections with each other and why others won’t.”
The cross-faculty team created the chip to mimic the natural
biological contact between brain cells, essentially tricking the brain
cells into believing that they are connecting with other brain cells. As
a result, the cells immediately connect with the chip, thereby allowing
researchers to view and record the two-way communication that would go
on between two normal functioning brain cells.
“We simulated what Mother Nature does in nature and provided brain
cells with an environment where they feel as if they are at home,” says
Syed. “This has allowed us to increase the sensitivity of our readings
and help neurons build a long-term relationship with our electronic
While the chip is currently used to analyze animal brain cells, this
increased resolution and the ability to make long-term recordings is
bringing the technology one step closer to being effective in the
recording of human brain cell activity.
“Human brain cell signals are smaller and therefore require more
sensitive electronic tools to be designed to pick up the signals,” says
Colin Dalton, adjunct professor in the Department of Electrical and
Computer Engineering at the Schulich School of Engineering and a
co-author on this study. Dalton is also the facility manager of the
University of Calgary’s Advanced Micro/nanosystems Integration Facility
(AMIF), where the chips were designed and fabricated.
Researchers hope the technology will one day be used as a tool to
bring personalized therapeutic options to patients facing neurological
ELI5: why do you see weird patterns when you close your eyes and apply pressure onto them?
This phenomenon is called phosphene.
When light hits the cells in the eye, these cells send a signal to the brain to give an image of what is seen. These cells are called photoreceptor cells, and their main means of activation is when a photon of light hits them. Another way to activate them is via mechanical stimulation (aka applying pressure to they eyes). When you apply mechanical stimulation, the subsequent activation of the cells will be random (not patterned), and when this signal is transmitted to the brain areas that are responsible for generating an image, you will see weird patterns instead of the normal images that would be generated by photon-induced stimulation.
Scientists track down possible new treatment for epilepsy
Increasing the concentration of specific fats in the brain could
suppress epileptic seizures. This is evident from ground-breaking
research carried out by the research groups of Professor Patrik
Verstreken (VIB-KU Leuven) and Professor Wim Versées (VIB-Vrije
Universiteit Brussel). The results of their close collaboration have
been published in the leading trade journal Nature Structural &
Professor Patrik Verstreken
specializes in brain research, focusing on synapses. These are the
junctions between two nerve cells where electrical signals are
transmitted. In various brain disorders — such as Parkinson’s disease —
there is impaired communication at these synapses.
Versées examines the processes which take place in our cells, right down
to the level of individual molecules and atoms. By figuring out the
three-dimensional structures of protein molecules, he tries to obtain
crucial information about their role in the cell and the mechanisms
which underlie various disorders.
The key role of TBC1D24 In
earlier research involving fruit flies, Professor Verstreken had
already demonstrated that a protein known as ‘Skywalker’ plays a crucial
role in maintaining communication between brain cells. An almost
identical protein operates in the human brain under the name ‘TBC1D24’.
Patrik Verstreken (VIB-KU Leuven): “Genetic mutations of the protein
TBC1D24 cause a deviation known as the DOOR syndrome. Alongside
deafness, deformed nails, brittle bones and mental retardation, this
serious genetic disorder is characterized by neurodegeneration, movement
disorders and epilepsy.”
Analysis with atomic precision By
joining forces with Professor Wim Versées at the VIB research center
for structural biology, the scientists were able to figure out the
three-dimensional structure of Skywalker, making it possible to study
the protein in microscopic detail.
Professor Wim Versées
(VIB-Vrije Universiteit Brussel): “Looking at Skywalker in this way gave
us completely new insights into the precise function of this protein,
and therefore also the function of the human protein TBC1D24. Among
other things, we discovered that it connects with specific brain fats.
And more importantly, this connection is impaired in over 70% of
patients with a TBC1D24 mutation.”
Suppression of epileptic seizures On
the basis of this discovery, the scientists increased the concentration
of specific brain fats in fruit flies with a Skywalker mutation. What
happened? The epileptic seizures in the sick fruit flies were completely
Professor Patrik Verstreken (VIB-KU Leuven): “Our
work shows that increasing specific brain fats at the synapses of
patients with a TBC1D24 mutation is a possible strategy for preventing
epileptic seizures. And although our work focuses on people with TBC1D24
mutations, we think that our findings could be relevant to various
forms of epilepsy.”
Scientific cross-pollination Professor
Wim Versées (VIB-Vrije Universiteit Brussel): “Our two research groups
will now continue to collaborate in order to seek out strategies for
increasing the concentration of specific fats in the brain to prevent
epileptic seizures. This research stems from cross-pollination between
structural biology, biochemistry and genetics, so we will certainly
continue down this interdisciplinary route.”
Scientists Uncover Common Cell Signaling Pathway Awry in Some Types of Autism
Brain cells grow faster in children with some forms of autism due to
distinct changes in core cell signaling patterns, according to research
from the laboratory of Anthony Wynshaw-Boris, MD, PhD, chair of the
department of genetics and genome sciences at Case Western Reserve
University School of Medicine, and a member of the Case Comprehensive
Cancer Center. Rapid cell growth can cause early brain overgrowth, a
common feature in 20-30% of autistic children. But, the genetics of
autistic children vary making it difficult to pinpoint common mechanisms
underlying the disease.
“Autism is a complex disorder with multiple genetic and non-genetic
factors,” explained Wynshaw-Boris. “Because the causes are diverse, it
may help to define a subset of patients that have a common [symptom], in
this case early brain overgrowth.”
In a study published in Molecular Psychiatry,
Wynshaw-Boris and his colleagues started with skin cell samples from
autistic children with enlarged brains and worked backward. Researchers
in the laboratory “reprogrammed” donated skin cells to produce cells
found in the developing brain including induced pluripotent stem cells
and neural progenitor cells. Stem and progenitor cells are important
therapeutic tools as they have the potential to grow into a multitude of
cell types. The researchers hypothesized that even though the children
in the study had different forms of autism, the precursor cells could be
used to find common molecular and cellular mechanisms.
The researchers discovered that cells derived from autistic donors
grew faster than those from control subjects and activated their genes
in distinct patterns. Genes related to cell growth were unusually
active, leading to more cells but fewer connections between them. This
can cause faulty cell networks unable to properly transmit signals in
the brain and enlarged heads during early development.
The researchers identified abnormal genes in the cells grown from
autistic donors as belonging to the Wnt signaling pathway. The Wnt genes
are critical for cell growth and serve as central players in cell
networks, interfacing with multiple signaling pathways. Wynshaw-Boris
previously identified the Wnt pathway as related to autism in mouse
models of the disease. In a separate study published in Molecular
Psychiatry earlier this year, the Wynshaw-Boris laboratory showed mice
lacking Wnt genes display autism-like symptoms including social anxiety
and repetitive behavior. The researchers could prevent these adult
symptoms by treating the mice with medications that activate Wnt
signaling in the uterus, during development.
“The Wnt pathway is one of the core developmental pathways conserved
from invertebrates to humans. Our studies solidify previous suggestions
that this pathway has a role in autism,” said Wynshaw-Boris.
Once they identified the dysfunctional signaling pathway in their
reprogrammed autistic samples, the researchers (including the
laboratories of Alysson Muotri, PhD at the University of California San
Diego and Fred Gage, PhD at the Salk Institute) attempted to correct it
by exposing mature nerve cells derived from autistic donors to drug
compounds. One drug currently being tested in clinical trials for autism
is insulin growth factor 1 (IGF-1). When the researchers added IGF-1 to
nerve cells derived from autistic donors, neural networks were
reestablished. It is unclear whether the positive effects of IGF-1 were
on the Wnt pathway, and the exact compensatory mechanism requires
Wynshaw-Boris’s studies in cell culture and mouse models of autism
confirm improper Wnt signaling can lead to rapid brain cell growth and
brain enlargement in the embryo, resulting in abnormal social behavior
after birth. The next step will be to determine which genes are most
impacted by Wnt signaling defects during early development, and how
these changes result in abnormal behavior. “We would also like to find
other drugs or compounds that may slow down the growth of the cells in
tissue culture,” said Wynshaw-Boris. Together, these findings may help
researchers unravel common ways brain cells can become impaired during
early development in carefully chosen subsets of patients and contribute
to symptoms across the autism spectrum.
In case I get arrested today, please everyone keep posting and
sharing as much information as you can here and seriously go in person in a
group to local media and demand that they cover this, civil rights violations
are rampant, a mans hands were broken with a baton, 85 people arrested, several
sprayed with bear mace, they released tear gas, they have a sound cannon out
there just matter of time til they use it, they jam the cell and wifi signals
and caused my phone to turn off at 40% battery for awhile.
the pipeline is
90%+ completed, this is the last stand on the sacred burial ground by the camps
and under the Missouri river, energy transfer partner company wants it done by
end of the month and the police are like their mercenaries. they built a larger
holding cell so they can arrest more people, they stripsearch people in jail,
they have been known to delete photos and video off of peoples phones.
helicopters and planes fly around us and identify our faces, our livestream
videos are censored, there are infiltrators causing disruption in the camps and
informants telling them everything. the media made a blackout so if you
searched standing rock nothing showed up.
action to your local media and demand they cover this, dont they have a code of
ethics as a profession?! north dakota is breaking so many laws and they need to
be held accountable!
action to your local government, demand that your senator and congress person
treating environmental activists like terrorists, look at those photos and
video who looks like the terrorist to you?
do you want to
have freedom in this country?! then take Action! we need everyone everywhere to
take to the streets and make calls and tell everyone you know and encounter
about what is happening!
do you want
clean drinking water?! then take action Now!
and Pray for
thank you I
(from Lolly Bee at Standing Rock, North Dakota)
This is the real deal. This has been going on
for months. Mainstream media is blocking it from being shown to the masses. In
some cases, search engines are blocking out access to live footage. Some of it
seems too audacious to accept, but it’s happening. It’s happening every day to
the peaceful protesters who are fighting against the Dakota Access Pipeline.
Unfortunately, the police has been targeting journalists and photojournalists
for arrest and police brutality, so much of the footage taken has been
confiscated. (Don’t believe me, check out what happened to Deia Schlosberg and
Amy Goodman, along with countless of other journalists of smaller platforms). I
did an experimental search on “bear mace” and “standing rock” and saw
for myself that the last article about this brutality was from early September
(even though there was a live video of it occurring once more just yesterday –
and this was a Google search, people. GOOGLE.)
The unethical and
abusive behavior by the armed officials needs to be shared and exposed. Please, do your part to share and reblog this so the world will see what is happening in North Dakota.
* so Lucas gets his license before the others because he was held back so he becomes the group’s driver literally everywhere
*the car used to be pappy Jo’s so it’s old
* which Maya makes fun of 24/7 and calls his “rusty steed” but she low key likes it because ya she doesn’t know much about cars but it has a classic old feel to it that she doesn’t know why but she loves it
*One day they are driving on some back road and the car stalls and they’re in the middle of nowhere with no cell signal
* Riley is of course crying and claiming she’s going to die while Farkle is trying to calm her down which is basically him holding her until she stops
*Lucas is trying to fix the car while Smackle attempts to help (mostly flirting with him and pointing out the obvious) she’s just sitting there like “I don’t think that’s supposed to be smoking” while Lucas is stressing out because he knows nothing about cars
*Maya climbed on top of the truck trying to get signal but gives up and is just laying on it bored and saying really unhelp advice “Huckleberry try checking the thing”
*Zay is sitting in the bed of the truck playing phone games while all this goes down. Until his phone dies and he’s freaking out because he was about to beat his high score. Then the situation dawns on him and he starts sayinf unhelpful things like “wow hopefully we won’t die” and Farkle bless his soul had just calmed Riley down but this made her cry again
*Farkle gives up and just lifts Riley onto the car next to Maya who immediately starts running her hands softly through Riley’s hair and muttering calming things
*Finally some car is driving down the road and pulls over, she sees the mental state of Riley and is just like “um how can I help” she literally looks under the hood, messes with a few things then tells him to start the car and it’s working in less than 5 minutes
*Riley jumps off the truck and hugs the lady while crying how she saved their lives
Sorry if there hasn’t been a WTW post for a few weeks! I’ve been trading over WT each Wednesday, I just forgot to actually make a post before I leave the house and I usually hang out at a friend’s place after class, so I don’t have the cell signal to upload one. I know, I’m the worst. But here’s hoping that today’s WTW will make up for it! I’ve got plenty of leftovers from previous giveaways, some of which were from Tapu Giveaways. Here is the list:
Clefable | Female | Level 50
Wigglytuff | Male | Level 50
Sawsbuck | “Leah” | Female | Level 100
Granbull | “Shane” | Male | Level 100
Bidoof | “Naegi” | Male | Level 50
Jigglypuff | “Maizono” | Female | Level 50
I’ll keep trading these until I either run out or I get too tired in the middle of the night (probably close to 1 a.m. EST since I’ve got an early morning class). Remember, if you happen across one of these Pokémon from IGN Ciara, send in a picture of the shiny and my trainer in Festival Plaza! I’ll give you a free shiny as a prize!
Prolonged space travel takes a severe toll on the human body. As we seriously consider the human species becoming space-faring, a big question stands. Even if we break free from Earth’s orbit and embark on long-duration journeys among the stars, can we adapt to the extreme environments of space?
Variation in gravitational strength is another challenge for space travelers. Until we develop artificial gravity in a space ship or on another planet, we should assume that astronauts will spend time living in microgravity
On Earth, human bone and muscle custodial cells respond to the stress of gravity’s incessant tugging by renewing old cells in processes known as remodeling and regeneration. But in a microgravity environment like Mars, human bone and muscle cells won’t get these cues, resulting in osteoporosis and muscle atrophy. So, how could we provide an artificial signal for cells to counteract bone and muscle loss?
This is speculative, but biochemically engineered microbes inside our bodies could churn out bone and muscle remodeling signaling factors. Or humans could be genetically engineered to produce more of these signals in the absence of gravity.
Radiation exposure and microgravity are only two of the many challenges we will encounter in the hostile conditions of space. But if we’re ethically prepared to use them, gene editing and microbial engineering are two flexible tools that could be adapted to many scenarios. In the near future, we may decide to further develop and tune these genetic tools for the harsh realities of space living.
The people saying it’s because of evaporative cooling are wrong. Menthol’s boiling point is 212 Celsius, much warmer than your body.
Menthol isn’t really cold, it just tricks your body into thinking it is. There’s a type of nerve cell that responds to things like temperature, pressure, pH, etc. Some of these cells have what’s called a TRPM8 receptor on their surface. When menthol comes into contact with a TRPM8 receptor it binds to it, which makes the affected cell open an ion channel that admits sodium and calcium ions into the cell. This in turn causes the nerve cell to send a signal to the brain that the brain interprets as coldness. A similar receptor, TRPV1, is why the capsaicin in hot peppers feels ‘hot’.
Basically, menthol binds to a receptor on certain temperature-sensitive nerve cells, causing them to fire, and your brain interprets this nervous activity as coldness.
EDIT: Okay, evaporative cooling probably does have something to do with it, and it isn’t necessary for a substance to reach it’s boiling point to evaporate. However, I’m willing to bet that the cooling sensation is caused overwhelmingly by TRPV8 activation.