cell programming

Decluttering: What to throw away

The other side of a lost earing.
Scraps of wrapping paper.
Cards with no sentimental value
Ticket stubs
Holey socks
Old t-shirts
dried flowers
magazines
hair elastics with extreme stretchiness
shoes you don’t wear
extra photo prints
tired bras
scarves you never wear
clothes that don’t fit
gifts you don’t like
old towels, makeup, toiletries, hangers, paperwork
extra buttons
expired sauces, medication, coupons
unused chew toys for your pets
dried up nail polish
DVD’s you don’t watch
CD’s you don’t listen to
damaged, or stained clothing
old prom dresses
scratched nonstick cookware
outdated electronics
rusty jewelry
Stockings with runs
Pens that don’t work
Necklaces and bracelets with broken clasps
Cables and wires you don’t use
Worn-out sheets and bedding
Empty or near-empty bottles of cleaning products
Worn-out bath mats
Broken electronics
Purses you never use
Flatware, plates, and glasses that don’t match the rest of your collection, plus dingy children’s plates you no longer use
Old pillows
Worn-out shoes
Wedding invites
Save-the-dates
Wedding favors you don’t use
Old wallets that you don’t use
Broken kitchen equipment
Spare furniture parts you don’t need
Furniture manuals
Boxes
Unused vases
Extra tupperware you don’t need
Old mail
Junk mail
Travel brochuresOld crayons or art supplies, plus markers that have run out of ink
Random containers and jars
Unused stationery, stickers, and sticky notes
Ripped denim
Old artwork or old children’s artwork
Used and ripped envelopes
Broken or old iPhone cases
Old unused batteries
Extra and unused coffee mugs
Old spices
Address labels for your old house
Wrinkled ribbon and bows for gift wrap
Cards or gifts from exes
Frequent shopper cards you never use
Matchbooks
Old shopping bags
Old calendars
Old folders
Magnets
Clothes that are outdated or from college
Broken Christmas decorations
Christmas lights that don’t work
Frayed towels
Expired food
Computer cords, firewire cord, etc. that you don’t use
Old and outdated software
CDs for old computer programs
Old cell phones
Hand-me-downs that you’re guilt-tripped into keeping
Freebie or promotional t-shirts you never wear
Old fortune cookie fortunes
Old bank statements
Old planners
Delete email subscriptions from sites
Delete emails you don’t need
Delete unwanted music from your iTunes
Extra buttons that come with newly purchased clothes
Games that are missing pieces
Old schoolbooks you’ll never use again
Papers you have backed up on the computer
Books you’ve already read and don’t want to display
Cell phone covers you’re over
Old manuals to electronics
Cell phone accessories you don’t use anymore

anonymous asked:

Oh come on girl, please don't be spreading false information and false hope about herbs and spices being cancer cures :(

hooooooly smokes

did i say herbs and spices were cancer cures???

I said that i started making juices for a loved one that contain ginger and turmeric because they have fantastic anti-cancer properties

After seeing this person’s body and mind be slowly destroyed through 3 years of chemotherapy and radiation, please allow me to share my thoughts on additional aids in healing their body and fighting tumour growth.

“Curcumin is the yellow pigment extracted from turmeric and is one of three known curcuminoids in turmeric. Curcumin has demonstrated incredible anti-cancer benefits. In countries where people eat turmeric daily at about 100 to 200 mg (roughly 1-2 teaspoons) over long periods of time, research has shown there to be lower rates of cancer. As far as research into turmeric and cancer, over 2,000 published studies have shown curcumin combats cancers of the breast, prostate, liver, colon, lung, pancreas and more. Many of these studies have shown curcumin actually stops cancer cells from dividing. Curcumin has also been shown to trigger apoptosis, or programmed cell death, which is the body’s natural and necessary way of ridding itself from damaged cells.”

https://www.mskcc.org/cancer-care/integrative-medicine/herbs/turmeric

https://thetruthaboutcancer.com/benefits-turmeric-cancer-treatment/

http://preventcancer.aicr.org/site/News2?page=NewsArticle&id=17275&news_iv_ctrl=0&abbr=res_

Please come to me when one of your parents is dying and you decide not to look into every possible avenue to help them.

I am not spreading misinformation, I think you missed the original post that the anon is asking me about:

http://agirlnamedally.tumblr.com/post/160548800435/hey-sunflower-i-would-love-for-you-to-elaborate

Nothing Ever Changes in Storybrooke -- Belle & Henry

Anonymous said: Nothing Ever Changes in Storybrooke prompt: There are people who mock Gold’s strange family, especially an useless, absent-minded Belle. Usually Gold just ignores them and Belle doesn’t seem to care. But sometimes Henry protests.

(Previous installments here)

Henry loved Belle. He was pretty sure Uncle Gold loved her, too, but for the most part everybody else avoided her and he didn’t know why. Kids at his school made fun of her to him sometimes for forgetting a lot so maybe that was it. She did forget a lot, but everybody forgot a lot and he couldn’t figure out why nobody else noticed that. She didn’t always seem to remember how old he was or what his favorite food was or what he’d gotten for Christmas, but nobody else did, either. Sometimes it was like he was the only one moving forward. he thought Uncle Gold might know what was going on, but he didn’t talk to him about it.

Keep reading

sun-su  asked:

hi! i sent u tht ask abt my mom having cancer, n i have a (rly dumb) question. i know shes on epoch-r, and i read about that, but im just. confused about how chemo in general works? ive tried looking it up but everywhere i looked says "chemo attacks cancer cells" and doesn't explain further.

hi hi hi!!! 

that’s totally not a dumb question. i’ve always been confused too, especially since there are so many cancer treatment terms and honestly it gets really confusing sometimes (like holy cow are cancer drug names awful to pronounce?)

historically, the term “chemotherapy” used to mean just any chemical compound (aka a drug) that can be used to treat a disease, such as antibacterial chemotherapy. and then the nomenclature slowly became known as just any drug that’s used to attack and kill cancer cells. this was way before anything like “targeted therapy” or “immunotherapy” was discovered, so you can look at chemotherapy being the grandfather or umbrella term for cancer-killing agents. 

chemotherapy is also used to describe a treatment that’s given systemically–as in it goes everywhere in the body, usually through intravenous (IV) injections. therefore it’s pretty darn useful to, for example, treat cancers that have metastasized to different organs. (that’s not the exclusive use of chemo tho; patients with primary tumors that haven’t metastasized can still use chemo). this is in comparison to radiation therapy, which uses radiation to blast a very very specific area of the body where the tumor is. 

the majority of the time, chemotherapy is a group of drugs that kill cancer cells because they attack their more-or-less unique characteristic of being crazy fast cell dividers. these drugs will often go after the mitosis machinery, and cause so much chaos that the cells have no choice but to undergo apoptosis, or a type of programmed cell death. 

however, chemo can’t really tell the different between a cancer cell and a healthy normal cell; it just so happens to be more effective at killing cells that divide quickly. so that’s why chemo regimens aren’t given over a really long period of time (treatment usually only lasts days), and why patients can experience side effects such as immunosuppression and gastrointestinal issues, as the immune cells and the cells lining our intestines are also fast dividers. they’re civilian casualties, so to say :(

certain chemos tend to work better with certain cancers, which is why there are specific chemo regimens. chemos are oftentimes given as a batch rather than individually. for example, EPOCH-R is a combo of drugs that work as a team to attack different aspects of the NHL cells, and can achieve much better results than if any of them went on a solo mission. here’s a breakdown of what each drug does:

Rituximab: this is an antibody that can bind specifically to B-cells, which in NHL have gone rogue and replication-happy. B-cells have a very specific protein on their surface, CD20, and rituximab gloms on like velcro. This causes natural killer cells and macrophages to recognize the B-cells as “foreign” and attack them. It also causes the complement system to be activated by the B-cells, which also furthers destruction of the cell. The downside of rituximab is it doesn’t discriminate between cancerous B-cells and normal B-cells though. 

Etoposide: these dudes inhibit the topoisomerase, which is an enzyme that helps unwind DNA during cell replication. when DNA unwinds, the downstream strands tend to get tangled and bent (think of unwinding one of those old-school phone cords–the part of the cord you’re not straightening gets super stressed and coils in on itself). Cells don’t like that, so they tell topoisomerase to go in and form small harmless nicks in the DNA to help relax it, and then when the DNA is unwound, it seals back the nick again. That last step is pretty crucial; without that action, DNA will just be floating around in fragments and the cell can’t function and will undergo apoptosis. so by inhibiting topoisomerase, etoposide is able to kill the cell. like most chemos tho, it can’t distinguish between cancer cells and non-cancer cells, but because cancer cells replicate so much faster than normal cells, and thus rely on topoisomerase so much more frequently, etoposide should be more effective in killing the cancer cells. 

Prednisolone: i don’t think the exact mechanism of how prednisolone kills cancer cells is well known. it’s used generally in low doses to dampen the immune system during allergic reactions, but with a high dose during chemo, it specifically causes immune cells (like NHL cells) to undergo apoptosis. 

Oncovin: aka vincristine (which imo is a much prettier name). this drug binds to a protein called tubulin. tubulin is required during mitosis, or cell division, to form microtubules–think of tubulin as like the fibers of a rope. microtubules form the mitotic spindles which separates the two daughter cells during cell division, so without tubulin, the cells can’t separate, things go haywire, and the cells undergo apoptosis. again, this drug isn’t specific to cancer cells, but relies on the faster rate of cell division in cancer cells to “spare” as many normal cells as possible. 

Cyclophosphamide: this drug has a metabolite that’s formed in NHL cells that’s able to form crosslinks in the DNA, rendering it almost impossible for the cell to create RNA (and protein), or to replicate. without these functions, the cell undergoes apoptosis. 

Hydroxydaunorubicin: aka doxorubicin. this drug is able to interacalate DNA, which means it’s able to get all nice and snug inside the DNA strand, and now the cell can’t synthesize RNA or proteins, or replicate (much like the effect of crosslinking of DNA). it’s akin to getting a rock in your shoe, and the presence of the rock causes you to cease all normal function and undergo apoptosis. that’s one deadly rock. it can also prevent topoisomerase from sealing DNA nicks (much like etoposide).

I hope that was a bit helpful! i maaayyy have delved into more detail than what you were looking for, but it’s all just really fascinating stuff…and i hope it gives you something to launch off of if you’re curious to learn more (and also feel free to ask me any questions you may have!)

good luck to your mom! i’m still rooting for her <3

August 4: The artists from Mirror Cells host an evening of presentations and conversations about their work with an interdisciplinary group of scholars, performers and curators. Tickets at whitney.org

Installation view of Mirror Cells (May 13—August 21, 2016). Whitney Museum of American Art, New York. Photograph by Genevieve Hanson, N.Y.

prompt by @red-lemoncake: “Dean and Castiel are married for several years, but nonetheless Dean can’t keep himself from using bad pickup-lines and lame come-on’s all the time.”


The first time Castiel meets his future husband, Dean drops shamelessly onto the bench right across from Castiel at the diner’s table and says, with the widest smile possible, “Good morning, sunshine! May I be forward and ask what your favorite silverware is? … Because I love to spoon,” and, against all odds, Castiel finds himself charmed by the man with the beautiful eyes and poor taste in pickup-lines almost instantly. He chuckles before he can help it and Dean looks like he won some kind of amazing prize.

That’s how everything starts.

*  * 

“Hey, handsome, fancy meeting you here. Do you come here often?”

“Dean, this is our kitchen! So yes, of course I’m staying here quite often. Thank you for noticing.”

*  * 

“Hey, beautiful, I lost my underwear, can I see yours?”

“Sure. The laundry basket is in the living room. And you’re free to start folding when you’re already in the process of rummaging through it.”

*  * 

“Sexy, you are by far the hottest person on earth. Like seriously! Let me have your babies!”

“Dean, firstly, that’s anatomically impossible. And secondly, there are currently three children living in this house. I’d say that’s enough for the next one, two years, wouldn’t you agree?”

“Well …”

“Shut up and clean the dishes.”

*  *

Hey, babe, I seem to have lost my phone number. May I borrow yours?”

“Well, Dean, my cell number should be programmed in your address book since forever and we share the same landline number, so I think you’re covered.”

*  *

“So, I heard you got the hots for me, Cas! Please tell me the rumors are true!”

“I will ask around and tell you my findings. How about that? Until then you could fix the clogged toilet, it might improve my opinion of you.”

*  *

“Do you have a map? Because I keep getting lost in your eyes.”

“There is probably an app for that.”

*  *

“Are you tired? ‘Cause you’ve been running around in my mind all day.”

“Actually, I am. Thank you for pointing it out. I should lie down a bit. Are you going to take care of the kids tonight?”

“Wait, what?”

“Thank you, Dean. And don’t forget that Emma demands at least five fairy tales before bedtime. You’ll need a lot of extra time.”

Cas –”

*  *

And Castiel guesses he should have begun to be annoyed at some point, hearing those horrible pickup-lines almost every single day for years now. But instead he finds himself smiling fondly more often than not when Dean looks so damned smug everytime he comes up with something new and allegedly witty.

Moreover, Castiel knows that, although he’s joking, Dean is serious about the whole thing at the same time. He’s never been good at voicing his feelings (at least without stammering and blushing) and these phrases are helping him showing his affection toward Castiel in a verbal form.

Granted, it may be a bit unusual, but Castiel grew to love it pretty soon.

(Furthermore, it quite satisfying to see Dean’s proud grin when Castiel surprises him with a nice come-back.)

And every night, as soon as they lie in their bed, facing each other, close and intimate, and Dean puts down his easygoing attitude for the time being and whispers instead, “You’re the best thing that ever happened to me, I love you so much,” in that soft voice of his, so full of love and adoration, and kisses him gently, Castiel knows that he’s the luckiest man alive.

Apoptosis

programmed cell death that reduces potential damage from contents released from a dying cell and mitigates ill effects of such contents on the surrounding tissue.”

AKA THE SPY AU THAT NO ONE BUT @eruriku ASKED FOR. ALSO @miraculousturtle THIS IS YOUR FAULT.

The first time they meet, she’s not quite sure who’s side he’s on.

They indulge in the golden splendor of the masque, dancing a swift Argentine tango. It’s a push and a pull, and the derisive smile that curls her lips into a full blossom as red as her mask. It entices him enough to keep going.

She knows it’s foolish and very dangerous. 

But there’s something sinfully delicious about his gloved hands, searing hot as they span the skin of her lower back. It’s just barely exposed by the risque dip of her red and black gown, and he’s taken full advantage of that, subtly moving what feels like clawed? fingers against the hollow at the end of her spine.

“You’re very bold, Monsieur Chat Noir.

Keep reading

Injured bones reconstructed by gene and stem cell therapies

A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones. Which opens a whole new realm of biotechnological possibilities for application to human injuries; potentially the eradication of osteopathic disorders such s arthritis, osteoporosis and bone cancers. 

This new technology has creates something of a revolution in osteopathic medicine, by combining an engineering approach with a biological approach to advance regenerative engineering, which I believe is the future of medicine.
The principal investigator and co-senior author of the research study (Dan Gazit, PhD, DMD, co-director of the Skeletal Regeneration and Stem Cell Therapy Program in the Department of Surgery and the Cedars-Sinai Board of Governors Regenerative Medicine Institute), is the man behind the study.

Currently, more than 2 million bone grafts, frequently necessitated by severe injuries involving traffic accidents, war or tumor removal, are performed worldwide each year. Such injuries can create gaps between the edges of a fracture that are too large for the bone to bridge on its own. The grafts require implanting pieces from either the patient’s or a donor’s bone into the gap.

But unfortunately, bone grafts carry numerous disadvantages, these including: 

Need of second surgical procedure
Limited availability
Donor site pain
Procurement morbidity
Everyone is not having bone which is suitable for autograft

One significant problem is that enough healthy bone is not always available for repairs. Surgeries to remove a bone piece, typically from the pelvis, and implant it can lead to prolonged pain and expensive, lengthy hospitalizations. Further, grafts from donors may not integrate or grow properly, causing the repair to fail.

This new technique developed by the Cedars-Sinai-led team however could provide a much-needed alternative to bone grafts.

What was the experiment?
In their experiment, the investigators constructed a matrix of collagen, a protein the body uses to build bones, and implanted it in the gap between the two sides of a fractured leg bone in laboratory animals. This matrix recruited the fractured leg’s own stem cells into the gap over a period of two weeks. To initiate the bone repair process, the team delivered a bone-inducing gene directly into the stem cells, using an ultrasound pulse and microbubbles that facilitated the entry of the gene into the cells.

Eight weeks after the surgery, the bone gap was closed and the leg fracture was healed in all the laboratory animals that received the treatment. Tests showed that the bone grown in the gap was as strong as that produced by surgical bone grafts.

This study is the first to demonstrate that ultrasound-mediated gene delivery to an animal’s own stem cells can effectively be used to treat nonhealing bone fractures, and it addresses a major orthopedic unmet need and offers new possibilities for clinical translation. This is a project that demonstrates how scientists from diverse disciplines can combine forces to find solutions to today’s medical challenges and help develop treatments for the patients of tomorrow. As after all, creativity and the birth of new ideas can only be sourced from watching, listening and collaborating with others. 

The Mountain Goats - Song Catalog

“Bluejays and Cardinals”
02-75 (U)
15-1
15-2 (U)
25 (U)
8-20 On a Weapons Charge (U)
Abandoning My Father Talking Blues (U)
Absolute Lithops Effect
Acceptable Damages Sutra (U)
Adair (U)
Adultery
Against Agamemnon
Against Pollution
Age of Kings
Agemo’s Hoops (U)
Alabama Nova
Alagemo
Alibi
All Devils Here Now (U)
All Frosting (U)
All Rooms Cable A/C Free Coffee
All Up the Seething Coast
Alpha Aquae (U)
Alpha Chum Gatherer (U)
Alpha Compunction (U)
Alpha Desperation March
Alpha Double Negative: Going to Catalina
Alpha Gelida
Alpha Incipiens
Alpha Negative
Alpha Omega
Alpha Rats Nest
Alpha Sun Hat
Alpha in Tauris
Alphabetizing
Alphonse Mambo
Ambivalent Landscape Z
Amy aka Spent Gladiator 1
An Inscription at Salonae (U)
Animal Mask
Answering the Phone
Anti-Music Song
Anti-Witchcraft Song (U)
Any Available Surface (U)
Are You Cleaning Off the Stone?
Attention All Pickpockets
Autoclave
Azo Tle Nelli in Tialticpac?
Baboon
Bad Luck Triple Star (U)
Bad Priestess
Bad Waves
Badger Song
Balance
Baltimore (was: Song for Prince Edward III)
Beach House
Beat the Devil
Beautiful Gas Mask
Billy the Kid’s Dream of the Magic Shoes
Birth of Serpents
Birthday Song: This Time Has Come (U)
Black Molly
Black Pear Tree
Blood Capsules
Blood Royal
Blueberry Frost
Blues in Dallas
Born Ready (was: Know the Way)
Brandy Let’s Go (U)
Bride (U)
Bring Our Curses Homes
Brisbane Hotel Sutra
Broom People
Burned My Tongue
Butter Teeth
Calcutta (U)
California Song
Cao Dai Blowout
Carmen Cicero (U)
Casetino’s Nursery (U)
Catherine Antrim’s Kids
Chanson du Bon Chose
Cheshire County
Chilean Fire Barrel (U)
Chinese House Flowers
Chinese Rifle Song
Chino Love Song 1979
Choked Out
Cobra Tattoo
Cobscrook Bay
Coco-Yam Song
Cold Milk Bottle
Collapsing Stars
Color in Your Cheeks
Columns Pillars Steps
Commandante
Communicating Doors
Cotton
Counterfeit Florida Plates
Counting Song for Bitter Children (U)
Crane (U)
Creature Song
Crows
Cruiserweights
Cry for Judas
Cubs in Five
Cut Off Their Thumbs #1 (U)
Cutter (U)
Damn These Vampires
Dance Music
Daniel 12:8 (third)
Deianara Crush
Deserters (U)
Design Your Own Container Garden
Deuteronomy 2:10
Dilaudid
Dinu Lipatti’s Bones
Dirty Old Town
Distant Stations
Dogs of Clinic 17
Don’t Take the Dogs Away
Down Here
Down to the Ark (U)
Downtown Seoul
Dub Capsules
Duke Ellington
Dutch Orchestra Blues
Early Spring
Earth Air Water Trees
Edvard Munch (U)
Elijah
Elizabeth Barrett Browning (U)
Emerging
Ending the Alphabet (U)
Enoch 18:14
Estate Sale Sign
Ethiopians (U)
Etiquette Song (U)
Eugene Sue (U)
Evening in Stalingrad
Exit Portland Oregon (U)
Extreme South #1 (U)
Ezekiel 7 and the Permanent Efficacy of Grace
Faithless Bacchant Song
Fall of the Star High School Running Back
Family Happiness
Fault Lines
Feed This End
Fire Editorial
First Few Desperate Hours
Flashing Lights
Flight 717: Going to Denmark
Flower Song (U)
For Denise Matthews (U)
Four New Trees (U)
Fresh Berries for You
Fresh Cherries in Trinidad
From TG&Y (U)
For Charles Bronson
Foreign Object
Full Flower
Game Shows Touch Our Lives
Genesis 3:23
Genesis 19:1-2
Genesis 30:3
Get Lonely
Ghosts (U)
Going Invisible (U)
Going Through Pomona (U)
Going to Alaska
Going to Bangor
Going to Bogotá
Going to Bolivia
Going to Brazil (U)
Going to Bridlington (U)
Going to Bristol
Going to Buffalo (U)
Going to California (U)
Going to Chino
Going to Cleveland
Going to Dade County (U)
Going to Federal Prison (U)
Going to France (U)
Going to Georgia
Going to Hell (U)
Going to Hungary
Going to Jamaica
Going to Japan
Going to Kansas
Going to Kirby Sigston
Going to Lebanon
Going to Lubbock
Going to Maine
Going to Malibu
Going to Marrakesh
Going to Mars (U)
Going to Maryland
Going to Mexico
Going to Miami (U)
Going to Michigan
Going to Monaco
Going to Morocco
Going to Norwalk
Going to Palestine (U)
Going to Port Washington
Going to Queens
Going to Reykjavik
Going to San Diego (U)
Going to Santiago
Going to Scotland
Going to Some Damned English City (U)
Going to Spain
Going to Spirit Lake (U)
Going to Tennessee
Going to Utrecht
Going to Wisconsin
Gojam Province 1968
Golden Boy
Golden Jackal Song
Good Morning to All Vultures (U)
Gravedigger
Greasepaint Friday (U)
Grendel’s Mother
Hail St. Sebastian (U)
Hair Match
Half Dead
Handball
Hardpan Song
Harlem Roulette
Hast Thou Considered the Tetrapod
Hatha Haill
Have to Explode
Hebrews 11:40
Heel Turn 1 (U)
Heel Turn 2
Heights
Hello Sarah (U)
Hello There Howard
Hello, Old Rabbit (U)
Heretic Pride
High Doses #2
High Hawk Season
Historiography
History of the Church (Part 1) (U)
Home Again Garden Grove
Horseradish Road
Hotel Road
How I Left the Ministry
How to Embrace a Swamp Creature
Hye Kye (U)
I Corinthians 13: 8-10
I Hear the Planets
I John 4:16
I Know You’ve Come to Take My Toys Away
I Love You, Let’s Light Ourselves on Fire (U)
I Meant Every Word I Said in New Delhi (U)
I Samuel 15:23
I Will Grab You by the Ears
I Wonder Where Our Love Has Gone
I’m So Lonesome I Could Cry
I’ve Got the Sex (U)
Ice Blue
Ice Cream, Cobra Man
Idylls of the King
If England Where What England Seems, Then We Would Only Have Our Dreams (U)
If You See Light
In Corolia
In Memory of Satan
In the Corn Fields (U)
In the Craters of the Moon
In the Hidden Places
In the Shadow of the Western Hills
Indonesia
Infidelity
Insurance Fraud #2
International Small Arms Traffic Blues
Isaiah 45:23
Island Garden Song
It Froze Me
It’s All Here in Brownsville
Italian Guns (U)
Itzcuintil-Totzli Days
Jaipur
Jam Eater Blues
Jeff Davis County Blues
Jenny
Keeping House
Kittens in Mittens (U)
Korean Bird Paintings
Lab Rat Blues
Lakeside View Apartments Suite
Last Man on Earth
Leaving Home
Lemon
Let the Dogs Come Out (U)
Letter from a Motel (U)
Letter from Belgium
Like a Bullet (U)
Linda Blair Was Born Innocent
Lion’s Teeth
Liza Forever Minelli
Lonesome Surprise
Love Love Love
Love Cuts the Strings
Love Hymn to Aphrodite
Lovecraft in Brooklyn
Luna
Magpie
Maize Stalk Drinking Blood
Malevolent Cityscape X
Malevolent Seascape Y (was: Ambivalent Seascape Y
Malted Milk (U)
Marduk T-Shirt Men’s Room Incident
Masher
Matthew 11:14-19
Matthew 25:21
Maybe Sprout Wings
Michael Myers’ Resplendent
Midland
Milk Song (U)
Million
Minnesota
Minor Joan Crawford Vehicle (U)
Mole
Moon Over Goldsboro
Mosquito Repellent
Mountain Goats Busking Song (U)
Mountain Goats Shirt Song (U)
Move (Chicago 196X)
My Favourite Things (U)
Naming Day
Narakaloka
Neon Orange Glimmer Song
Never Quite Free
New Britain
New Chevrolet in Flames
New Math (U)
New Monster Avenue
New Star Song
New World Emerging Blues (U)
New Zion
Night Light
Night of the Mules
Nikki Oh Nikki (U)
Nine Black Poppies
No Children
No, I Can’t
Noche del Guajolote
Noctifer Birmingham
Nova Scotia
Oceanographer’s Choice
Old College Try
Omega Blaster
One Frozen River (U)
One Winter at Point Alpha Privative
Onions
Only Existing Footage
Ontario
Orange Ball of Hate
Orange Ball of Love
Orange Ball of Pain
Orange Ball of Peace
Orange Ball of Pride (U)
Orange Ball of Shame (U)
Orange Ball of War (U)
Original Air-Blue Gown
Oslo 1888 (U)
Outer Scorpion Squadron
Ox Baker Triumphant
Pale Green Things
Palmcorder Yajna (was: Sacrifice)
Papagallo
Passaic, 1975 (U)
Peacocks
Pennsylvanian Dutch Treat (U)
Philippians 3:20-21
Pigs That Ran Straightaway into the Water, Triumph Of
Pink and Blue
Pinklon (U)
Please Come Home to Hamngatan
Poltergeist (U)
Porcile
Prana Ferox
Predator Eyes
Process of Elimination
Programmed Cell Death
Proverbs 6:27
Prowl Great Cain
Psalms 40:2
Pseudothyrum Song
Pure Crystal (U)
Pure Gold
Pure Heat
Pure Honey
Pure Intentions
Pure Love
Pure Milk
Pure Money
Pure Sound
Quetzalcoatl Comes Through
Quetzalcoatl Eats Plums
Quetzalcoatl is Born
Quito
Radical Evil Song (U)
Raid on Entebbe (U)
Rain Song
Raja Vocative
Real Good Girlfriend (U)
Red Choral Diamond Spray (U)
Red River Valley (U)
Red Southern Curl (U)
Resonant Bell World
Ribdate
Riches and Wonders
Rockin’ Rockin’ Pet Store (U)
Rockin’ Rockin’ Twilight of the Gods
Roger Patterson Van
Romans 10:9
Rotten Stinking Mouthpiece
Running Away with What Freud Said
Saigon Shrunken Panorama (was: Song for Anonymity)
Sail Babylon Springs
Sail On
San Bernardino
Sarcofago Live
Satanic Messiah
Sax Rohmer #1
Scavenger Babies (U)
Scotch Grove
See America Right
Seed Song
Seeing Daylight
Send Me an Angel
Sendero Luminoso Verdadadero
Seneca’s Trick Mirror
Sept. 15 1983
Sept 19th Triple X Love! Love!
Shadow Song
Sheket (Be Quiet)
Short Song About the 10 Freeway
Short Song for Justin Bieber and His Paparazzi (U)
Shower (U)
Sign of the Crow 2 (U)
Sinaloan Milk Snake Song
Slow West Vultures
Snakeheads
Snow Crush Killing Song
Snow Owl
Snow Song
So Desperate
Soft Targets
Solomon Revisited
Some Other Way
Some Swedish Trees
Somebody Else’s Parking Lot in Sebastopol (was: Somebody Else’s Parking Lot in Santa Cruz)
Something Blue (U)
Sometimes I Still Feel the Bruise (Trembling Blue Stars)
Song for an Old Friend
Song for Black Sabbath’s Second North American Tour (U)
Song for Cleomenes
Song for Dana Plato
Song for Dennis Brown
Song for God (U)
Song for Grey Valentine (U)
Song for John Davis
Song for Lonely Giants
Song for Mark and Joel
Song for My Stepfather (U)
Song for the Julian Calendar
Song for Roger Maris (U)
Song for the Shoreline (U)
Song for Tura Satana
Sourdoire Valley Song
Source Decay
Southwestern Territory
Southwood Plantation Road
Spent Gladiator 2
Spilling Toward Alpha
Stabbed to Death Outside San Juan
Stable Boy Song
Standard Bitter Love Song #1 (U)
Standard Bitter Love Song #4
Standard Bitter Love Song #5 (U)
Standard Bitter Love Song #6 (U)
Standard Bitter Love Song #7
Standard Bitter Love Song #8
Star Dusting
Stars Around Her
Stars Fell on Alabama
Steal Smoked Fish
Store (was: Aisle)
Straight Six
Sudden Oak Death
Sun Song
Supergenesis
Sure
Surrounded
Tahitian Ambrosia Maker
Tallahassee
Tampa (U)
Tape Travel is Lonely
Teenage World
Terminal Grain
Thank You Mario But Our Princess is in Another Castle
Thanks for the Dress
That
That Hippolytine Song (U)
The Admonishing Song
The Anglo-Saxons
The Autopsy Garland
The Bad Doctor
The Ballad of Bull Ramos
The Best Ever Death Metal Band in Denton
The Big Unit (U)
The Black Ice Cream Song
The Car Song (U)
The Coroner’s Gambit
The Cow Song
The Day the Aliens Came (or: Hawaiian Feeling)
The Diaz Brothers
The Doll Song (U)
The Garden Song
The Hot Garden Stomp
The House That Dripped Blood
The Lady from Shanghai
The Last Day of Jimi Hendrix’s Life
The Last Limit of Bhakti
The Legend of Chavo Guerrero
The Mess Inside
The Monkey Song
The Moon (U)
The Moon Song (U)
The Mummy’s Hand (U)
The New Potatoes (U)
The Only Thing I Know
The Pieman
The Pig Song (U)
The Plague (U)
The Recognition Scene
The River Song
The Sign
The Water Song
The Window Song
The Young Thousands
Their Will Always Be an Ireland (U)
Then the Letting Go
They Are Stone Swallowers
There Will Be No Divorce
Third Snow Song
This Magic Moment
This Year
Thucydides II-58 (U)
Tianchi Lake
Tollund Man
Tomato in the Grass (U)
Torch Song
Toolshed
Transcendental Youth
Transjordanian Blue
Treetop Song
Tribe of the Horned Heart (U)
Trick Mirror
Tug on the Line
Tulsa Imperative (U)
Twelve Hands High (was: Fit Alpha Vi) (was: Insane Horse)
Twin Human Highway Flares
Two Thousand Seasons
Tyler Lambert’s Grave (U)
Ultraviolet
Un Rêve Plus Long Que la Nuit (was: November Love Song)
Unmasked!
Until I Am Whole
Up the Wolves
US Mill
Used to Haunt
Waco
Wait for You
Warm Lonely Grave (U)
Warm Lonely Planet
Water Song II
Waving At You
We Have Seen the Enemy
We Shall All Be Healed (U)
We Were Patriots
Weekend in Western Illinois
West Country Dream
Werewolf Gimmick
White Cedar
Who You Are
Whole Wide World
Whon (U)
Wild Palm City (AKA Within You, Without You)
Wild Sage
Wishing the House Would Crash (U)
Wizard Bus a Hat
Woke Up New
World Cylinder
Wrong!
Yam, the King of Crops
Yoga
You and Me and a High Balcony (U)
You Need a Magician in Your Life (U)
You or Your Memory
You Were Cool (U)
You’re in Maya (U)
Young Caesar 2000
Your Belgian Things
_____

High cocaine doses ‘can cause brain to eat itself’

A study of mice found that the drug can trigger out-of-control “autophagy”, a process by which cells digest themselves.

When it is properly regulated, autophagy provides a valuable cleanup service – getting rid of unwanted debris that is dissolved away by enzymes within cell “pockets”.

Dr Prasun Guha, from Johns Hopkins University School of Medicine in the US, who led the research published in the journal Proceedings of the National Academy of Sciences, said: “A cell is like a household that is constantly generating trash. Autophagy is the housekeeper that takes out the trash – it’s usually a good thing. But cocaine makes the housekeeper throw away really important things, like mitochondria, which produce energy for the cell.”

The scientists carried out postmortems that showed clear signs of autophagy-induced cell death in the brains of mice given high doses of cocaine. They also found evidence of autophagy in the brain cells of mice whose mothers received the drug while pregnant.

The scientists showed that an experimental drug called CGP3466B was able to protect mouse nerve cells from cocaine death due to autophagy. Since the drug has already been tested in clinical trials to treat Parkinson’s and motor neurone disease, it is known to be safe in humans. But much more research is needed to find out whether the drug can prevent the harmful effects of cocaine in people, said the team.

Co-author Dr Maged Harraz said: “Since cocaine works exclusively to modulate autophagy versus other cell death programs, there’s a better chance that we can develop new targeted therapeutics to suppress its toxicity.”

Image: There were clear signs of autophagy-induced cell death in the brains of mice given high doses of cocaine. Credit: OJO Images/Alamy

Source: Guardian (Press Association)

So you want to die. So you’ve been eyeing the Drano under the sink. So you’ve been looking at your arteries like highways you could cleave with airplane-wing
steak knives.
So you’ve written about six different suicide notes and none of them says goodbye without actually saying goodbye in the perfect way.
So you’ve been Googling bridges.

I’m nodding. You’re clenching your fists. I know with the pain
even the bacteria in your intestines are tornadoed asunder.
But let’s stop comparing ourselves to natural disasters when we both know
you’re nothing like one. I promise not a mention of stars or ribcages. Drop the poetic
and let’s look each other in the eyes.

Wanna hear a name you should never give a child? Caenorhabditis elegans. It’s the roundworm.
They call it C. elegans on the streets. Every single roundworm has exactly 959
cells. Of 959
cells, 131 cells self-destruct. Scientists have mapped
the fate and the lineage of each and every one. This is non-negotiable.
Every roundworm on the face of the planet has exactly 959 cells and of them
131 cells will die. That cellular ceremony is called this.
Apoptosis.

This is not a biology textbook, but according to Barbara
Conradt and Ding Xue in “Programmed cell death” (wormbook.org), “Programmed cell death is an integral component of C. elegans development. Genetic studies in C. elegans have led to the identification of more
than two dozen genes that are important for the specification of which cells should live or die, the activation of the suicide program, and the dismantling and removal of dying cells.”

I know what’s underneath your tongue, tangoing
between your teeth: “I want to, but I can’t.” “I wish I could fight.”
“I’m so tired.” “My knuckles are broken open, decades fell into them,
my throat hurts, I want to close my eyes, I am numb. I am numb. I am numb.”
I know. I know because they’ve been underneath my tongue and sometimes still are.
I know because I’ve wondered what Drano tastes like.
I know because there’s still numbness between my toes.

And I know there is no combination of words, no right spin
to your master lock, no deadbolt thrown hard enough to keep you from the fogs.
But maybe this pain is a rite. Maybe this confusion, this numbness, this evolution into a streetlamp
is non-negotiable. Maybe this
is an integral component of your development, maybe there is a specification
of which parts of you should live or die, the activation of the suicide program,
the dismantling and removal of cells that chant dumb ways to die in your ear.
Maybe this is something to toughen your molars
and sharpen your jawline.

I know that it’s piercing the flesh around your spine, dipping into the
waters in you, that you’re coming to a standstill. So uncap the Drano. Stand
on that bridge. Pick up the blade. Maybe coming facefirst to this edge will reveal
the vastness of the space behind you. Maybe this
was programmed into you. The question is. Will you stay in this nightmare til it dissolves.
Will you keep clenching your fists. Creep to the edge. Look over it.
I won’t tell you to stay because I know you can’t.
I will tell you to grope desperately in the dark for a hand, and hold it like
an extra joint when you find one, because it will stay when you can’t. And anchor
the both of you down.

This is the apoptosis: you were not programmed to die in total, so
do not pull that trigger.
Not even C. elegans destroys itself completely. There are parts of you that
need to be swallowed whole, but only 131.
959-131 means 828 parts still studding your artery walls.
You may be breaking, but not all of you. When the winds come to sweep you up,
find roots and slip your limbs beneath them. Because I tell you this. Death
wants you completely. But you are not meant to be dissolved in total.
This is not how. This is not. This is not your deathtime.
This is apoptosis, breather. So breathe. Lose air sometimes, but breathe. Breathe.

—  Apoptosis (a proposal to the suicidal) | kira tang
2

This video shows cell apoptosis, or programmed cell death as seen under a microscope. First the nucleus and cytoplasm shrink, and then DNA and the cell starts to fragment. The cell may then be eaten or taken up by a phagocytic cell. (Video)

telegraph.co.uk
Cancer cells programmed back to normal by US scientists
Scientists have turned cancerous cells back to normal by switching back on the process which stops normal cells from replicating too quickly

By Sarah Knapton, Science Editor

Cancer cells have been programmed back to normal by scientists in a breakthrough which could lead to new treatments and even reverse tumour growth.

For the first time aggressive breast, lung and bladder cancer cells have been turned back into harmless benign cells by restoring the function which prevents them from multiplying excessively and forming dangerous growths.
Scientists at the Mayo Clinic in Florida, US, said it was like applying the brakes to a speeding car.

So far it has only been tested on human cells in the lab, but the researchers are hopeful that the technique could one day be used to target tumours so that cancer could be ‘switched off’ without the need for harsh chemotherapy or surgery.

“We should be able to re-establish the brakes and restore normal cell function,” said Profesor Panos Anastasiadis, of the Department for Cancer Biology.
“Initial experiments in some aggressive types of cancer are indeed very promising.

“It represents an unexpected new biology that provides the code, the software for turning off cancer." Cells need to divide constantly to replace themselves. But in cancer the cells do not stop dividing leading to huge cell reproduction and tumour growth.

The scientists discovered that the glue which holds cells together is regulated by biological microprocessors called microRNAs. When everything is working normally the microRNAs instruct the cells to stop dividing when they have replicated sufficiently. They do this by triggering production of a protein called PLEKHA7 which breaks the cell bonds. But in cancer that process does not work.

Scientists discovered they could switch on cancer in cells by removing the microRNAs from cells and preventing them from producing the protein.

(excerpt - click the link for the complete article)

anonymous asked:

Your stories about performing HSM is wild. I kind of want more.

Ok, it’s only been nine years, but still. It’s seared into my brain. Oh lordy:

  • There were two students who I continually referred to as Sharpay and Ryan because they embodied those characters to an unholy degree, who professed their love of the movie to anyone who would listen, as well as listing their immense acting credentials and why they should be given these important lead roles. The director hated them so much he purposefully put them in the background of every scene with no lines whatsoever. It was beautiful.
  • The whole show was simultaneously broadcast on two makeshift screens on either side of the stage like we were pretending to be a legitimate concert or something.
  • During the opening scene, when all of the cliques introduce themselves to the audience, each group was instructed to find a simple dance move that would represent that group. The skater/goth crowd (including me) spent the entire number doing the dance from Thriller. That was actually really fun.
  • During the “Winter Nights” opening, Troy refers to Gabriella as a “hot snowbunny”. Vomit.
  • Our director, despite that one point to his credit, was certifiably insane and had overly grandiose visions of what sort of deep metaphors he could insert into the design of the show. During “Stick to the Status Quo”, his big idea was that all of the different cliques would enter the stage representing other movies about outcasts finding their true selves. One of the cheerleaders had to do the lift from Dirty Dancing. A bunch of guys carried one girl in on a surfboard that was somehow supposed to represent the wedding scene in Fiddler on the Roof. Some other girls waltzed in dressed like they were witches from Beauxbatons for reasons none of us could discern. A bunch of grapevining represented My Big Fat Greek Wedding. My group, the skaters/goths, were humiliatingly forced to wear penguin hats and represent Happy Feet by rhythmically waddling across the stage. 
  • Behind all of this nonsense he put a line of people wearing dark robes and elaborate judge wigs carrying nooses that I think were supposed to represent the Salem Witch Trials, which was seriously messed up considering our school was down the street from Salem and literally built on the property of someone killed during the witch trials.
  • During the music break in this song, we were instructed to form a dance circle, and various groups were given leeway to do a short dance of their choosing. Irish stepdancing broke out. Some people did the Cotton Eye Joe. Someone else did the Worm. My friends and I did the dance from the end of The Breakfast Club.
  • Sharpay gets hit with a cake at the end, not chili cheese fries. We still had to wash her shirt every single night. Zeke had baked the cake to show he had a crush on Sharpay and was instructed to trip over something to smash it on her chest. When no one could think of a plausible reason for him to trip one of the other guys simply laid down in the middle of the stage and started doing pushups for no reason so that he could be tripped over.
  • “When There Was Me And You” is written in the book to be sung with a gospel choir as backup. This was taken literally, with robes and everything. Our school was very, very white. Said choir was also instructed to simultaneous perform the song in sign language while singing, and there was a ballet dancer twirling around in the background but no one knew why.
  • We built a giant extension off the stage for various parts of the show to walk into the audience like they were in a concert. If I remember correctly, it was supposed to be heart-shaped, but didn’t extend far enough so it looked like a McDonald’s sign.
  • When Troy and Gabriella sand “Breaking Free”, they were on this platform lit by spots, but literally the entire cast was still on the stage, unlit, and we were given nothing to do except watch the performance and look rapt. At some point someone in the cast realized that they had their cell phone on them and started waving it back and forth like a lighter at a concert. The next night the whole cast started waving their phones. The audience then proceeded to take out their phones and wave them back at us. Kids too little to have cell phones waved their programs. It was actually one of the coolest moments I’ve had in theater.
Let’s play a game called: What Agent Carter season 2 should have been.

Peggy and Howard defect further from the SSR, and call up the Howlies. Peggy and Jarvis try to track down Dottie Underwood, knowing that if she is still alive she’s too competent a threat for the meat heads at the SSR to handle, while the Howlies continue trying to locate the nest of tiny assassins over in Russia. Howard sort of runs mission control for both teams with the help of a few somewhat leggy scientists of course.

That’s how the two teams piece together that the pigtailed posse of assassins and Dottie are connected. They all meet up together at Howard’s base to formulate a plan of action. There are plans and fighting and kicking ass and saving the day so on and so forth. Howard’s “base” is where S.H.I.E.L.D. originates, starting small and growing from the ground up to become what we know it to be. They have their work cut out for them, though, because a splinter cell from the program managed to go underground, allowing the Black Widow program to take true roots and become a formidable opponent.

That’s what I would have done with season 2 had I been asked, but I guess musical dream sequence about a love triangle works too….not.

Discovery links rare, childhood neurodegenerative diseases to common problem in DNA repair

St. Jude Children’s Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging. The findings appear in the current issue of the scientific journal Nature Neuroscience.

Researchers showed for the first time that an enzyme required for normal DNA functioning causes DNA damage in the developing brain. DNA is the molecule found in nearly every cell that carries the instructions needed to assemble and sustain life.

The enzyme is topoisomerase 1 (Top1). Normally, Top1 works by temporarily attaching to and forming a short-lived molecule called a Top1 cleavage complex (Top1cc). Top1ccs cause reversible breaks in one strand of the double-stranded DNA molecule. That prompts DNA to partially unwind, allowing cells to access the DNA molecule in preparation for cell division or to begin production of the proteins that do the work of cells.

Different factors, including the free radicals that are a byproduct of oxygen metabolism, result in Top1ccs becoming trapped on DNA and accumulating in cells. This study, however, is the first to link the buildup to disease. The results also broaden scientific understanding of the mechanisms that maintain brain health.

Investigators made the connection between DNA damage and accumulation of Top1cc while studying DNA repair problems in the rare neurodegenerative disorders ataxia telangiectasia (A-T) and spinocerebellar ataxia with axonal neuropathy 1(SCAN1). The diseases both involve progressive difficulty with walking and other movement. This study showed that A-T and SCAN1 also share the buildup of Top1ccs as a common mechanism of DNA damage. A-T is associated with a range of other health problems, including an increased risk of leukemia, lymphoma and other cancers.

“We are now working to understand how this newly recognized source of DNA damage might contribute to tumor development or the age-related DNA damage in the brain that is associated with neurodegenerative disorders like Alzheimer’s disease,”said co-corresponding author Peter McKinnon, Ph.D., a member of the St. Jude Department of Genetics. The co-corresponding author is Sachin Katyal, Ph.D., of the University of Manitoba Department of Pharmacology and Therapeutics and formerly of St. Jude.

A-T and SCAN1 are caused by mutations in different enzymes involved in DNA repair. Mutations in the ATM protein lead to A-T. Alterations in the Tdp1 protein cause SCAN1.

Working in nerve cells growing in the laboratory and in the nervous system of specially bred mice, researchers showed for the first time that ATM and Tdp1 work cooperatively to repair breaks in DNA. Scientists also demonstrated how the proteins accomplish the task.

The results revealed a new role for ATM in repairing single-strand DNA breaks. Until this study, ATM was linked to double-strand DNA repair. ATM was also known to work exclusively as a protein kinase. Kinases are enzymes that use chemicals called phosphate groups to regulate other proteins.

Scientists reported that when Top1ccs are trapped ATM functions as a protein kinase and alert cells to the DNA damage. But researchers found ATM also serves a more direct role by marking the trapped Top1ccs for degradation by the protein complex cells use to get rid of damaged or unnecessary proteins. ATM accomplishes that task by promoting the addition of certain proteins called ubiquitin and SUMO to the Top1cc surface.

Tdp1 then completes the DNA-repair process by severing the chemical bonds that tether Top1 to DNA.

Mice lacking either Atm or Tdp1 survived with apparently normal neurological function. But compared to normal mice, the animals missing either protein had elevated levels of Top1cc. Those levels rose sharply during periods of rapid brain development and in response to radiation, oxidation and other factors known to cause breaks in DNA.

When researchers knocked out both Atm and Tdp1, Top1cc accumulation rose substantially as did a form of programmed cell death called apoptosis. Investigators reported that apoptosis was concentrated in the developing brain and few mice survived to birth. McKinnon said the results add to evidence that the brain is particularly sensitive to DNA damage.

Researchers then used the anti-cancer drug topotecan to link elevated levels of Top1cc to the cell death and other problems seen in mice lacking Atm and Tdp1. Topotecan works by trapping Top1ccs in tumor cells, resulting in the DNA damage that triggers apoptosis. Investigators showed that the impact of Top1cc accumulation was strikingly similar whether the cause was topotecan or the loss of Atm and Tdp1.

Genetically modified zebrafish may hold the key to tissue generation

While certainly eye-grabbing, these genetically engineered technicolor zebrafish aren’t just for show. These zebrafish, whose cells have been genetically programmed to glow different colors, are now helping scientists answer questions regarding tissue regeneration and how individual cells work together to heal the skin.

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