cell cam

Mucines et métastase

Les mucines sont des protéines fortement glycosylées qui peuvent être sécrétées ou associées à la membrane. Lorsqu'elles sont ancrées dans les membranes, elles peuvent être considérées comme des cell adhesion molecules (CAM) car sont impliquées dans des interactions cellulaires faibles.

A gauche on a schématiquement des cellules épithéliales normales (jaune), qui sont donc très cohésives l'unes à l'autres pour réaliser leur fonction de barrière grâce à des molécules d'adhésion latéralement (orange), et leur pôle apical est recouvert de mucines (violet).

Lorsqu'une cellule devient cancéreuse elle change de phénotype, c'est-à-dire qu'elle va exprimer des protéines de nature différentes ou dans des proportions anormales dans notre cas. Si elle se met à exprimer des mucines ailleurs que sur le pôle apical, notamment latéralement là où on ne devrait avoir que des molécules d'adhésion, alors les interactions faibles des mucines prend le dessus sur les interactions fortes des molécules d'adhésion et donc on a une perte d'adhésion entre la cellule cancéreuse et ses voisines. La cellule a changé de phénotype, qui n'est plus épithélial mais alors dit mésenchymateux : elle se détache alors et peut se disséminer ailleurs pour former un foyer cancéreux secondaire appelé métastase, à distance du foyer primaire.

Ce changement de phénotype est appelé transition épithélio-mésenchymateuse, et fait intervenir d'autres  molécules d'adhésions. On le trouve physiologiquement en embryologie durant la gastrulation.

Ces schémas ont été faits pour mes ED du Tutorat à partir des cours que j'ai retranscrit quand j'étais en première année de médecine. Ma seule source est le professeur de l'époque, et je peux avoir mal compris certaines choses, faire des approximations fausses, etc même si je fais de mon mieux. Croiser les sources permet d'avoir des informations plus fiables. N'hésitez pas à commenter pour discuter des sujets abordés ! Schémas et explications faits entre 2015 et 2016.

Just Friends (Pt 1/5) - Erik Durm

Erik was meant to fly home last night so I took the day off to be with him. However, his flight was cancelled so I was left by myself. I plopped onto the couch with a bowl of cereal and began flipping through random programs on TV.

“Five hundred channels and there is nothing on,” I grumbled to myself, unable to find anything of even little entertainment. Hearing my phone vibrate, I tossed the remote to the side and reached for my cell.

Cam: heyyyyy, when you get home I insist that you watch this cat video I’m about to send you

Y/N: I am home! But pls keep the cat video to yourself i still have nightmares about the last one

Cam: Whaaaaaat?! The workaholic took a day off??? Dear god you’re dying aren’t you

Y/N: nooo LOL, erik was supposed to fly in last night but his flight was cancelled L

Cam: ahh that sucks sorryyyyyy. I haven’t much to do today, up for a cup of coffee?

Y/N: yes omg save me from cable reality show hell

Cam: Heyyy -__- you know how I feel about the Kardashian <3

Y/N: shut up I’ll see you in a few

I rolled my eyes at my goofball of a best friend and set my phone on the table. I changed out of pajamas and into clothes that were about as comfy but more socially acceptable to wear in public. Grabbing a jacket and my purse, I was out the door in a jiffy. Our standard coffee shop was just a short walk down the block from Erik and I’s apartment. Upon entering, I immediately saw Cam sitting at a table with two drinks, two croissants and his phone hovering above.

“You’re instagramming again, aren’t you?” I sighed.

“Don’t say it like that,” he exclaimed. “It’s an art form.” He finished his picture and slid me one of the cups.

“Are you not going to offer me a croissant?” I scoffed.

“You don’t even like them,” he retorted, mouth full.

“I was just checking to see if you remembered,” I laughed, taking a sip of my drink. “But you know who does like croissants? Erik,” I sighed pathetically. “He always gets the ones with chocolate inside and then he ends up with chocolate on his lips. It’s really adorable,” I explained.

Cam looked at me with disgust before setting down his half eaten pastry. “Well, there goes my appetite,” he mumbled. I kicked him under the table gently, but laughed.

“I just miss him,” I whined, pouting dramatically.

“Well I’m sure he misses you too,” Cam said, “but I doubt he’s sitting around moping like you are. You should do something with your free time.”

“Like what?” I questioned.

“Well, what do you want to do?” Cam asked. I hesitated momentarily, but then spoke.

“You know that really big hiking trail in the countryside? The one where when you reach the top you can see the entire city and all the lights? Erik always said he’d take me, but he’s never had the time. I really want to climb it,” I said excitedly.

Cam looked down at his watch then tossed his empty cup into the trash as he rose from his seat.

“Where are you going?” I asked confusedly.

“If you want to see the sunset, we’ll have to leave now,” he said nonchalantly. I looked at him with happy surprise.

“Come on then,” he rushed, tugging at my hand, “this is going to make such a good Instagram post.”

We returned to our respective apartments to change into suitable hiking attire and then met back up at the coffee shop. Cam agreed to drive and we set off on our adventure.

“You know what this reminds me of?” I said, turning down the radio. Cam raised his eyebrows and waited for me to continue. “When we were like 10 or 11 and we wanted to go up to that big treehouse in the woods, but—“

“but your parents forbade you so we had to sneak over in the middle of the night,” he finished, laughing as he spoke. I nodded nostalgically and sighed.

“We haven’t done something like this in a long time. Growing up sucks,” I grimaced. “Agreed,” he sighed, turning the radio back up for the remainder of the drive. With no traffic, we flew across the highway, reaching our destination in no time.

This hike itself was not near as easy, but just as fun. We made it to the top with only minor bumps and bruises. “This is unbelievable,” I gasped, placing my hands on my hips and admiring the vast scenery in front of us.

“It’s like a painting,” Cam huffed, mirroring my stance. I took a seat on a flat rock as Cam whipped out his phone and began taking shots as the sun began to set.

“This has been such an amazing day,” I said, “thanks for not letting me mope, Cam.”

“Ahh,” he shrugged, “what are best friends for?” He took a seat beside me and swung an arm around my neck.

“I can’t wait to take Erik here,” I sighed, imagining how much he would love this.

“Y/N?” Cam said softly. I turned to look at him. “You really love him, right? Like Erik is definitely the love of your life, right?”

I smiled and slowly nodded. “He’s the one, Cam. I know it, Erik is who I want to spend the rest of my life with.” Cam studied me carefully for a moment then grinned.

“I’m really happy you found him,” he admitted.

“Me too,” I laughed. “Now we just have to find you someone,” I teased. Cam looked down and blushed slightly.

“Well, there may be someone,” he whispered.

“What, who?” I questioned excitedly.

“Remember that business trip I took? I met a girl. And she’s, I don’t know, she feels different. I miss her all the time. She’s so beautiful and funny. It’s all still new, but I think there’s something there,” he mumbled shyly.

“Ya know, maybe growing up doesn’t suck that much,” I joked, at peace with the fact that the both of us had found happiness. He nodded as we got back on our feet and headed home. We didn’t get back to the city until around midnight so Cam dropped me off right in front of my apartment. I waved goodbye sleepily as I got out of the car. When I opened the door to the apartment, I was confused as the why all the lights were on.

I hardly took one step inside before Erik surprised me by popping out from the kitchen.

“Where the hell have you been?”

What’s In My Bag: Coachella Edition

You guysss, it’s finally here. My favorite weekend of the year… COACHELLA!!! I’m sooo excited. The line-up is killer (can’t wait to see Disclosure!)! I’ve spent this past week packing for Coachella (yes, a week… it gets serious over here). I get asked a lot about what I’m going to wear, but I decided to shake things up a bit and share with you what’s INSIDE my bag when I’m frolicking around the grounds of Indio. Ok, here goes….

1. Camera: This is essential! In addition to the musical performances, there is dope art at Coachella, so def bring a camera to capture the moments. Cell cams work great too, but be sure to bring a battery pack b/c you’ll def drain your phone’s battery.

2. Ban Total Refresh Cooling Body Cloths: The desert is HOT. These cloths are perfect for keeping cool and staying fresh when you are on the go.

3. Jewelry: Accessories are a must. I’ll be rocking these vintage turquoise pieces and a Vanessa Mooney coin necklace.

4. Head Pieces: I like options, so I always bring a few headbands with me. Shop Krown head pieces are my faves!

5. Wildfox Sunnies: You 1000% need a pair of sunglasses at Coachella!

6. Good Energy: I carry this rose quartz heart and these special healing oil blends with me throughout the weekend. :)

7. Jergens BB Body Perfecting Skin Cream: Since the weather is scorching in Indio, there’s a lot of skin showing at the festival. So in addition to sun block, you want to make sure your skin is hydrated and looks flawless.

8. John Frieda Frizz Ease Extra Strength 6 Effects Serum: The days are long while at Coachella, so gotta keep your frizz tamed!

9. Bioré Self-Heating One Minute Mask: After a full day of music, art, parties, and fun you’ll want to give your face a nice deep clean before bed.

10. Coin purse: This is good to keep all the important stuff in one place (ID, cash, keys, and lipgloss).

And there you have it. Eeeeek I can’t believe it’s today! See you guys in Indio. :))

PS. The pattern in the background is from my Cleobella bag!


*Brought to you by KAO USA.

5

since I didn’t get good photos of my breads and reindeer pastries, here’s the sweet stuff I made for a work exam: glutein and milk free marzipan cake filled with raspberry jam and vanille buttercream, and chocolate-ginger-lime cakes with glisée and self-made chocolate decorations!

the dragon is called smöög and he’s smaug’s little bro. :-)