Large Protein Nanocages Could Improve Drug Design and Delivery  

Using novel computational and biochemical approaches, scientists have accurately designed and built from scratch 10 large protein icosahedra – polyhedra with 20 faces – similar to viral capsids that carry viral DNA. The designed structures are made of two different engineered proteins, present in 60 copies each, which self-assemble into icosahedra. They have a wide variety of potential applications, from targeted drug delivery to the development of more effective vaccines, the researchers say.  

The findings, reported on July 22, 2016 in Science, follow a report in Nature last month by the same team describing the creation of the first designed icosahedron made of 60 copies of a single protein subunit. The current paper describes the design and construction of 10 icosahedra from two different protein subunits.

“The remarkable thing is that the computational design model is really close to the actual structure,” said HHMI Investigator David Baker of the University of Washington Institute for Protein Design, who led the study. “These are definitely the largest structures that have been created using computational design methods … so it’s a real milestone for protein design, because we can design these really complicated structures from scratch on the computer and they come out exactly right.”

Computational models of the 10 successful designs are shown via molecular surface representations (design names are shown above each model).  Each design comprises a pairwise combination of pentameric (grey), trimeric (blue), or dimeric (orange) building blocks aligned along icosahedral fivefold, threefold, and twofold symmetry axes, respectively.  All models are shown to scale relative to the 30 nanometer scale bar. Credit: Jacob Bale, UW

sum-ay-yah  asked:

Hello, I am in love with this blog which I looked at ALL THE TIME. I am not from Tunisia but ever since I was younger I've loved and wanted to visit the country. What would be the best place to go? What do I need to do to try and fit in with the local people? Thank you xxx

hellooo and thank you a lot! this made my day really ^^ mmm for the places to go, there are a lot, so i’ll suggest some: try Hammamet and cities of Nabeul for typically touristic and beach-y stuff. a lot of beautiful beaches are in there. visit mdina in Tunis to see old architecture and try Tunisian sweets and Tea in traditional cafés. Tozeur is def a must-visit city. it is in the south and it is a heavenly oasis in the desert! besides, there are a lot of historical monuments all around Tunsia for different eras: capside, carthaginian, roman, islamic…

and for what you should do to fit, i have nothing special to say. we love tourists and try to accomodate them all the time. just try to be friendly and be yourself :))

i hope you visit us and have a nice stay xxx

P.S we are name twins ;)