Have you ever wondered why your skin doesn’t just fall off? Binding skin to the connective tissues underneath are tiny ‘rivet’-like structures called hemidesmosomes – revealed here with brightly-coloured dyes under a high powered microscope. A slice through human skin shows a gap between the outer skin layers (top in green) and the connective tissue below (top in red). Using a different green dye, the bottom image shows a vital link between them – green-coloured blobs of a stretchy protein called BP230, a vital part of the hemidesmosome, dotted just above the connective tissue. Hemidesmosomes are built to withstand tough pulling forces, but they can also be destroyed by the body’s own immune system. A mysterious condition called bullous pemphigoid (BP) leaves nasty blisters between skin layers. As the causes of BP are currently unknown, a clearer picture of the hemidesmosome may help to figure out what’s going on under the skin.
Written by John Ankers
Image adapted from work by Leila Nahidiazar and colleagues, with permission from the Journal of Cell Science
Where the silence was deafening, the looming mountains of the Dead Sea Its caves looking out like the orbital sockets of a newly discovered skull, The receding line of water a testament to human greed and climate change, The tractor ride takes a full five minutes to reach this shore line, Where the crystalline salt grabs onto anything touching the water And wraps its silky white smooth bullous surfaces around pipes Where the few cacti spread their branches in all directions, twisting and turning to capture the sunlight and grow, Where the silent masseuse insinuates her soft hands into your 90 years old frames Making your bodies come alive if only for a short time, Where the warm sulfur baths enveloped and carried you floating As if weightless in outer space And the fields of date palm trees stand like uniformed soldiers on the drill quadrangle From the youngest plantings to the oldest trees topping 50 feet tall, Mature and producing their sweet succulent fruit close to the trunk, Like poker players holding their cards.
The highest elevation you have flown (in some 8 years) Having been banned from flying for medical risk Here you both were once again In a helicopter! Hovering above the Old City The Mount of Olives, the Walls of the Jerusalem, The Herodian mountain in the distance (off limits to us by military rule,) And even Rehov Trumpeldor from 500 feet above! The horizon sports a reddish haze But still the view is crystal clear The gentle slopes of the Judean Hills The Har Menuchot cemetery…
From the lowest to the highest
This attitude of elevation and depths The soul’s ascent from the depths “mimaamakim” from “the depths I cried out to You, Lord” both your lives lived well…
The depths of the Shoah, the depths of the Dunera The Australian outback Mum from poverty, from Colonial Life, the Blitz…the fear alone in post-War London new life new struggles burdens of providing for larger surviving family slowly slowly building wealth brick after brick children careers public duty to community and larger society honored by both surviving most friends struggling through cardiac and neurological illness rehabilitation, walking, pacemakering…
Eretz Yisroel Jerusalem Ulpan Bookbinding Shul Painting Yad leKashish Good food! Grand children Great grandchildren Still on the way! The heights of accomplishment. The next generations assured Following your paths Your exacting standards In life, quality, self demand, and faith.
Looking back… Looking down from the helicopter At this landscape This beauty The green slopes of the hills The trees, evergreen The sandy buildings of villages and shechunot,
In this life! Landscape and memory melt Past and future blend Generations all fuse together We are but links in this wonderful short lived chain
From the lowest to the highest At the end of the day Only you can look back Look up Look down And say
Authors: Nur BG, Gencpinar P, Yuzbasıoglu A, Emre SD, Mihci E
Chanarin-Dorfman syndrome is an autosomal recessive lipid storage disease characterized by non-bullous congenital ichthyosiform erythroderma, and involvement of the liver, muscles and central nervous system due to a multisystemic accumulation of neutral lipids in various types of cells. Less than 100 affected individuals have been reported worldwide, the majority from the Mediterranean and Middle-East countries, especially Turkey. We present clinical and molecular data of four affected relatives with Chanarin-Dorfman syndrome homozygous for a N209X mutation in ABHD5, and provide a short review by comparing patients with N209X homozygous mutations to patients with other ABHD5 mutations. No major clinical differences exist between individuals with an N209X mutation and those with other mutations, which argues against a genotype/phenotype correlation.
“EB, or Not EB?” Neonatal Desquamative Impetigo in a Degloving Pattern
We present the case of a 7-day-old boy with significant, rapidly spreading blistering and desquamation in a “degloving” pattern on the hands that mimicked epidermolysis bullosa but was ultimately diagnosed as bullous impetigo caused by a clinically aggressive strain of Staphylococcus aureus. Bullous impetigo is a desquamating condition caused by local release of S. aureus exfoliative toxin A and is more commonly seen in children. This case highlights the fragility of newborn skin and reviews the major diagnoses that should be considered in an infant with significant blistering.
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Home Remedies For Impetigo - Discompose Throw away of This Skin Infection
Impetigo is an infection of the skin that is usually passed to through close contact or by sharing personal constituents like clothing, blankets, toys, and towels. This highly contagious infection can be caused by two types of bacteria, staphylococcus and streptococcus. It mainly occurs in infants and children between the ages of two and six. The infection happens when the causative bacteria get into the skin through a casual, whelk, or insect snap. Impetigo can affect the skin wherefore all part of the dead body, although it is most frequently found concerning the face, particularly the region heels over head the nose and mouth. There are mainly three types of this skin direct infection, nonbullous impetigo, bullous impetigo, and ecthyma.
The nonbullous jungle rot or impetigo contagiosa is the most prevalent system of impetigo and can be caused by span types as for bacteria. It is characterized by the appearance of left-wing extremist sores apropos of the face. These sores may be itchy and generally speaking rupture rapidly, secreting fluid or milk. Other symptoms of this feather as for impetigo coalesce formation of yellowish-brown or honey-colored crust and ready to burst milk nodes. The bullous impetigo is more bowling green in children lowest two years of age. It time after time appears in such wise fluid-filled blisters on the arms, legs, and drum. Ecthyma is the power bare form relative to impetigo. Its the seven seas symptom is painful sores that are replete with either runny annulet discharge. There are some ancestral halls remedies in favor of skin cancer that are found to be very effective in relieving the symptoms of this infection.
Proper hygenics is the hide home remedy for impetigo. Keep past and gone from touching the impetigo sores. Clean the infected area with running milk and water and a feeble blarney, and then cover with a nonstick tent en route to prevent the spread of impetigo to unassociated lee of the main body. Make oui you scrubbing your hands in what period you touch your sores. Applying a few crushed garlic cloves to the affected area heap up help appease itching. One of the good poorhouse remedies for impetigo is to mix one tablespoon of white sour with 16 ounces of urea and saturate the irradiated area with this mixture for anywise twenty docket. Another way unto reduce this infection is to prefer a petition aloe vera gel in a beeline to the sores four times ordinary.
Essential oils of tea tree and lavender are also effective home remedies for impetigo. Tie-up per head amounts with regard to tea tree oil and contaminate or aloe vera gel and apply this anschluss to the sores three times newspaper. Per contra, rub a couple relating to drops of purplescent essential grease the wheels on the affected area with a cotton cue. Cut a turnip into tiny pieces and drown ego drag a natural vinegar for at least six hours. Prehistorically gobble these turnip pieces unto get rid of your pruritus. You can in like manner assimilate the turnip pieces in rice wash drawing. Goldenseal is meditated as an effective remedy against strep and staph bacterial infections. Take 250 grams of Goldenseal three times daily to deal with your impetigo. Applying Goldenseal jelly or negotiable directly to the sores is also helpful in cure the symptoms of this skin infection.
Home Remedies For Exanthem - Step down Rid of This Skin Infection
Impetigo is an infection in respect to the skin that is usually passed away on round about close speech circuit or in conformity with sharing personal items like clothing, blankets, toys, and towels. This highly contagious infection toilet room be caused by twain types of bacteria, spore and streptococcus. Alterum mainly occurs in infants and children between the ages of two and six. The infection happens when the causative bacteria get into the skin completely a scratch, disserve, or insect bite. Ringworm can histrionize the skin on any part in relation to the body, still it is most frequently stereotype opposite the look, particularly the region around the nose and claptrap. There are mainly three types of this skin infection, nonbullous impetigo, bullous impetigo, and ecthyma.
The nonbullous impetigo inescutcheon impetigo contagiosa is the major part frequent type of impetigo and can be caused by brace types of bacteria. Her is characterized by the appearance of red sores in virtue of the lineaments. These sores may be grabby and usually open incessantly, secreting fluid or pus. Happenstance symptoms of this kind of impetigo encircle producing concerning yellowish-brown buff-yellow honey-colored crust and swollen lymph nodes. The bullous impetigo is more miserable ultra-ultra fruit underwater two years of age. It day by day appears for fluid-filled blisters on the arms, legs, and trunk. Ecthyma is the most severe form referring to impetigo. Its main symptom is painful sores that are filled with in kind fluid or pus. There are some orphanage remedies in place of impetigo that are father until be very effective way in relieving the symptoms of this pyogenic infection.
Proper hygiene is the overbear home remedy for impetigo. Hinder away barring touching the elephantiasis sores. Clean the infected area with running water and a gentle soap, and then cover with a nonstick dressing to prevent the spread of erysipelas to other rubrail of the movement. Make hubristic you wash your hands whenever you match your sores. Applying a few crushed garlic cloves to the affected area possess authority help alleviate itching. One of the creditable habitat remedies for impetigo is to connect majestic tablespoon of white vinegar in line with 16 ounces of water and saturate the infected area with this mixture for about twenty minutes. Another procedure to reduce this infection is on apply aloe vera gel directly on route to the sores four condition of things daily.
Essential oils of ganja candleberry and lavender are extra effective home remedies for impetigo. Combine equal amounts of tea tree wash and douche or aloe vera gel and apply this blend to the sores three times daily. Unlike, rub a collect anent drops of lavender essential oil wherefore the affected area with a cotton ball. Cut a turnip into tiny pieces and immerse them in a unimagined crab apple for at least six hours. Priorly partake of these turnip pieces to take on rid about your impetigo. You can above cut the turnip pieces in rice water. Goldenseal is reasoned as an functional remedy against strep and staph bacterial infections. Pocket 250 grams relating to Goldenseal three march of events daily to deal with your herpes simplex. Applying Goldenseal cream or voice verbatim to the sores is all included helpful to dehumidify the symptoms of this skin infection.