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Skin Pins

Have you ever wondered why your skin doesn’t just fall off? Binding skin to the connective tissues underneath are tiny ‘rivet’-like structures called hemidesmosomes – revealed here with brightly-coloured dyes under a high powered microscope. A slice through human skin shows a gap between the outer skin layers (top in green) and the connective tissue below (top in red). Using a different green dye, the bottom image shows a vital link between them – green-coloured blobs of a stretchy protein called BP230, a vital part of the hemidesmosome, dotted just above the connective tissue. Hemidesmosomes are built to withstand tough pulling forces, but they can also be destroyed by the body’s own immune system. A mysterious condition called bullous pemphigoid (BP) leaves nasty blisters between skin layers. As the causes of BP are currently unknown, a clearer picture of the hemidesmosome may help to figure out what’s going on under the skin.

Written by John Ankers

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From The Lowest To The Highest

Feb 2-3 2016

We went

from

the lowest point of earth: The Dead Sea

Where the silence was deafening, the looming mountains of the Dead Sea
Its caves looking out like the orbital sockets of a newly discovered skull,
The receding line of water a testament to human greed and climate change,
The tractor ride takes a full five minutes to reach this shore line,
Where the crystalline salt grabs onto anything touching the water
And wraps its silky white smooth bullous surfaces around pipes
Where the few cacti spread their branches in all directions, twisting and turning
to capture the sunlight and grow,
Where the silent masseuse insinuates her soft hands into your 90 years old frames
Making your bodies come alive if only for a short time,
Where the warm sulfur baths enveloped and carried you floating
As if weightless in outer space
And the fields of date palm trees stand like uniformed soldiers on the drill quadrangle
From the youngest plantings to the oldest trees topping 50 feet tall,
Mature and producing their sweet succulent fruit close to the trunk,
Like poker players holding their cards.

To

The highest elevation you have flown (in some 8 years)
Having been banned from flying for medical risk
Here you both were once again
In a helicopter!
Hovering above the Old City
The Mount of Olives, the Walls of the Jerusalem,
The Herodian mountain in the distance
(off limits to us by military rule,)
And even Rehov Trumpeldor from 500 feet above!
The horizon sports a reddish haze
But still the view is crystal clear
The gentle slopes of the Judean Hills
The Har Menuchot cemetery…

From the lowest to the highest

This attitude of elevation and depths
The soul’s ascent from the depths
“mimaamakim” from “the depths I cried out to You, Lord”
both your lives lived well…

from

The depths of the Shoah, the depths of the Dunera
The Australian outback
Mum from poverty, from Colonial Life,
the Blitz…the fear
alone in post-War London
new life
new struggles
burdens of providing for larger surviving family
slowly slowly building wealth brick after brick
children
careers
public duty to community and larger society
honored by both
surviving most friends
struggling through cardiac and neurological illness
rehabilitation, walking,
pacemakering…

to

Eretz Yisroel
Jerusalem
Ulpan
Bookbinding
Shul
Painting
Yad leKashish
Good food!
Grand children
Great grandchildren
Still on the way!
The heights of accomplishment.
The next generations assured
Following your paths
Your exacting standards
In life, quality, self demand, and faith.

Looking back…
Looking down from the helicopter
At this landscape
This beauty
The green slopes of the hills
The trees, evergreen
The sandy buildings of villages and shechunot,

In this life!
Landscape and memory melt
Past and future blend
Generations all fuse together
We are but links in this wonderful short lived chain

From the lowest to the highest
At the end of the day
Only you can look back
Look up
Look down
And say

“I have lived a good life”

PubMed: Chanarin-Dorfman syndrome: Genotype-Phenotype Correlation.: Related Articles

Chanarin-Dorfman syndrome: Genotype-Phenotype Correlation.

Eur J Med Genet. 2015 Apr;58(4):238-42

Authors: Nur BG, Gencpinar P, Yuzbasıoglu A, Emre SD, Mihci E

Abstract
Chanarin-Dorfman syndrome is an autosomal recessive lipid storage disease characterized by non-bullous congenital ichthyosiform erythroderma, and involvement of the liver, muscles and central nervous system due to a multisystemic accumulation of neutral lipids in various types of cells. Less than 100 affected individuals have been reported worldwide, the majority from the Mediterranean and Middle-East countries, especially Turkey. We present clinical and molecular data of four affected relatives with Chanarin-Dorfman syndrome homozygous for a N209X mutation in ABHD5, and provide a short review by comparing patients with N209X homozygous mutations to patients with other ABHD5 mutations. No major clinical differences exist between individuals with an N209X mutation and those with other mutations, which argues against a genotype/phenotype correlation.

PMID: 25682902 [PubMed - indexed for MEDLINE] http://dlvr.it/KM9RFm

“EB, or Not EB?” Neonatal Desquamative Impetigo in a Degloving Pattern

Abstract

We present the case of a 7-day-old boy with significant, rapidly spreading blistering and desquamation in a “degloving” pattern on the hands that mimicked epidermolysis bullosa but was ultimately diagnosed as bullous impetigo caused by a clinically aggressive strain of Staphylococcus aureus. Bullous impetigo is a desquamating condition caused by local release of S. aureus exfoliative toxin A and is more commonly seen in children. This case highlights the fragility of newborn skin and reviews the major diagnoses that should be considered in an infant with significant blistering.

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via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

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Home Remedies For Impetigo - Discompose Throw away of This Skin Infection

Impetigo is an infection of the skin that is usually passed to through close contact or by sharing personal constituents like clothing, blankets, toys, and towels. This highly contagious infection can be caused by two types of bacteria, staphylococcus and streptococcus. It mainly occurs in infants and children between the ages of two and six. The infection happens when the causative bacteria get into the skin through a casual, whelk, or insect snap. Impetigo can affect the skin wherefore all part of the dead body, although it is most frequently found concerning the face, particularly the region heels over head the nose and mouth. There are mainly three types of this skin direct infection, nonbullous impetigo, bullous impetigo, and ecthyma.

The nonbullous jungle rot or impetigo contagiosa is the most prevalent system of impetigo and can be caused by span types as for bacteria. It is characterized by the appearance of left-wing extremist sores apropos of the face. These sores may be itchy and generally speaking rupture rapidly, secreting fluid or milk. Other symptoms of this feather as for impetigo coalesce formation of yellowish-brown or honey-colored crust and ready to burst milk nodes. The bullous impetigo is more bowling green in children lowest two years of age. It time after time appears in such wise fluid-filled blisters on the arms, legs, and drum. Ecthyma is the power bare form relative to impetigo. Its the seven seas symptom is painful sores that are replete with either runny annulet discharge. There are some ancestral halls remedies in favor of skin cancer that are found to be very effective in relieving the symptoms of this infection.

Proper hygenics is the hide home remedy for impetigo. Keep past and gone from touching the impetigo sores. Clean the infected area with running milk and water and a feeble blarney, and then cover with a nonstick tent en route to prevent the spread of impetigo to unassociated lee of the main body. Make oui you scrubbing your hands in what period you touch your sores. Applying a few crushed garlic cloves to the affected area heap up help appease itching. One of the good poorhouse remedies for impetigo is to mix one tablespoon of white sour with 16 ounces of urea and saturate the irradiated area with this mixture for anywise twenty docket. Another way unto reduce this infection is to prefer a petition aloe vera gel in a beeline to the sores four times ordinary.

Essential oils of tea tree and lavender are also effective home remedies for impetigo. Tie-up per head amounts with regard to tea tree oil and contaminate or aloe vera gel and apply this anschluss to the sores three times newspaper. Per contra, rub a couple relating to drops of purplescent essential grease the wheels on the affected area with a cotton cue. Cut a turnip into tiny pieces and drown ego drag a natural vinegar for at least six hours. Prehistorically gobble these turnip pieces unto get rid of your pruritus. You can in like manner assimilate the turnip pieces in rice wash drawing. Goldenseal is meditated as an effective remedy against strep and staph bacterial infections. Take 250 grams of Goldenseal three times daily to deal with your impetigo. Applying Goldenseal jelly or negotiable directly to the sores is also helpful in cure the symptoms of this skin infection.

ONCE YOU GET THIS, SHARE 5 RANDOM FACTS ABOUT YOURSELF. THEN, PASS THIS ON TO 10 OF YOUR FOLLOWERS.

Tagged by: @gasteritis !!

1. I’ve got a genetic skin disorder with a really long name that makes it sound worse than it really is (non-bullous ichtyosiform erythroderma)

2. I wasn’t allowed to do my art exam my high-school because I’m almost certain my art teacher had it out for me.

3. I have a large plush alpaca that I have yet to name but they’re large and soft and shaped like a friend

4. To this day I can’t ride a bike or tie shoelaces. I’m turning 19 in March

5. I won a singing competition in primary (or elementary I guess) and I wanted to be singer before I wanted to become an artist. I’m honestly crap at both though.

Tagging: IDK WHO TO TAG if you wanna do this go ahead

Home Remedies For Exanthem - Step down Rid of This Skin Infection

Impetigo is an infection in respect to the skin that is usually passed away on round about close speech circuit or in conformity with sharing personal items like clothing, blankets, toys, and towels. This highly contagious infection toilet room be caused by twain types of bacteria, spore and streptococcus. Alterum mainly occurs in infants and children between the ages of two and six. The infection happens when the causative bacteria get into the skin completely a scratch, disserve, or insect bite. Ringworm can histrionize the skin on any part in relation to the body, still it is most frequently stereotype opposite the look, particularly the region around the nose and claptrap. There are mainly three types of this skin infection, nonbullous impetigo, bullous impetigo, and ecthyma.

The nonbullous impetigo inescutcheon impetigo contagiosa is the major part frequent type of impetigo and can be caused by brace types of bacteria. Her is characterized by the appearance of red sores in virtue of the lineaments. These sores may be grabby and usually open incessantly, secreting fluid or pus. Happenstance symptoms of this kind of impetigo encircle producing concerning yellowish-brown buff-yellow honey-colored crust and swollen lymph nodes. The bullous impetigo is more miserable ultra-ultra fruit underwater two years of age. It day by day appears for fluid-filled blisters on the arms, legs, and trunk. Ecthyma is the most severe form referring to impetigo. Its main symptom is painful sores that are filled with in kind fluid or pus. There are some orphanage remedies in place of impetigo that are father until be very effective way in relieving the symptoms of this pyogenic infection.

Proper hygiene is the overbear home remedy for impetigo. Hinder away barring touching the elephantiasis sores. Clean the infected area with running water and a gentle soap, and then cover with a nonstick dressing to prevent the spread of erysipelas to other rubrail of the movement. Make hubristic you wash your hands whenever you match your sores. Applying a few crushed garlic cloves to the affected area possess authority help alleviate itching. One of the creditable habitat remedies for impetigo is to connect majestic tablespoon of white vinegar in line with 16 ounces of water and saturate the infected area with this mixture for about twenty minutes. Another procedure to reduce this infection is on apply aloe vera gel directly on route to the sores four condition of things daily.

Essential oils of ganja candleberry and lavender are extra effective home remedies for impetigo. Combine equal amounts of tea tree wash and douche or aloe vera gel and apply this blend to the sores three times daily. Unlike, rub a collect anent drops of lavender essential oil wherefore the affected area with a cotton ball. Cut a turnip into tiny pieces and immerse them in a unimagined crab apple for at least six hours. Priorly partake of these turnip pieces to take on rid about your impetigo. You can above cut the turnip pieces in rice water. Goldenseal is reasoned as an functional remedy against strep and staph bacterial infections. Pocket 250 grams relating to Goldenseal three march of events daily to deal with your herpes simplex. Applying Goldenseal cream or voice verbatim to the sores is all included helpful to dehumidify the symptoms of this skin infection.