brain circuit

when i see good art of gascoigne i always intend to leave lots of really nice comments in the tags because wow!!!!!! REAL good!!!! but i’m always overcome with such an intense feeling of endearment that my brain short-circuits and my tags always end up being garbled shit like:

#there’s the guy
#yea…………………
#there he.
#thanks

8

Bonus (’cause I was lazy again):

Li©king Someone Pt. 2

In which Lance is jealous - no matter how much he tries to convince himself otherwise, and Kuro effectively shuts him up. By licking him. (and claiming him as his by the way ♥)

So… this one came out a bit different than I had originally planned. xD But I still like it though. The story is kind of a sequel to “He Wears Death Like Prada” written by the wonderful @bymidnightflame . Originally, that fic was supposed to be the story for my new Kuro comic. But somehow I ended up with this instead…? I don’t really know what happened.

Anyway, here are some headcanons for Kuro’s newest adventure :)

  • Back on earth Lance as well as his siblings established the “licking-rule”, which means that if you lick something like a chocolate bar, it’s yours.
  • Kuro used that rule on Keith right after he woke up from his last run-in with the Red Paladin in his private quarters. He did it to tease Shiro and well… because he wanted to lick Keith. (based on @bymidnightflame ‘s fic)
  • Lance gets pretty upset and jealous about this - he tries to tell himself it’s because everybody wants Keith, but in reality it’s only because one special person acts like he wants to get into Keith’s pants.
  • Hunk had his suspicions concerning Kuro’s behaviour towards Keith. There was something off in his opinion and bearing witness to whatever brain short circuit caused Kuro to lick Lance’s lips, only fueled those suspicions.
  • Shortly after the licking-incident Hunk joined the secret Luro-fanclub (which at that point consisted of Shiro, Keith and Coran)… He may have shedded one or two tears of joy over the fact that they had already given Kuro and Lance a ship name.

y’all thought that Trini is the one with a helpless ‘forgets how to speak’ crush on Kimberly but it’s actually the opposite I mean look at the deleted scenes Kim’s brain literally short-circuited when Trini ripped the locker door off and her bi ass had no idea how to communicate while Trini has been nothing but cool & chill during all their interactions 

Kimberly is helplessly crushing on our suave badass yellow gay bean and I’ll fiGHT YOU ON THIS

inspired by this video (sfw, but a sex toy is being used as car repair, so take that as you will)

“Laura’s gonna flip,” Derek says in dismay, looking at the huge dent in the driver’s side door of the Camaro. Her most precious possession, the car she’d been saving up for forever, the car she waxes and washes every weekend, the car that she let Derek borrow to go to the Mathletes competition in San Francisco because Derek had a basketball game on Friday and couldn’t make the official school bus, the car that Laura made him swear his life on, is now forever ruined.

“Damn, if there ever was a good place to curse, that would have been it,” Stiles says, crossing his arms and looking far more attractive than he had the right to. “C’mon, Derek. Just say it. Fuck.”

Derek blushes, watching the word tumble out of Stiles’ pink mouth. “No, I… there’s gotta be a way to fix it. But if I call her insurance people she’s gonna know…”

“It’s totally my fault,” Stiles says. “I was the one who wanted to go to Tastee Freeze on the way back, and let some dingbat hit you in the parking lot. Actually, it’s their fault, whoever can’t drive.”

Derek shakes his head. It’s his fault. He’d been having too much fun this weekend; he’d spent practically all of it with Stiles. He’d had a crush on him forever— in fact, joined Mathletes at his request, and the whole year of practice, of spending afternoons with Stiles poring over math problems, watching Stiles lick Cheeto dust off his fingers— it’s been too much. Coupled with the fact that Stiles actually just plain forgot to catch the bus on Friday, and then caught a ride with Derek, meant hours in the car listening to him sing along to Hamilton and muddle through the rap bits, and sleeping next to him in the four-to-a-room motel Saturday night, and waking up with Stiles’ face smashed into his shoulder.

Derek had been too overwhelmed by it all, too overwhelmed by Stiles. Getting the chance to spend time with his friend this weekend had just intensified his feelings, and he knows there’s no chance that Stiles will ever feel the same, so he’s just drinking it all in, savoring these moments when he can.

It had been a terrible parking job, the Camaro was at a weird angle, that’s why the person rounding the turn had hit him. Derek sighs. He guesses it’s for the best. He’ll just have to pay Laura back. For forever.

Stiles is studying the door, eyes narrowed in concentration. “Actually, it’s not that bad. They didn’t even scratch it. It’s just a dent. With the right amount of leverage…”

“I’m sorry, do you happen to have a magical car-door fixer in your overnight bag?”

Somehow, this causes Stiles to turn bright red. “Okay. I have an idea. But you have to promise not to laugh.”

“Okay…?”

Derek watches, perplexed, as Stiles pulls his duffle bag out of the back seat, and then rummages around in it.

“Promise not to laugh,” Stiles repeats.

“I promise.” Derek is confused, but sincere.

Stiles pulls a bright blue dildo out of the bag. It’s springy, and jiggles a little with the movement. There’s a thick vein running along the side, and the base even has… balls.

Derek’s brain short circuits, an image of Stiles, naked, working himself on the girth of the toy, his mouth open, panting, as he tries to get the right angle, skin flushed pink from pleasure…

“Fuck,” Derek says.

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jimin: *comes home to a big mess in his shared appartement with jungkook where no one else lives* jungkook why did you make such a mess??
jungkook: *cutely* hyung it wasn’t me
jimin: *defeated* u right….. it must’ve been me then

yo wat if they go back to earth and when they enter earth’s orbit lance is like is there something i can call my family with cuz they probably think im dead i dont wanna shock them…and he dials their home phone number without missing a beat and his mom picks up and is like “hello?” hella confused bc there’s no caller id and lance can’t even say hello back because his brain short circuits and his throat closes up because he didn’t realize just how bad he’d wanted to hear his mom’s voice again

4

1 / 2 / 3 / 4 / 5 / 6 / 7 / 8 / 9 / 10


Lena Luthor wasn’t usually a nervous person.  She could command an audience, she could dominate the boardroom, but right now?  She was panicking.

Honestly, Lena never really thought her friendship with Kara would reach a stage where she was slowly being introduced into the group, one by one.  Maggie had been first.  She and Lena had long since discussed the whole Maggie-arresting-Lena debacle, Maggie spending the better part of ten minutes apologising before Lena could get a word in edgewise.  She and Maggie had hit it off fairly quickly, bonding over their mutual love of Italian cuisine and various scientific magazines.

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anonymous asked:

Can you write scenario where boys (RFA and V + Saeran) try to kiss for the first time MC, but someone interrupt them? I love your headcannons and scenarios <3

Thanks! Hope you like these:) We made them extra fluffy~


Zen: 

  • You guys were on your first date
  • After having a nice dinner and a good time outside, he brings you back to his place
  • He wants to set the mood, so he brings you up to the rooftop of his apartment
  • You two are leaning against the railing and the stars are glittering above you
  • You two were standing apart, but then somehow you drifted closer
  • Zen feels goosebumps when your shoulders touch
  • His fingers brush against your hand, and you turn to face him
  • His breath is carried away in the wind when you turn to face him, your eyes reflecting the moon shining above
  • You’re just so beautiful in that moment and he finds himself inching forward in anticipating
  • He barely manages to whisper your name when you two are inches apart
  • A loud creak shatters the moment and another apartment resident seemed to have the same idea with his own girlfriend
  • With the moment already ruined, Zen just offers to walk you home since it’s getting late
  • You’re near your doorstep when you push yourself onto your toes and press a kiss to his lips
  • He’s stunned for a few minutes after–even after you retreat into your home
  • When it registers, adrenaline rushes through his veins and he just can’t stop grinning for the rest of the night

Yoosung:

  • You two are studying for your upcoming test and Yoosung takes every opportunity to be close to you
  • Thankfully the library is mostly empty
  • He’s feeling shy, but at the same time, he’s trying to be a little bolder today
  • When you ask a question, he makes his move and gently slides his arm behind you
  • He answers, but doesn’t move his arm away
  • A few more questions later, and you finally look at him
  • Your eyes lock, and Yoosung could feel those butterflies in his stomach
  • He felt like a schoolboy really…giddy and on cloud nine
  • You were so close, your cheeks dusted pink
  • He leans just a little bit closer
  • But then the librarian walks by
  • He pulls away and pretends to look at his book, his face hot
  • He doesn’t want to give up, so once she leaves, he tries it again
  • Again, the librarian passes by
  • By the third try, Yoosung gives up and pulls his arm back to his side
  • But his attempts didn’t go unnoticed
  • You call his name gently and he turns to look at you
  • He flinches when you’re mere inches from his face
  • Your finger grazes under his chin, pulling him closer until your lips brush against his in a gentle, feather light kiss
  • It lasted less than three seconds, but small currents of energy shot through him
  • When you pulled away, you were blushing and he stared at you slack jawed
  • He gives you a small smile before interlacing his fingers with yours and returning his attention back to his studies

Jumin:

  • He invited you to his house for a relaxing evening
  • You had a pleasant meal and a little wine, and now you were just enjoying each other’s company in his living room
  • The conversation led to dancing and you admitted you’ve never danced before
  • He puts some soft music on and moves the furniture out of the way
  • He extends his hand to you and offers to teach you
  • He’s an excellent teacher, and you have the waltz down in no time
  • Maybe because he’s really taking the lead and your focus is more on his grey eyes that are fixated on your own
  • It’s as if time stops, and the music in the background is slowly pulling you two closer
  • After a while, the gentle steps slow to a stand still
  • His grip on your waist tightens, and his eyes trail down to your lips
  • His heart is pounding and his head feels muddled
  • For once, he doesn’t try to control himself and lets his head lean forward
  • Your foreheads touch…then your noses brush together…his eyes flutter shut…
  • Then the yelp of a woman makes you two jump three feet apart
  • One of his cleaning staff entered but quickly fled upon seeing you
  • Jumin didn’t realize it was so late…and also that he forgot to lock the door
  • He apologetically goes to lock the door
  • When he returns, there is a thick silence between you two
  • You exchange hesitant glances and mumble a few broken syllables in attempt to start a sentence
  • Finally, Jumin can’t take it anymore
  • He cups your face and captures your mouth in a searing kiss
  • For the next few moments, you are lost in a swirl of heat, then you both pull away flushed and breathless
  • After you both recover, his lips twitch upwards in a small smile before pulling you back in his arms and leading you in a dance once again


Seven: 

  • It was another RFA party, and the guest list was huge
  • It was near the end of the night, and Seven noticed you were getting a little overwhelmed with the guests bombarding you
  • He interjects himself in the conversation and somehow manages to pull you away from the crowd
  • He asks if you want to escape the place for a little, and you can’t refuse
  • You two go to the convenient store across the street and get one bowl of ramen and two cans of iced coffee
  • Not wanting to return into the building again, you two just sit on the street curb and eat and talk
  • You start to notice Seven watching which noodles you pick before intently choosing one of his own with his chopsticks
  • You’re starting to catch on to what he’s doing
  • Finally, he succeeds and he manages to find the same noodle you had put in your mouth
  • He’s on the other end, and he suggests you two play a little game: see how far you can eat from both ends without breaking the noodle
  • He thinks it’s a great idea until the distance between your face and his gets smaller and smaller
  • The noodle breaks when you’re only a few centimeters apart
  • But neither one of you can find the willpower to move apart
  • He keeps inching closer, his gaze flitting down to your lips before snapping back to your eyes again
  • The warmth of your nearness banishes any chill in the air, and when your foreheads touch, he’s sure he’s going to burst into flames
  • The invisible string pulling you closer snaps when a familiar voice breaks the silence
  • Seven is vaguely aware of Yoosung calling you two back into the building and mildly scolding you for leaving in the first place
  • Seven’s face floods with heat and he’s mentally slapping himself for trying to get close to you in such a devious way
  • You two both stand and make your way towards the building, but just before you go in, you grab his arm
  • You grasp his tie and yank him down so his lips finally meet yours
  • His brain short circuits upon contact, and all he registers is the taste of coffee on your lips
  • His entire body goes into paralysis, and he barely remembers to kiss back before you pull away
  • You mutter a thank you, your cheeks red and yours eyes darting to the ground  
  • He’s left outside in a daze for a little longer before following you back inside

Saeran:

  • It was a nice breezy day, so you two decided to take a stroll
  • You guys take a rest under a large tree in this secluded area
  • You’re feeling a bit tired, so your head ends up falling between his shoulder and chest
  • His heart starts thumping a bit harder, but he tries to stay calm as you quietly talk to him
  • The wind teases your hair onto his cheeks, carrying your distinct sweet smell to his brain
  • He’s suddenly aware of every place you’re touching him, and his senses are overloading his mind
  • Then you look up at the same moment he looks down at you
  • He bites his lips and attempts to look away, but he just can’t
  • He opens his mouth in attempts to say something, but he’s not sure what exactly to say
  • Should he confess? Should he push you away? 
  • All the while, you two are drifting closer and closer
  • Just as he resolves to just kiss you already, some kid runs over and shamelessly asks for help to retrieve his kite from the tree above them
  • At first, Saeran was a little annoyed, but he couldn’t deny the kid
  • When he gets the kite and hands it off, you turn to him and press a chaste kiss to his cheek
  • He grabs your arm before you can retreat
  • His crashes his lips against yours, somehow translating all his unspoken emotions into a single touch
  • You’re the one left a little breathless as he takes your hand and continues walking as if nothing ever happened 

V:

  • You guys went out to get ice cream together
  • You two are just sitting by this nice closed area in this park, enjoying each other’s company
  • You notice he gets a smudge of it on his bottom lip
  • When you point it out, he asks if you can wipe it off for him since his hands are full with the ice cream and his camera
  • He leans forward, but because his sight hasn’t fully recovered so his depth perception is a bit off
  • He ends up getting really close to your face, but he doesn’t realize until his nose bumps with yours
  • Blushing a bit, he pulls a little back
  • He gets shivers when your thumb brushes against his bottom lip
  • Unknowingly, he gets closer until your noses are brushing against each other again
  • You are forced apart when a dog charges in between you
  • The owner comes by a little after and apologizes before catching his pet and returning to the trail
  • There’s a little awkward silence between you and V afterwards
  • He lets out a nervous chuckle before turning to you again
  • He asks if there’s still some ice cream on his lip, and you don’t miss the teasing interlaced in his voice
  • You take the bait and claim you would check before getting super close to his face once more
  • This time, the distance between you really does close with a delicate brush of the lips
  • It’s enough to send a thrill through your limbs
  • When you two are done eating, he lay back in the grass and you gently rest your head against his arm

Check out our other headcanons~ Masterlist

Suits, volleyball, and all the headcanon in between.

[Terushima, Futakuchi, Noya, Tanaka, Ushijima and Tendou here]
[Akiteru, Kei, Kageyama and Hinata here]
[Ladies of Karasuno here]

Kuroo.

  • Black on black. No tie, open two-buttoned suit jacket that hugs his waist, the top two buttons of his shirt are undone. Tailored wingtip derbies, black and matte- polished to perfection.
    • He’s actually the one who dislikes wearing suits the most (I mean, have you seen the guy, he literally looks like he throws on whatever he has lying on his bed).
    • Oh, but if you challenge him, or if the need arises- he’s going to be the sexiest guy in the room because he sure as hell isn’t going to lose at anything.
      • Hours of research and a lot of changing rooms is not going to be for nothing. If he’s going to suffer, he’s going to do some real damage before he goes (namely to your short-circuited brain and perhaps severe blood loss via nosebleed).
    • He tried the red and black combination once, until a girl actually came up to him and asked him which host club he worked at, and he’s stuck to black from then on.
    • Those undone buttons on his shirt? Collarbones. They’re so sharp that they can slice through paper, and it makes his neck slimmer and his smirk all the sexier.
    • Everything’s been absolutely tailored at least twice, and it’s so on purpose. Can you imagine those legs- miles and miles of slim height and oh, he knows you’re staring. He’ll wink right back.
      • Now that he thinks about it, he’s never had to buy his own drink before, and thus Kuroo’s legendary alcohol tolerance was born.

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Balancing Time and Space in the Brain: A New Model Holds Promise for Predicting Brain Dynamics

For as long as scientists have been listening in on the activity of the brain, they have been trying to understand the source of its noisy, apparently random, activity. In the past 20 years, “balanced network theory” has emerged to explain this apparent randomness through a balance of excitation and inhibition in recurrently coupled networks of neurons. A team of scientists has extended the balanced model to provide deep and testable predictions linking brain circuits to brain activity.

Lead investigators at the University of Pittsburgh say the new model accurately explains experimental findings about the highly variable responses of neurons in the brains of living animals. On Oct. 31, their paper, “The spatial structure of correlated neuronal variability,” was published online by the journal Nature Neuroscience.

The new model provides a much richer understanding of how activity is coordinated between neurons in neural circuits. The model could be used in the future to discover neural “signatures” that predict brain activity associated with learning or disease, say the investigators.

“Normally, brain activity appears highly random and variable most of the time, which looks like a weird way to compute,” said Brent Doiron, associate professor of mathematics at Pitt, senior author on the paper, and a member of the University of Pittsburgh Brain Institute (UPBI). “To understand the mechanics of neural computation, you need to know how the dynamics of a neuronal network depends on the network’s architecture, and this latest research brings us significantly closer to achieving this goal.”

Earlier versions of the balanced network theory captured how the timing and frequency of inputs—excitatory and inhibitory—shaped the emergence of variability in neural behavior, but these models used shortcuts that were biologically unrealistic, according to Doiron.

“The original balanced model ignored the spatial dependence of wiring in the brain, but it has long been known that neuron pairs that are near one another have a higher likelihood of connecting than pairs that are separated by larger distances. Earlier models produced unrealistic behavior—either completely random activity that was unlike the brain or completely synchronized neural behavior, such as you would see in a deep seizure. You could produce nothing in between.”

In the context of this balance, neurons are in a constant state of tension. According to co-author Matthew Smith, assistant professor of ophthalmology at Pitt and a member of UPBI, “It’s like balancing on one foot on your toes. If there are small overcorrections, the result is big fluctuations in neural firing, or communication.”

The new model accounts for temporal and spatial characteristics of neural networks and the correlations in the activity between neurons—whether firing in one neuron is correlated with firing in another. The model is such a substantial improvement that the scientists could use it to predict the behavior of living neurons examined in the area of the brain that processes the visual world.

After developing the model, the scientists examined data from the living visual cortex and found that their model accurately predicted the behavior of neurons based on how far apart they were. The activity of nearby neuron pairs was strongly correlated. At an intermediate distance, pairs of neurons were anticorrelated (When one responded more, the other responded less.), and at greater distances still they were independent.

“This model will help us to better understand how the brain computes information because it’s a big step forward in describing how network structure determines network variability,” said Doiron. “Any serious theory of brain computation must take into account the noise in the code. A shift in neuronal variability accompanies important cognitive functions, such as attention and learning, as well as being a signature of devastating pathologies like Parkinson’s disease and epilepsy.”

While the scientists examined the visual cortex, they believe their model could be used to predict activity in other parts of the brain, such as areas that process auditory or olfactory cues, for example. And they believe that the model generalizes to the brains of all mammals. In fact, the team found that a neural signature predicted by their model appeared in the visual cortex of living mice studied by another team of investigators.

“A hallmark of the computational approach that Doiron and Smith are taking is that its goal is to infer general principles of brain function that can be broadly applied to many scenarios. Remarkably, we still don’t have things like the laws of gravity for understanding the brain, but this is an important step for providing good theories in neuroscience that will allow us to make sense of the explosion of new experimental data that can now be collected,” said Nathan Urban, associate director of UPBI.

More Your Good Intentions by @dangerouscommiesubversive because I wanted to draw their faces so bad, but then things got a little intense and I gave up. You’ll find what’s responsible for my face being stuck below the cut

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  • me, after seeing Rogue One: ok this is a great movie and there's so much to talk about!
  • also me: VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VADER VA-
Switching off the brain

Switching off specific brain regions in a laboratory animal is an important type of experiment used to better understand how the brain works. A study published in Nature Methods by Singapore-based researchers identified effective inhibitors of brain activity in the important animal model Drosophila melanogaster, the common vinegar fly. These new tools are enabling researchers to better understand the relationship between neural circuits and behaviour, expanding our knowledge of the brain.

Neurons (brain cells) process information and control behaviour by sending signals to other neurons, hormone-releasing cells and muscles. A fuller understanding of the neuronal control of behaviour would accelerate the development of therapies for neurological and psychiatric disorders.

One of the ways researchers have tried to understand the neuronal control of behaviour is with optogenetics, a technique that uses light-sensitive proteins to control neuronal activity in living tissue. In optogenetics, neurons are genetically modified to express light-sensitive ion channels (proteins that conduct electricity), such that light exposure may be used to activate or inhibit electrical activity.

“There are many useful optogenetic tools to stimulate neural activity but not as many effective inhibitors,” explained Assistant Professor Adam Claridge-Chang, who led the research at Duke-NUS Medical School (Duke-NUS) and A*STAR’s Institute of Molecular and Cell Biology (IMCB).

Being able to inhibit neural circuits provides researchers the ability to determine the importance of a particular circuit in defining behaviour. In view of that, Asst Prof Claridge-Chang with Dr Farhan Mohammad and other colleagues explored the use of anion channelrhodopsins (ACRs) from an alga species (Guillardia theta) to inhibit neural activity.

In reading the paper that first described the ACRs, Dr Mohammad realized that ACRs conducted more current compared to other tools. “They are rapidly responsive, require low light intensities for actuation, so they seemed ideal for inhibiting brain activity in fly behaviour experiments,” said Dr Mohammad, a Research Fellow in the Claridge-Chang group.

The group genetically modified flies to express ACRs, and exposed these animals to light of different colours and intensities. In one of the experiments, ACR actuation paralysed climbing flies, causing them to fall abruptly. In another, illumination of ACRs in the animals’ sweet-sensing cells resulted in flies that avoided green light, as though they were avoiding the silencing of a sweet taste. At the cellular level, light actuation of ACRs produced dramatic reductions in electrical activity.

The work done at Duke-NUS and A*STAR’s IMCB indicated that ACRs are highly effective optogenetic tools for the inhibition of behavioural circuits.

“Since they are as powerful as existing methods, but much faster and easier to use, there has been huge interest from the Drosophila research community in adopting these tools,” reported Asst Prof Claridge-Chang, from the Duke-NUS Neuroscience and Behavioural Disorders Programme. “They make testing which circuits are necessary for a particular behaviour as convenient as testing for sufficiency.”

“Understanding any system is greatly aided by being able to remove components from that system and examine the resulting behaviour,” explained Asst Prof Claridge-Chang. “The ACRs are the seventh generation of optogenetic inhibitors, but the first that robustly inhibit Drosophila neuronal activity. Although our study is just newly published, this new technique is already on its way to becoming key tool for behaviour analysis.”