Thermal paper cash register receipts account for high bisphenol A (BPA) levels in humans

Bisphenol A (BPA) is a chemical that is used in a variety of consumer products, such as water bottles, dental composites and resins used to line metal food and beverage containers, and also is used in thermal paper cash register receipts. Now, research conducted at the University of Missouri is providing the first data that BPA from thermal paper used in cash register receipts accounts for high levels of BPA in humans. Subjects studied showed a rapid increase of BPA in their blood after using a skin care product and then touching a store receipt with BPA.

“BPA first was developed by a biochemist and tested as an artificial estrogen supplement,” said Frederick vom Saal, Curators Professor of Biological Sciences in the College of Arts and Science at MU. “As an endocrine disrupting chemical, BPA has been demonstrated to alter signaling mechanisms involving estrogen and other hormones. Store and fast food receipts, airline tickets, ATM receipts and other thermal papers all use massive amounts of BPA on the surface of the paper as a print developer. The problem is, we as consumers have hand sanitizers, hand creams, soaps and sunscreens on our hands that drastically alter the absorption rate of the BPA found on these receipts.”

In the study, researchers tested human subjects who cleaned their hands with hand sanitizer and then held thermal paper receipts. As an added step, subjects who had handled the thermal paper then ate French fries with their hands. The result was that BPA was absorbed very rapidly, vom Saal said.

“Our research found that large amounts of BPA can be transferred to your hands and then to the food you hold and eat as well as be absorbed through your skin,” vom Saal said. “BPA exhibits hormone-like properties and has been proven to cause reproductive defects in fetuses, infants, children and adults as well as cancer, metabolic and immune problems in rodents. BPA from thermal papers will be absorbed into your blood rapidly; at those levels, many diseases such as diabetes and disorders such as obesity increase as well. Use of BPA or other similar chemicals that are being used to replace BPA in thermal paper pose a threat to human health.”

BPA exposure during pregnancy causes oxidative stress in child, mother

Exposure to the endocrine-disrupting chemical bisphenol A (BPA) during pregnancy can cause oxidative damage that may put the baby at risk of developing diabetes or heart disease later in life, according to a new study published in the Endocrine Society’s journal Endocrinology.

Bisphenol A is a chemical used to manufacture plastics and epoxy resins. BPA is found in a variety of consumer products, including plastic bottles, food cans and cash register receipts.

Research has shown BPA is an endocrine disruptor – a chemical that mimics, blocks or interferes with the body’s hormones. The U.S. Centers for Disease Control and Prevention have estimated that more than 96 percent of Americans have BPA in their bodies.

Oxidative stress occurs when the body is exposed to high levels of free radicals – highly reactive chemicals that have the potential to harm cells when the body processes oxygen – and the body cannot neutralize the chemicals quickly enough to correct the imbalance. Some environmental toxins such as cigarette smoke, ionizing radiation or some metals may contain large amounts of free radicals or encourage the body to produce more of them, according to the National Cancer Institute at the National Institutes of Health.

“This study provides the first evidence that BPA exposure during pregnancy can induce a specific type of oxidative stress known as nitrosative stress in both the mother and offspring,” said the senior author, Vasantha Padmanabhan, MS, PhD, of the University of Michigan in Ann Arbor, MI. “Oxidative stress is associated with insulin resistance and inflammation, which are risk factors for diabetes and other metabolic disorders as well as cardiovascular disease.”

Almudena Veiga-Lopez, Subramaniam Pennathur, Kurunthachalam Kannan, Heather B. Patisaul, Dana C. Dolinoy, Lixia Zeng, Vasantha Padmanabhan. Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty Acids: Human Association and Interspecies Animal Testing Studies. Endocrinology, 2015; en.2014-1863 DOI: 10.1210/en.2014-1863

BPA harms dental enamel in young animals, mimicking human tooth defect

A tooth enamel abnormality in children, molar incisor hypomineralization (MIH), may result from exposure to the industrial chemical bisphenol A (BPA), authors of a new study conclude after finding similar damage to the dental enamel of rats that received BPA. The study results will be presented Friday at the Endocrine Society’s 97th annual meeting in San Diego.

“Human enamel defects may be used as an early marker of exposure to BPA and similar-acting endocrine disruptors,” Babajko said.


Is BPA really that bad for you?

Asked by anonymous


BPA, or Bisphenol A, is a compound found in the polycarbonate plastics that make up many consumer products, especially food and drink containers. This prevalence has prompted widespread concern about the safety of BPA.

The National Toxicology Program surveyed scientific literature on BPA and concluded that high levels of exposure warrants concern of developmental toxicity in infants and children. However, concern for adults is thought to be negligible.

The truth is that we still do not know the full extent of BPA’s effects because its effects have not been studied until recently. Emerging studies on rodent development suggest that BPA acts through an endocrine-disrupting mechanism. This means that BPA may be able to disrupt hormonal systems in the body as they develop.

People are concerned about BPA because of the possibility that it could have dangerous long-term effects, though studies in this area have not yet been completed because the concern over BPA toxicity is relatively recent.

The risk of BPA exposure can be minimized by choosing glass containers whenever possible and avoiding canned foods. Plastics, especially Type 3 and Type 7, are especially noted for high BPA content. 

Thank you for your question, and to read more, please visit http://www.niehs.nih.gov/health/topics/agents/sya-bpa/.

Answered by Claire R., Expert Leader.

Edited by Carrie K.

BPA exposure linked to autism spectrum disorder, study reports

A newly published study is the first to report an association between bisphenol-A (BPA), a common plasticizer used in a variety of consumer food and beverage containers, with autism spectrum disorder (ASD) in children. The study, by researchers at Rowan University School of Osteopathic Medicine (RowanSOM) and Rutgers New Jersey Medical School (NJMS), shows that BPA is not metabolized well in children with ASD.

The research appears online in Autism Research.

“It has been suspected for a lot of years that BPA is involved in autism, but there was no direct evidence,” said T. Peter Stein, of RowanSOM and the study’s lead author. “We’ve shown there is a link. The metabolism of BPA is different in some children with autism than it is in otherwise healthy children.”

T. Peter Stein, Margaret D. Schluter, Robert A. Steer, Lining Guo, Xue Ming. Bisphenol A Exposure in Children With Autism Spectrum Disorders. Autism Research, 2015; DOI: 10.1002/aur.1444

Are BPA-Free Bottles Just As Bad?

You may have heard by now that bisphenol A, a chemical commonly-used to make hard plastic and is found in many water bottles, can have harmful health effects. Due to evidence suggesting BPA can impair brain and reproductive development and other reasons, the FDA banned its use in baby bottles two years ago. Since then, evidence increasingly suggests that the chemical that manufacturers have replaced it with, bisphenol S, may be just as bad.”

Learn more from popsci.

BPA Chemical Affects Brain Development in Zebrafish

Bisphenol A, a chemical known as BPA that’s commonly used in consumer products, reportedly affects brain development in young zebrafish, causing concern that it can also negatively impact human brains still developing in the womb, according to new research.

While it would seem that zebrafish and humans are drastically different, and therefore their responses to environmental stimuli are different too, in actuality about 80 percent of the genes found in people have a counterpart in zebrafish (Danio rerio). Not to mention that both organisms share similar developmental processes, so it may be that bisphenol is dangerous to us as well.

Public concern had caused manufacturers to modify their products and replace BPA with a chemical called bisphenol S (BPS), which is often labeled as “BPA-free” and presumed to be safer. However, according to a new report in the journalProceedings of the National Academy of Sciences, exposure to both BPA and BPS changed the timing of when neurons were formed in the brains of zebrafish, leading to hyperactive behavior.

“These findings are important because they support that the prenatal period is a particularly sensitive stage, and reveals previously unexplored avenues of research into how early exposure to chemicals may alter brain development,” Cassandra Kinch, a PhD student at the University of Calgary, who was involved in the research, said in a press release.

(Photo : mikhailg / Fotolia)

Here’s Why You Should Skip Your Next Receipt

Most Millennials have likely heard about the negative health effects of BPA. You may have ditched your Nalgene water bottle when you found out that the plastic contained the endocrine-disrupting chemical. If you’re particularly cautious like me, you might even buy the more costly BPA-free cans of soup at your neighborhood grocery store (when you can afford them). But what about the receipt given after purchase? Ever wonder why the paper feels slightly powdery?

The receipt coating is BPA, too. And the level of BPA on receipts is much higher than those found in the linings of canned food. Plus, the chemical isn’t “fixed” like it is in plastics, making it even easier to absorb in this format – and possibly worse.

Infographic: BPA Exposure Has Impact Three Generations Later

When scientists exposed pregnant mice to levels of bisphenol A equivalent to those considered safe in humans, three generations of female mouse offspring experienced significant reproductive problems, including declines in fertility, sexual maturity and pregnancy success, the scientists report in the journal Toxicology and Applied Pharmacology.

Read more: http://www.laboratoryequipment.com/news/2015/04/infographic-bpa-exposure-has-impact-three-generations-later

stethoscopelife-deactivated2015 asked:

Hii there :) Why is bisphenol considered carcinogenic/ how does it act?

For those who aren’t aware, bisphenol is a carbon-based compound, used to make polycarbonate plastics, often used in containers that store food or drinks.

An evaluation of the then current scientific research in 2002 found that bisphenol A (BPA) ‘is not likely to be carcinogenic in humans’. Similar reviews also concluded that research on rodents had not been sufficiently carried out in order to state whether there was a carcinogenic effect. 

However, since then, research in 2012 found that BPA can affect the mammary glands (milk producing organs) in female primates, adding to concerns that it may be a weak carcinogen in humans.

It has been suggested that any carcinogenic activity of BPA could come from its oestrogenic effects - that it could act in a similar manner to the products of the breakdown of oestrogen. Several studies support the idea that these can react with DNA to cause mutations, leading to the initiation of cancer. This proposed study from 2010 planned to attempt to gather evidence that BPA can act in this way, though it hastens to point out that even if this evidence is obtained, BPA is still, at most, very weakly carcinogenic in humans. Though this was a few years ago, I haven’t managed to find any follow up, however.

In short, the research on BPA still isn’t conclusive. Still, hope that at least partially answers your question!

FOOD CHEMICALS: BPA Quick and Dirty Fun Facts


Oh sure, you are savvy and in the loop and already know that there are now hundreds of scientific replication studies demonstrating that the chemical Bisphenol-A (aka BPA) is a powerful endocrine disruptor that can adversely affect your hormones at even low levels but…

Did you know that…?


1-The two leading manufacturers of BPA are Dow Chemical and Bayer Chemical (aspirin maker and maker of the infamous bee killing chemical imidacloprid).


2-BPA is still commonly used by U.S. food packaging manufacturers in plastic bags (think snack foods and breakfast cereal), ‘hard’ (structured) plastic food containers, and metal cans used for food and drink–all of which have been shown to allow BPA to leach into the food. (Tomato paste and tomato sauce are the worst offenders by the way, as the acidic content can cause high levels of BPA to leach into the food.)


3-BPA Sales Are Booming A research group says that global sales of the dodgy plastic ingredient will jump 50 percent over the next five years.  Wha’?  (Hint:  China is the leading user of BPA so if you’re looking to avoid it, steer clear of things marked 'Made in China’.) [READ MORE]