bisphosphonate

Fosamax Not Cause of Woman’s Bone Fractures According to Merck

Currently a Manhattan Woman, Mrs. Graves is embroiled in a civil trial against Merck, the maker of Fosamax.  Mrs. Graves has gone through five major operations, including a lengthy surgery to replace her broken jaw with bone from her left arm, all of which has been caused by the use of Fosamax, according to Timothy M. O’Brien her lawyer.

Merck is claiming that Fosamax is not the root cause of Mrs. Graves’ problems.   Merck claims that Mrs. Graves was on other prescriptions besides Fosamax, like steroids to treat rheumatoid arthritis that weakened her immune system, leading to her jaw infection and healing problems, said Paul F. Strain, the lawyer for Merck.

 The lawsuit of Mrs. Graves is one the many bellwether cases filed against Merck which represents about 1,400 people all across the United States who claim they have developed bone fracture ailments after taking Fosamax. Merck had won the court’s decision in an earlier case; but in another, a judge proposed to reduce a plaintiff’s jury award to $1.5 million from $8 million dollars, both sides plan to appeal the ruling.

 In Mrs. Graves’s case, the trial is providing a palpable backdrop for a broadening debate among many doctors and researchers who are rethinking Fosamax and similar bone medications known as oral bisphosphonates, particularly as a treatment for women who have not yet developed osteoporosis.

 Food and Drug Administration, which first approved Fosamax in the 1990s to treat and prevent osteoporosis, along with reports in medical journals linking bisphosphonates with some rare medical problems including unusual thigh fractures, has heightened criticism of the long-term use of these medications with an advisory issued just last month.  This advisory states that Bisphosphonate products producers must places warning labels on any of their products that warn their consumers about the dangers and potential side effects of the their product.   These warnings according to many like Mrs. Graves, say that it’s already too late as they have suffered atypical bone fractures.

If you have been injured from the use of Fosamax then you should know your rights.  Many Femur Fracture Lawyer will give a free consultation on your potential case, so please consult one before taking any legal action.

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Halting bone-building osteoporosis drug use cuts risk for additional atypical femur fracture in half

Halting bone-building osteoporosis drug use cuts risk for additional atypical femur fracture in half

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10 Feb 2014

SAN FRANCISCO —There is growing evidence that supports an association between atypical fractures of the femur– a rare break of the thigh bone, typically without trauma – and the use of bisphosphonates, drugs proven to enhance bone density and reduce fracture incidence caused by osteoporosis. While the risk for suffering an atypical femur fracture while taking bisphosphonates is still…

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Study Looks at Predicting Fracture Risk After Women Stop Bisphosphonate Therapy

Study Looks at Predicting Fracture Risk After Women Stop Bisphosphonate Therapy

Main Point:

Age and testing of hip bone mineral density (BDM) when postmenopausal women discontinue bisphosphonate therapy can help predict the likelihood of fractures over the next five years.

Published in:

JAMA Internal Medicine 

Author:

Douglas C. Bauer, M.D., of the University of California, San Francisco, and colleagues.

Background:

Bisphosphonates can reduce the risk of hip and spine…

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Dr. Tripathy Discusses Bisphosphonate Studies

Medical management of avascular necrosis (AVN) primarily depends on the location and severity of disease, as well as the patient’s age and general health. Treatment outcomes correlate directly with the stage of the disease. No medical treatment has proven effective in preventing or arresting the disease process. In all patients, establish a firm diagnosis and exclude other conditions such as infections (osteomyelitis) and tumors. Commonly used medical measures for AVN include the following:

Conservative measures include limited weight bearing with crutches and pain medications. This may be beneficial and is a reasonable initial course of action if the involved segment is smaller than 15% and far from the weight-bearing region.

Immobilization may be helpful in some cases (eg, AVN of the distal femur or tibia). Two uncontrolled studies have shown that bisphosphonates are helpful in delaying collapse of the femoral head and thus delaying the need for surgical intervention. [17, 18] Longer-term data are required before this process can be completely understood and an unqualified recommendation can be made.

Statin therapy to prevent corticosteroid-induced AVN may be helpful. Pritchett reported a 1% incidence of AVN in 284 patients who were on statin therapy during the entire period of corticosteroid treatment (average, 7.5 y). [19] The use of high-dose corticosteroids carries a reported 3-20% incidence of AVN.

In advanced AVN, the disease course is unaffected by activity and will eventually require surgery.
Surgical CareTotal hip arthroplasty
Most patients with advanced disease (stage III and above) require total hip arthroplasty. Total hip arthroplasty provides excellent pain relief for many years, although most young patients require repeat surgery. With high failure rates (10-50% after 5 y), patients with AVN will probably need a second total hip arthroplasty during their lifetime.
Cheung et al reported excellent long-term survival of cementless total hip arthroplasty for managing AVN of the hip. In their review of 182 total hip arthroplasties 117 of them for AVN, 19.1- year survival was 97.1% for AVN patients and 96.2% for non-AVN patient

Refrence:medscape by medicalgraph

U of I study: Before you start bone-building meds, try dietary calcium and supplements

U of I study: Before you start bone-building meds, try dietary calcium and supplements

- “Bisphosphonates, for instance, disrupt normal bone remodeling by shutting down the osteoclasts— the cells that break down old bone to make new bone. When that happens, new bone is built on top of old bone. Yes, your bone density is higher, but the bone’s not always structurally sound,” 

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Public release date: 2-May-2011
URBANA – Has a bone density scan placed you at risk for osteoporosis,…

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Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones

Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones: Hypothesis: Drug delivered to the oval window can diffuse to the apex of the human cochlea.
Background: We have previously demonstrated that zoledronate, a nitrogen-containing bisphosphonate, can arrest the sensorineural hearing loss in cochlear otosclerosis. We have also shown that, in animals, delivery of bisphosphonate into the cochlea can dramatically increase delivery efficiency. Intracochlear drug delivery has the potential to increase local concentration of drug while decreasing the risk of systemic toxicity. In the present study, a fluorescently labeled bisphosphonate compound (6-FAM-ZOL) was introduced into the human cochlea through the oval window and its distribution within the temporal bone was quantified.
Methods: In three fresh human temporal bones, we introduced 6-FAM-ZOL via the oval window. We compared these specimens to control specimens treated with artificial perilymph alone. Specimens were then processed, embedded into methyl methacrylate, and ground to the mid-modiolar axis. We quantified the fluorescence in confocal images.
Results: We found 6-FAM-ZOL to be distributed up to the apical cochlear turn. In specimens treated with 6-FAM-ZOL, we identified a strong baso-apical gradient of fluorescent signal along the lateral cochlear wall and the modiolus both in the scala vestibuli and in the scala tympani.
Conclusion: Bisphosphonate introduced via the oval window in the human cochlea can be delivered up to the apical cochlear turn. Interscalar communication is likely to play an important role in determining patterns of drug delivery in the inner ear.

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There was no improve in the likelihood of stroke or cardiovascular mortality applying the use of bisphosphonates nevertheless they did warn this could possibly be due to shorter-term stick to-up with individuals, as comply with-up was an typical of two to six years, which may perhaps not be adequate to record stroke information when “a single may have expected an increased rate of stroke in older patients with atrial fibrillation.

Ask specialist is the an additional. Urology, Neurosurgery, Plastic Surgery and Cardiothoracic surgery can also be offered for MCh (Master of Chirurgy). Students have grow to be additional conscious about their career in order that selecting correct course is necessary as it is the merely way that guarantees their great professional life. It may be d for popular goods of all. . Tags: skilled Cardiologists in Orange CountyPhysical Fitness Tactics For Accomplish An Outstanding Physical Fitness By: Alfred J. They can also add their request by mailing these education sites and fetch the moment responses. There are four significant buildings that can accommodate students. Students have grow to be additional conscious about their profession to ensure that selecting appropriate course is essential as it is the merely system that guarantees their fantastic experienced life. There was no http://www.valuemd.com/ross-university-school-medicine/30453-difference-mbbs-md.html improve in the possibility of stroke or cardiovascular mortality with all the use of bisphosphonates however they did warn this could possibly be due to shorter-term stick to-up with sufferers, as adhere to-up was an typical of two to 6 years, which may possibly not be sufficient to record stroke information when "a single could have expected an elevated price of stroke in older individuals with atrial fibrillation.. Government ENT Hospital - specializes in ENT disorders.

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Tags: shiksha , education , profession , profession possibilities , profession prospects , engineering , mba , healthcare , mbbs , study abroad , study places , foreign education , college ,. Properly, it has grow to be incredibly important for any new company to market place more than the internet.

Video: Injustice Can not Defeat Injustice. Tags: fitness life, get in shape, grow to be fitterHow Sleep Apnea Causes Cardiac Threat: An Insight By: Nicholas Hedge - If you may well be sensing that your loved one’s snoring mbbs in philippines is becoming one thing graver than simply disturbance then it is time for you personally to dig deep to the challenge. According to the researchers getting bisphosphonates intravenously "induces a release of tumor necrosis element alpha, interleukin six, and inhibition farnesyl pyrophosphate synthase inside the mevalonate pathway, leading to the accumulation of pyrophosphate,” which, when elevated in concentration, can “activate an inflammatory cascade and modify the expression of proteins that deal with intracellular calcium” and improve danger for arrhythmias.

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Hypocalcemia in Malignancy - Unexpected but Common.

Hypocalcemia in Malignancy - Unexpected but Common.

Cureus. 2015;7(12):e442

Authors: Diniotis B, Sternberg E, Shakuntala S, Chiha M, Khosla P

Abstract
One of the most common metabolic abnormalities found in patients with malignancy is hypercalcemia. Hypocalcemia is a rare occurrence and is often found to be associated with renal failure and patients taking bisphosphonate therapy for bone metastasis in this patient population. Here, we present two different case reports with hypocalcemia. A 66-year-old female with a recent diagnosis of tonsillar diffuse B-cell lymphoma admitted with complaints of generalized weakness after one cycle of R-CHOP, found to have neutropenia, a low calcium level, high PTH, and low 25-hydroxy Vitamin D levels. She was given calcium gluconate and supplemental 25-hydroxy Vitamin D. On day 2, the patient’s symptoms and counts improved. The second patient was a 64-year-old male with recurrent metastatic laryngeal carcinoma, along with a second locally advanced primary rectal adenocarcinoma, presented with severe hypocalcemia and a low PTH level. The patient was on adjuvant chemotherapy and exhibited Chvostek’s sign, along with perioral numbness, tingling, and twitching sensations, which eventually led to dysphagia. He was treated with calcium gluconate, calcitriol, and calcium carbonate. Signs and symptoms, along with lab values, improved on day 4. These cases suggest that calcium kinetics and 25-hydroxy Vitamin D levels need to be monitored in these patient populations in a routine manner.

PMID: 26858923 [PubMed]



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Long-term use of osteoporosis medication associated with increased risk of atypical fractures

Long-term use of osteoporosis medication associated with increased risk of atypical fractures

Public release date: 22-Feb-2011

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English: Structural similarity between a bisphosphonate group and a pyrophosphate molecule (Photo credit: Wikipedia)

- In the primary analysis, the researchers found that use of bisphosphonates for 5 years or longer was associated with a 2.7 times higher odds of hospitalization for subtrochanteric or femoral shaft fracture compared with transient use (less than…

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Intracochlear Drug Delivery Through the Oval Window in Fresh Cadaveric Human Temporal Bones

Hypothesis: Drug delivered to the oval window can diffuse to the apex of the human cochlea. Background: We have previously demonstrated that zoledronate, a nitrogen-containing bisphosphonate, can arrest the sensorineural hearing loss in cochlear otosclerosis. We have also shown that, in animals, delivery of bisphosphonate into the cochlea can dramatically increase delivery efficiency. Intracochlear drug delivery has the potential to increase local concentration of drug while decreasing the risk of systemic toxicity. In the present study, a fluorescently labeled bisphosphonate compound (6-FAM-ZOL) was introduced into the human cochlea through the oval window and its distribution within the temporal bone was quantified. Methods: In three fresh human temporal bones, we introduced 6-FAM-ZOL via the oval window. We compared these specimens to control specimens treated with artificial perilymph alone. Specimens were then processed, embedded into methyl methacrylate, and ground to the mid-modiolar axis. We quantified the fluorescence in confocal images. Results: We found 6-FAM-ZOL to be distributed up to the apical cochlear turn. In specimens treated with 6-FAM-ZOL, we identified a strong baso-apical gradient of fluorescent signal along the lateral cochlear wall and the modiolus both in the scala vestibuli and in the scala tympani. Conclusion: Bisphosphonate introduced via the oval window in the human cochlea can be delivered up to the apical cochlear turn. Interscalar communication is likely to play an important role in determining patterns of drug delivery in the inner ear.

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Taking a break from osteoporosis drugs can protect bones

Taking a break from osteoporosis drugs can protect bones

Public release date: 18-Nov-2010

- Researchers found that bone  density remained stable for three years in patients who took a drug holiday from bisphosphonates, a popular class of osteoporosis drugs that can cause fractures in the thigh bones and tissue decay in  the jaw bone.

- patients can relatively safely discontinue their treatment for at least three years

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MAYWOOD, Ill. — Taking time off…

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MA-27 Trial Exemestane vs.Anastrozole, Bisphosphonates, , Osteoporosis, azure trial, and Zoledronate with Dr. Ruth O'regan, MD

Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis http://www.mdlinx.com/dentistry/medical-news-article/2016/02/08/osteoporosis/6514818/ DDDENT.com International Social Dental Network

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Medication-related osteonecrosis of the jaw associated with bisphosphonates and denosumab in osteoporosis

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Oral Diseases

Vitamin D status should be monitored in all cancer patients and treated by adequate vitamin D3 supplementation.

PMID:  Med Monatsschr Pharm. 2015 Dec ;38(12):512-6. PMID: 26837159 Abstract Title:  [Vitamin D in oncology: Update 2015]. Abstract:  Vitamin D deficiency is associated with increased incidence of breast and colon cancer as well as with an unfavourable course of non-Hodgkin lymphoma. Vitamin D deficiency is common in cancer patients and is associated with poor cancer prognosis and disease progression. In breast cancer patients under polychemotherapy with anthracycline and taxane, a significant drop in 25(OH)D levels was observed. Osteo-malacia represents a new and previously unreported risk factor for the development of bisphosphonate-related osteonecrosis of the jaw. In vitamin D deficiency (until it is corrected) oral and parenteral bisphosphonates should not be used. Vitamin D status should be monitored in all cancer patients and treated by adequate vitamin D3 supplementation. This applies in particular to cancer patients with poor nutritional status, treatment with aromatase inhibitors, bisphosphonates, and CTX containing anthracycline, taxane and monoclonal antibodies as well as in cases of muscular or mucocutaneous disorders, fatigue and tumor cachexia.

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