wow! such a nice and warm weather, it feels like spring!
me, muttering under my breath:
shut the fuck up!!!!!!!!!!!!!!!!!!!! it's JANUARY it's not supposed to be this warm yet!!!!!!!!!!! global warming is HERE and our cold snowy beautiful winters are forever history!!!!!! yet we are doing NOTHING about the case!!!!!!!! and even if we did something trump is the president of united states now and he's going to FUCK everything UP because his climate decisions will affect EVERYBODY!!!ON!THIS!PLANET! this weather is not _NICE AND WARM___ WHAT THE FUCKKK it's the awaiting HELLFIRE THAT'S RADIATING HEAT UPON US SO SHUT UP
An NPR listener asked if it would be possible to power a house using a bicycle so we teamed up with physicist and writer Adam Frank to find out. Turns out it would be really difficult! Watch our full explanation here:
Warfarin (C19H16O4) is an extremely important drug; it is used as an anticoagulant, and is routinely used to prevent blood clotting and the subsequent migration of the clots to other parts of the body, which could cause severe effects such as cardiac arrest and hypoxia of tissues.
It was first discovered when a mysterious case of cattle bleeding to death after minor medical procedures occurred in the 1920s. This were traced back to mouldy fodder made from sweet clover, and upon analysis, warfarin was found to be responsible for the effects. Since then, it has been used as a useful life-saving drug worldwide.
Warfarin acts by inhibiting Vitamin K epoxide and quinone reductases, which are responsible for regenerating Vitamin K. Since Vitamin K is needed for the carboxylation and thus activation of proteins responsible for blood cells to adhere to each other, a lower amount of clotting factors is produced, and consequently blood clotting is inhibited.
Warfarin does have side effects: most commonly, due to the decrease in blood clotting, the risk of bleeding, or more severely, haemorrhaging, increases. Other possible adverse effects, such as necrosis or osteoporosis, are uncommon. However, consumption of particular foods, such as ginger and garlic, and drugs, especially antibiotics, can increase the risk of side effects by impeding the metabolism of warfarin.
Warfarin has also been used as a rat poison since 1948, although its usage has been declining due to increasing resistance to it as well as the emergence of more potent poisons.