In the amphibian world, the axolotl is the replacement-parts king.
endangered Mexican salamander serves as its own NAPA store for lost body
parts, able to fully regenerate limbs, tail, heart, spine and
eyes—making it a model of curiosity for regenerative biologists.
Most of the scientific focus to date has been on trained on the
blastema, a remarkable cluster of cells that forms at the base of an
amputated limb or damaged tissue and is the modus operandi for
regeneration. It somehow coordinates a symphony of instructions to
re-grow muscle, cartilage, bone, blood vessels, skin—all at the right
place and right time to make a good-as-new limb.
But scientists with the Morgridge Institute for Research regenerative biology team shifted attention to the axolotl’s embryonic origins for new clues to the creature’s rare skills. In work published in the summer of 2016 in the journal Developmental Biology,
researchers looked at 17 different development stages of axolotl
embryos and found a highly unusual series of bursts in changes in gene
expression, followed by stable periods, that is unique in developmental
These “waves and troughs” of genetic change appear three times: When
the genome is first activated, during formation of the early gut and
during formation of the nervous system. This pattern gives scientists
three hot targets for comparison to the existing bank of information on
mature axolotl limb regeneration.
The axolotl, a
remarkable model organism capable of complete limb and organ
regeneration. Credit: Morgridge Institute for Research
i made an adoptable species called aoxls, which are basically inspired by axolotls because they are adorable ;; anyway a few have already been adopted from my FA so i decided to make my own aoxl baby ;u;