antibiotics!!!

New antibiotic found in human nose

You may have heard about drugs disappearing into people’s noses. But at a meeting here this week and in a new paper, scientists presented the opposite: A new antibiotic that has, quite literally, emerged from the human nose. The compound is produced by one species of nose-dwelling bacterium to kill another microbe, which kills thousands of people every year.

The study is “yet another demonstration that we should look to nature for solutions to the problems nature throws at us,” says Andrew Read, an evolutionary biologist at Pennsylvania State University, University Park, who was not involved with the work.

Any new antibiotic is welcome because the world is running out of these life-saving drugs. But the researchers behind the new finding believe that studying the microbial warfare going on inside our bodies may lead to not just one, but a whole slew of novel drugs. “We’ve found a new concept of finding antibiotics,” Andreas Peschel, a bacteriologist at the University of Tübingen in Germany, said on Tuesday at the EuroScience Open Forum, a biennial science and policy meeting. “We have preliminiary evidence at least in the nose that there is a rich source of many others, and I’m sure that we will find new drugs there.”

anonymous asked:

How do you deal with people claiming that hard science is inherently superior to everything else?

The “vaccines and antibiotics have done more for humanity than all of physics combined” argument is usually my go to (see that one xkcd I’m too lazy to look up and link)

Also I like telling them that I handle antibiotic resistant E. coli on a daily basis and am therefore more hardcore than they could ever hope to be (they never know that lab E. coli is basically harmless so)

Honestly usually I just ignore them because they’re probably not the type of people I even want to waste time arguing with so

nature.com
The nose knows how to kill MRSA
Bacteria from the human body produce an antibiotic that seems to kill resistant bacteria.

A new antibiotic was right under our noses — or rather, in them. Produced by a bacterium living in the human nose, the molecule kills the potentially deadly methicillin-resistant Staphylococcus aureus (MRSA) in mice and rats.

Staphylococcus aureus resides in the noses of 1 in 3 people without causing a problem. MRSA — an S. aureus strain resistant to many antibiotics — is found in 2 in 100. In a small percentage of cases, the bacterium escapes to the bloodstream, causing infection. MRSA kills 11,000 people annually in the United States alone.

Big, big news: they’ve isolated a new antibiotic molecule which operates via a different mechanism than most of the ones we have that are rapidly losing effectiveness. The CDC estimates 23,000 Americans die every year from antibiotic-resistant bacterial infections, and a RAND/KPMG study a couple years ago estimated 10 million worldwide could die from these infections by 2050. That’s more per year than cancer.

I often despair at humanity, but we deserve a shout-out when we do amazing things.  

This Week
  • 1 dental bridge removal
  • 1 root canal
  • 1 oral thrush diagnosis*
  • 3 Xanax
  • 28 antibiotics
  • 3 antifungal pills
  • 1 blood test
  • 2 bottles of antifungal rinse
  • 1 day-long leadership retreat
  • 1 hiring committee to chair
  • 1 flight (tomorrow night)
  • 1 shattering creator interview
  • 1 shattered fandom

*who even gets this? Me, that’s who. Me.

Might be inactive tonight.

Y'all know how good my family’s luck is so as of right now, my mom is in the hospital with a really bad leg infection. They think it might be a bad flare up from her lymphoma but they’re not sure so they’re doing ultrasounds, X-rays and pumping her full of antibiotics. She’s staying over night so we’ll probably leave to go home later. Depending on what time I get back, I’ll try to get something out for you guys tonight. 💕

anonymous asked:

prompt attached to your recent prompt: george gets ben home from the hospital later and is a cuddly schmoop of clinginess.

“Careful.”

“I’m being careful, George,” Ben huffs, swatting another invasive, helpful hand away as he makes his way slowly towards the couch.

George had said he’d done it up for him, so he wouldn’t have to walk far for anything. So he wouldn’t toss and turn in his sleep and (as George was worried) tear his stitches.

Pillows piled high and blankets and already the table pulled over so Ben can have easy access to his antibiotics and painkillers and water and whatever else George insisted on Gilbert getting when he sent him to restock the kitchen.

Ben stands, shifting his weight and George nudges him towards the couch.

“You first,” Ben says, shifting closer.

It doesn’t take much convincing for George to lie back on the couch, one leg off and one stretched out. And Ben settles between them perfectly, his back to George’s chest. Arms tentative around him.

Giving his side a wide berth.

He feels George’s face press against the side of his neck slightly damp, but warm.

He squeezes his hand, softly, under his own, “M fine, George. Promise.”

There is a good reason why Russia has firmly said no to GMO.

  by jimstone.is

“And the reason is that once the food is GMO, it will do whatever the genetic programmer wants to the people who eat it.  And that is too much to trust anyone with in this day and age.  The article to the left is an old one.  There are many such articles, but many of them cannot be found thanks to Google, and an agenda.

They have experimented with getting corn to naturally grow antibiotics, and many other medications, including prozac and other antidepressants and mind control drugs.  Corn is not the only one, bananas were also used in early experiments for vaccinating people, as have many other food crops.

So if you think you are going to be able to avoid developing autism or some other vaccine related disorder just because you avoided getting shots, think again, they are working overtime to make the very food you need to survive your worst possible enemy.  No wonder why they banned GMO labeling in the U.S., Do you think there might be an agenda?.”

AUDREYBIDWELL SAID: OH NO! SENDING ALL THE BEST WISHES TO YOU GUYS, HOPE SHE’S ALRIGHT!


Thank you so much. Her blood work and xrays were normal; so the vet thinks she was getting an infection. After 1 night of nausea medicine and a new antibiotic, she got up this morning and is starting to return to her normal self. 

Gonorrhea May Soon Be Resistant to all Antibiotics

Gonorrhea may soon become untreatable.

The Centers for Disease Control and Prevention reported Thursday that the wily Neisseria gonorrhoeae bacteria may be developing resistance to the only two antibiotics left that can cure the sexually transmitted disease.

The drugs, azithromycin and ceftriaxone, are used in combination to treat gonorrhea, a strategy experts hope will prolong the period during which these critical drugs will work.

But a nationwide surveillance program showed rises in the percentage of gonorrhea samples that were resistant to one or the other drug in 2014. In the case of azithromycin, there was a fourfold rise in the portion of samples that were resistant.

The rates are still modest: the percentage of samples resistant to azithromycin rose from 0.6 percent to 2.5 percent, and for ceftriaxone it doubled, from 0.4 percent to 0.8 percent. But these are red flags for scientists tracking gonorrhea’s march through the antibiotic armamentarium.

Mouse study finds link between gut bacteria and neurogenesis

Antibiotics strong enough to kill off gut bacteria can also stop the growth of new brain cells in the hippocampus, a section of the brain associated with memory, reports a study in mice published May 19 in Cell Reports. Researchers also uncovered a clue to why– a type of white blood cell seems to act as a communicator between the brain, the immune system, and the gut.

“We found prolonged antibiotic treatment might impact brain function,” says senior author Susanne Asu Wolf of the Max-Delbrueck-Center for Molecular Medicine in Berlin, Germany. “But probiotics and exercise can balance brain plasticity and should be considered as a real treatment option.”

Wolf first saw clues that the immune system could influence the health and growth of brain cells through research into T cells nearly 10 years ago. But there were few studies that found a link from the brain to the immune system and back to the gut.

In the new study, the researchers gave a group of mice enough antibiotics for them to become nearly free of intestinal microbes. Compared to untreated mice, the mice who lost their healthy gut bacteria performed worse in memory tests and showed a loss of neurogenesis (new brain cells) in a section of their hippocampus that typically produces new brain cells throughout an individual’s lifetime. At the same time that the mice experienced memory and neurogenesis loss, the research team detected a lower level of white blood cells (specifically monocytes) marked with Ly6Chi in the brain, blood, and bone marrow. So researchers tested whether it was indeed the Ly6Chi monocytes behind the changes in neurogenesis and memory.

In another experiment, the research team compared untreated mice to mice that had healthy gut bacteria levels but low levels of Ly6Chi either due to genetics or due to treatment with antibodies that target Ly6Chi cells. In both cases, mice with low Ly6Chi levels showed the same memory and neurogenesis deficits as mice in the other experiment who had lost gut bacteria. Furthermore, if the researchers replaced the Ly6Chi levels in mice treated with antibiotics, then memory and neurogenesis improved.

“For us it was impressive to find these Ly6Chi cells that travel from the periphery to the brain, and if there’s something wrong in the microbiome, Ly6Chi acts as a communicating cell,” says Wolf.

Luckily, the adverse side effects of the antibiotics could be reversed. Mice who received probiotics or who exercised on a wheel after receiving antibiotics regained memory and neurogenesis. “The magnitude of the action of probiotics on Ly6Chi cells, neurogenesis, and cognition impressed me,” she says.

But one result in the experiment raised more questions about the gut’s bacteria and the link between Ly6Chi and the brain. While probiotics helped the mice regain memory, fecal transplants to restore a healthy gut bacteria did not have an effect.

“It was surprising that the normal fecal transplant recovered the broad gut bacteria, but did not recover neurogenesis,” says Wolf. “This might be a hint towards direct effects of antibiotics on neurogenesis without using the detour through the gut. To decipher this we might treat germ free mice without gut flora with antibiotics and see what is different.”

In the future, researchers also hope to see more clinical trials investigating whether probiotic treatments will improve symptoms in patients with neurodegenerative and psychiatric disorders.“We could measure the outcome in mood, psychiatric symptoms, microbiome composition and immune cell function before and after probiotic treatment,” says Wolf.

npr.org
'Nose-y' Bacteria Could Yield A New Way To Fight Infection
The search for lifesaving antibiotics is on. Scientists have turned up one promising candidate in an unlikely place — the human nose.

With antibiotic-resistant super bugs on the rise, researchers are on an urgent hunt for other bacteria that might yield chemicals we can harness as powerful drugs. Scientists once found most of these helpful bacteria in soil, but in recent decades this go-to search location hasn’t delivered.

Now, researchers at the University of Tübingen in Germany say that to find at least one promising candidate, we need look no further than our own noses.

The scientists report Wednesday in the journal Nature that a species of bacteria inside the human nose produces a substance capable of killing a range of bacteria, including the strain of drug-resistant Staphylococcus aureus known as MRSA.

The Tübingen team is delighted with their find. “It was totally unexpected,” says study author Andreas Peschel.

Continue Reading.

Dan’s Live show 7/26/16
  • The poor bean is still sick
  • he has nothing against painting his nails bless
  • the antibiotics are going to his head
  • he legit invented rap
  • favorite kids book is Winnie The Pooh 
  • phil can’t wink 
  • sickness is now his branding 
  • fabby dabby ding dong 
  • he promises to record the day Phil gets his wisdom teeth removed
  • We’re his beautiful nuggets 
  • he bought a onesie
  • phil wearing all black omfg 
  • dan’s joining twenty one pilots  
  • he uses final cut pro 
  • gaming videos coming up
  • he expects us to move on from DJ Howell 
gofundme.com
Click here to support Rex Needs Some Help! by Quail Engstrom
Meet Rex, a 7 month old fancy pigeon who could use some help with her vet bills. Rex is my emotional support animal; I had been struggling with anxiety, depression and panic disorder for over four years before this bird came into my life. Since then she has helped improve my health and life as a...

The campaign is up, everyone! Please spread the word, it’ll mean so much <3

On 7/11/16 Rex’s cloaca prolapsed due to an egg not forming properly and getting stuck, the next day she was rushed to the vet’s and, for seven hours, had to stay there in the ICU to see if the egg would pass on its own. When it didn’t the vets had to use local anesthesia to work it out themselves. That afternoon she was able to come home with some antibiotics and anti inflammatory medication to help her recover. It was a traumatic experience for both of us, but she was a good sport and continued to try and stay cheerful throughout the ordeal!

Now Rex is doing better, but her struggle isn’t over. Rex is a chronic egg layer, meaning that she lays more eggs than she should, which is detrimental to her health. She also has an irregular brooding pattern, meaning that she lays not only more eggs than as healthy, but without much break between each clutch. Most pigeons who lay infertile eggs will set for 20 days or so before giving up, however Rex wil only sit for a little over 7 days before pushing them out of her nest and starting again after a week or two! This means that she isn’t able to regain the nutrients that she is supposed to during the 20 day period, she is depriving herself of the calcium and vitamins she needs to keep herself healthy.

The vet has reccomended that Rex be spayed. This is where we need your help.

Spaying is much more complicated on birds than mammals, they’re so small that it is a very specialized surgery that can be risky. Luckily Cornell has done a great job of refining the procedure and it can be done fairly safety on birds much smaller than this little dove, it does have a pretty hefty price tag however. The surgery will cost $600 not including the hospital stay, any complications, exams, medications, the consultation, on average all the expenses combined can get up to $1200. Rex’s family is on a pretty tight budget and she could really use your help!

Thank you <3

sciencedaily.com
Antibiotics weaken Alzheimer's disease progression through changes in the gut microbiome: Long-term antibiotic treatment in mice decreases levels of disease-causing plaques and enhances neuroinflammatory activity of microglial cells -- ScienceDaily

Long-term treatment with broad spectrum antibiotics decreased levels of amyloid plaques, a hallmark of Alzheimer’s disease, and activated inflammatory microglial cells in the brains of mice in a new study by neuroscientists.