Mutants and Masterminds: Yes you can do the thing.
GURPS: Fill out these forms in triplicate.
Dungeons & Dragons 3rd Edition: Yes, but it’s really not worth it unless you are a Dream Elf with the Godblooded feat and at least five levels in the Thingomancer Prestige class from Complete Thing. Or you could just play a Wizard, they get The Thing as a 3rd level spell.
Call of Cthulu: You can do the thing, but you REALLY don’t want to.
FATE: That depends, can you bullshit the GM into believing that one of your vaguely-worded aspects supports you doing The thing?
7th Sea: Only if the thing is properly dramatic!
Shadowrun: Yes, but you’ll need a bathtub full of D6s.
Paranoia: The thing is treason.
Dungeons & Dragons 5th Edition:
[I copied the above from this brilliant post, and I reblogged as text because I really felt the need to add the gif for 5e, and chat posts don’t allow gifs, dammit.]
So we have a memory wiped Anubis, Thor with a hammer that causes sex changes and turns things into beavers, a powerless Eldritch abomination, the Doctor whom hears all of our voices, and a chef who may or may not be Superman.
“If you’re calling someone a garbage person, then for some reason you felt like the previous insults that were available to you weren’t strong enough,” says McCulloch. (Suechting agrees–"a garbage person is so massively awful that, like Cthulhu or the bone structure of Ted Cruz’s face, all one can do is signify the impossibility of describing them,“ he writes.) Run hard enough on the hyperbole treadmill, and you end up with the prenominal "garbage"–and "sewer,” and “dumpster,” and their many related accoutrements.
There is one synonym notably absent from this putrid panoply–the simple, elegant “trash.” This word, it turns out, is largely reserved for “fandom trash,” an active scene on Tumblr that allows refuse-minded verbal maestros to turn the can on themselves. Click around the online fandom sphere for a while, and you might see Lin Manuel-Miranda’s devotees referring to themselves as “Hamilton trash,” or thirsty Star Wars buffs calling Kylo Ren “my trash son.” (In the slightly baffled words of Miranda himself, “The kids, when they like something on the internet, they call themselves the trash of the thing.”)
“It’s kind of like a guilty favorite,” explains McCulloch–"like, I think I’m a little bit too obsessed with this, so I’m going to pre-emptively insult myself about it before anyone else has a chance.“
Lovecraftian Bestiary: Creatures of the Cthulhu Mythos & Our World, S. Petersen, L. Willis/Chaosium, 1999; creators: Miklós Kónya and Noḉmi Vari; 2013 via Lovecraft eZine ; Image should magnify when clicked, but here’s the link just in case