Look, another piece for Resbang!  This time for the amazing and wonderful fic Aduro by BitterNovemberSoul, which is perfect and wonderful and just read it.   I’m so glad I was able to be helpful and volunteer to do this, and I was even more glad I was able to get it done around my traveling and all that other stuff that comes with the holiday season.

Thanks so much to everyone involved for another awesome Resonance Bang!  I know there were some issues, but I think all in all this year went really well considering there were quite a few more people to coordinate than there were last year.  And I’m just super happy I could be a part of it and be able to lend a hand where I was able! 

Happy New Year to all the awesome peeps in the Soul Eater fandom and even those who aren’t in the fandom!  It was a great year, now here’s to hoping for 2015!  Cheers!

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This was basically Whirled’s reaction when I broadcasted this picture on Whirled :3 (Please right-click and “View Image” if you cannot fully see it)

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Researchers Reprogram Tumor’s Cells to Attack Itself

Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found. The findings, published in OncoImmunology, demonstrate a new approach in immunotherapy that can be applied in a variety of cancer types.

“By introducing an attenuated and safe form of the bacteria Listeria monocytogenes (Lm), in collaboration with Aduro Biotech Inc., we found that the attenuated bacteria is taken up by the immunosuppressive cells and transforms them from cells that protect the tumor into cells that attack the tumor,” said Steve Fiering, PhD, lead author of the study.

Tumors protect themselves from attack by the immune system by generating an immunosuppressive microenvironment. The study’s results found that Lm has a significant impact in increasing the amount of pro-inflammatory cytokines and chemokines, and recruiting immune effector cell subsets, that strongly support anti-tumor immunity. Modifying the immunosuppressive tumor microenvironment remains an approach that can be combined with other immune-based treatment to treat other cancers in addition to ovarian cancer.


Funding was provided by Dartmouth Immunobiology of Myeloid and Lymphoid Cells NIH Training Grant 5T32AI007363-22 (P.H.L.); Dartmouth Center of Nanotechnology Excellence NIH 1 U54 CA151662 (S.F.); Center for Molecular, Cellular, and Translational Immunological Research NIGMS 1P30RR032136-01 (S.F.); Norris Cotton Cancer Support Grant P30 CA023108 (S.F.)