The Friedal-Crafts Reaction (Alkylation, Acylation through EAS)

The Friedal-Crafts reactions are a set of reactions used to attach groups to an aromatic ring. Alkylation and acylation can be successfully done through electrophilic aromatic substitution, paying close attention to electron donating and withdrawing groups. 

In alkylation, the product will be more nucleophilic than the reactant due to addition of electron donating groups (alkyl groups) thus multiple alkylations may occur. (Why is alkyl an electron donating group?  Click here to see a previous post about alkyl groups.)

On the other hand, acylation will not occur multiple times because the product is less reactive than the reactants due to the addition of an electron withdrawing group (an acyl group). 

* If the chlorine is not on a tertiary carbon, there is a possibility it will rearrange to form a more stable carbocation. 

Pathway specific targeting in anticancer therapies [7.7]

Pathway specific targeting in anticancer therapies [7.7]

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Pathway specific targeting in anticancer therapies

Larry H. Bernstein, MD, FCAP, Writer and Curator

7.7 Pathway specific targeting in anticancer therapies

7.7.1 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by…

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Today’s experiment is to do a Friedel-Crafts acylation of anisole to determine which isomer of methoxyacetophenone will form. My hypothesis was that the 2’ isomer will form because the H on the second C will be the most deshielded and thus the most easily lost. Comment if you have an alternate hypothesis! I am unable to change mine but other opinions are interesting.
#organicchemistry #collegechem #organicchem #friedel-crafts #acylation #anisol

My latest custom. As you can see, an Alice in Wonderland pony. ^^

She was done for the Christmas Swap in the German forum. My partner loves Alice and she is a big fan of G4 Trixie and Spike. So I had the crazy idea of combining these things.

Pony used to be a Pinkie Pie. I used a new way of painting her. After cleaning, I painted the symbol on in white acylic paint. Then I added the colours bit by bit. She was then rehaired with Mylittlecustom hair in Yellow Fever, Lemonade (?) and Golden Goddess (?) (I’m not sure about the colours right now, will have to check that ^^)
Eyes are sealed with varnish.

I gave the Cheshire cat the colours of Spike. And the Mad Hatter became “The Great and Powerful Trixie”.  I had been wondering about doing the March Hare and the Dormouse as Snips and Snails, but in the end decided against it. ^^


“ The beast looked upon the face of beauty, and beauty stayed his hand. And from that day forward, he was as one dead.”

Sculpture of King Kong looking down at Ann. I really liked this movie! Any movie about an animal’s friendship/love for a human touches me greatly ^^ I was inspired by this scene 

The sculpture was handmade with super sculpey medium polymer clay and painted with acylics. The base has realistic grass and bushes, all made with Woodland Scenics products.