acylation

4

The Friedal-Crafts Reaction (Alkylation, Acylation through EAS)

The Friedal-Crafts reactions are a set of reactions used to attach groups to an aromatic ring. Alkylation and acylation can be successfully done through electrophilic aromatic substitution, paying close attention to electron donating and withdrawing groups. 

In alkylation, the product will be more nucleophilic than the reactant due to addition of electron donating groups (alkyl groups) thus multiple alkylations may occur. (Why is alkyl an electron donating group?  Click here to see a previous post about alkyl groups.)

On the other hand, acylation will not occur multiple times because the product is less reactive than the reactants due to the addition of an electron withdrawing group (an acyl group). 

* If the chlorine is not on a tertiary carbon, there is a possibility it will rearrange to form a more stable carbocation. 

Pathway specific targeting in anticancer therapies [7.7]

Pathway specific targeting in anticancer therapies [7.7]

Pathway specific targeting in anticancer therapies

Larry H. Bernstein, MD, FCAP, Writer and Curator

http://pharmaceuticalintelligence.com/2013/04/09/larryhbern/Pathway_specific_targeting_in_anticancer_therapies

7.7 Pathway specific targeting in anticancer therapies

7.7.1 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by…

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3

Hopeswerke  posted yesterday some rlly nice sketches in the ACEO forum that were for a 3-card Set of the crystal Gems(-Steven) so I just had to make a counterpart with the Homeworld Gems XD

I chose each card to be a counterpart to one of her cards and they are arranged here to match that :D (I drew them in a different order, Peridot, Lapis and then Jasper)

I would’ve preferred Yellow Diamond instead of Lapis, since the latter isn’t rlly part of the group but the tiny Glimpse we’ve gotten of her isn’t enough yet for a reference.

I wanted to make these quick(since I don’t have much free time atm Uu) so I picked Kraftpaper since I have a small stack of it already cut in shape for ACEO, you only see a bit of it in the Jasper card. 

It’s also a nice paper to work with color pencils on.  The white Highlights are done wit Acylic paint though but I have to be careful since the paper is quite thin. (it’s not even bought Kraftpaper but A4 sized envelopes I cut apart)

It was a lot of fun and I’ll probably add more, since these can be done so quickly and are so much fun!

Check out Hopes Set here! :)