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The Friedal-Crafts Reaction (Alkylation, Acylation through EAS)

The Friedal-Crafts reactions are a set of reactions used to attach groups to an aromatic ring. Alkylation and acylation can be successfully done through electrophilic aromatic substitution, paying close attention to electron donating and withdrawing groups. 

In alkylation, the product will be more nucleophilic than the reactant due to addition of electron donating groups (alkyl groups) thus multiple alkylations may occur. (Why is alkyl an electron donating group?  Click here to see a previous post about alkyl groups.)

On the other hand, acylation will not occur multiple times because the product is less reactive than the reactants due to the addition of an electron withdrawing group (an acyl group). 

* If the chlorine is not on a tertiary carbon, there is a possibility it will rearrange to form a more stable carbocation. 

Pathway specific targeting in anticancer therapies [7.7]

Pathway specific targeting in anticancer therapies [7.7]

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Pathway specific targeting in anticancer therapies

Larry H. Bernstein, MD, FCAP, Writer and Curator

7.7 Pathway specific targeting in anticancer therapies

7.7.1 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by…

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“ The beast looked upon the face of beauty, and beauty stayed his hand. And from that day forward, he was as one dead.”

Sculpture of King Kong looking down at Ann. I really liked this movie! Any movie about an animal’s friendship/love for a human touches me greatly ^^ I was inspired by this scene 

The sculpture was handmade with super sculpey medium polymer clay and painted with acylics. The base has realistic grass and bushes, all made with Woodland Scenics products.