Da-Hua

2

“Calves have a dark cape and saddle, with little or no scarring on their body. As Risso’s dolphins age, their coloration lightens from black, dark gray or brown to pale gray or almost white. Their bodies are usually heavily scarred, with scratches from teeth raking between dolphins, as well as circular markings from their prey (e.g., squid), cookie-cutter sharks (Isistius brasiliensis), and lampreys.”
http://www.nmfs.noaa.gov/pr/species/mammals/cetaceans/rissosdolphin.htm

Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer

Publication date: July 2016 Source:Molecular Immunology, Volume 75 Author(s): Yun-Feng Ma, Yi Ren, Cai-Jun Wu, Xiao-Hui Zhao, Hua Xu, Da-Zhou Wu, Jiru Xu, Xiao-Lian Zhang, Yanhong Ji Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon cancer, the most commonly diagnosed cancer in China. Thus, we evaluated whether IL-24 could inhibit the progression of colon cancer in murine models with intact immune competence and explored the mechanisms underlying the immunological effects of IL-24 on colon canc…

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Substitute Princess ep 14

Omg!!

So I loves this episode and as always looking forward to the next one. So I think Da Hua is feeling something for Terry as well during the knife scene I saw her looking at him to and it might have been the music but I think she’s starting to feel something. Also I still see Terry doing “bad things” to keep Da Hua BUT since Guan Jun is going to do bad things next episode then its alright I guess. I hate that they keep interrupting Terry and Da Hua when they’re out together! Also I officially want to kill Da Hua’s father! Fucken son of a bitch who the fucken hell does he think he is betting all that fucken money! How is it that he’s ok with selling his daughter like that! Because that’s what he wants to do! I like how guan jun made that third condition.

Excited to see if Terry finally tells Mr Du that his daughter is dead and what will happen.

P.S. I have always been opposed to da hua and guan jun going out in public. I told you da hua but you wouldn’t listen to me!

Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer

Publication date: July 2016Source:Molecular Immunology, Volume 75
Author(s): Yun-Feng Ma, Yi Ren, Cai-Jun Wu, Xiao-Hui Zhao, Hua Xu, Da-Zhou Wu, Jiru Xu, Xiao-Lian Zhang, Yanhong Ji
Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon cancer, the most commonly diagnosed cancer in China. Thus, we evaluated whether IL-24 could inhibit the progression of colon cancer in murine models with intact immune competence and explored the mechanisms underlying the immunological effects of IL-24 on colon cancer progression in vivo. In these murine models, we found that IL-24 promoted CD4+ T cells and CD8+ T cells to secrete interferon gamma and enhanced the cytotoxicity of CD8+ T cells in vivo. More importantly, we demonstrated that IL-24 transformed the tumor microenvironment and enhanced antitumor effects in favor of tumor eradication. Additionally, IL-24 expression correlated inversely with the clinical stage of human colorectal cancer. Thus, our study establishes a role of IL-24 in promoting antitumor immune responses and supports the development of a novel cytokine immunotherapy against colon cancer.
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Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer

Publication date: July 2016Source:Molecular Immunology, Volume 75
Author(s): Yun-Feng Ma, Yi Ren, Cai-Jun Wu, Xiao-Hui Zhao, Hua Xu, Da-Zhou Wu, Jiru Xu, Xiao-Lian Zhang, Yanhong Ji
Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon cancer, the most commonly diagnosed cancer in China. Thus, we evaluated whether IL-24 could inhibit the progression of colon cancer in murine models with intact immune competence and explored the mechanisms underlying the immunological effects of IL-24 on colon cancer progression in vivo. In these murine models, we found that IL-24 promoted CD4+ T cells and CD8+ T cells to secrete interferon gamma and enhanced the cytotoxicity of CD8+ T cells in vivo. More importantly, we demonstrated that IL-24 transformed the tumor microenvironment and enhanced antitumor effects in favor of tumor eradication. Additionally, IL-24 expression correlated inversely with the clinical stage of human colorectal cancer. Thus, our study establishes a role of IL-24 in promoting antitumor immune responses and supports the development of a novel cytokine immunotherapy against colon cancer.
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Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer

Publication date: July 2016
Source:Molecular Immunology, Volume 75
Author(s): Yun-Feng Ma, Yi Ren, Cai-Jun Wu, Xiao-Hui Zhao, Hua Xu, Da-Zhou Wu, Jiru Xu, Xiao-Lian Zhang, Yanhong Ji
Interleukin-24 (IL-24) is a novel tumor suppressor and can mediate the induction of Th1-type cytokines from peripheral blood mononuclear cells. The individual properties of IL-24 have been previously examined; however, its in vivo immunological consequences and antitumor properties have not been previously evaluated with respect to colon cancer, the most commonly diagnosed cancer in China. Thus, we evaluated whether IL-24 could inhibit the progression of colon cancer in murine models with intact immune competence and explored the mechanisms underlying the immunological effects of IL-24 on colon cancer progression in vivo. In these murine models, we found that IL-24 promoted CD4+ T cells and CD8+ T cells to secrete interferon gamma and enhanced the cytotoxicity of CD8+ T cells in vivo. More importantly, we demonstrated that IL-24 transformed the tumor microenvironment and enhanced antitumor effects in favor of tumor eradication. Additionally, IL-24 expression correlated inversely with the clinical stage of human colorectal cancer. Thus, our study establishes a role of IL-24 in promoting antitumor immune responses and supports the development of a novel cytokine immunotherapy against colon cancer.



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