Rough ER (RER) is involved in some protein production, protein folding, quality control and despatch
Called ‘rough’ because studded with ribosomes
Smooth ER (SER) is associated with the production and metabolism of fats and steroid hormones
Smooth because no ribosomes and is associated with smooth, slippery fats.
Continuous membrane of flattened sacs (cisternae) and network tubules, touching nuclear membrane.
Membrane bound ribosomes firmly attached to the outer cytosolic side of the RER
However these are constantly being bound and released - will only bind when specific protein-nucleic acid complex forms in cytosol
Proteins are made by the ribosomes on the surface of the RER - translation
Then (some) are threaded inside RER to be modified and transported
RER working with membrane bound ribosomes takes polypeptides and amino acids from the cytosol and continues protein assembly including, at an early stage, recognising a ‘destination label’ attached to each of them.
Proteins are produced for the plasma membrane, Golgi apparatus, secretory vesicles, lysosomes, endosomes and the ER.
Some proteins into the lumen (inside) of the RER; others are processed in RER membrane itself
Lumen: some proteins have sugar groups added to form glycoproteins; some have metal groups added
EG: in RER four polypeptide chains are brought together to form haemoglobin.
Protein folding unit lumen of the rough ER: proteins folded to produce biochemical architecture which will provide ‘lock and key’ and other recognition and linking sites.
Protein quality control section
Lumen: incorrectly formed or incorrectly folded proteins rejected.
Rejects stored in the lumen or sent for recycling for eventual breakdown to amino acids.
A form of cystic fibrosis = missing single amino acid, phenylanaline, in a particular position in the protein construction. Quality control section spots the error and rejects, however individual would have been better off with poor product than none at all
From Rough ER to Golgi In most cases proteins are transferred to the Golgi apparatus for ‘finishing’. They are conveyed in vesicles or possibly directly between the ER and Golgi surfaces. After ‘finishing’ they are delivered to specific locations.
Whats anp and ep stand for? I tried googling it but im not sure what to typr?
It’s part of Onno Van Der Harts theory of structural dissociation 😊
ANP = apparently normal part - these are parts with 0 connection to trauma emotionally or hold trauma responses, they often want to “get on” with life for them and for the system
EP = Emotional Parts. They often hold trauma memories and a key to knowing if they’re an EP is also noting if they’re on the fight/flight/freeze spectrum of alertness (if they often run ‘outside’ of your window of tolerance, where as ANP’s will generally stay within the window)