Nolan closed by clarifying the longstanding debate of Batman’s standing at Princeton, thanks to a scene from Batman begins. “The most important thing about Bruce Wayne — yes, he attended Princeton, but he didn’t graduate,” he said to roaring applause. “So as of tomorrow, you are all already better than Batman!”
this is amazing! i had no idea he gave the commencement speech at princeton! this was on monday, june 1, 2015. it’s a terrific speech. love that he talks about how he met emma too <3
You mustn’t be afraid to dream a little bigger, darling.
Christopher Nolan, a director known for bending reality, gave an amazingly reality-based commencement address at Princeton on Monday. I had to read through it twice but I think he was trying to explain what Inception is about. Basically, he advised graduates to live in the present, not in fantasy worlds, and said that dreams are achieved by going out and dealing with reality.
Because his unconventional words relate to Inception, and things Tom has said, I’m posting some of them here. [long post] [random bolding]
- on reality vs. dreams
“In the great tradition of these speeches, generally someone says something along the lines of ‘Chase your dreams,’ but I don’t want to tell you that because I don’t believe that,” Nolan told the students at Class Day. “I don’t want you to chase your dreams. I want you to chase your reality. I want you to understand that you chase your reality not at the expense of your dreams, but as the foundation of your dreams.”
“I feel that over time, we started to view reality as the poor cousin to our dreams, in a sense. … I want to make the case to you that our dreams, our virtual realities, these abstractions that we enjoy and surround ourselves with — they are subsets of reality.”
- on Inception
“The way the end of [Inception] worked, Leonardo DiCaprio’s character Cobb — he was off with his kids, he was in his own subjective reality. He didn’t really care anymore, and that makes a statement: perhaps, all levels of reality are valid. The camera moves over the spinning top just before it appears to be wobbling, it was cut to black.
What do geneticists think will be possible when the the new gene-splicing CRISPR is fully operational on patients?
For those of us unfamiliar, CRISPR is a revolutionary new genetic splicing technology. Gene splicing refers to modifications to a gene transcript that can result in different proteins being made from a single gene. Interestingly, CRISPR’s inception began when dairy scientists discovered that bacteria used to create yogurt (by transforming lactose into lactic acid) had incorporated snippets of benign viruses into its genome. To their surprise, the incorporated DNA would create toxic agents to thwart infective viruses. In 2007, dairy scientists realized that they could effectively fortify bacteria by adding spacer DNA, which does not code for any protein sequence, from a virus. Then, five years later, as Time Magazine writer Alice Park skilfully describes, professors Jennifer Doudna and Emanuelle Charpentier noticed “up to 40% of bacteria developed a particular genetic pattern in their genomes. What they found were sequences of genes immediately followed by the same sequence in reverse, known as palindromic sequences. Further, bits of random DNA bases cropped up after each such pairing and right before the next one. After the dairy bacteria transcribed its spacer DNA and palindromic sequence into RNA, it self-spliced those segments into shorter fragments, with an enzyme called CAS9”. As you may be wondering, CRISPR stands for “clustered regularly interspaced short palindromic repeats”.
It is important for us to emphasize the versatility of this method. In the 2007 article, Doudna and Charpentier go into depth regarding the many benefits of the new genetic technology. These include the potential to “systematically analyze gene functions in mammalian cells, study genomic rearrangements and the progression of cancers or other diseases, and potentially correct genetic mutations responsible for inherited disorders”. As you might imagine, this opens up possibilities that were previously science fiction. Currently, painful blood transfusions are commonplace in the treatment of many diseases such as sickle cell anemia. Sickle cell affects red blood cells, which are made by stem cells in bone marrow. Soon, Massachusetts Institute of Technology synthetic biologist Feng Zhang envisions that this will soon no longer be necessary. She predicts that after doctors extract some of the marrow, scientists will splice out the defective fragment of DNA using CRISPR from the removed stem cells, then bathe the cells in a solution containing the non-sickle-cell sequence. As the DNA repairs itself naturally, it picks up the correct sequence and incorporates it into the stem cell genomes. After this one-time procedure, the stem cells would give rise to more red blood cells with the healthy gene. Eventually, the blood system would be repopulated with normal cells.
The treatment of HIV using CRISPR would be very similar. In this potential treatment, “patients would provide a sample of blood stem cells from their bone marrow, which would be treated with CRISPR to remove the CCR5 gene, and these cells would be transplanted back to the patient. Since the bone marrow stem cells populate the entire blood and immune system, the patient would eventually have blood cells that were protected, or “immunized,” against HIV”.
Despite this extraordinary potential, no biological technology comes without serious ethical concerns. As Jennifer Douda says herself, CRISPR “really requires us to careful thought to how we employ such a tool: What are we trying to do with it, what are the appropriate applications, how can we use it safely?”
Check out her book The Stem Cell Hope for learning about the future of stem cell technology.
Sources: Park, Alice. “A New Gene-Splicing Technique.” 100 New Scientific Discoveries: Fascinating, Unbelievable and Mind-expanding Stories. New York, NY: TIME, 2014. 92-95. Print.
Park, Alice. “It May Be Possible To Prevent HIV Even Without a Vaccine.” Time. Time, 6 Nov. 2014. Web.
Doudna, Jennifer A., and Charpentier, Emmanuelle (2014). The new frontier of genome engineering with CRISPR-Cas9. Science, 346(6213), 1258096–1258096. doi:10.1126/science.1258096
Answered by: Teodora S., Expert Leader and Expert John M.
What's your top 10 favorite movies that you would recommend
i don’t watch a lot of movies but some of them that changed the way i looked at things were 12 years a slave, lagaan, perfume, the breakfast club, the man from earth and rang de basanti and there are other movies that i like like the illusionist, a beautiful mind, phone booth, big hero 6, v for vendetta, black swan and inception. besides these i love movies like legally blonde and mean girls and other movies i watched as a kid.
Official Name: l0nd0ninnit
Birth Name: Rebecca
Average hours of sleep: 4hrs (I blame tumblr and bonkai lol)
The last thing I googled: List of TCA nominees
Nickname(s): Becca and Becs
Birthday: July 21st
Sexual orientation: Heterosexual
Favourite colour: Pink
One place that makes you happy: music festivals
Favourite film: Inception
What am I wearing right now: H&M top and skinny jeans from Topshop
Last book read: Lolita by Vladmir Nabokov
Most used phrase: fuck, fuck it, amazing, wow
First words that come to your mind: Kai, Bonkai,
ascendant, spleen…notice a pattern? lol
Last thing said to your family member: I love
Favourite beverage(s): water and tea (green and peppermint are my faves)
Favourite food: Anything from the continent of Asia.
Last film I watched in the cinema: The Avengers: Age of Ultron
Dream vacation: Switzerland
Dream pet: Wolf
Dream job: music supervisor for television shows
I TAG all of my followers!! No one is left out