Does handling your snakes have anything to do with why they would be hissing? I have ball pythons and there's one who suddenly didn't seem very happy (his hot spot is 89F and his cool side is ~80F) he had eaten about 3-4 days before, was out of his hide. I went to pick him up and he just kinda huffed at me. That's all I can describe it. Does he hate me?
Huffing is super normal! Kabuki likes to grumble at me picking him up too, but once he’s out, he’s usually fine. If you continue to notice them remaining tense, defensive, or stressed, then don’t push him!