Zayn’s always had Louis, and thought he always would. But, when high school starts and that all changes, he’s left with nothing but old memories and a damaged heart. (a growing up AU where Louis’ the boy next door, and Zayn’s hopelessly devoted)
The night feels like it moves quickly, melting away as they all get steadily drunker; Zayn watches the boys eat and laugh and shove each other around and feels suddenly very glad to be with them, incredibly lucky to have all of them to himself. Especially you..
Chorea: purposeless movement of limbs, due to a loss of GABAergic neurons of neostriatum (caudate nucleus and putamen) of indirect pathway.
Personality changes, dementia, tendency for suicide
Fragile X Syndrome
CGG trinucleotid repeat
X dominant, FMR 1
Mental retardation, large ears and jaw. post-pubertal macro-orchidism (males), attention deficit disorder (females)
GAA trinucleotid repeat
Autosomal recessive, Frataxin gene, chromosome 9
Neuronal degeneration: dorsal root ganglia, Clarke column (spinocerebellar tract), posterior column of spinal cord, dentate nucleus, Purkinje cells, Betz neurons, CN nuclei of VII, X, XII
Progressive gait & limb ataxia, arreflexia, hypertrophic cardiomyopathy, axonal sensory neuropathy, kyphoscoliosis, dysarthria, hand clumsiness, loss of sense of position, impaired vibratory sensation.