...or lab mouse

Sometimes i feel like my work environment is the nerdy scientist version of B99

Evidence:

  • My 6’ 7″ coworker Paul who eats an entire 8 serving danish by himself at morning meetings 
  • The lab tech who just spent over an hour telling me about the superior taste of ghee and how to cook with it 
  • My adorable gay supervisor
  • Our intimidating postdoctoral researcher visiting from the UK who won’t say anything about her personal life
  • The time where the lab mouse got lost and they had to tear apart the lab to find it while also pretending like nothing was wrong 
  • My coworker being called down by security because an officer went to write her a parking ticket and they were concerned she had dead bodies in her car (she didn’t)
  • The topless incident in Spain 
  • 5 researchers trying to move a tech out of our head researcher’s house at 2 am because she was supposed to be house sitting for 6 months, but forgot when our boss would be back
  • Lots of puns about sterile procedure

shinyiuxray  asked:

does flug have a lab rat/guinea pig/mouse/ect. ? ? you could always use the kids no im joking dont do that ((also i 4got to say artist ily and you deserve all the love in the world //smorch//))

2

Why does this feel like Molly Hooper’s version of the skull on the mantel? I hope that’s what it is somehow.

(Okay, maybe because I want fandom to start drawing cute taxidermied-skateboarding-mouse comics after Series 4. A GIRL CAN DREAM.)

I guess Kira doesn’t totally trust Rachel…Maybe she’s just using her to find out what is special about her, since her mom just wants to run…but it’s still hard to see her basically choose Rachel over Sarah.

And I’m pretty sure she hurt that mouse (her lab rat/since she’s essentially a lab rat now) or she cut herself to see how she heals. She’s getting creepy again!

youtube

A Lab mouse dreaming about space traveling.

This is a Digital project I did during the school year in Vancouver Film school.
Done in Animate CC.

Enjoy!

Examples of experimental models of human cancer and their use. Modelling human cancer in other organisms allows us to observe and monitor the effect of therapies against the cancer before actually administering it to patients. This is best done in animal models as their biology is most similar to humans’. Non-animal, eukaryotic models are still useful for studying oncogenic processes in pathways that are conserved between the model and humans.

Genetic strategies

Classical transgenic mice use a tissue-specific promoter to drive the expression of an gene. The aim is to express the gene only in a particular tissue, and see if it causes tumours to form. It should also identify driver and passenger mutations. The downfall of this strategy is that oncogenes usually acts to de-differentiate the cell, so that would switch off the promoter that is driving its expression, resulting in a self-inhibitory feedback loop. Classical knockout mice have one or both copies of a gene knocked out in the germline, so all cells have the knockout. This is good for studying sporadic versus familial loss of heterozygosity events, but there is no control over where and when that gene is deactivated.

Inducible systems include the tet on and tet off systems, where tetracycline/doxycyline results in the induction (tet on) or inhibition (tet off) of the transcription of a gene. In tet on, doxycyline binds a transactivator that drives transcription; in its absence, there is no transcription. In tet off, the transactivator binds the locus without doxycycline; in its presence, the transactivator dissociates from the gene.

Cre-lox systems work by recombining DNA across lox sites. Any sequences occurring in between the lox sites are said to be “floxed”, and is removed upon Cre presence.

The ER-Tam system is a switchable system that works on the protein level. Proteins fused with the estrogen recetor (ER) are not functional unless tamoxifen is present. Tamoxifen can be removed to make the protein nonfunctional again.

in vivo models

Mouse models are widely used due to their evolutionary and genetic similarity to humans. Differences do exist, such as telomere length and mutation rate. They can be the recipient of xenografts and their cancers largely resemble human cancers.

Flies and yeast do not get cancer, but instead serve as models for oncogenic pathways. They can be subject to genetic and chemical screens to identify putative driver mutations causing pathway deregulation, and to identify drugs that can combat such mutations.

Culture

Cell cultures are generally not useful for monitoring tumours, because tumours are complex organs made of many cell types, and culture conditions usually maximise prolferation. Organoid culture allows growth of organs in 3D from a patient biopsy. This can be subjected to functional assays, drug screens, and genome editing for truly personalised therapy that is specific to the patient. However, this shares a common downfall with cell culture in that there is no contribution from the tumour microenvironment in a culture.

Further reading:

  • Sharpless, N.E.; DePinho, R.A. 2006. “The mighty mouse: genetically engineered mouse models in cancer drug development.” Nature Reviews Drug Discovery 5 (9):741-754.
  • Vidal, M.; Cagan, R.L. 2006. “Drosophila models for cancer research.” Current Opinion in Genetics & Development 16:10-16.
  • Xu, H.; Tomaszewski, J.M.; McKay, M.J. 2011. “Can corruption of chromosome cohesion create a conduit to cancer?” Nature Reviews Cancer 11 (3):199-210.

As most of you know, when I’m reading a story a lot of the time I relate it to a particular song or piece of music. I decided to make a master post with all the autumn exchange fics I read and their respective songs. Enjoy! Steph xo

* Business & Pleasure by Ashley @justanchorandhope                                        Black Lab - This Night (https://www.youtube.com/watch?v=8cucFfpsqf8)

* Sweet Nothing by Alice @afitzgeraldfic                                                           MS MR - All The Things Lost (https://www.youtube.com/watch?v=hKYGp6Pt2Dw)

* These Days by Nat @stylesprimes                                                                  Dan Auerbach - When The Night Comes (https://www.youtube.com/watch?v=Nz22S17pjdQ) // The Veils - Sun Gangs (https://www.youtube.com/watch?v=TauslIhFh7w)

* Space Oddity by Kath @bioluminescentwriting                                          Patrick Watson - Luscious Life (https://www.youtube.com/watch?v=grnw6K9nVvc)

* Don’t You Play A Song About Love by Essie @alwaysinstylesfics                     The Big Pink - Velvet (https://www.youtube.com/watch?v=0KjZ7ogkWiM)

* Double Vision by Hannah @beggingforfics                                                     Yeah Yeah Yeahs - Hysteric (https://www.youtube.com/watch?v=fqKjIquR5Bc)

* Breathless by Sav @lifesbetterasamermaid                                                       Roo Panes - Indigo Home (https://www.youtube.com/watch?v=V0WDqWlswQ8)

* Treble & Bass by Essie @alwaysinstylesfics                                                   Thomas Newman - Whisper of a Thrill (https://www.youtube.com/watch?v=BGVYI-rvm38)

* My Heart’s For You, It Lies Awake by Em @hurrricanes                                   Pogues - Love You Til the End (https://www.youtube.com/watch?v=4QCPOGptn0U)

* Beers, Booths, & Bisous by Fran @fromherlips                                                Leon Bridges - Smooth Sailin’ (https://www.youtube.com/watch?v=HYplnRjMVhM)

* Don’t Stray by Lissie @actmyageofficial                                                       Metric - Wanderlust (https://www.youtube.com/watch?v=lTHG7f8ob1c)

* Little Green by Kath @bioluminescentwriting                                                 Modest Mouse - Blame It On the Tetons (https://www.youtube.com/watch?v=e1UzPkkuOtU)

* We’ll Be Outlaws by Noelle @inficwetrust                                                  Misstress Barbara - I’m Running (https://www.youtube.com/watch?v=QBOgLEAZbjw)

* Better Than Pumpkin Spice by Allison @littlebird006                                 Freelance Whales - We Could Be Friends (https://www.youtube.com/watch?v=g09WSFuSnF0)

* Turn Up The Light That Keeps Me Awake by Alice @afitzgeraldfic                    Lord Huron - The Night We Met (https://www.youtube.com/watch?v=KtlgYxa6BMU)

* Beautiful Boy by Nicki @inkoasis                                                                       TV on the Radio - Keep Your Heart (https://www.youtube.com/watch?v=16DwZFBQovo)

* High Hopes by Erin @blacklungsblueeyes                                                      Sam Roberts - Words and Fire (https://www.youtube.com/watch?v=-KOnSP7q8z4)

* Letters to the Sky by Nicki @inkoasis                                                     Trespassers William - Fragment (https://www.youtube.com/watch?v=ic9p2JC99Lc)

* Caffeine & Gravity by Dagny @dagnywrites                                            Aqualung - You Turn Me Around (https://www.youtube.com/watch?v=ievTxVRgdHk)

OOC: okay! I know his eye colors can look confusing since I go between traditional and digital. So in short. They’re pink!
However I felt it needed more explanation for anyone who wants to color him correctly.

traditionally, I use these three markers. Very pink and cute!

digitally, i use things in these two general areas on my color pallet. a peachy red or a red pink.

Realistically, his eyes would be icy blue, however, I wanted him to have the look more of a lab mouse or rabbit. So I kept his pink eyes.

TLDR; They are pink, not red

BH6 Catboy/Dogboy AU Headcanons Part 3

Doodle Post 1 - Post 2 - Post 3 - Post 4  - Post 5 -

Headcanons 1 - 2 - 3 - 4 - 5 - 6 -


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so this is either a huge coincidence or foreshadowing for the keen eye fans, but @orphanbeige pointed out percival’s spiny mouse here. it and kemp’s spiny mouse are known for being the only mammals documented to have regenerative healing abilities. i’m 99% sure that the mouse rachel gives to kira is meant to be one of those mice. 

but a grey mouse could be literally any lab mouse, right? not necessarily. rat and mice labs use subjects that have been artificially selected for ideal experimentation traits over multiple generations. there are companies out there that specialize in breeding rats/mice or providing breed-ready rats/mice so labs can have subjects suited for their experiments. the genetically engineered mice stem from the common house mouse though, not either of these mice. but dyad is testing on kira. reliable tests need a control. these two species of mice are the only viable controls known to the scientific community because we know dyad is interested in kira’s (accelerated) regenerative healing.