i find it very cool interesting that the girls all ended up with jobs that aren't what was expected of them.
sasha chose not to use her leadership skills to pursue a career, because she knows how her being a leader feeds into her worst qualities, like being controlling and manipulative. no, instead of "bossing her way through life" she chooses to help people. specifically by giving kids the therapy that and help she so desperately needed when she was a kid.
and marcy, who has always been very intelligent, and was expected by everyone to take a very academic career path instead chose to become an artist. she creates a webcomic because she loves fiction. she pursues something she is incredibly passionate about and not what people (i have to assume including her parents) expect of her.
and anne who didn't know what she wanted to do, and who didn't really have any expectations placed on her... well, she was offered a job by god, declined, and then chose to become a herpetologist. seriously though the fact that she pursued science, and specifically biology, is also something unexpected considering how she was barely passing school, and always chose "the easy path". but she found her passion, and a way to keep her memories of amphibia alive, and she followed that path that she chose for herself.