“Your ambition should be to get as much life out of living as you possibly can – as much enjoyment, as much interest, as much experience, as much understanding. And not to simply be what is generally called a “success”.”

“Never speak of marriage as an achievement. Find ways to make clear to her that marriage is not an achievement, nor is it what she should aspire to. A marriage can be happy or unhappy, but it is not an achievement. We condition girls to aspire to marriage and we do not condition boys to aspire to marriage, and so there is already a terrible imbalance at the start. The girls will grow up to be women preoccupied with marriage. The boys will grow up to be men who are not preoccupied with marriage. The women marry those men. The relationship is automatically uneven because the institution matters more to one than the other.”

“Educate yourself. When a question about a certain topic pops up, google it. Watch movies and documentaries. When something sparks your interest, read about it. Read read read. Study, learn, stimulate your brain. Don’t just rely on the school system, educate that beautiful mind of yours.”

BEYONCÉ KNOWLES CARTER BIGGER, the extended cut from Disney’s The Lion King (2019).

• beta-lactam family 
• Gram-positive bacteria = thick cell walls containing high levels of peptidoglycan
• gram-negative bacteria = thinner cell walls with low levels of peptidoglycan and surrounded by a lipopolysaccharide (LPS) layer that prevents antibiotic entry 
• penicillin is most effective against gram-positive bacteria where DD-transpeptidase activity is highest.

• amoxicillin
• ampicillin
• bacampicillin
• oxacillin
• penicillin

• Penicillin inhibits the bacterial enzyme transpeptidase, responsible for catalysing the final peptidoglycan crosslinking stage of bacterial cell wall synthesis.
• Cells wall is weakened and cells swell as water enters and then burst (lysis)
• Becomes permanently covalently bonded to the enzymes’s active site (irreversible)

• production of beta-lactamase - destroys the beta-lactam ring of penicillin and makes it ineffective (eg Staphylococcus aureus - most are now resistant)
• In response, synthetic penicillin that is resistant to beta-lactamase is in use including egdicloxacillin, oxacillin, nafcillin, and methicillin. 
• Some is resistant to methicillin - methicillin-resistant Staphylococcus aureus (MRSA).  
• Demonstrating blanket resistance to all beta-lactam antibiotics -extremely serious health risk.

“sometime later in my life, when i’ll be in my 30s, i’ll look back to these days and i’ll be so proud i made it out alive. this is the image i keep in mind when tough times come around. i fixate my eyes on the future, my future and i imagine myself as a fully grown adult. now, i don’t know where i’ll end up, what am i going to be doing or who i will become but there is only one detail i care about, and that is if i’ll be there at all.”