The US does not have the cohesiveness to have a general strike. It really doesn't; those can't happen when so much of the working world is isolated from other workers. (The last "general strike" in the US was in 1919 - in Seattle alone. 65,000 workers struck in support of shipyard workers.)
What we can get, is several unions striking at once, and more unions supporting them - refusing to cross picket lines, while otherwise doing their jobs.
Writers' and Actors' strikes can effectively shut down the entertainment industries - there'll be a gap before that's obvious (because studios can still broadcast/stream projects that are complete) but it doesn't take long for them to push into panic mode if they can't do any new production.
A distribution strike, like UPS, can shut down a whole lot of mainstream businesses. The corporate shills will try to talk about the tiny fragment of a percentage of their work that relates to medical emergencies; they will NOT be talking about how much money they're saving using UPS instead of private couriers. They won't be talking about how, if these workers are providing such a necessary and vital service, why aren't they being paid more?
The idea of the United Auto Workers striking fills me with glee, because omg we do. not. need. as many cars as we have; we don't need replacement cars every three or five years; barring weird accidents, almost nobody needs a new car THIS year... but wow a few weeks of shutdown would send car manufacturers into screaming fits because they're conditioned to think that every quarter is supposed to have increased sales based on the previous one. They really don't want to think about "the US has 332 million people and 287 million cars, so, more than 1 car per household, and that's... probably enough? For a while, anyway."
They don't want to think, "Maybe we could reduce production, increase production time, add more safety features, add more safety features for the workers, because HEY THERE ARE ENOUGH CARS; we should be doing maintenance, not growth--"
Nope. So I hope they strike.
- reinstatement of a cost-of-living adjustment (COLA) that was eliminated during the Great Recession
- stronger job security;
- the end of a grow-in (tiered) pay system that has members earning different wages and benefits
- general salary increases - executives got bonuses over the last few years, record profits recorded, etc.