I hope you can forgive me butchering this comic, but there’s a lot of detail in the consistency here and a lot of people in the notes are saying they don’t get it. Here’s all of the panels chronologically, with a brief explanation.
The whole comic takes place in one room.
500,957,406,073 B.C. - The earth is slowly forming over many years.
10,650,010 B.C. - Dinosaurs roamed the earth.
100,097 B.C. - Humans leave hand prints and make art.
1750 - Native Americans have a settlement with tipi tents at this location, implying that this is likely in the Great Plains region.
1850 - A native American man lays in the grass with a hatchet or tomahawk in his hand, presumably dead.
1860 - European livestock is imported to the location.
1860 - A sapling sprouts.
1870 - A farm is established at the location with pigs and chickens. The sapling has grown into a young tree.
1901 - Two men discuss the layout of a home to be built on the location. The sapling is now a fully grown tree and the farm is gone.
1902 - A builder starts constructing the foundation of the home. The tree casts a shadow in the background.
1915 - A person in dancing shoes in the living room says that “life’s a lotta hard work.”
1920 - Someone carries a gramophone into the living room.
1922 - Two women are in the living room, one on the phone.
1929 - A radio in the living room says “right after a work from our sponsor”, someone in the room snarks that “money talks”.
1939 - An argument happens. “Can’t you listen! Don’t you have a brain in your head!”
1944 - A gathering in the living room. There is a picture of cows on the wall.
1945 - A man on a seat says to “skip it”.
1955 - Likely an argument. “Who’s a chicken!”
1956 - A woman twirls her dress.
1957 - A man and a woman, who presumably own the house and have been together since the 1939 new years based on the hair, are in the living room. Their son is born at home and named William. They take care of him.
1959 - William is two years old and playing with a striped ball.
1960 - William watches television. The second panel this year is unclear. A person is either falling or doing a handstand.
1963 - William cries out because of the storm.
1964 - William is told to smile for a picture.
1965 - Another baby is present (William’s little sister), people are trying to get her to speak so they can catch her first words on tape recorder.
1966 - William watches a rocket launch on TV. It is probably the Gemini space program, and may be when astronauts Armstrong and Scott first launched into space and docket two spacecraft while in orbit for the first time.
1967 - William tells his mother that it is 5:30 while she plays the piano.
1968 - William’s sister’s birthday party. She plays Pin The Tail On The Donkey while their mother scolds him for stealing a cookie from the party tray.
1971 - William’s sister, now a teenager, brings someone a drink. She already thought to put ice in it for them. Despite thinking ahead before, she drops it and it shatters. The other person says “it’s only a glass.”
1973 - William’s mom cleans.
1974 - William graduates high-school at 17 years old. His father sets up a curtain and takes a picture of him in his cap and gown in front of it.
1975 - William’s birthday party.
1978 - William looks in the mirror while getting ready. He is listening to music and adjusting his hair.
1983 - William’s mom cleans.
1984 - William is told to smile for a Christmas photo. A child plays with a trainset under the tree.
1985 - William’s father (visibly more bald than him) looks through old photos. There are probably other people with him, but the panel only shows him.
1986 - William’s father wears what appears to be a paper novelty native American headband. William meets a woman at a party.
1987 - William’s father rests on the living room chair.
1988 - A room of people is hushed so they can watch a projector.
1989 - William’s father is looking for the newspaper that is in the living room. His vision may be getting worse with age since he couldn’t see it.
1990 - William’s fahter on a rocking chair asks for the time. The family dog looks out the window.
1993-1996 - William’s mother cleans over the years, revealing the whole phrase she says each time she does it. “The more I clean, the more it gets dirty.”
1997 - William tells his parents where he is in the house.
1999 - The room is empty. A mouse is caught in a mouse trap. A cat walks by.
2000 - A new family moves in. A man brings in boxes.
2027 - William is an older man in a suit. He says, “It’s been 30 years since I’ve seen this place” and the woman who lives there tells him that hes free to look around. Later that year, her husband tells her that the man she knew who used to live there (William) has died in his sleep. She cuts him off, visibly pregant, saying “Honey?“. Given the start of the comic, where William’s mother starts saying the same thing, she is about to enter labor.
2028 - Their child plays with dinosaurs. He plays with a toy model of the exact one that walked where his living room would be.
2029 - A fire occurs in the living room and is put out.
2030 - A baseball is thrown though the window. The house is demolished later that year, and the window is still broken.
2032 - The house is gone. The stump of the tree remains.
2033 - A group of men half-bury a large metal orb. There is later an ensemble band present, surrounding it. Two officiators stand next to it. It could be a memorial, or a time capsule.
I encourage you to reread the original order! There are a lot of details and themes present here.