Neural Stem Cells Wall Chart.
stemcell.comNeural stem cells are capable of self-renewal and can generate neurons, astrocytes and oligodendrocytes. During nervous system development, NSCs within the primitive neural ectoderm give rise to neural progenitors, which rapidly become regionally and temporally specified, first generating large projection neurons and later small interneurons and glia. Small numbers of NSCs persist in the adult brain. They proliferate slowly and produce new neurons throughout life to replenish cells in the hippocampus and olfactory bulb. NSCs and progenitor cells can be isolated from embryonic stem cells, induced pluripotent stem cells, and fetal and adult brain samples. They can be induced to differentiate into neurons and glia in vitro and in vivo. NSCs grown in culture allow in vitro modeling of nervous system development and diseases. NSCs are also under investigation as potential therapeutic agents for neurodegenerative diseases and nervous system injury.
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Methods in Genomic Neuroscience
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable scope are now being routinely solved in neuroscience and many other areas of biomedical research. The results of these studies, in turn, are having, and will continue to have, profound impact on experimental approaches and designs for manipulating genes, the genome, and model organisms as a means of gaining insights into nervous system functioning and complex behavior.Methods in Genomic Neuroscience provides newcomers and experienced researchers with a reference guide for applying powerful, state-of-the-art molecular genetic techniques to the study of neural and behavioral systems. It thereby provides a foundation by which data on gene expression and function may be used to develop new therapeutic strategies for brain diseases. Authored by researchers in the forefront of genomic neuroscience, the book addresses state-of-the-art tools and technologies for global analysis of genes influencing the nervous system and its disorders. An emphasis is placed on massively parallel approaches for analyzing the avalanche of data that is being generated from the full genomic sequence of humans and model systems.
Methods in Genomic Neuroscience Specific topics include human sequence variation, methods for discovering disease vulnerability genes, gene-environmental interaction, gene expression analysis using DNA microarrays, random mutagenesis, gene trap approaches for studying brain development, neural stem cells, gene targeting, and gene delivery.
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems
Complex physiopathological relationships have been proven to exist between two of the body’s most vital organs; the brain and the heart. In Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems Antonio Giordano, Umberto Galderisi and a panel of the most respected authorities in their field offer an in-depth analysis of the differentiation process in two systems that have profound relationships with one another. The text looks at several aspects of the cardiovascular and nervous systems from a new point of view, describing the differences and similarities in their differentiation pathways with an emphasis on the role of cell cycle regulation and cell differentiation. Topics discussed include neurogenesis in the central nervous system, neural stem cells, and the basic-helix-loop-helix transcription factors in neural differentiation. Ground-breaking and authoritative, Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems is a must have for all researchers in cardiovascular medicine and neuroscience and will prompt the scientific community to perceive cell cycle regulation and differentiation under a novel and more comprehensive light.
Cell Cycle Regulation and Differentiation in Cardiovascular and Neural Systems
