“Dear Mr. Anthony van Leeuwenhoek,
Your letter of October 10th has been received here with amusement. Your account of myriad "little animals" seen swimming in rainwater, with the aid of your so-called "microscope," caused the members of the society considerable merriment when read at our most recent meeting. Your novel descriptions of the sundry anatomies and occupations of these invisible creatures led one member to imagine that your "rainwater" might have contained an ample portion of distilled spirits-- imbibed by the investigator. Another member raised a glass of clear water and exclaimed, "Behold, the Africk of Leeuwenhoek." For myself, I withhold judgment as to the sobriety of your observations and the veracity of your instrument. However, a vote having been taken among the members--accompanied I regret to inform you, by considerable giggling--it has been decided not to publish your communication in the Proceedings of this esteemed society... ”
—If you ever get sad about being under-appreciated, just remember that this was the British Royal Society’s initial response to the guy who basically founded the entire field of microbiology.