That’s how Elyn Saks,
law professor and mental health advocate, describes the delusions,
hallucinations, memory loss and mental fragmentation that schizophrenia
The mental disorder affects millions of people worldwide but the cause of its wide-ranging symptoms remains largely unknown.
At Brandeis University, researchers believe they have discovered an
abnormality in the schizophrenic brain that could be responsible for
many of the disease’s symptoms and could provide a drug target for
Led by John Lisman,
the Zalman Abraham Kekst Chair in Neuroscience and professor of
biology, and Matthew Wilson of MIT, the research team published their
findings in a recent issue of the Journal of Biological Psychiatry. The paper was co-authored by Aranda Duan, Carmen Varela, Yuchun Zhang, Yinghua Shen, Lealia Xiong, and Matthew Wilson.
Unusual neural oscillations — brain waves — have long been associated
with schizophrenia. The oscillations, called delta waves, are similar
to slow oscillations seen in normal brains during sleep, but in
schizophrenic brains, they occur during wakefulness. The connection
between these oscillations and schizophrenic symptoms, particularly
cognitive deficits such as memory impairment, has long been unclear.
Lisman and his team set out to understand that connection by
artificially producing delta waves in mammalian brains using a new
technique called optogenetics, which activates brain signals using
When the delta frequency light was turned on, Lisman observed
disruption in the working memory of rats. When it was turned off, the
rodents were once again able to perform working memory tasks. More
important, Lisman and his team were able activate the abnormal
oscillations only in a tiny subpart of the thalamus, a region of the
brain that has long been a focus of schizophrenia research.
An information hub and relay center, the thalamus is central to
working memory, sleep, consciousness and sensory-information processing.
“The oscillations produce an artificial signal that jams normal
communication,” Lisman says. “The part of the thalamus that is supposed
to carry information about working memory couldn’t do the task at all
with these sleep-like delta waves. We suspect the abnormal delta
oscillations seen in patients with schizophrenia are producing a similar
jamming of normal signals.”
(Image caption: The green axons of thalamic neurons can be seen as they innervate the
hippocampus. It is these axons, when stimulated by light, that jam
communication. Credit: Lisman Lab)
Delta waves require a specific type of ion channel called a T-type Ca
channel. These channels are of particular interest because they are one
of the few types of ion channel implicated in schizophrenia by genetic
studies. The next step, Lisman says, is to figure out what kind of
agents could be used to block these channels.
“If you could block these channels, you could block these bad
oscillations,” he says. “That may have therapeutic value in patients.”
[NEWS] 150531 Park Yuchun to enter the army on August 27
Singer-cum-actor Park Yuchun will be joining the military on August 27.
Park Yuchun’s agency C-JeS Entertainment said to OSEN on May 31: “He’s expected to join the army and to serve on August 27″. He will be embarking as the second one [of JYJ] following Kim Jaejoong, since Kim Jaejoong is in the middle of his military service before him.
Park Yuchun is holding his solo fanmeeting ‘Housewarming party : Epi 2′ at Korea University’s Tiger Dome on May 30~31; and is working on filming for movie ‘Lucid Dream’.
Source:OSEN Translated by: rilanna of JYJ3 Shared by:JYJ3
[NEWS] JYJ Park Yoo Chun Confirmed to Enlist in August via Soompi
I teared up while reading the article.. So happy for Shinhwa but at the same time jealous because they were able to protect their name and stay together..I want the same thing to happen to our 5 boys 😢 AKTF
[PIC/OTHER INSTAGRAM] 150526 Park brothers with a baby, back when Yuhwan was filming ‘A Thousand Days’ Promise’
[PHOTO] #백상예술대상 시청중. 영화#해무 로 #박유천 씨가 #신인상 받으셨네용. 축하드려요. #석한별 이 #천일의약속 에서 #수애 언니랑 #김래원 오빠의 딸로 나오면서 #박유환 조카로도 나왔었는데 그때 동생 응원을 위해 #SBS 로 피자사들고 놀러온 #믹키유천 씨 품에 안겨서도 사진찍고 #이샛별 엄마는 피자먹느라 바쁘고 ㅋㅋ 이때가 3년전인가.. 두분다 많이 멋있어 지셨고, 우리한별이도 많이컸네♡ instagram.com/p/3JT9YnFMPQ
[TRANS] In the middle of watching the #BaeksangArtsAwards. #ParkYuchun -ssi got the #[Best]NewcomerAward with movie #SeaFog. Congratulations. #SukHanbyul was coming on as #KimRae-Won oppa’s daughter with #SooAe unnie and had also came on as #ParkYuhwan ‘s niece in #AThousandDays’Promise. She was taken in the photo where she’s even enfolded in the arms of #Micky Yuchun-ssi who visited bringing pizza carryout into #SBS to support his little brother back then
#LeeSaesbyul -umma was busy eating the pizza ㅋㅋ This was 3 years ago.. […]
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Source:star860424 Translated by: rilanna of JYJ3 Additional gif credit: as tagged Shared by:JYJ3