Research Focus: Viral replication

The protein ICP8 (infected cell protein 8) of Herpes Simplex Virus 1 (HSV-1) has a vital role in viral replication, being involved in DNA replication, recombination, and repair. To determine the structure of ICP8 when bound to single stranded DNA, researchers used a method called single particle reconstruction, which uses specialized software to generate a 3D structure from the 2D electron microscopy images. The reconstructed structure of ICP8 (blue) shows that it is comprised of two nine-subunit rings that are stacked on top of each other and illustrates a hypothesized mechanism joining two single DNA strands (red lines) to form a double helix. One of the original electron microcopy images used for single particle reconstruction can be seen in the background. The NIH National Cancer Institute, National Institute of General Medical Sciences, and National Institute of Environmental Health Sciences provided support for this research.

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Gökhan Tolun1,2, Alexander M. Makhov1,3, Steven J. Ludtke4, and Jack D. Griffith1*

1University of North Carolina at Chapel Hill, Chapel Hill, NC
2National Institutes of Health, Bethesda, MD
3University of Pittsburgh School of Medicine, Pittsburgh, PA
4Baylor College of Medicine, Houston, TX

wrenchwiitch said:

fantine and cosette going on walks in the neighborhood and cosette needing to pet every. dog. every single dog all of the dogs will be petted by cosette and fantine has accepted it and soon all the dogs know cosette and they all love her (may or may not be based off my own childhood experiences w/ neighborhood dogs)

yES. GOOD and fantine is terribly allergic to dogs so they can’t get one of their own but cosette just loves them so much so one day when they’re going to valjean’s he warns fantine to stay back a few feet and then he opens the door and this lil golden retriever baby with a ribbon around its neck comes bo uncing out to meet cosette and lick her all over her beaming lil face and the pup stays at valjean’s but cosette can visit it whenever she wants and she takes it on walks to meet the other neighborhood dogs too o mgmgmg

UNC Chapel Hill is a school which has received a lot of recent criticism over handling of sexual assault cases, to put it mildly. In this Jezebel article they discuss how the former dean of students was told to underreport cases of sexual violence. It’s been a messy and incredibly victim blaming situation, which has resulted in students filing against the Dept of Education. The girl Andrea, quoted in both of these articles is both a survivor and a friend of mine. She is utterly remarkable and so brave and resillient despite the stuff she has faced from administrators. Another mentioned, Landen Gambill, has been told that she has violated the honour code of the school for creating an ‘intimidating environment’ for her rapist, despite the fact she has NEVER identified him by name. She asked if, by being raped, she had violated the honour code and they said yes. They said YES. I am basically shaking as I’m writing this and we need your help because this is not just a problem here, and this same stuff is probably happening across college campuses. Please, please share this, send the message out that NO ONE should ever be punished for their rape or treated the way these, and other women have been. Please help us bring some attention to this. We need you. 

Twitter

update Jezebel has reported on this! and huff post!

#STANDWITHLANDEN

Update: Andrea speaks out

I still deal with the physical and detrimental mental effects of my rape, and they haunt me daily,
But nothing has scarred me more that hearing how my University, whose seal I wear proudly around my neck, has purposely silenced the voices of my fellow survivors.

I feel unsafe at UNC, because I have felt the screams trapped in my throat, and I have heard the stories of survivors. I have heard the stories of survivors who reported, who asked for help, who went through the process, and who lost - their stories are just like mine.

I have listened to, and relived these stories because no one else wants to believe it happens here.

It’s destroying me, because, in spite of the betrayal and the blood shed, Carolina is still in my mind.

After years, months, and hours of writing our stories, reliving our nightmares, and speaking out, our University chooses to maintain that silence. They will only respond to a complaint, they will only deny underreporting numbers, and are determined to fight us down.

But, we did not survive an attack on our lives to let the school we love mark us and ignore us.
We did not survive sexual assault to let this University shame us away.
Not without a fight.

thank you so so much to you who have helped spread the word, please tweet #standwithlanden!

THE PROCESS OF WRITING A FINAL PAPER

1. Read the prompt

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2. Decide you’d rather be doing anything else in the world besides writing your paper

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3. Hours later, reluctantly start the paper

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4. But then somehow get sucked into binge watching Netflix

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5. Panic because you’ve now wasted hours and written less than a paragraph

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6. Decide to get super focused on finishing your paper

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7. Realize what you wrote was crap and start all over

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8. Run out of ideas to write but still have pages to go to reach the minimum word count so…

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9. Continue to BS until you reach a conclusion, even if it doesn’t make any sense. Because hey, at least you finished right?

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youtube

Kevin Kantor - “Honest Confessions on Letting Go” (CUPSI 2014)

"You were afraid of the monster in your closet, and I was afraid it had already climbed into bed with us."

Performing for University of Northern Colorado at the 2014 College Unions Poetry Slam Invitational.

4

If anyone in the Chapel Hill, NC area wants a kitten, these five still need homes. We have a couple people interested in the calico runt, but the others (especially the black kitten, who is the sweetest  and cuddliest of them all) still need placement! If you aren’t right in Chapel Hill, we can drive out to meet you.

The kittens get along with other cats and dogs, provided that the dog/cat isn’t aggressive to them. Please send me or Ash a message if you’re interested.

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