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From the Theodore Roosevelt Conservation Partnership and Bass Pro Shops, watch as Steve describes the importance of preserving our swamp and wetlands areas to protect the sporting way of life in this week’s Conservation Field Notes.

Last minute edits with Senior Producer, Walter Ray Watson (far left) #MorningEdition’s host David Greene (left) #NPR’s Special Correspondent Michele Norris (middle) and Morning Edition Editor Arnie Seipel (right) getting ready to tape the next @theracecardproject segment about food traditions!

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Degradation of Tiam1 by Casein Kinase 1 and the SCFβTrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K signaling.

Degradation of Tiam1 by Casein Kinase 1 and the SCFβTrCP Ubiquitin Ligase Controls the Duration of mTOR-S6K signaling.

J Biol Chem. 2014 Aug 14;

Authors: Magliozzi R, Kim J, Low TY, Heck AJ, Guardavaccaro D

Abstract
T-cell lymphoma invasion and metastasis 1 (Tiam1) is a guanine nucleotide exchange factor that specifically controls the activity of the small GTPase Rac, a key regulator of cell adhesion, proliferation and survival. Here, we report that in response to mitogens, Tiam1 is degraded by the ubiquitin-proteasome system via the SCFbetaTrCP ubiquitin ligase. Mitogenic stimulation triggers the binding of Tiam1 to the F-box protein betaTrCP via its degron sequence and subsequent Tiam1 ubiquitylation and proteasomal degradation. The proteolysis of Tiam1 is prevented by betaTrCP silencing, inhibition of CK1 and MEK, or mutation of the Tiam1 degron site. Expression of a stable Tiam1 mutant that is unable to interact with betaTrCP results in sustained activation of the mTOR/S6K signaling and increased apoptotic cell death. We propose that the SCFbetaTrCP-mediated degradation of Tiam1 controls the duration of the mTOR-S6K signaling pathway in response to mitogenic stimuli.

PMID: 25124033 [PubMed - as supplied by publisher]



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Are you having a meaningful summer? A CALL FOR VOLUNTEERS

Are you having a meaningful summer? A CALL FOR VOLUNTEERS

TRCP is looking for people who can serve for free in maintaining the project’s database.  No experience needed (we’ll train you!).  Contact the TRCP coordinator, Mr. Henry G. Calilung, at 0943-310-8290 or email hgc.hedcen@gmail.com if you’re interested.

Don’t waste these summer hours.  Do something that will make you a better person for a better earth.

PS Except for the one time training…

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In 3…2…1!

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In this week’s Conservation Field Notes from the Theodore Roosevelt Conservation Partnership and Bass Pro Shops, Steve explains how climate change will impact the futures of sportsmen and women. 

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